AiPD: Autoinhibited Protein Database

Gene name	CYP4A25
Protein name	Cytochrome P450 4A25
Names	CYPIVA25, Fatty acid omega-hydroxylase, Long-chain fatty acid omega-monooxygenase
Species	Sus scrofa (Pig)
KEGG Pathway
EC number	1.14.14.80: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

218-309 (Predicted disordered autoinhibitory region) PR

218-309 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8SPK0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for Q8SPK0

Type	Name	Position	InterPro Accession
conserved_site	Cytochrome P450, conserved site	444 - 453	IPR017972

		Description
EC Number	1.14.14.80	With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
heme binding	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding	Binding to an iron (Fe) ion.
long-chain fatty acid omega-hydroxylase activity	Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized

Name	Definition
No GO annotations for biological process

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9VXY0	Cyp4s3	Probable cytochrome P450 4s3	Drosophila melanogaster (Fruit fly)	PR
Q9VVN6	Cyp312a1	Probable cytochrome P450 312a1	Drosophila melanogaster (Fruit fly)	PR
Q9V7G5	Cyp4aa1	Probable cytochrome P450 4aa1	Drosophila melanogaster (Fruit fly)	PR
Q9VMS8	Cyp4ac2	Probable cytochrome P450 4ac2	Drosophila melanogaster (Fruit fly)	PR
Q9VMS7	Cyp4ac3	Probable cytochrome P450 4ac3	Drosophila melanogaster (Fruit fly)	PR
Q9V559	Cyp4p3	Probable cytochrome P450 4p3	Drosophila melanogaster (Fruit fly)	PR
Q5TCH4	CYP4A22	Cytochrome P450 4A22	Homo sapiens (Human)	PR
Q86W10	CYP4Z1	Cytochrome P450 4Z1	Homo sapiens (Human)	PR
Q02928	CYP4A11	Cytochrome P450 4A11	Homo sapiens (Human)	PR
Q91WL5	Cyp4a12a	Cytochrome P450 4A12A	Mus musculus (Mouse)	PR
O35728	Cyp4a14	Cytochrome P450 4A14	Mus musculus (Mouse)	PR
Q8SPK1	CYP4A24	Cytochrome P450 4A24	Sus scrofa (Pig)	PR
P24464	Cyp4a12	Cytochrome P450 4A12	Rattus norvegicus (Rat)	PR
P20816	Cyp4a2	Cytochrome P450 4A2	Rattus norvegicus (Rat)	PR
P20817	Cyp4a14	Cytochrome P450 4A14	Rattus norvegicus (Rat)	PR
Q9LUC5	CYP72A15	Cytochrome P450 72A15	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LUC8	CYP72A13	Cytochrome P450 72A13	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LUC9	CYP72A11	Cytochrome P450 72A11	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LUC6	CYP72A14	Cytochrome P450 72A14	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SHG5	CYP72C1	Cytochrome P450 72C1	Arabidopsis thaliana (Mouse-ear cress)	PR