AiPD: Autoinhibited Protein Database

P22680

Gene name	CYP7A1
Protein name	Cytochrome P450 7A1
Names	24-hydroxycholesterol 7-alpha-hydroxylase, CYPVII, Cholesterol 7-alpha-hydroxylase, Cholesterol 7-alpha-monooxygenase
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1581
EC number	1.14.14.23: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

115-189 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

115-189 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for P22680

Entry ID	Method	Resolution	Chain	Position	Source
3DAX	X-ray	215 A	A/B	25-503	PDB
3SN5	X-ray	275 A	A/B	25-503	PDB
3V8D	X-ray	190 A	A/B	25-503	PDB
AF-P22680-F1	Predicted				AlphaFoldDB

437 variants for P22680

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV002535386 RCV000734630 CA177300274 rs922546527	108	A>T	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar dbSNP gnomAD
CA4756655 RCV002535146 RCV000730188 rs539485428	364	R>Q	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA4756914 rs763096344	4	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs763096344 CA371298657	4	T>K		No	ClinGen ExAC TOPMed gnomAD
CA371298616 rs1459584618	5	S>C		No	ClinGen TOPMed
RCV000733746 CA4756912 rs528066345	9	G>R		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs771917069 CA4756909	10	I>V		No	ClinGen ExAC TOPMed
rs745519772 CA4756908	11	A>V		No	ClinGen ExAC gnomAD
CA4756907 rs778544430	13	A>T		No	ClinGen ExAC gnomAD
rs147162838 CA4756906 RCV000593135	13	A>V		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1014526226 CA177300750	15	C>R		No	ClinGen TOPMed
CA371298425 rs1480684850	16	C>S		No	ClinGen TOPMed
rs748850568 CA4756905	16	C>Y		No	ClinGen ExAC gnomAD
CA371298389 rs1350022744	17	C>S		No	ClinGen TOPMed gnomAD
rs1350022744 CA371298391	17	C>Y		No	ClinGen TOPMed gnomAD
rs778099251 CA4756904	18	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel CA371298365 rs1180280041	19	W>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
CA4756902 rs200846540	27	R>M		No	ClinGen 1000Genomes ExAC gnomAD
rs752006313 CA4756881	28	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA4756880 rs780606427	29	T>M		No	ClinGen ExAC TOPMed gnomAD
CA371297086 rs780606427	29	T>R		No	ClinGen ExAC TOPMed gnomAD
rs754562223 CA4756877	30	G>S		No	ClinGen ExAC TOPMed gnomAD
CA4756876 rs761807364	32	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1367645025 CA371297052	33	P>S		No	ClinGen gnomAD
rs1434830576 CA371297037	34	L>P		No	ClinGen gnomAD
rs1295805340 CA371297040	34	L>V		No	ClinGen gnomAD
RCV000338265 rs138113674 CA4756875	36	N>K		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA4756874 rs767467704	40	P>S		No	ClinGen ExAC gnomAD
rs1356970363 CA371296955	41	Y>H		No	ClinGen gnomAD
rs1429939198 CA371296942	42	L>V		No	ClinGen gnomAD
rs1554558878 RCV000598476 COSM454710 CA371296906	45	A>S	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ClinVar Ensembl NCI-TCGA dbSNP
CA371296886 rs1216827686	47	Q>*		No	ClinGen TOPMed
CA371296873 rs1345898355	48	F>V		No	ClinGen TOPMed
rs180916341 CA4756869	49	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4756870 COSM1100722 rs762648850	49	G>S	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA371296853 rs180916341	49	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	50	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371296807 rs1256765959	52	P>R		No	ClinGen gnomAD
rs189424028 CA4756868 RCV000727970	53	L>F		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA4756866 rs148278254	54	E>D		No	ClinGen ESP ExAC gnomAD
CA4756867 rs747673005	54	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA177300481 rs969443490	57	R>G		No	ClinGen TOPMed
rs769256926 CA4756865	58	A>V		No	ClinGen ExAC gnomAD
CA4756864 rs747570322	60	Q>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	62	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4756863 rs780453940	63	H>N		No	ClinGen ExAC gnomAD
CA177300475 rs113258453	63	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1476565097 CA371296544	63	H>R		No	ClinGen TOPMed
rs1563484926 RCV000731655 CA371296506	64	G>D		No	ClinGen ClinVar Ensembl dbSNP
rs750595419 CA371296495	65	H>D		No	ClinGen ExAC gnomAD
rs750595419 CA4756861	65	H>Y		No	ClinGen ExAC gnomAD
