P20817

PR
Gene name
Cyp4a14
Protein name
Cytochrome P450 4A14
Names
CYPIVA14, Cytochrome P450-LA-omega 3, Lauric acid omega-hydroxylase, Long-chain fatty acid omega-monooxygenase
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:298423
EC number
1.14.14.80: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

230-314 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P20817

Entry ID Method Resolution Chain Position Source
AF-P20817-F1 Predicted AlphaFoldDB

No variants for P20817

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P20817

No associated diseases with P20817

1 regional properties for P20817

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 447 - 456 IPR017972

Functions

Description
EC Number 1.14.14.80 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Endoplasmic reticulum membrane; Peripheral membrane protein
  • Microsome membrane; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

5 GO annotations of molecular function

Name Definition
alkane 1-monooxygenase activity Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O.
arachidonic acid monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
long-chain fatty acid omega-hydroxylase activity Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized

5 GO annotations of biological process

Name Definition
arachidonic acid metabolic process The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
icosanoid biosynthetic process The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids.
kidney development The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
lauric acid metabolic process The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources.
linoleic acid metabolic process The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.

22 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9V7G5 Cyp4aa1 Probable cytochrome P450 4aa1 Drosophila melanogaster (Fruit fly) PR
Q9VVN6 Cyp312a1 Probable cytochrome P450 312a1 Drosophila melanogaster (Fruit fly) PR
Q9VXY0 Cyp4s3 Probable cytochrome P450 4s3 Drosophila melanogaster (Fruit fly) PR
Q9VMS8 Cyp4ac2 Probable cytochrome P450 4ac2 Drosophila melanogaster (Fruit fly) PR
Q9VMS7 Cyp4ac3 Probable cytochrome P450 4ac3 Drosophila melanogaster (Fruit fly) PR
Q9V559 Cyp4p3 Probable cytochrome P450 4p3 Drosophila melanogaster (Fruit fly) PR
Q5TCH4 CYP4A22 Cytochrome P450 4A22 Homo sapiens (Human) PR
Q86W10 CYP4Z1 Cytochrome P450 4Z1 Homo sapiens (Human) PR
Q02928 CYP4A11 Cytochrome P450 4A11 Homo sapiens (Human) PR
O35728 Cyp4a14 Cytochrome P450 4A14 Mus musculus (Mouse) PR
Q9GJX5 CYP4A21 Taurochenodeoxycholic 6 alpha-hydroxylase Sus scrofa (Pig) PR
Q8SPK1 CYP4A24 Cytochrome P450 4A24 Sus scrofa (Pig) PR
Q8SPK0 CYP4A25 Cytochrome P450 4A25 Sus scrofa (Pig) PR
P24464 Cyp4a12 Cytochrome P450 4A12 Rattus norvegicus (Rat) PR
P20816 Cyp4a2 Cytochrome P450 4A2 Rattus norvegicus (Rat) PR
Q5KQH7 CYP714D1 Cytochrome P450 714D1 Oryza sativa subsp japonica (Rice) PR
Q0DS59 CYP714B2 Cytochrome P450 714B2 Oryza sativa subsp japonica (Rice) PR
Q9LUC5 CYP72A15 Cytochrome P450 72A15 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC6 CYP72A14 Cytochrome P450 72A14 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC8 CYP72A13 Cytochrome P450 72A13 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LUC9 CYP72A11 Cytochrome P450 72A11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SHG5 CYP72C1 Cytochrome P450 72C1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGFSVFTPTR SLDGVSGFFQ GAFLLSLFLV LFKAVQFYLR RQWLLKALEK FPSTPSHWLW
70 80 90 100 110 120
GHDLKDREFQ QVLTWVEKFP GACLQWLSGS KTRVLLYDPD YVKVVLGRSD PKASGIYQFL
130 140 150 160 170 180
APWIGYGLLL LNGKKWFQHR RMLTPAFHYG ILKPYVKIMA DSVNIMLDKW EKLDDQDHPL
190 200 210 220 230 240
EIFHYVSLMT LDTVMKCAFS HQGSVQLDVN SRSYTKAVED LNNLTFFRVR SAFYGNSIIY
250 260 270 280 290 300
NMSSDGRLSR RACQIAHEHT DGVIKMRKAQ LQNEEELQKA RKKRHLDFLD ILLFAKMEDG
310 320 330 340 350 360
KSLSDEDLRA EVDTFMFEGH DTTASGISWV FYALATHPEH QERCREEVQS ILGDGTSVTW
370 380 390 400 410 420
DHLDQIPYTT MCIKEALRLY PPVPSVSREL SSPVTFPDGR SIPKGITTTI LIYGLHHNPS
430 440 450 460 470 480
YWPNPKVFDP SRFSPDSPRH SHAYLPFSGG ARNCIGKQFA MNELKVAVAL TLLRFELLPD
490 500
PTRIPVPMAR LVLKSKNGIH LRLKKLR