AiPD: Autoinhibited Protein Database

Q96HF1

Gene name	SFRP2 (FRP2, SARP1, FKSG12, UNQ361/PRO697)
Protein name	Secreted frizzled-related protein 2
Names	FRP-2, sFRP-2, Secreted apoptosis-related protein 1, SARP-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6423
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

127-208 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

127-208 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q96HF1

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96HF1-F1	Predicted				AlphaFoldDB

214 variants for Q96HF1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA071687 rs770485715 RCV000207374	209	D>G	Anophthalmia-microphthalmia syndrome [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
TCGA novel	1	M>?	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767318221 CA358482901	2	L>P		No	ClinGen ExAC TOPMed gnomAD
rs767318221 CA3111594	2	L>R		No	ClinGen ExAC TOPMed gnomAD
rs1339097251 CA358482866	4	G>D		No	ClinGen TOPMed
CA358482863 rs1339097251	4	G>V		No	ClinGen TOPMed
TCGA novel	5	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762120819 CA3111589	7	S>W		No	ClinGen ExAC TOPMed gnomAD
CA358482776 rs1373042834	10	L>P		No	ClinGen gnomAD
rs1323829313 CA358482770	11	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1323829313 CA358482768	11	L>V		No	ClinGen TOPMed gnomAD
CA358482743 rs1265091323	12	F>L		No	ClinGen TOPMed
rs376390256 CA108696795	14	A>T		No	ClinGen TOPMed gnomAD
CA358482715 rs1171982836	14	A>V		No	ClinGen gnomAD
CA3111583 rs772407898	16	H>R		No	ClinGen ExAC TOPMed gnomAD
CA358482667 rs1455008597	17	C>*		No	ClinGen TOPMed gnomAD
CA358482664 rs1455008597	17	C>W		No	ClinGen TOPMed gnomAD
CA3111582 rs144496209	18	C>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA108696776 rs977206372	19	L>P		No	ClinGen Ensembl
rs977206372 CA358482637	19	L>R		No	ClinGen Ensembl
CA358482625 rs1206787522	20	G>D		No	ClinGen gnomAD
CA358482631 rs1233522473	20	G>R		No	ClinGen gnomAD
CA358482629 rs1233522473	20	G>S		No	ClinGen gnomAD
rs372453250 CA3111580	21	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs748918381 CA3111579	22	A>T		No	ClinGen ExAC TOPMed gnomAD
rs747851787 COSM1240163 CA3111576	23	R>C	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA3111574 rs370321307	23	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3111575 rs370321307	23	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747851787 CA358482585	23	R>S		No	ClinGen ExAC gnomAD
CA358482561 rs1374040117	24	G>E		No	ClinGen gnomAD
rs1175322643 CA358482572	24	G>R		No	ClinGen TOPMed
rs914770377 CA108696694	26	F>L		No	ClinGen Ensembl
rs4076441 CA358482528	26	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA108696692 rs377498509	27	L>V		No	ClinGen ESP gnomAD
rs779538599 CA108696685	29	G>S		No	ClinGen TOPMed gnomAD
rs1029220340 CA108696680	29	G>V		No	ClinGen TOPMed
CA3111570 rs754081413	30	Q>H		No	ClinGen ExAC gnomAD
rs144480119 CA3111569	31	P>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1172239100 CA358482461	31	P>L		No	ClinGen gnomAD
COSM263616 rs1285226817 CA358482429	33	F>L	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
CA3111567 rs752945147	34	S>F		No	ClinGen ExAC gnomAD
CA3111565 rs1553961455	35	Y>C		No	ClinGen Ensembl
rs1324425816 CA358482405	35	Y>H		No	ClinGen TOPMed
rs1256791588 CA358482366	37	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs759948174 CA3111563	37	R>H		No	ClinGen ExAC gnomAD