rs1467207833 CA371296445	67	F>S		No	ClinGen TOPMed
rs143198855 CA177300471	68	T>I		No	ClinGen ESP TOPMed
RCV000593605 rs1554558853 CA371296390	69	C>F		No	ClinGen ClinVar Ensembl dbSNP
CA371296280 rs753952585	73	G>E		No	ClinGen ExAC TOPMed gnomAD
rs753952585 CA4756858	73	G>V		No	ClinGen ExAC TOPMed gnomAD
rs377254635 CA4756857	75	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA177300467 rs377254635	75	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA371296216 rs1428867550	76	V>I		No	ClinGen TOPMed gnomAD
rs751553125 CA4756855	77	H>L		No	ClinGen ExAC TOPMed gnomAD
CA177300465 rs751553125	77	H>R		No	ClinGen ExAC TOPMed gnomAD
CA4756854 rs766189113	78	F>I		No	ClinGen ExAC gnomAD
rs762661210 CA4756853	79	I>V		No	ClinGen ExAC gnomAD
TCGA novel	82	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371296024 rs1249881963	84	S>P		No	ClinGen gnomAD
rs545869846 CA4756850	85	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs545869846 CA371295992	85	Y>F		No	ClinGen 1000Genomes ExAC gnomAD
rs62621283 CA4756849 VAR_059152 RCV000963911	86	H>N		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA177300459 rs62621283	86	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1267555538 CA371295953	87	K>E		No	ClinGen TOPMed gnomAD
CA177300456 rs1026092643	90	C>*		No	ClinGen Ensembl
rs267601959 CA177300453	92	G>E		No	ClinGen Ensembl
CA4756846 rs775869319	92	G>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	94	Y>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772428979 CA4756845	96	D>A		No	ClinGen ExAC TOPMed
rs772428979 CA177300450	96	D>G		No	ClinGen ExAC TOPMed
rs753399056 CA371295645	96	D>H		No	ClinGen gnomAD
rs753399056 CA177300452	96	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4756842 rs757436505	99	K>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	99	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4756843 rs757436505	99	K>T		No	ClinGen ExAC TOPMed gnomAD
rs200836103 CA4756839	100	F>C		No	ClinGen 1000Genomes ExAC gnomAD
CA4756840 rs777813512	100	F>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
VAR_001259	100	F>S		No	UniProt
CA177300444 rs899803163	104	T>S		No	ClinGen TOPMed gnomAD
rs766241318 CA4756837	105	S>A		No	ClinGen ExAC gnomAD
CA371295291 rs1181579739	105	S>C		No	ClinGen gnomAD
rs750214616 CA4756836 RCV000731926	106	A>E		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs750214616 CA4756835	106	A>V		No	ClinGen ExAC TOPMed gnomAD
CA4756832 rs535484729	107	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761546326 CA4756833	107	K>T		No	ClinGen ExAC gnomAD
CA371295031 rs922546527	108	A>S		No	ClinGen gnomAD
CA177300272 rs976616207	108	A>V		No	ClinGen Ensembl
rs1369817379 CA371294972	111	H>Q		No	ClinGen gnomAD
CA177300270 rs577011584	112	R>G		No	ClinGen 1000Genomes
CA4756815 rs757122872	112	R>K		No	ClinGen ExAC gnomAD
rs753487730 CA4756814	113	S>N		No	ClinGen ExAC gnomAD
rs753487730 CA371294953	113	S>T		No	ClinGen ExAC gnomAD
rs763865825 CA4756813	114	I>T		No	ClinGen ExAC gnomAD
CA4756812 rs760194463	116	P>L		No	ClinGen ExAC TOPMed gnomAD
RCV000732628 rs1563484457 CA371294918	116	P>S		No	ClinGen ClinVar Ensembl dbSNP
CA4756810 rs372015675	117	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	118	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	121	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1171018064 CA371294817	124	N>K		No	ClinGen gnomAD
CA4756809 rs759944158	126	N>K		No	ClinGen ExAC gnomAD
rs1018490874 CA177300263	127	D>G		No	ClinGen Ensembl
rs1391016723 COSM298632 CA371294791	127	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
TCGA novel	129	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4756807 rs771215892	130	I>F		No	ClinGen ExAC gnomAD
rs771215892 CA4756808	130	I>V		No	ClinGen ExAC gnomAD
CA371294709 rs1198262246	134	Q>*		No	ClinGen gnomAD
CA371294712 rs1198262246	134	Q>K		No	ClinGen gnomAD
CA371294704 rs1346619804	134	Q>L		No	ClinGen gnomAD
CA4756802 rs781119853	135	G>D		No	ClinGen ExAC gnomAD
CA4756801 rs768849156	138	L>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	139	N>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4756800 rs779007978	142	T>K		No	ClinGen ExAC gnomAD
