AiPD: Autoinhibited Protein Database

Q86W10

Gene name	CYP4Z1
Protein name	Cytochrome P450 4Z1
Names	CYPIVZ1, Laurate 7-monooxygenase
Species	Homo sapiens (Human)
KEGG Pathway	hsa:199974
EC number	1.14.14.1: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

173-335 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

173-335 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q86W10

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q86W10-F1	Predicted				AlphaFoldDB

426 variants for Q86W10

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA340231420 rs1284796723	3	P>H		No	ClinGen TOPMed gnomAD
rs763125700 CA840329	4	S>C		No	ClinGen ExAC TOPMed gnomAD
rs763125700 CA340231432	4	S>F		No	ClinGen ExAC TOPMed gnomAD
CA840332 rs762137487	5	W>C		No	ClinGen ExAC TOPMed gnomAD
CA840331 rs751710132	5	W>R		No	ClinGen ExAC TOPMed gnomAD
rs1188735783 CA340231442	5	W>S		No	ClinGen gnomAD
CA840333 rs767665833	7	Q>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs267598629 CA22014368	8	E>K		No	ClinGen Ensembl
CA340231481 rs1179465400	9	L>I		No	ClinGen gnomAD
rs1418584594 CA340231496	10	M>V		No	ClinGen gnomAD
rs368380182 CA22014372	11	A>V		No	ClinGen ESP TOPMed
CA840336 rs372321679	12	H>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA840338 rs780534056	12	H>Q		No	ClinGen ExAC gnomAD
rs754400619 CA340231535	13	P>H		No	ClinGen ExAC TOPMed gnomAD
rs754400619 CA840339	13	P>R		No	ClinGen ExAC TOPMed gnomAD
rs375915739 CA840341	17	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs368911622 CA840342	21	C>F		No	ClinGen ESP ExAC
TCGA novel	22	M>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA840343 rs746529579	22	M>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	23	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA840344 rs770566853	27	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1340000860 CA340231758	29	V>L		No	ClinGen gnomAD
TCGA novel	31	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA840346 rs1553154607	34	Q>*		No	ClinGen Ensembl
rs1441076599 CA340231906	37	R>K		No	ClinGen gnomAD
CA840349 rs769783483	38	W>*		No	ClinGen ExAC gnomAD
rs564652252 CA22014437	39	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA340231931 rs1318144948	39	M>L		No	ClinGen TOPMed
CA840350 rs775555015	39	M>T		No	ClinGen ExAC TOPMed gnomAD
rs768825844 CA840352	42	A>D		No	ClinGen ExAC gnomAD
TCGA novel	42	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA840353 rs555609744	43	L>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1171645139 CA340232004	44	H>Q		No	ClinGen gnomAD
rs1284298719 CA340231994	44	H>Y		No	ClinGen TOPMed
CA22014453 rs868399298	47	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1329277173 CA340232074	48	A>E		No	ClinGen gnomAD
rs767710259 CA840355	49	P>T		No	ClinGen ExAC
rs145478155 CA840356	50	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA22014454 rs922487285	51	A>V		No	ClinGen TOPMed
rs1447320288 CA340232113	52	H>D		No	ClinGen TOPMed
rs761013597 CA840357	52	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1557619506 CA340232131	53	W>*		No	ClinGen Ensembl
rs142469011 CA840358	53	W>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA340232165 rs1274504569	54	F>L		No	ClinGen gnomAD
rs1234005820 CA340232153	54	F>S		No	ClinGen gnomAD
rs1485079244 CA340232176	55	Y>C		No	ClinGen gnomAD
rs1465152336 CA340232173	55	Y>H		No	ClinGen TOPMed
TCGA novel	55	Y>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754308581 CA840359	58	K>R		No	ClinGen ExAC gnomAD
rs753212900 CA840385	60	F>S		No	ClinGen ExAC TOPMed gnomAD
CA840386 rs74509104	62	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA22014801 rs202134276	62	P>S		No	ClinGen 1000Genomes
CA340232504 rs750072642	65	E>D		No	ClinGen ExAC TOPMed gnomAD
rs200543514 CA22014850 CA840390	66	F>L		No	ClinGen 1000Genomes
CA340232532 rs1341663166	66	F>S		No	ClinGen gnomAD