CA3111562 rs369290690	38	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1211825906 CA358482324	39	N>H		No	ClinGen gnomAD
CA358482213 rs1232273632	44	P>T		No	ClinGen gnomAD
CA3111559 VAR_051963 rs4643790	45	A>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs386680891 CA108696619	45	A>V		No	ClinGen Ensembl
rs1221529302 CA358482169	46	N>K		No	ClinGen gnomAD
CA358482069 rs1270382627	54	E>K		No	ClinGen TOPMed
rs1579132027 CA358482040	55	Y>*		No	ClinGen Ensembl
rs1313004211 CA358482048	55	Y>H		No	ClinGen gnomAD
CA358481994 rs1480499370	58	M>V		No	ClinGen TOPMed
CA3111555 rs768693726	59	R>G		No	ClinGen ExAC TOPMed gnomAD
rs746895350 CA3111554	59	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1579131990 CA358481959	61	P>A		No	ClinGen Ensembl
rs1346255421 CA358481952	61	P>H		No	ClinGen gnomAD
rs1579131985 CA358481945	62	N>H		No	ClinGen Ensembl
CA358481933 rs779169377	62	N>K		No	ClinGen ExAC TOPMed gnomAD
CA358481893 rs1428327342	65	G>R		No	ClinGen TOPMed
rs1476274432 CA358481885	65	G>V		No	ClinGen TOPMed gnomAD
CA3111547 rs767751716	66	H>Q		No	ClinGen ExAC gnomAD
rs753164723 CA3111548	66	H>Y		No	ClinGen ExAC gnomAD
rs760130726 CA3111546	67	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1048233435 CA108696537	68	T>N		No	ClinGen Ensembl
rs752091964 CA3111545	69	M>T		No	ClinGen ExAC gnomAD
rs1579131925 CA358481757	72	V>G		No	ClinGen Ensembl
rs772645804 CA3111542	73	L>M		No	ClinGen ExAC TOPMed gnomAD
rs556787764 CA3111541	77	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761355765 CA3111540	78	A>P		No	ClinGen ExAC gnomAD
CA358481679 rs761355765	78	A>T		No	ClinGen ExAC gnomAD
CA358481658 COSM126920 rs1391282818	79	W>*	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1456096804 CA358481664	79	W>R		No	ClinGen gnomAD
CA3111538 rs768299995	80	I>M		No	ClinGen ExAC gnomAD
CA3111539 rs776535023	80	I>V		No	ClinGen ExAC gnomAD
CA3111535 rs772075948	83	V>I		No	ClinGen ExAC TOPMed gnomAD
CA3111536 rs772075948	83	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1202897391 CA358481593	84	M>V		No	ClinGen TOPMed
CA358481563 rs1293941621	85	K>R		No	ClinGen TOPMed
rs767842776 CA108696494	89	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA3111532 rs756408557	90	D>H		No	ClinGen ExAC gnomAD
CA108696486 rs913805619	91	T>I		No	ClinGen TOPMed gnomAD
rs1273745312 CA358481403	93	K>N		No	ClinGen gnomAD
CA358481380 rs1429884682	95	L>Q		No	ClinGen TOPMed
rs1389907923 CA358481258	99	F>L		No	ClinGen TOPMed
CA108696480 rs928317938	99	F>L		No	ClinGen TOPMed gnomAD
CA358481289 rs928317938	99	F>V		No	ClinGen TOPMed gnomAD
rs1041389056 CA108696472	100	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1366672257 CA358481182	102	V>I		No	ClinGen TOPMed
CA108696438 rs1035127970	105	D>N		No	ClinGen TOPMed
rs758904161 CA3111525	106	D>N		No	ClinGen ExAC gnomAD
CA108696433 rs1002309285	107	L>I		No	ClinGen TOPMed
CA358481031 rs1327186201	108	D>H		No	ClinGen gnomAD
CA3111523 rs764627420	109	E>D		No	ClinGen ExAC TOPMed gnomAD
CA3111524 rs533800119 COSM350979	109	E>K	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs1162814359 CA358480959	110	T>I		No	ClinGen gnomAD
CA358480844 rs776175695	114	C>*		No	ClinGen ExAC gnomAD
CA358480707 rs1405447492	119	V>A		No	ClinGen TOPMed
CA3111518 rs775356830	119	V>L		No	ClinGen ExAC gnomAD
CA3111516 rs200416071	124	R>H		No	ClinGen TOPMed gnomAD
rs745780901 CA3111514	126	A>S		No	ClinGen ExAC TOPMed gnomAD
rs773382763 CA3111513	128	V>I		No	ClinGen ExAC TOPMed gnomAD