COSM1202906 CA4756799 rs779007978	142	T>M	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
RCV000315439 CA10605913 rs886043760	143	E>K		No	ClinGen ClinVar TOPMed dbSNP gnomAD
CA371294597 rs1191355886	144	S>N		No	ClinGen TOPMed
CA371294582 rs1371380962	145	M>R		No	ClinGen TOPMed gnomAD
rs1414257275 CA371294588	145	M>V		No	ClinGen gnomAD
CA4756798 rs757073508	146	M>T		No	ClinGen ExAC gnomAD
rs753721942 CA4756797	149	L>I		No	ClinGen ExAC gnomAD
rs1419311083 CA371294524	150	Q>E		No	ClinGen gnomAD
rs201114135 CA371294510 COSM1457633	151	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA177300249 rs201114135	151	R>G		No	ClinGen gnomAD
rs777753834 CA4756796	151	R>H		No	ClinGen ExAC gnomAD
CA371294506 rs777753834	151	R>P		No	ClinGen ExAC gnomAD
rs1184707982 CA371294497	152	I>T		No	ClinGen gnomAD
CA371294488 rs1160411231	153	M>T		No	ClinGen TOPMed
rs1361955643 COSM1202905 CA371294480	154	R>K	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs939210405 CA177300247 COSM1100719	155	P>L	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA4756793 rs752449158	157	V>A		No	ClinGen ExAC TOPMed gnomAD
CA177300244 rs368522187	158	S>C		No	ClinGen ESP
rs1563484353 CA371294446	158	S>T		No	ClinGen Ensembl
rs759086567 CA4756791	160	N>K		No	ClinGen ExAC gnomAD
rs1246691908 CA371294406	161	S>A		No	ClinGen TOPMed gnomAD
rs886353028 CA371294362	163	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs886353028 CA177300240	163	T>S		No	ClinGen TOPMed gnomAD
CA371294357 rs1351261361	164	A>D		No	ClinGen gnomAD
rs766893445 CA371294359	164	A>S		No	ClinGen ExAC gnomAD
RCV000390157 rs766893445 CA4756789	164	A>T	Variant assessed as Somatic; 5.096e-05 impact. [NCI-TCGA]	No	ClinGen ClinVar ExAC NCI-TCGA dbSNP gnomAD
rs906511867 CA177300237	165	A>T		No	ClinGen Ensembl
CA371294343 RCV000734574 rs1354168442	166	W>*		No	ClinGen ClinVar TOPMed dbSNP gnomAD
CA371294338 rs1354168442 COSM751110	166	W>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1408171822 CA371294349	166	W>R		No	ClinGen gnomAD
rs763263465 CA4756788	169	E>D		No	ClinGen ExAC gnomAD
rs1407459669 CA371294291	170	G>V		No	ClinGen gnomAD
rs773532618 CA4756787	171	M>L		No	ClinGen ExAC gnomAD
CA371294257 TCGA novel rs1464005837	172	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
CA371294263 rs1585643966	172	Y>C		No	ClinGen Ensembl
CA177300235 rs1046698163	173	S>A		No	ClinGen TOPMed
CA4756785 rs761938421	177	R>*		No	ClinGen ExAC gnomAD
rs776916391 CA4756784	177	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4756783 rs768561553	178	V>M		No	ClinGen ExAC gnomAD
CA371294173 rs1265587357	179	M>I		No	ClinGen TOPMed
rs747138282 CA4756782	182	A>S		No	ClinGen ExAC gnomAD
rs1222007109 CA371294126	183	G>R		No	ClinGen gnomAD
CA4756781 rs778958664	185	L>*		No	ClinGen ExAC gnomAD
rs1287639962 CA371294077	186	T>I		No	ClinGen gnomAD
rs770963981 CA4756780	187	I>V		No	ClinGen ExAC TOPMed gnomAD
CA4756779 rs749290143	190	R>G		No	ClinGen ExAC TOPMed gnomAD
CA4756778 rs776702193	191	D>G		No	ClinGen ExAC TOPMed gnomAD
CA4756777 rs756001088	192	L>I		No	ClinGen ExAC TOPMed gnomAD
CA4756776 rs72647413 RCV000729753	193	T>I		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs374585203 CA4756775	194	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA371293970 rs1563484266	194	R>S		No	ClinGen Ensembl
rs201046553 CA4756773	195	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM2719734 rs771901033 CA4756774 RCV000729085	195	R>W	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ClinVar ExAC TOPMed dbSNP gnomAD
CA371293953 rs1458172567	196	D>G		No	ClinGen gnomAD
rs765911554 CA4756772	198	Q>*		No	ClinGen ExAC
rs1391471723 CA371293913	199	K>R		No	ClinGen gnomAD
CA177300215 rs930310389	201	H>Q		No	ClinGen TOPMed gnomAD
rs765455964 CA4756769	201	H>R		No	ClinGen ExAC gnomAD
CA4756770 rs750996469	201	H>Y		No	ClinGen ExAC gnomAD
CA371293851 rs1478880503	204	N>H		No	ClinGen gnomAD
CA371293841 rs1250846388	204	N>K		No	ClinGen gnomAD
CA371293800 rs558718775	207	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs568918027 CA4756767	207	D>H		No	ClinGen 1000Genomes ExAC gnomAD
CA371293734 rs1316452469	211	Q>R		No	ClinGen TOPMed gnomAD
