O81077
PR
Gene name |
CYP707A2 (At2g29090, T9I4.17) |
Protein name |
Abscisic acid 8'-hydroxylase 2 |
Names |
ABA 8'-hydroxylase 2, Cytochrome P450 707A2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G29090 |
EC number |
1.14.14.137: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O81077
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O81077-F1 | Predicted | AlphaFoldDB |
51 variants for O81077
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_2_12499061_G_A | 7 | S>L | No | 1000Genomes | |
| tmp_2_12499062_A_G | 7 | S>P | No | 1000Genomes | |
| ENSVATH01921834 | 8 | S>Y | No | 1000Genomes | |
| ENSVATH05621705 | 21 | A>G | No | 1000Genomes | |
| ENSVATH13462828 | 28 | V>A | No | 1000Genomes | |
| tmp_2_12498987_C_T | 32 | V>I | No | 1000Genomes | |
| ENSVATH13462826 | 46 | R>I | No | 1000Genomes | |
| ENSVATH13462825 | 47 | L>I | No | 1000Genomes | |
| tmp_2_12498921_T_A | 54 | M>L | No | 1000Genomes | |
| ENSVATH01921832 | 56 | L>M | No | 1000Genomes | |
| tmp_2_12498845_T_G | 79 | N>T | No | 1000Genomes | |
| ENSVATH13462772 | 81 | Y>N | No | 1000Genomes | |
| ENSVATH05621695 | 83 | D>N | No | 1000Genomes | |
| ENSVATH13462770 | 95 | V>L | No | 1000Genomes | |
| ENSVATH13462768 | 128 | P>Q | No | 1000Genomes | |
| ENSVATH14568021 | 129 | E>K | No | 1000Genomes | |
| ENSVATH00253366 | 157 | P>L | No | 1000Genomes | |
| ENSVATH00253365 | 159 | V>I | No | 1000Genomes | |
| tmp_2_12498225_G_A | 161 | H>Y | No | 1000Genomes | |
| ENSVATH05621692 | 178 | S>F | No | 1000Genomes | |
| tmp_2_12497725_G_A | 196 | S>L | No | 1000Genomes | |
| ENSVATH13462739 | 208 | D>E | No | 1000Genomes | |
| ENSVATH05621679 | 214 | Y>C | No | 1000Genomes | |
| ENSVATH05621678 | 216 | R>H | No | 1000Genomes | |
| ENSVATH05621677 | 224 | M>I | No | 1000Genomes | |
| ENSVATH05621675 | 227 | D>G | No | 1000Genomes | |
| ENSVATH13462738 | 230 | G>C | No | 1000Genomes | |
| ENSVATH13462718 | 241 | I>R | No | 1000Genomes | |
| tmp_2_12497189_C_T | 242 | E>K | No | 1000Genomes | |
| ENSVATH13462717 | 253 | K>N | No | 1000Genomes | |
| ENSVATH05621668 | 276 | R>H | No | 1000Genomes | |
| ENSVATH05621667 | 277 | N>I | No | 1000Genomes | |
| ENSVATH13462715 | 280 | S>I | No | 1000Genomes | |
| tmp_2_12496981_T_G | 311 | H>P | No | 1000Genomes | |
| tmp_2_12496967_G_T | 316 | L>I | No | 1000Genomes | |
| ENSVATH13462705 | 325 | F>V | No | 1000Genomes | |
| ENSVATH05621662 | 326 | S>C | No | 1000Genomes | |
| tmp_2_12496539_T_C | 332 | K>R | No | 1000Genomes | |
| tmp_2_12496522_T_A | 338 | I>F | No | 1000Genomes | |
| tmp_2_12496503_C_T | 344 | R>K | No | 1000Genomes | |
| ENSVATH05621661 | 347 | P>A | No | 1000Genomes | |
| ENSVATH13462704 | 350 | T>S | No | 1000Genomes | |
| tmp_2_12496234_C_G | 399 | E>Q | No | 1000Genomes | |
| ENSVATH13462700 | 404 | P>S | No | 1000Genomes | |
| ENSVATH05621655 | 408 | D>E | No | 1000Genomes | |
| ENSVATH13462689 | 441 | M>I | No | 1000Genomes | |
| ENSVATH13462688 | 442 | L>F | No | 1000Genomes | |
| ENSVATH01921796 | 459 | D>Y | No | 1000Genomes | |
| ENSVATH05621639 | 472 | K>N | No | 1000Genomes | |
| tmp_2_12495052_C_T | 479 | V>I | No | 1000Genomes | |
| tmp_2_12495045_G_C | 481 | P>R | No | 1000Genomes |
No associated diseases with O81077
1 regional properties for O81077
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 424 - 433 | IPR017972 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.14.137 | With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| (+)-abscisic acid 8'-hydroxylase activity | Catalysis of the reaction: (+)-abscisate + H(+) + NADPH + O(2) = (+)-8'-hydroxyabscisate + H(2)O + NADP(+). |
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| iron ion binding | Binding to an iron (Fe) ion. |
| monooxygenase activity | Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. |
| oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| abscisic acid catabolic process | The chemical reactions and pathways resulting in the breakdown of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. |
| abscisic acid metabolic process | The chemical reactions and pathways involving abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. |
| release of seed from dormancy | The process in which the dormant state is broken in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated upon release. |
| response to red light | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. |
| response to red or far red light | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. |
