Q94IA6
PR
Gene name |
CYP90D1 |
Protein name |
3-epi-6-deoxocathasterone 23-monooxygenase CYP90D1 |
Names |
3-dehydro-6-deoxoteasterone synthase, (22R,23R)-22,23-dihydroxy-campest-4-en-3-one synthase, (22R,23R)-22,23-dihydroxycampesterol synthase, 6-deoxoteasterone synthase, Cytochrome P450 90D1, Teasterone synthase |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G13730 |
EC number |
1.14.14.147: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q94IA6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q94IA6-F1 | Predicted | AlphaFoldDB |
37 variants for Q94IA6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05824512 | 9 | F>L | No | 1000Genomes | |
| ENSVATH00321550 | 23 | K>E | No | 1000Genomes | |
| ENSVATH00321549 | 27 | L>I | No | 1000Genomes | |
| ENSVATH05824509 | 40 | H>Q | No | 1000Genomes | |
| ENSVATH00321548 | 45 | Q>H | No | 1000Genomes | |
| ENSVATH05824508 | 68 | V>I | No | 1000Genomes | |
| tmp_3_4500614_G_A | 75 | R>C | No | 1000Genomes | |
| tmp_3_4500480_T_A | 92 | K>M | No | 1000Genomes | |
| tmp_3_4500436_C_G | 107 | E>Q | No | 1000Genomes | |
| ENSVATH05824507 | 116 | D>A | No | 1000Genomes | |
| tmp_3_4500330_C_T | 142 | G>E | No | 1000Genomes | |
| ENSVATH00321545 | 142 | G>R | No | 1000Genomes | |
| tmp_3_4500245_G_C | 170 | H>Q | No | 1000Genomes | |
| ENSVATH05824505 | 190 | D>E | No | 1000Genomes | |
| ENSVATH13912693 | 213 | L>S | No | 1000Genomes | |
| ENSVATH05824495 | 218 | R>K | No | 1000Genomes | |
| tmp_3_4499802_C_G | 219 | E>D | No | 1000Genomes | |
| ENSVATH05824494 | 222 | N>I | No | 1000Genomes | |
| tmp_3_4499741_G_A | 240 | H>Y | No | 1000Genomes | |
| ENSVATH10659084 | 241 | R>T | No | 1000Genomes | |
| ENSVATH05824493 | 252 | Q>R | No | 1000Genomes | |
| ENSVATH05824492 | 254 | E>K | No | 1000Genomes | |
| ENSVATH05824491 | 267 | K>N | No | 1000Genomes | |
| ENSVATH10659082 | 283 | K>N | No | 1000Genomes | |
| ENSVATH10659081 | 296 | N>T | No | 1000Genomes | |
| ENSVATH13912692 | 302 | M>V | No | 1000Genomes | |
| ENSVATH13912691 | 316 | A>V | No | 1000Genomes | |
| tmp_3_4499495_C_T | 322 | D>N | No | 1000Genomes | |
| tmp_3_4499477_T_C | 328 | N>D | No | 1000Genomes | |
| ENSVATH13912689 | 361 | K>R | No | 1000Genomes | |
| ENSVATH05824483 | 399 | A>V | No | 1000Genomes | |
| ENSVATH05824481 | 406 | L>F | No | 1000Genomes | |
| ENSVATH13912688 | 412 | E>D | No | 1000Genomes | |
| tmp_3_4498882_C_T | 412 | E>K | No | 1000Genomes | |
| ENSVATH10659078 | 430 | S>C | No | 1000Genomes | |
| ENSVATH10659077 | 431 | S>G | No | 1000Genomes | |
| tmp_3_4498695_C_T | 446 | D>N | No | 1000Genomes |
No associated diseases with Q94IA6
1 regional properties for Q94IA6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 435 - 444 | IPR017972 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.14.147 | With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| (22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity | Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + O2 + NADPH + H+ <=> 3-dehydro-6-deoxoteasterone + NADP + H2O. |
| 3-epi-6-deoxocathasterone C-23 hydroxylase activity | Catalysis of the reaction: H+ + 3-epi-6-deoxocathasterone + reduced (NADPH-hemoprotein reducdtase) + O2 = 6=deoxotyphasterol + oxidized (NADPH-hemoprotein reductase) + H2O. |
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| iron ion binding | Binding to an iron (Fe) ion. |
| monooxygenase activity | Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. |
| oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| brassinosteroid biosynthetic process | The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects. |
| brassinosteroid homeostasis | Any process involved in the maintenance of an internal steady state of brassinosteroids within an organism or cell. |
| leaf development | The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure. |
| petal development | The process whose specific outcome is the progression of the petal over time, from its formation to the mature structure. |
| stamen development | The process whose specific outcome is the progression of the stamen over time, from its formation to the mature structure. |
| sterol metabolic process | The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