CA4756765 rs761022978 COSM3766786	212	F>I	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs370087640 CA371293725	212	F>L		No	ClinGen ESP ExAC TOPMed
rs773285427 CA4756761	213	D>G		No	ClinGen ExAC gnomAD
rs749230759 CA4756763	213	D>H		No	ClinGen ExAC gnomAD
rs749230759 COSM1100716 CA4756762	213	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA177300207 rs925723960	214	K>E		No	ClinGen TOPMed gnomAD
CA371293707 rs1314040550	215	V>A		No	ClinGen TOPMed
CA177300205 rs747942969	218	A>D		No	ClinGen Ensembl
rs1389461227 CA371293670	221	A>V		No	ClinGen gnomAD
rs1319185520 CA371293664	222	G>D		No	ClinGen gnomAD
TCGA novel	222	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	224	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1450992936 CA371293653	224	P>L		No	ClinGen gnomAD
CA177300199 rs945734831	224	P>S		No	ClinGen Ensembl
rs922242272 CA177300197	225	I>F		No	ClinGen Ensembl
rs911358597 CA177300195	226	H>Q		No	ClinGen TOPMed gnomAD
TCGA novel	228	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371293628 rs1415758299	228	F>V		No	ClinGen gnomAD
rs747994158 CA4756758	231	A>S		No	ClinGen ExAC gnomAD
COSM1457630 CA4756757 rs780668040	231	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA4756755 rs746711199	232	H>Y		No	ClinGen ExAC gnomAD
CA4756754 VAR_018376 rs8192874 COSM1457629	233	N>S	large_intestine [Cosmic]	No	ClinGen cosmic curated UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1212338772 CA371293586	234	A>V		No	ClinGen gnomAD
CA4756753 rs141299456 RCV000731674	235	R>Q		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs778528720 CA177300188	235	R>W		No	ClinGen gnomAD
rs192455108 CA4756752	239	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA371293554 rs1563484152	240	E>*		No	ClinGen Ensembl
rs146594981 CA177300184	241	S>N		No	ClinGen ESP TOPMed gnomAD
CA177300182 rs373964068	243	R>K		No	ClinGen ESP TOPMed
rs370924818 CA4756748	244	H>Q		No	ClinGen ESP ExAC gnomAD
rs760969537 CA4756747	245	E>A		No	ClinGen ExAC TOPMed gnomAD
rs1449615116 CA371293521	245	E>K		No	ClinGen gnomAD
rs376522590 CA4756746	248	Q>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs767634039 CA371293487	249	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4756744 rs150039957	250	R>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	252	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4756743 rs530012264	253	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA371293441 rs1414482574	254	S>A		No	ClinGen gnomAD
rs1183620680 CA371293432 RCV000729483	255	E>K		No	ClinGen ClinVar TOPMed dbSNP gnomAD
TCGA novel	256	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200100159 CA177300170	257	I>S		No	ClinGen 1000Genomes
COSM310454 rs1484757800 CA371293385	258	S>I	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1484757800 CA371293387	258	S>N		No	ClinGen TOPMed gnomAD
COSM422096 CA371293382 rs1450713836	258	S>R	urinary_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
CA4756738 rs139396617	260	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM3699122 rs139396617 CA4756737 RCV000324317	260	R>L	large_intestine [Cosmic]	No	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1026171025 CA177300166	260	R>S		No	ClinGen TOPMed gnomAD
CA4756736 rs771524490	261	M>T		No	ClinGen ExAC gnomAD
CA371293341 rs1227195073	262	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs151320685 CA177300162	264	N>S		No	ClinGen ESP TOPMed gnomAD
rs1563484081 CA371293299	265	D>Y		No	ClinGen Ensembl
CA4756732 rs565488904	269	T>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1024942782 CA177300156	272	D>A		No	ClinGen TOPMed gnomAD
RCV000727980 rs778199686 CA4756730 COSM3834864	273	L>P	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ClinVar ExAC NCI-TCGA dbSNP gnomAD
CA371293146 rs1350372922	276	A>D		No	ClinGen gnomAD
rs756548694 CA4756729	276	A>P		No	ClinGen ExAC gnomAD
COSM1457628 CA371293088 rs1210055982	281	V>M	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA4756727 rs767871705	283	L>F		No	ClinGen ExAC TOPMed gnomAD
rs528732489 CA4756726	284	W>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs528732489 CA4756725	284	W>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA371293046 rs1182997313	285	A>T		No	ClinGen TOPMed gnomAD