| sterol metabolic process | The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
38 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9VYQ5 | Cyp318a1 | Probable cytochrome P450 318a1 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VXY0 | Cyp4s3 | Probable cytochrome P450 4s3 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VMS7 | Cyp4ac3 | Probable cytochrome P450 4ac3 | Drosophila melanogaster (Fruit fly) | PR |
| Q9V559 | Cyp4p3 | Probable cytochrome P450 4p3 | Drosophila melanogaster (Fruit fly) | PR |
| Q9V7G5 | Cyp4aa1 | Probable cytochrome P450 4aa1 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VMS8 | Cyp4ac2 | Probable cytochrome P450 4ac2 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VVN6 | Cyp312a1 | Probable cytochrome P450 312a1 | Drosophila melanogaster (Fruit fly) | PR |
| Q02928 | CYP4A11 | Cytochrome P450 4A11 | Homo sapiens (Human) | PR |
| Q86W10 | CYP4Z1 | Cytochrome P450 4Z1 | Homo sapiens (Human) | PR |
| Q5TCH4 | CYP4A22 | Cytochrome P450 4A22 | Homo sapiens (Human) | PR |
| P13584 | CYP4B1 | Cytochrome P450 4B1 | Homo sapiens (Human) | PR |
| Q6ZWL3 | CYP4V2 | Cytochrome P450 4V2 | Homo sapiens (Human) | PR |
| B6SSW8 | CYP714B3 | Cytochrome P450 714B3 | Zea mays (Maize) | PR |
| O35728 | Cyp4a14 | Cytochrome P450 4A14 | Mus musculus (Mouse) | PR |
| Q91WL5 | Cyp4a12a | Cytochrome P450 4A12A | Mus musculus (Mouse) | PR |
| Q9GJX5 | CYP4A21 | Taurochenodeoxycholic 6 alpha-hydroxylase | Sus scrofa (Pig) | PR |
| Q8SPK1 | CYP4A24 | Cytochrome P450 4A24 | Sus scrofa (Pig) | PR |
| P24464 | Cyp4a12 | Cytochrome P450 4A12 | Rattus norvegicus (Rat) | PR |
| P20816 | Cyp4a2 | Cytochrome P450 4A2 | Rattus norvegicus (Rat) | PR |
| G3V7X8 | Cyp26b1 | Cytochrome P450 26B1 | Rattus norvegicus (Rat) | PR |
| Q05JG2 | CYP707A5 | Abscisic acid 8'-hydroxylase 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q0DS59 | CYP714B2 | Cytochrome P450 714B2 | Oryza sativa subsp japonica (Rice) | PR |
| Q6F4F5 | CYP724B1 | Cytochrome P450 724B1 | Oryza sativa subsp japonica (Rice) | PR |
| Q5KQH7 | CYP714D1 | Cytochrome P450 714D1 | Oryza sativa subsp japonica (Rice) | PR |
| Q9SHG5 | CYP72C1 | Cytochrome P450 72C1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C788 | CYP704B1 | Cytochrome P450 704B1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZUX1 | CYP94C1 | Cytochrome P450 94C1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUC9 | CYP72A11 | Cytochrome P450 72A11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUC8 | CYP72A13 | Cytochrome P450 72A13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUC6 | CYP72A14 | Cytochrome P450 72A14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUC5 | CYP72A15 | Cytochrome P450 72A15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6TBX7 | CYP97C1 | Carotene epsilon-monooxygenase, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64697 | CYP710A1 | Cytochrome P450 710A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64698 | CYP710A2 | Cytochrome P450 710A2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94IA6 | CYP90D1 | 3-epi-6-deoxocathasterone 23-monooxygenase CYP90D1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SAA9 | CYP51G1 | Sterol 14-demethylase | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96242 | CYP74A | Allene oxide synthase, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6EIG3 | cyp26b1 | Cytochrome P450 26B1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQISSSSSSN | FFSSLYADEP | ALITLTIVVV | VVVLLFKWWL | HWKEQRLRLP | PGSMGLPYIG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ETLRLYTENP | NSFFATRQNK | YGDIFKTHIL | GCPCVMISSP | EAARMVLVSK | AHLFKPTYPP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SKERMIGPEA | LFFHQGPYHS | TLKRLVQSSF | MPSALRPTVS | HIELLVLQTL | SSWTSQKSIN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TLEYMKRYAF | DVAIMSAFGD | KEEPTTIDVI | KLLYQRLERG | YNSMPLDLPG | TLFHKSMKAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IELSEELRKV | IEKRRENGRE | EGGLLGVLLG | AKDQKRNGLS | DSQIADNIIG | VIFAATDTTA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SVLTWLLKYL | HDHPNLLQEV | SREQFSIRQK | IKKENRRISW | EDTRKMPLTT | RVIQETLRAA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SVLSFTFREA | VQDVEYDGYL | IPKGWKVLPL | FRRIHHSSEF | FPDPEKFDPS | RFEVAPKPYT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YMPFGNGVHS | CPGSELAKLE | MLILLHHLTT | SFRWEVIGDE | EGIQYGPFPV | PKKGLPIRVT |
| PI |