O35728
PR
Gene name |
Cyp4a14 |
Protein name |
Cytochrome P450 4A14 |
Names |
CYPIVA14, Lauric acid hydroxylase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13119 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O35728
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O35728-F1 | Predicted | AlphaFoldDB |
37 variants for O35728
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3022990 | 5 | L>V | No | EVA | |
| rs216479428 | 21 | W>G | No | EVA | |
| rs262007231 | 47 | T>A | No | EVA | |
| rs212037738 | 63 | H>Q | No | EVA | |
| rs247002531 | 120 | F>L | No | EVA | |
| rs3388704721 | 142 | M>K | No | EVA | |
| rs8239731 | 160 | A>V | No | EVA | |
| rs3388701089 | 172 | K>N | No | EVA | |
| rs3388708467 | 179 | P>L | No | EVA | |
| rs250272687 | 183 | F>V | No | EVA | |
| rs229791808 | 185 | C>S | No | EVA | |
| rs3388700184 | 193 | T>I | No | EVA | |
| rs3388690433 | 202 | Q>* | No | EVA | |
| rs230066032 | 213 | L>S | No | EVA | |
| rs3388698139 | 218 | V>F | No | EVA | |
| rs3388706753 | 228 | R>L | No | EVA | |
| rs214511558 | 229 | L>M | No | EVA | |
| rs243595967 | 247 | R>C | No | EVA | |
| rs3394190602 | 259 | H>N | No | EVA | |
| rs3394749525 | 259 | H>Q | No | EVA | |
| rs27496720 | 285 | H>R | No | EVA | |
| rs3388704108 | 290 | D>G | No | EVA | |
| rs8249608 | 300 | R>K | No | EVA | |
| rs218489926 | 308 | L>V | No | EVA | |
| rs3388700187 | 332 | Y>C | No | EVA | |
| rs3388690139 | 333 | A>T | No | EVA | |
| rs3388701177 | 335 | A>V | No | EVA | |
| rs3388706745 | 341 | Q>K | No | EVA | |
| rs3388690128 | 349 | Q>* | No | EVA | |
| rs3388701093 | 352 | L>P | No | EVA | |
| rs3388681162 | 394 | V>A | No | EVA | |
| rs3388703566 | 394 | V>L | No | EVA | |
| rs3388704171 | 400 | R>S | No | EVA | |
| rs27496721 | 402 | I>L | No | EVA | |
| rs220647708 | 408 | A>T | No | EVA | |
| rs249973361 | 420 | R>S | No | EVA | |
| rs3388704130 | 488 | I>N | No | EVA |
No associated diseases with O35728
1 regional properties for O35728
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 446 - 455 | IPR017972 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
11 GO annotations of molecular function
| Name | Definition |
|---|---|
| 16-hydroxypalmitate dehydrogenase activity | Catalysis of the reaction: 16-hydroxypalmitate + NADP <=> H+ + 16-oxo-palmitate + NADPH. |
| alkane 1-monooxygenase activity | Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O. |
| arachidonic acid binding | Binding to arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. |
| arachidonic acid epoxygenase activity | Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid. |
| arachidonic acid monooxygenase activity | Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. |
| fatty acid binding | Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. |
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| iron ion binding | Binding to an iron (Fe) ion. |
| laurate hydroxylase activity | Catalysis of the reaction: dodecanoate + NADPH + O2 + H+ <=> 11-hydroxylaurate + NADP + H2O. |
| leukotriene-B4 20-monooxygenase activity | Catalysis of the reaction: leukotriene B4 + O2 + reduced |
| long-chain fatty acid omega-hydroxylase activity | Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| arachidonic acid metabolic process | The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. |
| epoxygenase P450 pathway | The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. |
| icosanoid biosynthetic process | The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids. |
| kidney development | The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. |
| lauric acid metabolic process | The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources. |
| leukotriene metabolic process | The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. |
| linoleic acid metabolic process | The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. |
| long-chain fatty acid metabolic process | The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
| positive regulation of icosanoid secretion | Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell. |
38 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9VYQ5 | Cyp318a1 | Probable cytochrome P450 318a1 | Drosophila melanogaster (Fruit fly) | PR |
