Q9Z1N6
PR
Gene name |
Sfrp4 |
Protein name |
Secreted frizzled-related sequence protein 4 |
Names |
FRP-4, sFRP-4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20379 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Z1N6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z1N6-F1 | Predicted | AlphaFoldDB |
22 variants for Q9Z1N6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs39959128 | 3 | R>G | No | EVA | |
| rs1131733500 | 14 | R>H | No | EVA | |
| rs3389273759 | 25 | E>G | No | EVA | |
| rs3389269531 | 31 | M>K | No | EVA | |
| rs3403853561 | 33 | R>M | No | EVA | |
| rs3403953973 | 37 | W>G | No | EVA | |
| rs3389279597 | 59 | E>G | No | EVA | |
| rs3389279572 | 79 | A>V | No | EVA | |
| rs3389271238 | 85 | C>F | No | EVA | |
| rs3389244700 | 87 | L>M | No | EVA | |
| rs3389264050 | 104 | A>V | No | EVA | |
| rs3389273909 | 189 | T>A | No | EVA | |
| rs3389202046 | 195 | Y>F | No | EVA | |
| rs3389264022 | 229 | P>A | No | EVA | |
| rs3403925801 | 245 | C>* | No | EVA | |
| rs3389282782 | 247 | H>R | No | EVA | |
| rs3389256361 | 249 | L>M | No | EVA | |
| rs3389269521 | 270 | N>K | No | EVA | |
| rs3389239603 | 287 | W>L | No | EVA | |
| rs3389286842 | 294 | Q>K | No | EVA | |
| rs37000063 | 323 | P>L | No | EVA | |
| rs3389256389 | 324 | P>S | No | EVA |
No associated diseases with Q9Z1N6
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| Wnt-protein binding | Binding to a Wnt-protein, a secreted growth factor involved in signaling. |
17 GO annotations of biological process
| Name | Definition |
|---|---|
| bone morphogenesis | The process in which bones are generated and organized. |
| canonical Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| negative regulation of canonical Wnt signaling pathway | Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| negative regulation of DNA-binding transcription factor activity | Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
| negative regulation of JNK cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. |
| negative regulation of non-canonical Wnt signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway. |
| negative regulation of sodium-dependent phosphate transport | Any process that stops, prevents, or reduces the frequency, rate or extent of sodium-dependent phosphate transport. |
| phosphate ion homeostasis | Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell. |
| positive regulation of apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of canonical Wnt signaling pathway | Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| positive regulation of epidermal cell differentiation | Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of keratinocyte apoptotic process | Any process that activates or increases the frequency, rate or extent of keratinocyte apoptotic process. |
| positive regulation of receptor internalization | Any process that activates or increases the frequency, rate or extent of receptor internalization. |
| regulation of BMP signaling pathway | Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O19116 | SFRP1 | Secreted frizzled-related protein 1 | Bos taurus (Bovine) | PR |
| Q9DEQ4 | SFRP1 | Secreted frizzled-related protein 1 | Gallus gallus (Chicken) | PR |
| O57328 | FZD1 | Frizzled-1 | Gallus gallus (Chicken) | PR |
| Q9IA96 | SFRP2 | Secreted frizzled-related protein 2 | Gallus gallus (Chicken) | PR |
| Q8N474 | SFRP1 | Secreted frizzled-related protein 1 | Homo sapiens (Human) | PR |
| Q9ULW2 | FZD10 | Frizzled-10 | Homo sapiens (Human) | PR |
| Q96HF1 | SFRP2 | Secreted frizzled-related protein 2 | Homo sapiens (Human) | PR |
| O75084 | FZD7 | Frizzled-7 | Homo sapiens (Human) | PR |
| Q9UP38 | FZD1 | Frizzled-1 | Homo sapiens (Human) | PR |
| Q14332 | FZD2 | Frizzled-2 | Homo sapiens (Human) | PR |
| O00144 | FZD9 | Frizzled-9 | Homo sapiens (Human) | PR |
| O60353 | FZD6 | Frizzled-6 | Homo sapiens (Human) | PR |
| Q6FHJ7 | SFRP4 | Secreted frizzled-related protein 4 | Homo sapiens (Human) | PR |
| O70421 | Fzd1 | Frizzled-1 | Mus musculus (Mouse) | PR |
| P97299 | Sfrp2 | Secreted frizzled-related protein 2 | Mus musculus (Mouse) | PR |
| Q61090 | Fzd7 | Frizzled-7 | Mus musculus (Mouse) | PR |
| Q8C4U3 | Sfrp1 | Secreted frizzled-related protein 1 | Mus musculus (Mouse) | PR |
| Q9JIP6 | Fzd2 | Frizzled-2 | Mus musculus (Mouse) | PR |
| Q08463 | Fzd1 | Frizzled-1 | Rattus norvegicus (Rat) | PR |
| Q08464 | Fzd2 | Frizzled-2 | Rattus norvegicus (Rat) | PR |
| Q9JLS4 | Sfrp4 | Secreted frizzled-related protein 4 | Rattus norvegicus (Rat) | PR |
| Q7YRN1 | SFRP4 | Secreted frizzled-related protein 4 | Macaca mulatta (Rhesus macaque) | PR |
| Q5BL72 | fzd7 | Frizzled-7 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLRSILVALC | LWLRLALGVR | GAPCEAVRIP | MCRHMPWNIT | RMPNHLHHST | QENAILAIEQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YEELVDVNCS | SVLRFFLCAM | YAPICTLEFL | HDPIKPCKSV | CQRARDDCEP | LMKMYNHSWP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ESLACDELPV | YDRGVCISPE | AIVTDLPEDV | KWIDITPDMM | VQERSFDADC | KRLSPDRCKC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KKVKPTLATY | LSKNYSYVIH | AKIKAVQRSG | CNEVTTVVDV | KEIFKSLSPI | PRTQVPLITN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSCQCPHILP | HQDVLIMCYE | WRSRMMLLEN | CLVEKWRDQL | SRRSIQWEER | LQEQQRTIQD |
| 310 | 320 | 330 | 340 | 350 | |
| KKQIASRTSR | TSRSNPPKSK | GRPPAPKPAS | PKKNIKARSA | PKKSNLKKSA | S |