CA340232559 rs1244688646	67	E>D		No	ClinGen TOPMed gnomAD
rs1326871510 CA340232538	67	E>K		No	ClinGen TOPMed gnomAD
CA840392 rs755791121	70	H>P		No	ClinGen ExAC TOPMed gnomAD
rs779877978 CA840393	71	K>E		No	ClinGen ExAC TOPMed gnomAD
CA840394 rs749021898	71	K>R		No	ClinGen ExAC gnomAD
CA840396 rs754793906	74	E>A		No	ClinGen ExAC gnomAD
CA340232797 rs1256577866	76	Y>C		No	ClinGen gnomAD
CA22014877 rs899483543	77	P>A		No	ClinGen TOPMed
rs748081051 CA840398	78	C>R		No	ClinGen ExAC TOPMed gnomAD
rs748081051 CA840399	78	C>S		No	ClinGen ExAC TOPMed gnomAD
CA840402 rs369394518	80	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs779049952 CA22014895	81	P>L		No	ClinGen TOPMed gnomAD
CA840404 rs759942772	83	W>G		No	ClinGen ExAC gnomAD
rs765578888 CA840405	83	W>S		No	ClinGen ExAC gnomAD
rs1395744486 CA340232935	84	V>A		No	ClinGen TOPMed gnomAD
rs1311229506 CA340232945	85	G>*		No	ClinGen TOPMed gnomAD
CA340232948 rs1557620035	85	G>E		No	ClinGen Ensembl
rs1311229506 COSM288593 CA340232939	85	G>R	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA22014917 rs781053315	86	P>H		No	ClinGen gnomAD
CA340232968 rs781053315	86	P>L		No	ClinGen gnomAD
rs776044257 CA840408	88	T>M	Variant assessed as Somatic; 0.0001848 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs776044257 CA840407	88	T>R		No	ClinGen ExAC TOPMed gnomAD
CA840410 rs749906835	89	M>I		No	ClinGen ExAC gnomAD
CA340233009 rs1351127579	89	M>V		No	ClinGen gnomAD
rs769543799 CA840411	92	S>N		No	ClinGen ExAC gnomAD
rs1252643400 CA340233088	93	V>I		No	ClinGen gnomAD
CA340233090 rs1252643400	93	V>L		No	ClinGen gnomAD
CA840412 rs565485246	94	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs868678474 CA22014965	95	D>N		No	ClinGen TOPMed
CA840414 rs754776635	96	P>Q		No	ClinGen ExAC gnomAD
rs753600181 CA840413	96	P>S		No	ClinGen ExAC gnomAD
CA840416 rs752567740	97	D>G		No	ClinGen ExAC gnomAD
CA840415 rs778608363	97	D>H		No	ClinGen ExAC
rs758218840 CA840417	98	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs373456415 CA840418	99	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs577489518 CA840419 COSM1343186	102	L>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs111268513 CA22014987	102	L>P		No	ClinGen Ensembl
rs771067083 CA840420	103	L>M		No	ClinGen ExAC gnomAD
rs1569695320 CA340233247	103	L>P		No	ClinGen Ensembl
rs375117322 CA840421	104	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	105	R>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746127297 CA840422	105	R>T		No	ClinGen ExAC TOPMed gnomAD
CA840424 rs181315648	107	D>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs181315648 CA840423	107	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA340234221 rs1422159796	122	G>D		No	ClinGen gnomAD
rs774973940 CA840445	123	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs762445971 CA840446	123	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs201511396 CA22018130	124	G>E		No	ClinGen Ensembl
rs772732845 CA840447	124	G>R		No	ClinGen ExAC gnomAD
rs1437054116 CA340234255	126	V>A		No	ClinGen TOPMed gnomAD
CA840448 rs775955044	127	T>N		No	ClinGen ExAC gnomAD
rs540867697 CA840449	130	G>S		No	ClinGen 1000Genomes ExAC
CA340234334 rs1399206420	133	W>*		No	ClinGen gnomAD
rs920975226 CA22018161	133	W>C		No	ClinGen TOPMed
CA340234330 rs1399206420	133	W>L		No	ClinGen gnomAD
CA840451 rs371107865	133	W>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA340234341 rs1569713302	134	K>E		No	ClinGen Ensembl
CA840454 rs146576339 COSM910386	137	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs146576339 CA340234378	137	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340234380 rs1228830023	137	R>H		No	ClinGen TOPMed gnomAD
CA340234412 CA340234410 rs1288972235	140	V>L		No	ClinGen TOPMed gnomAD
CA840455 rs763928046	142	P>T		No	ClinGen ExAC gnomAD
rs757146734 CA840457	145	N>I		No	ClinGen ExAC gnomAD