CA3111511 rs748210745	131	A>T		No	ClinGen ExAC TOPMed gnomAD
CA3111510 rs781288672	133	G>C		No	ClinGen ExAC gnomAD
CA358480472 rs781288672	133	G>R		No	ClinGen ExAC gnomAD
CA358480434 rs1579131699	136	W>S		No	ClinGen Ensembl
rs1386284967 CA358480426	137	P>T		No	ClinGen TOPMed
rs1237141458 CA358480404	138	D>G		No	ClinGen gnomAD
CA3111508 rs747444264	138	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs1322908089 CA358480391	139	M>T		No	ClinGen gnomAD
rs1211199779 CA358480396	139	M>V		No	ClinGen gnomAD
CA358480382 rs1392041995	140	L>I		No	ClinGen gnomAD
CA3111506 rs758949251	140	L>P		No	ClinGen ExAC gnomAD
rs1429393209 CA358480376	141	E>Q		No	ClinGen gnomAD
CA358480367 rs1579131655	142	C>G		No	ClinGen Ensembl
COSM3718643 CA3111503 rs376726694	144	R>H	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	147	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763657211 CA3111500	148	D>E		No	ClinGen ExAC gnomAD
rs1376999870 CA358480305	148	D>N		No	ClinGen gnomAD
rs775477124 CA358480263	150	D>E		No	ClinGen ExAC TOPMed gnomAD
CA3111499 rs374977998	150	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs568751579 CA358480257	151	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs568751579 CA3111497	151	L>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs759366315 CA3111495	153	I>F		No	ClinGen ExAC TOPMed gnomAD
rs1274810088 CA358480198	155	L>H		No	ClinGen gnomAD
rs199551756 CA3111490	156	A>G		No	ClinGen 1000Genomes ExAC gnomAD
rs1286600673 CA358480177	157	S>C		No	ClinGen TOPMed gnomAD
rs747207310 CA3111489	157	S>N		No	ClinGen ExAC gnomAD
rs772454059 CA3111487	158	S>R		No	ClinGen ExAC gnomAD
rs746191282 CA3111486	159	D>N		No	ClinGen ExAC gnomAD
rs1579131526 CA358480128	160	H>P		No	ClinGen Ensembl
rs1401345215 CA358480114	161	L>P		No	ClinGen gnomAD
CA358480090 rs1471143961	163	P>L		No	ClinGen gnomAD
CA358480081 rs1180904088	164	A>V		No	ClinGen gnomAD
CA3111483 rs753354046	166	E>K		No	ClinGen ExAC gnomAD
rs777406941 CA3111482	166	E>V		No	ClinGen ExAC TOPMed gnomAD
CA3111461 rs377226693	168	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1432648460 CA358479748	171	V>I		No	ClinGen gnomAD
rs1319836346 CA358479727	172	C>*		No	ClinGen gnomAD
TCGA novel	172	C>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs956924570 CA108694392	175	C>F		No	ClinGen Ensembl
TCGA novel	177	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751372172 COSM3714722 CA358479616	180	D>E	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA3111458 rs754658364	180	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs376506469 CA3111455	182	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs376506469 CA3111456	182	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1165285468 CA358479566	184	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1000842314 CA108694380	185	I>T		No	ClinGen TOPMed gnomAD
CA358479555 rs1560811008	185	I>V		No	ClinGen Ensembl
rs1188447113 CA358479537	186	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA358479539 rs1460149316	186	M>T		No	ClinGen TOPMed
CA3111451 rs189204130 COSM3392740	188	T>M	pancreas [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA358479452 rs1274022002	193	D>G		No	ClinGen gnomAD
CA358479045 rs1218622791	200	V>M		No	ClinGen gnomAD
CA108691615 rs1019463922	201	K>N		No	ClinGen TOPMed
CA358479028 rs1560809804	202	E>G		No	ClinGen Ensembl
rs767611732 CA3111426	206	I>V		No	ClinGen ExAC gnomAD
rs759496190 CA3111425	207	N>S		No	ClinGen ExAC gnomAD
