Q8SPK1

PR
Gene name
CYP4A24
Protein name
Cytochrome P450 4A24
Names
CYPIVA24, Fatty acid omega-hydroxylase, Long-chain fatty acid omega-monooxygenase
Species
Sus scrofa (Pig)
KEGG Pathway
EC number
1.14.14.80: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

221-307 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8SPK1

Entry ID Method Resolution Chain Position Source
AF-Q8SPK1-F1 Predicted AlphaFoldDB

19 variants for Q8SPK1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3476445502 9 A>V No EVA
rs1112827464 82 L>R No EVA
rs786464900 84 R>L No EVA
rs788102615 200 G>D No EVA
rs711340778 202 A>T No EVA
rs703245147 202 A>V No EVA
rs790931531 209 H>Q No EVA
rs1113960258 224 I>T No EVA
rs1108651269 226 T>S No EVA
rs788905059 242 E>K No EVA
rs3474820077 246 N>S No EVA
rs3473518845 293 R>Q No EVA
rs787301506 436 R>Q No EVA
rs789558970 482 P>H No EVA
rs3471234276 483 I>T No EVA
rs3469770626 484 A>V No EVA
rs3470033050 485 T>I No EVA
rs3469968445 486 P>A No EVA
rs336363110 491 N>H No EVA

No associated diseases with Q8SPK1

1 regional properties for Q8SPK1

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 444 - 453 IPR017972

Functions

Description
EC Number 1.14.14.80 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
long-chain fatty acid omega-hydroxylase activity Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized

No GO annotations of biological process

Name Definition
No GO annotations for biological process

38 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VYQ5 Cyp318a1 Probable cytochrome P450 318a1 Drosophila melanogaster (Fruit fly) PR
Q9V559 Cyp4p3 Probable cytochrome P450 4p3 Drosophila melanogaster (Fruit fly) PR
Q9VMS7 Cyp4ac3 Probable cytochrome P450 4ac3 Drosophila melanogaster (Fruit fly) PR
Q9VMS8 Cyp4ac2 Probable cytochrome P450 4ac2 Drosophila melanogaster (Fruit fly) PR
Q9VVN6 Cyp312a1 Probable cytochrome P450 312a1 Drosophila melanogaster (Fruit fly) PR
Q9VXY0 Cyp4s3 Probable cytochrome P450 4s3 Drosophila melanogaster (Fruit fly) PR
Q9V7G5 Cyp4aa1 Probable cytochrome P450 4aa1 Drosophila melanogaster (Fruit fly) PR
P13584 CYP4B1 Cytochrome P450 4B1 Homo sapiens (Human) PR
Q6ZWL3 CYP4V2 Cytochrome P450 4V2 Homo sapiens (Human) PR
Q86W10 CYP4Z1 Cytochrome P450 4Z1 Homo sapiens (Human) PR
Q5TCH4 CYP4A22 Cytochrome P450 4A22 Homo sapiens (Human) PR
Q02928 CYP4A11 Cytochrome P450 4A11 Homo sapiens (Human) PR
B6SSW8 CYP714B3 Cytochrome P450 714B3 Zea mays (Maize) PR
O35728 Cyp4a14 Cytochrome P450 4A14 Mus musculus (Mouse) PR
Q91WL5 Cyp4a12a Cytochrome P450 4A12A Mus musculus (Mouse) PR
Q9GJX5 CYP4A21 Taurochenodeoxycholic 6 alpha-hydroxylase Sus scrofa (Pig) PR
Q8SPK0 CYP4A25 Cytochrome P450 4A25 Sus scrofa (Pig) PR
G3V7X8 Cyp26b1 Cytochrome P450 26B1 Rattus norvegicus (Rat) PR
P20816 Cyp4a2 Cytochrome P450 4A2 Rattus norvegicus (Rat) PR
P24464 Cyp4a12 Cytochrome P450 4A12 Rattus norvegicus (Rat) PR
P20817 Cyp4a14 Cytochrome P450 4A14 Rattus norvegicus (Rat) PR
Q05JG2 CYP707A5 Abscisic acid 8'-hydroxylase 1 Oryza sativa subsp japonica (Rice) PR
Q0DS59 CYP714B2 Cytochrome P450 714B2 Oryza sativa subsp japonica (Rice) PR
Q6F4F5 CYP724B1 Cytochrome P450 724B1 Oryza sativa subsp japonica (Rice) PR
Q5KQH7 CYP714D1 Cytochrome P450 714D1 Oryza sativa subsp japonica (Rice) PR
Q9C788 CYP704B1 Cytochrome P450 704B1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZUX1 CYP94C1 Cytochrome P450 94C1 Arabidopsis thaliana (Mouse-ear cress) PR
O81077 CYP707A2 Abscisic acid 8'-hydroxylase 2 Arabidopsis thaliana (Mouse-ear cress) PR
O64698 CYP710A2 Cytochrome P450 710A2 Arabidopsis thaliana (Mouse-ear cress) PR
O64697 CYP710A1 Cytochrome P450 710A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q94IA6 CYP90D1 3-epi-6-deoxocathasterone 23-monooxygenase CYP90D1 Arabidopsis thaliana (Mouse-ear cress) PR
Q6TBX7 CYP97C1 Carotene epsilon-monooxygenase, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC5 CYP72A15 Cytochrome P450 72A15 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC6 CYP72A14 Cytochrome P450 72A14 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC8 CYP72A13 Cytochrome P450 72A13 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC9 CYP72A11 Cytochrome P450 72A11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SHG5 CYP72C1 Cytochrome P450 72C1 Arabidopsis thaliana (Mouse-ear cress) PR
Q6EIG3 cyp26b1 Cytochrome P450 26B1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MTVPALASAS GLLQVASLLG LLLLLLKAAQ LYLHRQWLLK ALQQFPSPPS HWLYGHSREF
70 80 90 100 110 120
QEESELPPLL KRVEKYPSAC ALWRWGTRAM VLVYDPDYMK VVLARSDPKN SVVYRLLIPW
130 140 150 160 170 180
IGCGLLLLNG QTWFQRRRML TPAFHYDILK PYVGLMAKSV QVMLDKWEQL VAQDPRLEIV
190 200 210 220 230 240
GPVSLMTLDT IMKCAFSHQG SAQTDGDSHS YIQAIWDLKN LFSIRTKSAF LQNDIIYRLS
250 260 270 280 290 300
PEGRKNHRAA RIAHQHTDRV IQLRKAQLQK QGEMENVRKK RHLDFLDILL LARMEKGNSL
310 320 330 340 350 360
SDTDLRAEVD TFMFEGHDTT ASGISWILYA LASHPEHQQR CREEIQGLLG DGTSITWDHL
370 380 390 400 410 420
DQMPYTTMCI KEALRLYPPV PGVSRELSKP ITFPDGRSLP AGITLSLSIY GLHHNPQVWP
430 440 450 460 470 480
NPEEFDPSRF APGSARHSHA FMPFSGGSRN CIGKQFAMNE MKVAVALTLL RFELAPDPSR
490 500
KPIATPEVVL NSKNGIHLKL RKLP