CA840459 rs750416622	146	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1448902750 CA340234497	147	S>G		No	ClinGen TOPMed
CA340234536 rs1261472100	152	F>C		No	ClinGen TOPMed gnomAD
rs1441622373 CA340234540	153	I>V		No	ClinGen gnomAD
CA340234559 rs1421571469	155	M>I		No	ClinGen gnomAD
rs1413639367 CA340234554	155	M>T		No	ClinGen TOPMed gnomAD
rs150940120 CA840461	155	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA340234566 rs1159912418	156	M>I		No	ClinGen gnomAD
CA340234565 rs1569713459	156	M>T		No	ClinGen Ensembl
rs749569807 CA840462	157	S>C		No	ClinGen ExAC
CA840463 rs200076743	158	E>K		No	ClinGen ExAC TOPMed gnomAD
CA340234574 rs200076743	158	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs150189598 CA840464	160	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA840467 rs368708579	161	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs375669698 CA840465	161	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs745363805 CA840468	162	M>V		No	ClinGen ExAC gnomAD
rs769158046 CA840489	169	E>G		No	ClinGen ExAC gnomAD
CA840488 rs552332557	169	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA340234673 rs775025928	170	H>N		No	ClinGen ExAC TOPMed gnomAD
rs748820256 CA840491	170	H>P		No	ClinGen ExAC TOPMed gnomAD
rs775025928 CA840490	170	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA840492 rs768243149	172	A>D		No	ClinGen ExAC gnomAD
rs774000221 CA840493	173	Q>K		No	ClinGen ExAC gnomAD
rs375028977 CA840494	176	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs148896426 CA840495	176	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA840498 rs766245765	178	E>*		No	ClinGen ExAC TOPMed gnomAD
CA340234743 rs1220808443	181	Q>E		No	ClinGen TOPMed gnomAD
rs1259315140 CA340234747	181	Q>L		No	ClinGen gnomAD
CA340234768 rs1193632172	184	S>C		No	ClinGen gnomAD
CA340234784 rs1569716955	187	T>P		No	ClinGen Ensembl
rs138229917 CA22019457	189	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs753910598 CA840500	189	D>G		No	ClinGen ExAC gnomAD
rs753024597 CA840503	192	M>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	193	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA840504 rs758670291	193	K>R		No	ClinGen ExAC TOPMed gnomAD
rs778242775 CA340234832	194	C>G		No	ClinGen ExAC gnomAD
CA840505 rs778242775	194	C>R		No	ClinGen ExAC gnomAD
CA340234833 rs1307181285	194	C>Y		No	ClinGen gnomAD
rs751900894 CA840506	195	A>D		No	ClinGen ExAC gnomAD
rs1460403785 CA340234838	195	A>T		No	ClinGen gnomAD
rs1360881941 CA340234844	196	F>V		No	ClinGen TOPMed
rs757734855 CA840507	198	H>Q		No	ClinGen ExAC gnomAD
CA840508 rs781568179	199	Q>H		No	ClinGen ExAC gnomAD
CA840509 rs748734462	200	G>S		No	ClinGen ExAC gnomAD
rs768224738 CA840510	201	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs200729848 CA840511	204	L>M		No	ClinGen 1000Genomes ExAC gnomAD
CA840513 rs771651766	205	D>N		No	ClinGen ExAC gnomAD
CA340234918 rs1340518492	206	S>N		No	ClinGen gnomAD
CA840523 rs764245113	207	T>A		No	ClinGen ExAC gnomAD
CA340234964 rs1173317124	207	T>N		No	ClinGen TOPMed
CA340234974 rs1364010627	208	L>P		No	ClinGen gnomAD
rs1475425929 CA340234993	210	S>P		No	ClinGen TOPMed gnomAD
CA340234990 rs1475425929	210	S>T		No	ClinGen TOPMed gnomAD
rs751895440 CA840524	211	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA340235037 rs368048506	214	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340235039 rs368048506	214	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA840525 rs368048506	214	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	215	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1380837458 CA340235086	218	L>V		No	ClinGen gnomAD
CA340235099 rs1460991814	219	S>N		No	ClinGen TOPMed gnomAD
TCGA novel	222	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781664549 CA840526	224	Q>H		No	ClinGen ExAC gnomAD