rs766417104 COSM606104 CA4756724	286	S>L	lung Variant assessed as Somatic; 0.0 impact. endometrium [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1428300224 CA371293004	291	I>T		No	ClinGen TOPMed
CA4756722 rs776499055	291	I>V		No	ClinGen ExAC gnomAD
CA371292992 rs768382295	293	A>E		No	ClinGen ExAC TOPMed gnomAD
CA4756721 rs768382295	293	A>V		No	ClinGen ExAC TOPMed gnomAD
rs760487952 CA4756720	295	F>S		No	ClinGen ExAC TOPMed gnomAD
CA371292970 rs535428616 CA4756719	296	W>C		No	ClinGen ExAC TOPMed gnomAD
CA371292976 rs1212431115	296	W>R		No	ClinGen gnomAD
rs771684358 CA4756718	297	S>C		No	ClinGen ExAC gnomAD
CA371292956 rs1228501501	298	L>F		No	ClinGen gnomAD
CA371292947 rs1337108179	300	Q>K		No	ClinGen gnomAD
CA4756717 rs745559202	301	M>T		No	ClinGen ExAC gnomAD
rs142476981 CA4756716	303	R>K		No	ClinGen ESP ExAC gnomAD
RCV000122470 CA232149 rs386352295	303	R>W		No	ClinGen ClinVar Ensembl dbSNP
CA4756698 rs759226176	305	P>L		No	ClinGen ExAC gnomAD
rs773883139 CA4756697	306	E>A		No	ClinGen ExAC TOPMed gnomAD
CA371292513 rs1382956556	306	E>D		No	ClinGen gnomAD
CA371292511 rs1158082014	307	A>S		No	ClinGen gnomAD
CA177299683 rs1018695052	307	A>V		No	ClinGen Ensembl
rs997514726 CA177299682	308	M>T		No	ClinGen TOPMed
CA371292490 rs1226796958	310	A>S		No	ClinGen TOPMed
RCV000597848 rs140288234 CA4756696	313	E>K		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA371292463 rs1379619448	314	E>*		No	ClinGen gnomAD
CA4756695 rs147153175	315	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA371292441 rs1249151601	317	R>K		No	ClinGen gnomAD
rs1249151601 CA371292440	317	R>T		No	ClinGen gnomAD
rs1445792240 CA371292428	319	L>S		No	ClinGen gnomAD
rs1476719974 CA371292411	321	N>T		No	ClinGen gnomAD
CA177299679 rs779835043	322	A>D		No	ClinGen TOPMed gnomAD
CA177299677 rs779835043	322	A>V		No	ClinGen TOPMed gnomAD
CA371292395 rs1245630081	324	Q>*		No	ClinGen gnomAD
CA4756693 rs773812952	324	Q>R		No	ClinGen ExAC gnomAD
CA371292375 rs1282082517	327	S>G		No	ClinGen TOPMed gnomAD
COSM1202904 CA371292376 rs1282082517	327	S>R	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs781679073 CA4756690	328	L>S		No	ClinGen ExAC TOPMed gnomAD
CA177299673 rs143476559	330	G>D		No	ClinGen ESP TOPMed
rs1199690733 CA371292353 RCV000592220	330	G>S		No	ClinGen ClinVar TOPMed dbSNP gnomAD
CA4756688 rs201041588	332	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs755365230 CA4756689	332	P>S		No	ClinGen ExAC gnomAD
rs1490754779 CA371292331	333	I>M		No	ClinGen gnomAD
CA4756687 rs374601769	335	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA371292300 rs1311330677	338	A>T		No	ClinGen gnomAD
CA4756685 rs758465037	342	D>A		No	ClinGen ExAC gnomAD
TCGA novel	344	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765352511 CA4756683	344	P>T		No	ClinGen ExAC gnomAD
rs756035111 CA4756682 COSM1489354	346	L>F	breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA4756681 VAR_018377 rs8192875	347	D>N		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1272194471 CA371292093	349	I>K		No	ClinGen gnomAD
rs746150781 CA4756662	350	I>V		No	ClinGen ExAC gnomAD
CA4756661 rs778961537 COSM3699121	353	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs778961537 CA371292063	353	S>W		No	ClinGen ExAC TOPMed gnomAD
rs1351320462 CA371292048	356	L>F		No	ClinGen gnomAD
CA177297688 rs908982662	357	S>P		No	ClinGen Ensembl
rs767461666 CA4756658	358	S>G		No	ClinGen ExAC TOPMed gnomAD
CA371292034 rs1440463845	358	S>R		No	ClinGen gnomAD
CA371292030 rs1335606150	359	A>S		No	ClinGen gnomAD
rs1414467556 CA371292024	360	S>P		No	ClinGen gnomAD
CA371292018 rs1324634115	361	L>F		No	ClinGen TOPMed gnomAD
CA371292019 rs1324634115	361	L>V		No	ClinGen TOPMed gnomAD
rs149291486 CA4756656	364	R>W	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1168837944 CA371291985	366	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1399961344 CA371291983	367	K>E		No	ClinGen TOPMed
rs138607943 CA4756654	367	K>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA4756653 rs369328699	369	D>E		No	ClinGen ESP ExAC gnomAD
TCGA novel	369	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4756652 rs761420413 CA4756651	373	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1232031956 CA371291932	374	L>H		No	ClinGen TOPMed gnomAD