| Q9V559 | Cyp4p3 | Probable cytochrome P450 4p3 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VMS7 | Cyp4ac3 | Probable cytochrome P450 4ac3 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VMS8 | Cyp4ac2 | Probable cytochrome P450 4ac2 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VVN6 | Cyp312a1 | Probable cytochrome P450 312a1 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VXY0 | Cyp4s3 | Probable cytochrome P450 4s3 | Drosophila melanogaster (Fruit fly) | PR |
| Q9V7G5 | Cyp4aa1 | Probable cytochrome P450 4aa1 | Drosophila melanogaster (Fruit fly) | PR |
| P13584 | CYP4B1 | Cytochrome P450 4B1 | Homo sapiens (Human) | PR |
| Q6ZWL3 | CYP4V2 | Cytochrome P450 4V2 | Homo sapiens (Human) | PR |
| Q86W10 | CYP4Z1 | Cytochrome P450 4Z1 | Homo sapiens (Human) | PR |
| Q5TCH4 | CYP4A22 | Cytochrome P450 4A22 | Homo sapiens (Human) | PR |
| Q02928 | CYP4A11 | Cytochrome P450 4A11 | Homo sapiens (Human) | PR |
| B6SSW8 | CYP714B3 | Cytochrome P450 714B3 | Zea mays (Maize) | PR |
| Q91WL5 | Cyp4a12a | Cytochrome P450 4A12A | Mus musculus (Mouse) | PR |
| Q8SPK1 | CYP4A24 | Cytochrome P450 4A24 | Sus scrofa (Pig) | PR |
| Q9GJX5 | CYP4A21 | Taurochenodeoxycholic 6 alpha-hydroxylase | Sus scrofa (Pig) | PR |
| Q8SPK0 | CYP4A25 | Cytochrome P450 4A25 | Sus scrofa (Pig) | PR |
| P24464 | Cyp4a12 | Cytochrome P450 4A12 | Rattus norvegicus (Rat) | PR |
| G3V7X8 | Cyp26b1 | Cytochrome P450 26B1 | Rattus norvegicus (Rat) | PR |
| P20816 | Cyp4a2 | Cytochrome P450 4A2 | Rattus norvegicus (Rat) | PR |
| P20817 | Cyp4a14 | Cytochrome P450 4A14 | Rattus norvegicus (Rat) | PR |
| Q05JG2 | CYP707A5 | Abscisic acid 8'-hydroxylase 1 | Oryza sativa subsp japonica (Rice) | PR |
| Q6F4F5 | CYP724B1 | Cytochrome P450 724B1 | Oryza sativa subsp japonica (Rice) | PR |
| Q0DS59 | CYP714B2 | Cytochrome P450 714B2 | Oryza sativa subsp japonica (Rice) | PR |
| Q5KQH7 | CYP714D1 | Cytochrome P450 714D1 | Oryza sativa subsp japonica (Rice) | PR |
| Q9C788 | CYP704B1 | Cytochrome P450 704B1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZUX1 | CYP94C1 | Cytochrome P450 94C1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81077 | CYP707A2 | Abscisic acid 8'-hydroxylase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64698 | CYP710A2 | Cytochrome P450 710A2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64697 | CYP710A1 | Cytochrome P450 710A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94IA6 | CYP90D1 | 3-epi-6-deoxocathasterone 23-monooxygenase CYP90D1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6TBX7 | CYP97C1 | Carotene epsilon-monooxygenase, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUC5 | CYP72A15 | Cytochrome P450 72A15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUC6 | CYP72A14 | Cytochrome P450 72A14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUC8 | CYP72A13 | Cytochrome P450 72A13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUC9 | CYP72A11 | Cytochrome P450 72A11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SHG5 | CYP72C1 | Cytochrome P450 72C1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6EIG3 | cyp26b1 | Cytochrome P450 26B1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGFFLFSPTR | YLDGISGFFQ | WAFLLSLFLV | LFKAVQFYLR | RQWLLKTLQH | FPCMPSHWLW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GHHLKDKELQ | QILIWVEKFP | SACLQCLSGS | NIRVLLYDPD | YVKVVLGRSD | PKASGIYQFF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| APWIGYGLLL | LNGKKWFQHR | RMLTPAFHYD | ILKPYVKIMA | DSVNIMLDKW | EKLDGQDHPL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EIFHCVSLMT | LDTVMKCAFS | YQGSVQLDEN | SKLYTKAVED | LNNLTFFRLR | NAFYKYNIIY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NMSSDGRLSH | HACQIAHEHT | DGVIKMRKSQ | LQNEEELQKA | RKKRHLDFLD | ILLFARMEDR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NSLSDEDLRA | EVDTFMFEGH | DTTASGISWI | FYALATHPEH | QQRCREEVQS | ILGDGTSVTW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DHLGQMPYTT | MCIKEALRLY | PPVISVSREL | SSPVTFPDGR | SIPKGITATI | SIYGLHHNPR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FWPNPKVFDP | SRFAPDSSHH | SHAYLPFSGG | SRNCIGKQFA | MNELKVAVAL | TLLRFELLPD |
| 490 | 500 | ||||
| PTRIPVPIAR | LVLKSKNGIH | LCLKKLR |