CA340235156 rs1200630012	224	Q>K		No	ClinGen TOPMed
CA840527 rs147199588	225	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA840530 rs778352142	225	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA840529 rs778352142	225	R>L		No	ClinGen ExAC TOPMed gnomAD
CA840528 rs147199588	225	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA840534 rs770687313 CA340235184	226	M>I		No	ClinGen ExAC TOPMed gnomAD
CA840533 rs199974985	226	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs199974985 CA840532	226	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA840535 rs776686295	229	F>V		No	ClinGen ExAC gnomAD
rs745842351 CA840536	231	H>Y		No	ClinGen ExAC gnomAD
rs769885808 CA840537	232	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA840539 rs762956296	234	D>N		No	ClinGen ExAC gnomAD
CA840541 rs774507515	238	K>Q		No	ClinGen ExAC gnomAD
rs1400394033 CA340235336	240	S>I		No	ClinGen TOPMed
rs762227421 CA840542	241	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA840543 rs767921964	242	Q>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	243	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1363397601 CA340235451	246	F>C		No	ClinGen TOPMed gnomAD
CA840544 rs750814802	249	F>L		No	ClinGen ExAC gnomAD
rs756562508 CA840545	249	F>S		No	ClinGen ExAC TOPMed gnomAD
rs1403608509 CA340235501	250	N>D		No	ClinGen TOPMed gnomAD
CA840546 rs766881208	250	N>S		No	ClinGen ExAC TOPMed gnomAD
CA340235514 rs1335250432	251	Q>K		No	ClinGen gnomAD
rs752181365 CA840547	253	L>P		No	ClinGen ExAC gnomAD
CA340235594 rs1443768844	255	Q>H		No	ClinGen TOPMed
rs757912181 CA840548	256	F>I		No	ClinGen ExAC TOPMed gnomAD
rs757912181 CA340235600	256	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1159251255 CA340237181	258	E>V		No	ClinGen TOPMed
rs761027908 CA840563	260	V>L		No	ClinGen ExAC gnomAD
CA840565 rs754358760	263	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA840567 rs377341729	264	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA840566 rs757902695	264	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1481046658 CA340237223	265	K>E		No	ClinGen TOPMed
CA840569 rs147693904	267	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA840568 rs147693904	267	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA840571 rs202177126	271	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1197689248 CA340237288	274	Q>R		No	ClinGen gnomAD
CA840573 rs756043045	275	D>H		No	ClinGen ExAC gnomAD
CA340237310 rs1557628710	277	T>I		No	ClinGen Ensembl
rs780029967 CA840574	278	Q>R		No	ClinGen ExAC gnomAD
rs1346049275 CA340237330	280	R>M		No	ClinGen TOPMed
CA840577 rs768753257	280	R>S		No	ClinGen ExAC TOPMed gnomAD
rs748235991 CA840578	281	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM3718379 RCV000963055 rs146391078 CA840579	281	R>H	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs146391078 CA340237335	281	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340237340 rs1279841440	282	W>*		No	ClinGen gnomAD
CA840581 rs557601500	282	W>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs539294690 CA840580	282	W>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200948225 CA22023759	285	L>V		No	ClinGen Ensembl
CA840582 rs376220100	287	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1158480404 CA340237378	288	L>V		No	ClinGen TOPMed
rs759919491 CA840584	290	S>N		No	ClinGen ExAC gnomAD
CA840583 rs575780043	290	S>R		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	291	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1304959586 CA340237400	291	A>T		No	ClinGen gnomAD
CA840612 rs199842930	293	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1415793074 CA340238418	294	E>G		No	ClinGen gnomAD
rs754866665 COSM3771764 CA840614	294	E>K	Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA840616 rs778699945	297	K>E		No	ClinGen ExAC gnomAD