rs1232031956 CA371291931	374	L>P		No	ClinGen TOPMed gnomAD
CA4756650 rs777238502	376	D>N		No	ClinGen ExAC gnomAD
RCV000597302 CA4756649 rs117423932	377	G>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA371291885 rs1363692933	381	I>L		No	ClinGen TOPMed
CA4756648 rs761294119	381	I>S		No	ClinGen ExAC gnomAD
CA4756647 rs775707649	382	R>*		No	ClinGen ExAC TOPMed gnomAD
rs772557610 COSM280280 CA4756646	382	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs746027683 CA4756645	386	I>F		No	ClinGen ExAC gnomAD
CA4756643 rs770946033	387	I>T		No	ClinGen ExAC TOPMed gnomAD
rs779124979 CA4756644	387	I>V		No	ClinGen ExAC TOPMed gnomAD
rs749397517 CA4756642	388	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4756640 rs754847133	390	Y>H		No	ClinGen ExAC gnomAD
rs779707560 CA4756638	392	Q>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs779707560 CA4756639	392	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA4756636 CA371291800 rs750037867	394	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1160670347 CA371291805	394	M>V		No	ClinGen gnomAD
CA371291798 rs1184962029 COSM1552972	395	H>N	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1406825308 CA371291787	396	L>S		No	ClinGen gnomAD
CA4756634 RCV000886346 RCV000368943 rs142708991	398	P>A		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs142708991 CA4756635	398	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA177297617 rs1012727318	399	E>G		No	ClinGen Ensembl
rs1455455573 CA371291745	402	P>L		No	ClinGen gnomAD
CA177297614 rs779251933	402	P>T		No	ClinGen TOPMed
CA371291739 rs1251060298	403	D>V		No	ClinGen gnomAD
CA371291735 rs1192994825	404	P>A		No	ClinGen TOPMed gnomAD
rs1192994825 CA371291736	404	P>S	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs761084132 CA4756631	405	L>F		No	ClinGen ExAC TOPMed gnomAD
CA4756632 rs372341079	405	L>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA4756600 rs745860537	406	T>I		No	ClinGen ExAC gnomAD
TCGA novel	406	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745860537 CA371291710	406	T>S		No	ClinGen ExAC gnomAD
rs1470643026 CA371291703	407	F>L		No	ClinGen gnomAD
CA371291707 rs1326349852	407	F>V		No	ClinGen TOPMed
rs1231634282 CA371291682	410	D>G		No	ClinGen TOPMed
CA4756598 rs757124756	410	D>H		No	ClinGen ExAC gnomAD
CA371291665 rs777507940	412	Y>*		No	ClinGen ExAC gnomAD
CA371291670 rs1157876121	412	Y>H		No	ClinGen gnomAD
rs766284289 RCV000727683	413	L>missing		No	ClinVar dbSNP
rs546561123 CA4756594	416	N>D		No	ClinGen ExAC gnomAD
CA371291632 rs1273228573	417	G>E		No	ClinGen gnomAD
rs201787113 CA4756592	417	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	419	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371291617 rs752124663	419	T>I		No	ClinGen ExAC TOPMed gnomAD
CA4756588 rs752124663	419	T>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	420	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773258821 CA4756585	422	T>I		No	ClinGen ExAC gnomAD
CA177297334 rs1027036041	424	Y>C		No	ClinGen TOPMed gnomAD
CA371291576 rs752679173	425	C>*		No	ClinGen ExAC TOPMed gnomAD
rs1585640698 CA371291581	425	C>R		No	ClinGen Ensembl
CA371291567 rs776760317	426	N>K		No	ClinGen ExAC gnomAD
rs768925733 CA4756581	428	L>F		No	ClinGen ExAC gnomAD
CA4756580 rs376754937	429	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs370236722 CA4756577	431	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs151122002 CA4756578 RCV000338273	431	K>R		No	ClinGen ClinVar 1000Genomes TOPMed dbSNP gnomAD
rs1421122064 CA371291523	433	Y>C		No	ClinGen gnomAD
TCGA novel	433	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA177297313 rs899918229	434	Y>*		No	ClinGen TOPMed
rs777464708 CA4756574	434	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs777464708 CA4756575	434	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs770804582 CA4756576	434	Y>H		No	ClinGen ExAC gnomAD
rs201341987 CA4756573	435	M>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1255495349 COSM1100714 CA371291514	435	M>V	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA4756572 rs747810583	437	F>L		No	ClinGen ExAC gnomAD
