Q9SAA9
PR
Gene name |
CYP51G1 (CYP51A2, EMB1738, At1g11680, F25C20.17) |
Protein name |
Sterol 14-demethylase |
Names |
Cytochrome P450 51A2, Cytochrome P450 51G1, AtCYP51, Obtusifoliol 14-demethylase, Protein EMBRYO DEFECTIVE 1738 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G11680 |
EC number |
1.14.14.154: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SAA9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SAA9-F1 | Predicted | AlphaFoldDB |
19 variants for Q9SAA9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04560145 | 6 | E>A | No | 1000Genomes | |
| ENSVATH04560145 | 6 | E>V | No | 1000Genomes | |
| ENSVATH04560146 | 13 | G>S | No | 1000Genomes | |
| ENSVATH00018262 | 21 | V>I | No | 1000Genomes | |
| tmp_1_3939006_T_C | 28 | S>P | No | 1000Genomes | |
| tmp_1_3939057_G_T | 45 | A>S | No | 1000Genomes | |
| ENSVATH11002100 | 57 | L>V | No | 1000Genomes | |
| ENSVATH04560149 | 62 | I>V | No | 1000Genomes | |
| tmp_1_3939113_G_A | 63 | M>I | No | 1000Genomes | |
| tmp_1_3939173_G_T | 83 | K>N | No | 1000Genomes | |
| tmp_1_3939187_T_C | 88 | I>T | No | 1000Genomes | |
| tmp_1_3939662_T_G | 182 | L>V | No | 1000Genomes | |
| tmp_1_3939707_C_A | 197 | L>I | No | 1000Genomes | |
| ENSVATH11002101 | 229 | R>C | No | 1000Genomes | |
| ENSVATH00018265 | 310 | Y>F | No | 1000Genomes | |
| tmp_1_3940086_C_T | 323 | A>V | No | 1000Genomes | |
| tmp_1_3940142_C_A | 342 | R>S | No | 1000Genomes | |
| ENSVATH11002103 | 409 | S>T | No | 1000Genomes | |
| tmp_1_3940370_G_A | 418 | A>T | No | 1000Genomes |
No associated diseases with Q9SAA9
1 regional properties for Q9SAA9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 426 - 435 | IPR017972 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.14.154 | With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| iron ion binding | Binding to an iron (Fe) ion. |
| methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. |
| monooxygenase activity | Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. |
| oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
| sterol 14-demethylase activity | Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| methylation | The process in which a methyl group is covalently attached to a molecule. |
| sterol biosynthetic process | The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
| sterol metabolic process | The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P22680 | CYP7A1 | Cytochrome P450 7A1 | Homo sapiens (Human) | PR |
| P18125 | Cyp7a1 | Cytochrome P450 7A1 | Rattus norvegicus (Rat) | PR |
| O81077 | CYP707A2 | Abscisic acid 8'-hydroxylase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64698 | CYP710A2 | Cytochrome P450 710A2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64697 | CYP710A1 | Cytochrome P450 710A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94IA6 | CYP90D1 | 3-epi-6-deoxocathasterone 23-monooxygenase CYP90D1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96242 | CYP74A | Allene oxide synthase, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELDSENKLL | KTGLVIVATL | VIAKLIFSFF | TSDSKKKRLP | PTLKAWPPLV | GSLIKFLKGP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IIMLREEYPK | LGSVFTVNLV | HKKITFLIGP | EVSAHFFKAS | ESDLSQQEVY | QFNVPTFGPG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VVFDVDYSVR | QEQFRFFTEA | LRVNKLKGYV | DMMVTEAEDY | FSKWGESGEV | DIKVELERLI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ILTASRCLLG | REVRDQLFDD | VSALFHDLDN | GMLPISVLFP | YLPIPAHRRR | DRAREKLSEI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FAKIIGSRKR | SGKTENDMLQ | CFIESKYKDG | RQTTESEVTG | LLIAALFAGQ | HTSSITSTWT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GAYLMRYKEY | FSAALDEQKN | LIAKHGDKID | HDILSEMDVL | YRCIKEALRL | HPPLIMLMRA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SHSDFSVTAR | DGKTYDIPKG | HIVATSPAFA | NRLPHIFKDP | DTYDPERFSP | GREEDKAAGA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FSYIAFGGGR | HGCLGEPFAY | LQIKAIWSHL | LRNFELELVS | PFPEIDWNAM | VVGVKGNVMV |
| RYKRRQLS |