O70421
PR
Gene name |
Fzd1 |
Protein name |
Frizzled-1 |
Names |
Fz-1, mFz1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14362 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O70421
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O70421-F1 | Predicted | AlphaFoldDB |
27 variants for O70421
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs250144360 | 38 | A>T | No | EVA | |
| rs3388739482 | 77 | V>* | No | EVA | |
| rs3388728904 | 90 | P>S | No | EVA | |
| rs3388742246 | 104 | S>T | No | EVA | |
| rs3388741222 | 117 | P>L | No | EVA | |
| rs3388736147 | 120 | T>K | No | EVA | |
| rs3394607252 | 122 | I>S | No | EVA | |
| rs3388734570 | 178 | A>T | No | EVA | |
| rs3388734630 | 189 | A>T | No | EVA | |
| rs3388728932 | 197 | M>I | No | EVA | |
| rs3388736180 | 200 | F>I | No | EVA | |
| rs3388736180 | 200 | F>L | No | EVA | |
| rs3388742251 | 284 | H>L | No | EVA | |
| rs3388742847 | 288 | E>K | No | EVA | |
| rs3395164623 | 311 | L>V | No | EVA | |
| rs3388739334 | 313 | F>I | No | EVA | |
| rs3388742565 | 411 | S>N | No | EVA | |
| rs3388741725 | 429 | K>R | No | EVA | |
| rs3388738919 | 437 | A>P | No | EVA | |
| rs3388741174 | 441 | Y>F | No | EVA | |
| rs3388731050 | 478 | N>K | No | EVA | |
| rs3388746760 | 571 | S>R | No | EVA | |
| rs3388736131 | 574 | I>N | No | EVA | |
| rs3395231490 | 580 | Q>H | No | EVA | |
| rs3388715058 | 603 | L>V | No | EVA | |
| rs3388741767 | 606 | L>R | No | EVA | |
| rs3388738923 | 617 | W>* | No | EVA |
No associated diseases with O70421
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell surface | The external part of the cell wall and/or plasma membrane. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| frizzled binding | Binding to a frizzled (fz) receptor. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| identical protein binding | Binding to an identical protein or proteins. |
| PDZ domain binding | Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
| Wnt receptor activity | Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| Wnt-protein binding | Binding to a Wnt-protein, a secreted growth factor involved in signaling. |
24 GO annotations of biological process
| Name | Definition |
|---|---|
| astrocyte-dopaminergic neuron signaling | Cell-cell signaling that mediates the transfer of information from an astrocyte to a dopaminergic neuron. |
| autocrine signaling | Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type. |
| canonical Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. |
| canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in mesenchymal stem cell differentiation. |
| canonical Wnt signaling pathway involved in osteoblast differentiation | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in osteoblast differentiation. |
| cell-cell signaling | Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. |
| endothelial cell differentiation | The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. |
| hard palate development | The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes. |
| membranous septum morphogenesis | The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum. |
| muscular septum morphogenesis | The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum. |
| negative regulation of BMP signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. |
| negative regulation of canonical Wnt signaling pathway | Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of oxidative stress-induced neuron death | Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death. |
| outflow tract morphogenesis | The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. |