TCGA novel	297	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA840617 rs752678703	298	D>G		No	ClinGen ExAC TOPMed gnomAD
CA340238526 rs1306246695	300	S>C		No	ClinGen TOPMed
rs758440812 CA840618	300	S>P		No	ClinGen ExAC gnomAD
rs1156657141 CA340238534	301	E>K		No	ClinGen gnomAD
CA340238556 rs1360891523	302	A>E		No	ClinGen TOPMed gnomAD
CA340238565 rs1360891523	302	A>V		No	ClinGen TOPMed gnomAD
CA840620 rs747113273	303	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1436038844 CA340238576	303	D>G		No	ClinGen TOPMed
rs1335938854 CA340238573	303	D>Y		No	ClinGen gnomAD
CA840621 rs757365683	305	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs1025067732 CA22025613	308	V>L		No	ClinGen TOPMed gnomAD
CA840623 rs549833831	310	T>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1430502668 CA340238698	311	F>C		No	ClinGen TOPMed gnomAD
rs1430502668 CA340238695	311	F>Y		No	ClinGen TOPMed gnomAD
CA340238706 rs1204875907	312	M>L		No	ClinGen gnomAD
rs749854611 CA840626	312	M>T		No	ClinGen ExAC gnomAD
rs769322320 CA840627	315	G>R		No	ClinGen ExAC TOPMed gnomAD
CA840629 rs760233218	316	H>L		No	ClinGen ExAC gnomAD
rs772804055 CA840628	316	H>N		No	ClinGen ExAC gnomAD
CA340238768 rs760233218	316	H>R		No	ClinGen ExAC gnomAD
rs776401055 CA840631	321	S>R		No	ClinGen ExAC gnomAD
TCGA novel	322	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1190916823 CA340238850	323	I>V		No	ClinGen TOPMed
CA840632 rs759228438	324	S>F		No	ClinGen ExAC gnomAD
CA840634 rs568325668	325	W>*		No	ClinGen 1000Genomes ExAC gnomAD
rs972928351 CA22025679	325	W>C		No	ClinGen TOPMed
rs568325668 CA840633	325	W>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1263533473 CA340238922	327	L>H		No	ClinGen TOPMed
CA340238914 rs1403774117	327	L>I		No	ClinGen gnomAD
CA340238950 rs1218298296	329	C>R		No	ClinGen TOPMed
CA340238980 rs1333431048	330	L>F		No	ClinGen TOPMed gnomAD
rs764032618 CA840636	331	A>E		No	ClinGen ExAC gnomAD
rs1336641403 CA340238990	331	A>T		No	ClinGen gnomAD
rs1277941543 CA340239035	333	Y>*		No	ClinGen gnomAD
CA340239052 rs1370207758	335	E>K		No	ClinGen gnomAD
CA840637 rs375128008	336	H>N		No	ClinGen ESP ExAC TOPMed
rs375128008 CA22025711	336	H>Y		No	ClinGen ESP ExAC TOPMed
rs781259201 CA840639	337	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs781259201 CA22025735	337	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1222732005 CA340239117	338	Q>E		No	ClinGen TOPMed
rs1340893286 CA340239148	340	C>R		No	ClinGen TOPMed
CA340239156 rs1322023348	340	C>Y		No	ClinGen gnomAD
CA840640 rs202100105	341	R>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs756404977 COSM1687637 CA840641	341	R>Q	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1436665985 COSM3490473 CA340239202	343	E>K	Variant assessed as Somatic; 0.0 impact. liver [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs780530512 CA840642	344	I>V		No	ClinGen ExAC gnomAD
CA22025753 rs267598632	345	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs769215859 CA840644	348	L>I		No	ClinGen ExAC gnomAD
CA22025765 rs371837744	351	G>E		No	ClinGen ESP gnomAD
rs369575084 CA840646	351	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA840647 rs144381041	354	I>T		No	ClinGen ESP ExAC
rs149156333 CA840675	356	W>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs149156333 CA840674	356	W>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1489165239 CA340240036	360	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA340240051 rs1219462326	361	Q>R		No	ClinGen TOPMed
CA840677 rs201097161	364	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs760900078 CA840678	365	T>A		No	ClinGen ExAC TOPMed gnomAD
CA840679 rs766692536	366	T>M		No	ClinGen ExAC TOPMed gnomAD
CA340240094 rs766692536	366	T>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA340240098 rs1569750966	367	M>T		No	ClinGen Ensembl
CA840681 rs755361561	367	M>V		No	ClinGen ExAC TOPMed gnomAD