rs780673203 CA4756571	439	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1585640654 CA371291488	439	S>T		No	ClinGen Ensembl
rs367898327 CA371291479	440	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
COSM3735320 rs367898327 CA4756569	440	G>E	skin [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs878898857 CA177297293	442	T>A		No	ClinGen Ensembl
TCGA novel	442	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs552280210 CA4756568	443	I>L		No	ClinGen 1000Genomes ExAC gnomAD
rs552280210 CA4756567	443	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1216751891 CA371291461	444	C>R		No	ClinGen TOPMed gnomAD
rs750778526 CA4756566	445	P>L		No	ClinGen ExAC gnomAD
rs1327924474 CA371291449	446	G>R		No	ClinGen gnomAD
CA4756564 rs762092457	447	R>S		No	ClinGen ExAC gnomAD
rs764215156 CA4756562	448	L>F		No	ClinGen ExAC gnomAD
CA4756563 rs754119848	448	L>W		No	ClinGen ExAC
rs1319004357 CA371291432	449	F>I		No	ClinGen TOPMed gnomAD
rs770873945 CA4756561	450	A>P		No	ClinGen ExAC TOPMed gnomAD
CA4756559 rs770873945	450	A>S		No	ClinGen ExAC TOPMed gnomAD
rs770873945 CA4756560	450	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4756558 rs199557345	450	A>V		No	ClinGen ExAC TOPMed gnomAD
rs976831279 CA371291422	451	I>L		No	ClinGen TOPMed gnomAD
rs976831279 CA177297264	451	I>V		No	ClinGen TOPMed gnomAD
CA371291406 rs769540638	453	E>A		No	ClinGen ExAC gnomAD
CA4756556 rs769540638	453	E>G		No	ClinGen ExAC gnomAD
RCV000305369 rs755342899 CA4756557	453	E>K		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1468435777 CA371291397	454	I>S		No	ClinGen gnomAD
rs1265969053 CA371291387	456	Q>E		No	ClinGen gnomAD
rs747766938 CA4756555	458	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	459	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs891054570 CA177297250	459	I>N		No	ClinGen TOPMed gnomAD
rs768104199 CA4756553 CA371291348	461	M>I		No	ClinGen ExAC TOPMed gnomAD
CA371291350 rs1554558012 RCV000592678	461	M>T		No	ClinGen ClinVar Ensembl dbSNP
rs779580378 CA4756552	462	L>F		No	ClinGen ExAC gnomAD
CA4756551 rs779580378 RCV000592851	462	L>V		No	ClinGen ClinVar ExAC dbSNP gnomAD
rs1293307020 CA371291335	464	Y>H		No	ClinGen TOPMed
TCGA novel	468	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM751111 rs1306463275 CA371291291	470	I>L	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
CA4756548 RCV000728754 rs779269724	470	I>T		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA4756546 rs754062589	472	G>S		No	ClinGen ExAC gnomAD
CA371291263 rs1172165463	474	A>P		No	ClinGen TOPMed gnomAD
rs764439951 CA4756545	474	A>V		No	ClinGen ExAC gnomAD
rs1374163646 CA371291255	475	K>R		No	ClinGen TOPMed gnomAD
rs1018328362 CA177297199	477	P>S		No	ClinGen Ensembl
CA4756544 rs761014779	480	D>E		No	ClinGen ExAC gnomAD
CA4756543 rs148119788	481	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs148119788 CA371291218	481	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA4756541 rs201171633	483	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4756540 rs201171633	483	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4756539 rs201171633	483	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1202903 rs143725488 RCV000731822 CA4756542	483	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs761620465 CA4756538	484	A>V		No	ClinGen ExAC gnomAD
CA371291182 rs1563482013	487	G>D		No	ClinGen Ensembl
rs776227029 CA4756537	487	G>S		No	ClinGen ExAC gnomAD
CA371291175 rs1229694535	488	I>T		No	ClinGen TOPMed gnomAD
CA4756535 rs148977608	490	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs148977608 CA4756536	490	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA371291159 rs1415550085	491	P>S		No	ClinGen gnomAD
rs746326323 CA4756532	493	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1311386037 CA371291136	494	D>V		No	ClinGen gnomAD
CA371291128 rs757599711	495	I>M		No	ClinGen ExAC TOPMed gnomAD
rs779307775 CA4756531	495	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1170211276 CA371291118	497	F>L		No	ClinGen gnomAD
rs749635200 CA4756529	498	K>N		No	ClinGen ExAC TOPMed gnomAD
CA371291110 rs1355414870	498	K>Q		No	ClinGen TOPMed
rs1192340088 CA371291068	503	H>R		No	ClinGen gnomAD