| planar cell polarity pathway involved in neural tube closure | The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure. |
| positive regulation of DNA-binding transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of neuron projection development | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| regulation of presynapse assembly | Any process that modulates the frequency, rate or extent of presynapse assembly. |
| response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| ventricular septum morphogenesis | The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O19116 | SFRP1 | Secreted frizzled-related protein 1 | Bos taurus (Bovine) | PR |
| Q9DEQ4 | SFRP1 | Secreted frizzled-related protein 1 | Gallus gallus (Chicken) | PR |
| Q9IA96 | SFRP2 | Secreted frizzled-related protein 2 | Gallus gallus (Chicken) | PR |
| O57328 | FZD1 | Frizzled-1 | Gallus gallus (Chicken) | PR |
| Q8N474 | SFRP1 | Secreted frizzled-related protein 1 | Homo sapiens (Human) | PR |
| Q9ULW2 | FZD10 | Frizzled-10 | Homo sapiens (Human) | PR |
| Q96HF1 | SFRP2 | Secreted frizzled-related protein 2 | Homo sapiens (Human) | PR |
| O75084 | FZD7 | Frizzled-7 | Homo sapiens (Human) | PR |
| Q14332 | FZD2 | Frizzled-2 | Homo sapiens (Human) | PR |
| O00144 | FZD9 | Frizzled-9 | Homo sapiens (Human) | PR |
| O60353 | FZD6 | Frizzled-6 | Homo sapiens (Human) | PR |
| Q6FHJ7 | SFRP4 | Secreted frizzled-related protein 4 | Homo sapiens (Human) | PR |
| Q9UP38 | FZD1 | Frizzled-1 | Homo sapiens (Human) | PR |
| P97299 | Sfrp2 | Secreted frizzled-related protein 2 | Mus musculus (Mouse) | PR |
| Q61090 | Fzd7 | Frizzled-7 | Mus musculus (Mouse) | PR |
| Q8C4U3 | Sfrp1 | Secreted frizzled-related protein 1 | Mus musculus (Mouse) | PR |
| Q9JIP6 | Fzd2 | Frizzled-2 | Mus musculus (Mouse) | PR |
| Q9Z1N6 | Sfrp4 | Secreted frizzled-related sequence protein 4 | Mus musculus (Mouse) | PR |
| Q9JLS4 | Sfrp4 | Secreted frizzled-related protein 4 | Rattus norvegicus (Rat) | PR |
| Q08464 | Fzd2 | Frizzled-2 | Rattus norvegicus (Rat) | PR |
| Q08463 | Fzd1 | Frizzled-1 | Rattus norvegicus (Rat) | PR |
| Q7YRN1 | SFRP4 | Secreted frizzled-related protein 4 | Macaca mulatta (Rhesus macaque) | PR |
| Q5BL72 | fzd7 | Frizzled-7 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEEAAPSES | RAAGRLSLEL | CAEALPGRRE | EVGHEDTASH | RRPRADPRRW | ASGLLLLLWL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LEAPLLLGVR | AQAAGQVSGP | GQQAPPPPQP | QQSGQQYNGE | RGISIPDHGY | CQPISIPLCT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DIAYNQTIMP | NLLGHTNQED | AGLEVHQFYP | LVKVQCSAEL | KFFLCSMYAP | VCTVLEQALP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PCRSLCERAR | QGCEALMNKF | GFQWPDTLKC | EKFPVHGAGE | LCVGQNTSDK | GTPTPSLLPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FWTSNPQHGG | GGYRGGYPGG | AGTVERGKFS | CPRALRVPSY | LNYHFLGEKD | CGAPCEPTKV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YGLMYFGPEE | LRFSRTWIGI | WSVLCCASTL | FTVLTYLVDM | RRFSYPERPI | IFLSGCYTAV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AVAYIAGFLL | EDRVVCNDKF | AEDGARTVAQ | GTKKEGCTIL | FMMLYFFSMA | SSIWWVILSL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TWFLAAGMKW | GHEAIEANSQ | YFHLAAWAVP | AIKTITILAL | GQVDGDVLSG | VCFVGLNNVD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ALRGFVLAPL | FVYLFIGTSF | LLAGFVSLFR | IRTIMKHDGT | KTEKLEKLMV | RIGVFSVLYT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VPATIVIACY | FYEQAFRDQW | ERSWVAQSCK | SYAIPCPHLQ | GGGGVPPHPP | MSPDFTVFMI |
| 610 | 620 | 630 | 640 | ||
| KYLMTLIVGI | TSGFWIWSGK | TLNSWRKFYT | RLTNSKQGET | TV |