CA340240123 rs1160349659	370	K>R		No	ClinGen gnomAD
rs1569750988 CA340240137	372	C>F		No	ClinGen Ensembl
rs373398954 CA840684	374	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs778146409 CA840685	374	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1159495159 CA340240153	375	L>F		No	ClinGen TOPMed gnomAD
rs1384955053 CA340240156	375	L>P		No	ClinGen gnomAD
rs142306823 CA840687	376	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1381027534 CA340240162	376	Y>C		No	ClinGen gnomAD
rs138601503 CA840688	377	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs999250046 CA22028202	377	A>P		No	ClinGen TOPMed gnomAD
rs999250046 CA340240165	377	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs748981833 CA840689	378	P>L		No	ClinGen ExAC TOPMed gnomAD
CA340240169 rs1355393737	378	P>T		No	ClinGen gnomAD
CA340240178 rs1435648285	379	V>A		No	ClinGen TOPMed
CA340240175 rs1348211256	379	V>I		No	ClinGen gnomAD
rs761531357 CA840692	382	I>M		No	ClinGen ExAC gnomAD
CA22028208 rs1010770929	383	S>P		No	ClinGen TOPMed gnomAD
CA340240200 rs1010770929	383	S>T		No	ClinGen TOPMed gnomAD
CA840694 rs773077143	384	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA840693 rs201816403	384	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs760812035 CA840695	386	L>V		No	ClinGen ExAC TOPMed gnomAD
rs766602882 CA840696	387	D>N		No	ClinGen ExAC TOPMed gnomAD
rs776879110 CA340240231	388	K>R		No	ClinGen ExAC gnomAD
rs776879110 CA840697	388	K>T		No	ClinGen ExAC gnomAD
rs759780604 CA840698	389	P>H		No	ClinGen ExAC gnomAD
rs1179243011 CA340240236	389	P>S		No	ClinGen gnomAD
CA340240245 rs4926802	390	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340240251 rs1312419675	391	T>I		No	ClinGen TOPMed
CA340240249 rs1312419675	391	T>N		No	ClinGen TOPMed
rs758756410 CA840701	392	F>L		No	ClinGen ExAC gnomAD
rs28463559 VAR_048461	393	P>L		No	UniProt dbSNP
CA340240270 rs1305796096	394	D>V		No	ClinGen gnomAD
CA840702 rs144526298	396	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA22028249 rs918418362	398	L>F		No	ClinGen Ensembl
rs1263733337 CA340240303	400	A>S		No	ClinGen gnomAD
CA340240308 rs1231869810	401	G>R		No	ClinGen gnomAD
rs747792357 CA840735	401	G>V		No	ClinGen ExAC gnomAD
rs1215297611 CA340242065	402	I>R		No	ClinGen gnomAD
CA840736 rs376411085	403	T>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA340242116 rs1292731078	405	F>Y		No	ClinGen gnomAD
CA22031588 rs972386823	407	N>D		No	ClinGen TOPMed
rs777659874 CA840737	407	N>S		No	ClinGen ExAC gnomAD
CA340242145 rs972386823	407	N>Y		No	ClinGen TOPMed
rs370572165 CA840738	410	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA22031590 rs942852654	410	A>S		No	ClinGen Ensembl
CA340242195 rs370572165	410	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA340242214 rs1486478234	411	L>P		No	ClinGen gnomAD
rs770923489 CA840739	412	H>Q		No	ClinGen ExAC gnomAD
CA340242223 rs1404814898	412	H>Y		No	ClinGen Ensembl
CA22031594 rs375806778	415	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA840740 rs375806778	415	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs201881781 CA840741	420	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1384184947 CA340242371	421	P>T		No	ClinGen gnomAD
rs1404390352 CA340242388	422	Q>E		No	ClinGen TOPMed
CA840762 rs374435579	423	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs201141014 CA22031902	426	P>S		No	ClinGen 1000Genomes
CA840764 rs774626847	428	R>T		No	ClinGen ExAC gnomAD
rs1206792114 CA340242922	432	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs762156478 CA840765	433	N>S		No	ClinGen ExAC TOPMed gnomAD
CA840766 rs772462300	434	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1319397097 CA340242949	435	E>G		No	ClinGen TOPMed
CA840769 rs531603801	437	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773593990 CA840767	437	I>V		No	ClinGen ExAC gnomAD