No associated diseases with P22680

1 regional properties for P22680

Type	Name	Position	InterPro Accession
conserved_site	Cytochrome P450, conserved site	437 - 446	IPR017972

Functions

		Description
EC Number	1.14.14.23	With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization	Endoplasmic reticulum membrane ; Single-pass membrane protein Microsome membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

5 GO annotations of molecular function

Name	Definition
24-hydroxycholesterol 7alpha-hydroxylase activity	Catalysis of the reaction: (24S)-hydroxycholesterol + O2 + reduced = (24S)-7alpha-dihydroxycholesterol + H+ + H2O + oxidized
cholesterol 7-alpha-monooxygenase activity	Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O.
heme binding	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding	Binding to an iron (Fe) ion.
steroid hydroxylase activity	Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.

14 GO annotations of biological process

Name	Definition
bile acid and bile salt transport	The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
bile acid biosynthetic process	The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
bile acid signaling pathway	The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
cellular response to cholesterol	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
cellular response to glucose stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
cholesterol catabolic process	The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
cholesterol homeostasis	Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
negative regulation of collagen biosynthetic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
negative regulation of fatty acid biosynthetic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
positive regulation of cholesterol biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
regulation of bile acid biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
response to ethanol	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
sterol metabolic process	The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P18125	Cyp7a1	Cytochrome P450 7A1	Rattus norvegicus (Rat)	PR
Q9SAA9	CYP51G1	Sterol 14-demethylase	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MMTTSLIWGI	AIAACCCLWL	ILGIRRRQTG	EPPLENGLIP	YLGCALQFGA	NPLEFLRANQ
70	80	90	100	110	120
RKHGHVFTCK	LMGKYVHFIT	NPLSYHKVLC	HGKYFDWKKF	HFATSAKAFG	HRSIDPMDGN
130	140	150	160	170	180
TTENINDTFI	KTLQGHALNS	LTESMMENLQ	RIMRPPVSSN	SKTAAWVTEG	MYSFCYRVMF
190	200	210	220	230	240
EAGYLTIFGR	DLTRRDTQKA	HILNNLDNFK	QFDKVFPALV	AGLPIHMFRT	AHNAREKLAE
250	260	270	280	290	300
SLRHENLQKR	ESISELISLR	MFLNDTLSTF	DDLEKAKTHL	VVLWASQANT	IPATFWSLFQ
310	320	330	340	350	360
MIRNPEAMKA	ATEEVKRTLE	NAGQKVSLEG	NPICLSQAEL	NDLPVLDSII	KESLRLSSAS
370	380	390	400	410	420
LNIRTAKEDF	TLHLEDGSYN	IRKDDIIALY	PQLMHLDPEI	YPDPLTFKYD	RYLDENGKTK
430	440	450	460	470	480
TTFYCNGLKL	KYYYMPFGSG	ATICPGRLFA	IHEIKQFLIL	MLSYFELELI	EGQAKCPPLD
490	500
QSRAGLGILP	PLNDIEFKYK	FKHL