rs763381743 CA3111422 COSM1052272	208	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs763381743 CA3111424	208	R>G		No	ClinGen ExAC TOPMed gnomAD
rs773710868 CA3111421	208	R>Q		No	ClinGen ExAC
rs1307742957 CA358478972	211	K>T		No	ClinGen gnomAD
rs1174718399 CA358478959	213	I>V		No	ClinGen TOPMed
rs1579127371 CA358478942	215	E>D		No	ClinGen Ensembl
CA358478915 rs1560809786	219	K>T		No	ClinGen Ensembl
rs1174550403 CA358478896	222	Y>H		No	ClinGen gnomAD
rs746452136 CA3111416	229	E>K		No	ClinGen ExAC gnomAD
CA358478843 rs1334778619	230	R>G		No	ClinGen TOPMed
rs1251397921 CA358478841	230	R>T		No	ClinGen TOPMed gnomAD
rs1021032920 CA108691547	235	S>*		No	ClinGen TOPMed gnomAD
CA358478803 COSM117303 rs1021032920	235	S>L	ovary [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA108691544 rs951340434	239	L>F		No	ClinGen Ensembl
rs1209329846 CA358478747	243	L>F		No	ClinGen gnomAD
CA3111413 rs745728569	250	M>V		No	ClinGen ExAC
rs1226045936 CA358478674	252	D>A		No	ClinGen TOPMed gnomAD
CA358478676 COSM1162201 rs1269418288	252	D>N	pancreas [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs995413065 CA108691542	254	N>K		No	ClinGen TOPMed gnomAD
TCGA novel	254	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1178577005 CA358478648	254	N>T		No	ClinGen Ensembl
CA358478639 rs778665160	255	A>P		No	ClinGen ExAC TOPMed gnomAD
rs778665160 COSM1225447 CA3111412	255	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1301528697 CA358478626	256	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA3111410 rs753743362	257	Y>C		No	ClinGen ExAC gnomAD
CA3111409 rs763890885	258	L>V		No	ClinGen ExAC TOPMed gnomAD
CA358478578 rs1411385162	260	M>T		No	ClinGen gnomAD
rs1455728690 CA358478583	260	M>V		No	ClinGen gnomAD
TCGA novel	261	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358478563 rs1165886589	261	G>E		No	ClinGen TOPMed gnomAD
CA358478510 rs1425847380	265	G>D		No	ClinGen gnomAD
rs751527740 CA3111407	266	G>R		No	ClinGen ExAC gnomAD
rs766692048 CA3111406	267	E>K		No	ClinGen ExAC gnomAD
CA3111405 rs763257920	269	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1174827923 CA358478453	270	I>N		No	ClinGen TOPMed
rs773765944 CA3111404	272	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3111403 rs765668271	273	V>L		No	ClinGen ExAC gnomAD
rs1246532190 CA358478392	274	K>E		No	ClinGen gnomAD
rs762231333 CA3111402	275	R>Q		No	ClinGen ExAC gnomAD
TCGA novel	276	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777214656 CA3111401	279	G>A		No	ClinGen ExAC TOPMed gnomAD
CA358478285 rs777214656	279	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1395838329 CA358478277	280	Q>*		No	ClinGen gnomAD
rs1002871980	282	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3111400 rs768984513	285	R>G		No	ClinGen ExAC gnomAD
rs760233107 CA3111399	285	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1579127219 CA358478150	287	S>P		No	ClinGen Ensembl
rs1163966443 CA358478134	288	R>C		No	ClinGen gnomAD
rs1459585567 CA358478129	288	R>H		No	ClinGen TOPMed gnomAD
COSM1664121 rs1459585567 CA358478125	288	R>L	kidney prostate [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
COSM291429 CA3111397 rs774857018	291	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs771814142 CA3111396	291	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1186205421 CA358478069	292	K>Q		No	ClinGen TOPMed gnomAD
rs749026873 CA3111392	296	C>Q		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q96HF1