CA340242982 CA340242983 rs1187296208	438	H>Q		No	ClinGen TOPMed gnomAD
CA340242996 rs1446238110	440	Y>H		No	ClinGen Ensembl
CA840770 rs766916827	441	A>V		No	ClinGen ExAC TOPMed gnomAD
CA340243034 rs1355308921	443	I>M		No	ClinGen gnomAD
CA840771 rs550113245	443	I>T		No	ClinGen 1000Genomes ExAC gnomAD
rs762583234 CA840772	444	P>L		No	ClinGen ExAC TOPMed gnomAD
CA340243070 rs1474044051	446	S>L		No	ClinGen gnomAD
rs1229976684	450	R>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1204320599 CA340243168	451	N>T		No	ClinGen TOPMed
rs139887951 CA840792	452	C>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA840791 rs139887951	452	C>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs767280490 CA840793	453	I>M		No	ClinGen ExAC gnomAD
CA22032410 rs1044614444	453	I>T		No	ClinGen TOPMed
rs1448657007 CA340243207	455	Q>*	Variant assessed as Somatic; 4.627e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA340243245 rs1297930202	458	A>V		No	ClinGen TOPMed
CA340243251 rs1448887826	459	I>T		No	ClinGen gnomAD
CA840796 rs766218898	459	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1166994764 CA340243275	461	E>D		No	ClinGen gnomAD
rs1003187628 CA22032436	461	E>G		No	ClinGen TOPMed
TCGA novel	461	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1362515073 CA340243292	463	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs753850057 CA840797	463	K>T		No	ClinGen ExAC gnomAD
rs754935445 CA840798	464	V>M		No	ClinGen ExAC TOPMed gnomAD
rs778928371 CA840799	465	A>P		No	ClinGen ExAC gnomAD
rs778928371 CA340243309	465	A>T		No	ClinGen ExAC gnomAD
CA340243329 rs748233968	467	A>S		No	ClinGen ExAC TOPMed gnomAD
rs748233968 CA840800	467	A>T		No	ClinGen ExAC TOPMed gnomAD
CA840801 COSM2157009 rs145758676	472	R>C	central_nervous_system Variant assessed as Somatic; 4.625e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA840802 rs778116331	472	R>H		No	ClinGen ExAC gnomAD
CA340243385 rs1325376306	473	F>L		No	ClinGen gnomAD
rs747332699 CA840803	474	K>E		No	ClinGen ExAC gnomAD
rs771368249 CA840804	474	K>R		No	ClinGen ExAC gnomAD
rs1173846409 CA340243400	475	L>Q		No	ClinGen TOPMed
rs1383047423 CA340243408	476	A>G		No	ClinGen gnomAD
rs1383047423 CA340243409	476	A>V		No	ClinGen gnomAD
CA340243435 rs776982528	479	H>D		No	ClinGen ExAC gnomAD
CA840806 rs746327744	479	H>R		No	ClinGen ExAC gnomAD
CA840805 rs776982528	479	H>Y		No	ClinGen ExAC gnomAD
CA340243445 rs1205667257	480	S>L		No	ClinGen gnomAD
CA840807 CA340243456 rs770453315	481	R>S		No	ClinGen ExAC TOPMed gnomAD
CA22032503 rs200917257	483	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA
rs761419989 CA840809	485	P>R		No	ClinGen ExAC gnomAD
rs571972072 CA840810 COSM910391	487	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes NCI-TCGA TOPMed
rs767060662 CA840812	487	R>H		No	ClinGen ExAC TOPMed gnomAD
rs767060662 CA22032534	487	R>L		No	ClinGen ExAC TOPMed gnomAD
CA340243527 rs1236281928	488	Q>P		No	ClinGen TOPMed
TCGA novel	490	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA840814 rs199507217	491	L>F		No	ClinGen 1000Genomes ExAC gnomAD
CA340243568 rs1209990571	491	L>P		No	ClinGen TOPMed
rs753610164 CA840816	492	K>*		No	ClinGen ExAC gnomAD
CA340243614 rs1159690392	495	N>D		No	ClinGen gnomAD
rs1277235002 CA340243655	498	H>P		No	ClinGen TOPMed
CA22032557 rs375736249	499	V>A		No	ClinGen ESP TOPMed
rs1455236747 CA522616868	499	V>G		No	ClinGen gnomAD
CA340243684 rs1406092263	500	F>S		No	ClinGen gnomAD
TCGA novel	502	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	502	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA840819 rs765174674	503	K>N		No	ClinGen ExAC gnomAD
CA840818 rs754846563	503	K>R		No	ClinGen ExAC gnomAD
rs1239477453 CA340243736	504	V>F		No	ClinGen gnomAD
rs759035167	504	V>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs752762340 CA840820	505	C>*		No	ClinGen ExAC