38 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9VYQ5 | Cyp318a1 | Probable cytochrome P450 318a1 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VXY0 | Cyp4s3 | Probable cytochrome P450 4s3 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VMS7 | Cyp4ac3 | Probable cytochrome P450 4ac3 | Drosophila melanogaster (Fruit fly) | PR |
| Q9V559 | Cyp4p3 | Probable cytochrome P450 4p3 | Drosophila melanogaster (Fruit fly) | PR |
| Q9V7G5 | Cyp4aa1 | Probable cytochrome P450 4aa1 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VMS8 | Cyp4ac2 | Probable cytochrome P450 4ac2 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VVN6 | Cyp312a1 | Probable cytochrome P450 312a1 | Drosophila melanogaster (Fruit fly) | PR |
| Q02928 | CYP4A11 | Cytochrome P450 4A11 | Homo sapiens (Human) | PR |
| Q86W10 | CYP4Z1 | Cytochrome P450 4Z1 | Homo sapiens (Human) | PR |
| Q5TCH4 | CYP4A22 | Cytochrome P450 4A22 | Homo sapiens (Human) | PR |
| P13584 | CYP4B1 | Cytochrome P450 4B1 | Homo sapiens (Human) | PR |
| Q6ZWL3 | CYP4V2 | Cytochrome P450 4V2 | Homo sapiens (Human) | PR |
| B6SSW8 | CYP714B3 | Cytochrome P450 714B3 | Zea mays (Maize) | PR |
| O35728 | Cyp4a14 | Cytochrome P450 4A14 | Mus musculus (Mouse) | PR |
| Q91WL5 | Cyp4a12a | Cytochrome P450 4A12A | Mus musculus (Mouse) | PR |
| Q9GJX5 | CYP4A21 | Taurochenodeoxycholic 6 alpha-hydroxylase | Sus scrofa (Pig) | PR |
| Q8SPK1 | CYP4A24 | Cytochrome P450 4A24 | Sus scrofa (Pig) | PR |
| P24464 | Cyp4a12 | Cytochrome P450 4A12 | Rattus norvegicus (Rat) | PR |
| P20816 | Cyp4a2 | Cytochrome P450 4A2 | Rattus norvegicus (Rat) | PR |
| G3V7X8 | Cyp26b1 | Cytochrome P450 26B1 | Rattus norvegicus (Rat) | PR |
| Q05JG2 | CYP707A5 | Abscisic acid 8'-hydroxylase 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q0DS59 | CYP714B2 | Cytochrome P450 714B2 | Oryza sativa subsp japonica (Rice) | PR |
| Q6F4F5 | CYP724B1 | Cytochrome P450 724B1 | Oryza sativa subsp japonica (Rice) | PR |
| Q5KQH7 | CYP714D1 | Cytochrome P450 714D1 | Oryza sativa subsp japonica (Rice) | PR |
| Q9SHG5 | CYP72C1 | Cytochrome P450 72C1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C788 | CYP704B1 | Cytochrome P450 704B1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZUX1 | CYP94C1 | Cytochrome P450 94C1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUC9 | CYP72A11 | Cytochrome P450 72A11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUC8 | CYP72A13 | Cytochrome P450 72A13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUC6 | CYP72A14 | Cytochrome P450 72A14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUC5 | CYP72A15 | Cytochrome P450 72A15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6TBX7 | CYP97C1 | Carotene epsilon-monooxygenase, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64697 | CYP710A1 | Cytochrome P450 710A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64698 | CYP710A2 | Cytochrome P450 710A2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81077 | CYP707A2 | Abscisic acid 8'-hydroxylase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SAA9 | CYP51G1 | Sterol 14-demethylase | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96242 | CYP74A | Allene oxide synthase, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6EIG3 | cyp26b1 | Cytochrome P450 26B1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDTSSSLLFF | SFFFFIIIVI | FNKINGLRSS | PASKKKLNDH | HVTSQSHGPK | FPHGSLGWPV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IGETIEFVSS | AYSDRPESFM | DKRRLMYGRV | FKSHIFGTAT | IVSTDAEVNR | AVLQSDSTAF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VPFYPKTVRE | LMGKSSILLI | NGSLHRRFHG | LVGSFLKSPL | LKAQIVRDMH | KFLSESMDLW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SEDQPVLLQD | VSKTVAFKVL | AKALISVEKG | EDLEELKREF | ENFISGLMSL | PINFPGTQLH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RSLQAKKNMV | KQVERIIEGK | IRKTKNKEED | DVIAKDVVDV | LLKDSSEHLT | HNLIANNMID |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MMIPGHDSVP | VLITLAVKFL | SDSPAALNLL | TEENMKLKSL | KELTGEPLYW | NDYLSLPFTQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KVITETLRMG | NVIIGVMRKA | MKDVEIKGYV | IPKGWCFLAY | LRSVHLDKLY | YESPYKFNPW |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RWQERDMNTS | SFSPFGGGQR | LCPGLDLARL | ETSVFLHHLV | TRFRWIAEED | TIINFPTVHM |
| 490 | |||||
| KNKLPIWIKR | I |