4 regional properties for Q96HF1

Type	Name	Position	InterPro Accession
domain	Netrin domain	172 - 295	IPR001134
domain	Netrin module, non-TIMP type	186 - 289	IPR018933
domain	Frizzled domain	35 - 157	IPR020067
domain	SFRP2, cysteine-rich domain	36 - 163	IPR041764

Functions

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
collagen-containing extracellular matrix	An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

5 GO annotations of molecular function

Name	Definition
endopeptidase activator activity	Binds to and increases the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
fibronectin binding	Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
integrin binding	Binding to an integrin.
receptor ligand activity	The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands).
Wnt-protein binding	Binding to a Wnt-protein, a secreted growth factor involved in signaling.

57 GO annotations of biological process

Name	Definition
BMP signaling pathway	The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
branching involved in blood vessel morphogenesis	The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
canonical Wnt signaling pathway	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
cardiac left ventricle morphogenesis	The process in which the left cardiac ventricle is generated and organized.
cardiac muscle cell apoptotic process	A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
cell-cell signaling	Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
cellular response to extracellular stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
cellular response to X-ray	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).
chondrocyte development	The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.
collagen fibril organization	Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.
convergent extension involved in axis elongation	The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism.
digestive tract morphogenesis	The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.
embryonic digit morphogenesis	The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.
hematopoietic stem cell proliferation	The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop.
male gonad development	The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
mesodermal cell fate specification	The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
negative regulation of BMP signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
negative regulation of canonical Wnt signaling pathway	Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
negative regulation of cardiac muscle cell apoptotic process	Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
negative regulation of cell growth	Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
negative regulation of cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
negative regulation of dermatome development	Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of epithelial cell proliferation	Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
negative regulation of epithelial to mesenchymal transition	Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
negative regulation of gene expression	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage.
negative regulation of JUN kinase activity	Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.
negative regulation of mesodermal cell fate specification	Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification.
negative regulation of peptidyl-tyrosine phosphorylation	Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
negative regulation of planar cell polarity pathway involved in axis elongation	Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in axis elongation.
negative regulation of Wnt signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
outflow tract morphogenesis	The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
planar cell polarity pathway involved in axis elongation	The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation.
planar cell polarity pathway involved in neural tube closure	The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure.
positive regulation of angiogenesis	Any process that activates or increases angiogenesis.
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of canonical Wnt signaling pathway	Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of cell adhesion mediated by integrin	Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin.
positive regulation of cell growth	Any process that activates or increases the frequency, rate, extent or direction of cell growth.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of fat cell differentiation	Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
positive regulation of osteoblast differentiation	Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
positive regulation of peptidyl-serine phosphorylation	Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
post-anal tail morphogenesis	The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance.
regulation of midbrain dopaminergic neuron differentiation	Any process that modulates the frequency, rate or extent of midbrain dopaminergic neuron differentiation.
regulation of neuron projection development	Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
regulation of stem cell division	Any process that modulates the frequency, rate or extent of stem cell division.
response to nutrient	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
sclerotome development	The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.
stem cell fate specification	The process in which a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
Wnt signaling pathway involved in somitogenesis	The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis.

24 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O19116	SFRP1	Secreted frizzled-related protein 1	Bos taurus (Bovine)	PR
Q9DEQ4	SFRP1	Secreted frizzled-related protein 1	Gallus gallus (Chicken)	PR
O57328	FZD1	Frizzled-1	Gallus gallus (Chicken)	PR
Q9IA96	SFRP2	Secreted frizzled-related protein 2	Gallus gallus (Chicken)	PR
Q863H1	SFRP2	Secreted frizzled-related protein 2	Canis lupus familiaris (Dog) (Canis familiaris)	PR
O00144	FZD9	Frizzled-9	Homo sapiens (Human)	PR
O75084	FZD7	Frizzled-7	Homo sapiens (Human)	PR
Q14332	FZD2	Frizzled-2	Homo sapiens (Human)	PR
Q6FHJ7	SFRP4	Secreted frizzled-related protein 4	Homo sapiens (Human)	PR
Q8N474	SFRP1	Secreted frizzled-related protein 1	Homo sapiens (Human)	PR
Q9ULW2	FZD10	Frizzled-10	Homo sapiens (Human)	PR
Q9UP38	FZD1	Frizzled-1	Homo sapiens (Human)	PR
O60353	FZD6	Frizzled-6	Homo sapiens (Human)	PR
Q9Z1N6	Sfrp4	Secreted frizzled-related sequence protein 4	Mus musculus (Mouse)	PR
O70421	Fzd1	Frizzled-1	Mus musculus (Mouse)	PR
Q9JIP6	Fzd2	Frizzled-2	Mus musculus (Mouse)	PR
Q61090	Fzd7	Frizzled-7	Mus musculus (Mouse)	PR
P97299	Sfrp2	Secreted frizzled-related protein 2	Mus musculus (Mouse)	PR
Q8C4U3	Sfrp1	Secreted frizzled-related protein 1	Mus musculus (Mouse)	PR
Q08463	Fzd1	Frizzled-1	Rattus norvegicus (Rat)	PR
Q9JLS4	Sfrp4	Secreted frizzled-related protein 4	Rattus norvegicus (Rat)	PR
Q08464	Fzd2	Frizzled-2	Rattus norvegicus (Rat)	PR
Q7YRN1	SFRP4	Secreted frizzled-related protein 4	Macaca mulatta (Rhesus macaque)	PR
Q5BL72	fzd7	Frizzled-7	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MLQGPGSLLL	LFLASHCCLG	SARGLFLFGQ	PDFSYKRSNC	KPIPANLQLC	HGIEYQNMRL
70	80	90	100	110	120
PNLLGHETMK	EVLEQAGAWI	PLVMKQCHPD	TKKFLCSLFA	PVCLDDLDET	IQPCHSLCVQ
130	140	150	160	170	180
VKDRCAPVMS	AFGFPWPDML	ECDRFPQDND	LCIPLASSDH	LLPATEEAPK	VCEACKNKND
190	200	210	220	230	240
DDNDIMETLC	KNDFALKIKV	KEITYINRDT	KIILETKSKT	IYKLNGVSER	DLKKSVLWLK
250	260	270	280	290
DSLQCTCEEM	NDINAPYLVM	GQKQGGELVI	TSVKRWQKGQ	REFKRISRSI	RKLQC