No associated diseases with Q86W10

1 regional properties for Q86W10

Type	Name	Position	InterPro Accession
conserved_site	Cytochrome P450, conserved site	445 - 454	IPR017972

Functions

		Description
EC Number	1.14.14.1	With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization	Endoplasmic reticulum membrane ; Single-pass type II membrane protein Microsome membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

5 GO annotations of molecular function

Name	Definition
arachidonic acid 14,15-epoxygenase activity	Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid.
aromatase activity	Catalysis of the reduction of an aliphatic ring to yield an aromatic ring.
fatty acid in-chain hydroxylase activity	Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O.
heme binding	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding	Binding to an iron (Fe) ion.

2 GO annotations of biological process

Name	Definition
arachidonic acid metabolic process	The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
lauric acid metabolic process	The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources.

38 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9VYQ5	Cyp318a1	Probable cytochrome P450 318a1	Drosophila melanogaster (Fruit fly)	PR
Q9V559	Cyp4p3	Probable cytochrome P450 4p3	Drosophila melanogaster (Fruit fly)	PR
Q9VMS7	Cyp4ac3	Probable cytochrome P450 4ac3	Drosophila melanogaster (Fruit fly)	PR
Q9VMS8	Cyp4ac2	Probable cytochrome P450 4ac2	Drosophila melanogaster (Fruit fly)	PR
Q9VVN6	Cyp312a1	Probable cytochrome P450 312a1	Drosophila melanogaster (Fruit fly)	PR
Q9VXY0	Cyp4s3	Probable cytochrome P450 4s3	Drosophila melanogaster (Fruit fly)	PR
Q9V7G5	Cyp4aa1	Probable cytochrome P450 4aa1	Drosophila melanogaster (Fruit fly)	PR
Q6ZWL3	CYP4V2	Cytochrome P450 4V2	Homo sapiens (Human)	PR
Q5TCH4	CYP4A22	Cytochrome P450 4A22	Homo sapiens (Human)	PR
Q02928	CYP4A11	Cytochrome P450 4A11	Homo sapiens (Human)	PR
P13584	CYP4B1	Cytochrome P450 4B1	Homo sapiens (Human)	PR
B6SSW8	CYP714B3	Cytochrome P450 714B3	Zea mays (Maize)	PR
O35728	Cyp4a14	Cytochrome P450 4A14	Mus musculus (Mouse)	PR
Q91WL5	Cyp4a12a	Cytochrome P450 4A12A	Mus musculus (Mouse)	PR
Q8SPK1	CYP4A24	Cytochrome P450 4A24	Sus scrofa (Pig)	PR
Q9GJX5	CYP4A21	Taurochenodeoxycholic 6 alpha-hydroxylase	Sus scrofa (Pig)	PR
Q8SPK0	CYP4A25	Cytochrome P450 4A25	Sus scrofa (Pig)	PR
G3V7X8	Cyp26b1	Cytochrome P450 26B1	Rattus norvegicus (Rat)	PR
P20816	Cyp4a2	Cytochrome P450 4A2	Rattus norvegicus (Rat)	PR
P24464	Cyp4a12	Cytochrome P450 4A12	Rattus norvegicus (Rat)	PR
P20817	Cyp4a14	Cytochrome P450 4A14	Rattus norvegicus (Rat)	PR
Q05JG2	CYP707A5	Abscisic acid 8'-hydroxylase 1	Oryza sativa subsp japonica (Rice)	PR
Q6F4F5	CYP724B1	Cytochrome P450 724B1	Oryza sativa subsp japonica (Rice)	PR
Q0DS59	CYP714B2	Cytochrome P450 714B2	Oryza sativa subsp japonica (Rice)	PR
Q5KQH7	CYP714D1	Cytochrome P450 714D1	Oryza sativa subsp japonica (Rice)	PR
Q9C788	CYP704B1	Cytochrome P450 704B1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9ZUX1	CYP94C1	Cytochrome P450 94C1	Arabidopsis thaliana (Mouse-ear cress)	PR
O81077	CYP707A2	Abscisic acid 8'-hydroxylase 2	Arabidopsis thaliana (Mouse-ear cress)	PR
O64698	CYP710A2	Cytochrome P450 710A2	Arabidopsis thaliana (Mouse-ear cress)	PR
O64697	CYP710A1	Cytochrome P450 710A1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q94IA6	CYP90D1	3-epi-6-deoxocathasterone 23-monooxygenase CYP90D1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6TBX7	CYP97C1	Carotene epsilon-monooxygenase, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LUC5	CYP72A15	Cytochrome P450 72A15	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LUC6	CYP72A14	Cytochrome P450 72A14	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LUC8	CYP72A13	Cytochrome P450 72A13	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LUC9	CYP72A11	Cytochrome P450 72A11	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SHG5	CYP72C1	Cytochrome P450 72C1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6EIG3	cyp26b1	Cytochrome P450 26B1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MEPSWLQELM	AHPFLLLILL	CMSLLLFQVI	RLYQRRRWMI	RALHLFPAPP	AHWFYGHKEF
70	80	90	100	110	120
YPVKEFEVYH	KLMEKYPCAV	PLWVGPFTMF	FSVHDPDYAK	ILLKRQDPKS	AVSHKILESW
130	140	150	160	170	180
VGRGLVTLDG	SKWKKHRQIV	KPGFNISILK	IFITMMSESV	RMMLNKWEEH	IAQNSRLELF
190	200	210	220	230	240
QHVSLMTLDS	IMKCAFSHQG	SIQLDSTLDS	YLKAVFNLSK	ISNQRMNNFL	HHNDLVFKFS
250	260	270	280	290	300
SQGQIFSKFN	QELHQFTEKV	IQDRKESLKD	KLKQDTTQKR	RWDFLDILLS	AKSENTKDFS
310	320	330	340	350	360
EADLQAEVKT	FMFAGHDTTS	SAISWILYCL	AKYPEHQQRC	RDEIRELLGD	GSSITWEHLS
370	380	390	400	410	420
QMPYTTMCIK	ECLRLYAPVV	NISRLLDKPI	TFPDGRSLPA	GITVFINIWA	LHHNPYFWED
430	440	450	460	470	480
PQVFNPLRFS	RENSEKIHPY	AFIPFSAGLR	NCIGQHFAII	ECKVAVALTL	LRFKLAPDHS
490	500
RPPQPVRQVV	LKSKNGIHVF	AKKVC