AiPD: Autoinhibited Protein Database

O75084

Gene name	FZD7
Protein name	Frizzled-7
Names	Fz-7, hFz7, FzE3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8324
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-72 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

10 structures for O75084

Entry ID	Method	Resolution	Chain	Position	Source
4Z33	X-ray	245 A	C/D	569-574	PDB
5T44	X-ray	199 A	A/B	31-168	PDB
5URV	X-ray	220 A	A/B	30-168	PDB
5WBS	X-ray	288 A	A/B/C/D/E/F/G/H	30-174	PDB
6NE2	X-ray	130 A	A	46-163	PDB
6NE4	X-ray	165 A	A	46-163	PDB
6O3A	X-ray	210 A	E	42-179	PDB
6O3B	X-ray	250 A	C/H	42-179	PDB
7EVW	EM	322 A	R	38-574	PDB
AF-O75084-F1	Predicted				AlphaFoldDB

448 variants for O75084

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA2059407 rs61754568	2	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA350335906 rs1339441816	4	P>S		No	ClinGen TOPMed
CA350335921 rs1225758862	6	A>V		No	ClinGen TOPMed
CA2059409 rs760851152	9	P>T		No	ClinGen ExAC gnomAD
CA350335941 rs1559184035	10	L>F		No	ClinGen Ensembl
CA350335939 rs1559184035	10	L>I		No	ClinGen Ensembl
CA350335942 rs1361659381	10	L>R		No	ClinGen gnomAD
CA2059410 rs766841500	11	S>P		No	ClinGen ExAC gnomAD
CA350335954 rs1346323424	12	S>F		No	ClinGen gnomAD
CA64006627 rs960364984	12	S>P		No	ClinGen TOPMed
CA64006653 rs992928365	15	L>F		No	ClinGen TOPMed gnomAD
rs201450666 CA2059413	16	C>R		No	ClinGen 1000Genomes ExAC gnomAD
CA350335979 rs982634074	17	A>S		No	ClinGen TOPMed gnomAD
rs982634074 CA64006659	17	A>T		No	ClinGen TOPMed gnomAD
rs765568446 CA2059414	17	A>V		No	ClinGen ExAC TOPMed gnomAD
CA2059415 rs751179155	19	V>A		No	ClinGen ExAC gnomAD
rs913200191 CA64006665	19	V>L		No	ClinGen Ensembl
rs978758739 CA64006689	21	A>P		No	ClinGen TOPMed gnomAD
CA350336000 rs1368729594	21	A>V		No	ClinGen gnomAD
rs35111363 CA350336014	24	G>A		No	ClinGen TOPMed gnomAD
VAR_049292 CA64006705 rs35111363	24	G>D		No	ClinGen UniProt TOPMed dbSNP gnomAD
rs755615030 VAR_033024 CA2059419	24	G>S		No	ClinGen UniProt ExAC dbSNP gnomAD
rs749235803 CA2059421	25	A>G		No	ClinGen ExAC TOPMed gnomAD
CA350336018 rs1202328038	25	A>S		No	ClinGen TOPMed
rs778919859 CA2059423	28	A>V		No	ClinGen ExAC TOPMed gnomAD
CA350336037 rs1339508761	29	G>S		No	ClinGen gnomAD
rs748369771 CA2059424	30	A>T		No	ClinGen ExAC gnomAD
rs942992895 CA64006751	30	A>V		No	ClinGen Ensembl
rs1487949232 CA350336058	32	A>V		No	ClinGen gnomAD
rs1189250451 CA350336066	33	Q>H		No	ClinGen gnomAD
CA2059425 rs772362388	34	P>L		No	ClinGen ExAC gnomAD
rs1559184103 CA350336077	35	Y>F		No	ClinGen Ensembl
TCGA novel	35	Y>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1187805781 CA350336081	36	H>D		No	ClinGen gnomAD
CA350336084 rs1388213273	36	H>R		No	ClinGen gnomAD
rs140084102 CA2059428	38	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747045136 CA2059427	38	E>K		No	ClinGen ExAC gnomAD
rs1273976498 CA350336098	38	E>V		No	ClinGen TOPMed
TCGA novel	41	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA350336116 rs1337389467	41	I>V		No	ClinGen TOPMed
CA2059430 rs200796298	42	S>T		No	ClinGen ExAC gnomAD
CA350336136 rs1434787939	44	P>L		No	ClinGen gnomAD
CA2059432 rs775886653	44	P>S		No	ClinGen ExAC TOPMed
CA350336140 rs1367964884	45	D>G		No	ClinGen TOPMed gnomAD
rs763317919 CA2059433	45	D>N		No	ClinGen ExAC gnomAD
CA350336155 rs1320755268	47	G>A		No	ClinGen gnomAD
CA350336156 rs1320755268	47	G>D		No	ClinGen gnomAD
rs933713760 CA64006828	47	G>S		No	ClinGen Ensembl
rs755630577 CA2059436	48	F>V		No	ClinGen ExAC gnomAD
CA2059438 rs753811424	51	P>A		No	ClinGen ExAC gnomAD
CA350336182 rs754930210	51	P>L		No	ClinGen ExAC gnomAD
CA2059439 rs754930210	51	P>R		No	ClinGen ExAC gnomAD
CA2059440 rs779007814	52	I>V		No	ClinGen ExAC TOPMed gnomAD
rs758298218 CA2059442	54	I>M		No	ClinGen ExAC gnomAD
rs747242944 CA2059444	55	P>Q		No	ClinGen ExAC gnomAD
CA2059443 rs778092158	55	P>S		No	ClinGen ExAC gnomAD
rs1574985408 CA350336223	58	T>M		No	ClinGen Ensembl
rs776638713 CA2059446	59	D>H		No	ClinGen ExAC gnomAD
CA350336233 rs1559184154	60	I>V		No	ClinGen Ensembl
rs1292758672 CA350336240	61	A>P		No	ClinGen Ensembl
rs746371122 CA2059447	61	A>V		No	ClinGen ExAC gnomAD
CA2059450 rs763259152	63	N>H		No	ClinGen ExAC gnomAD
CA350336270 rs1471966906	65	T>N		No	ClinGen TOPMed
CA350336279 rs1212605455	66	I>M		No	ClinGen TOPMed
rs765901552 CA2059454	72	G>C		No	ClinGen ExAC gnomAD
rs753231460 CA2059455	72	G>D		No	ClinGen ExAC gnomAD
rs547303593 CA64006960	74	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs547303593 CA2059456	74	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1482347697 CA350336328	75	N>I		No	ClinGen gnomAD
CA64006994 rs777749596	78	D>E		No	ClinGen ExAC gnomAD
CA2059459 rs758245010	78	D>N		No	ClinGen ExAC gnomAD
rs1157412361 CA350336363	80	G>C		No	ClinGen gnomAD
rs1401825150 CA350336370	81	L>H		No	ClinGen gnomAD
CA350336374 rs1226692312	82	E>*		No	ClinGen TOPMed
rs780544230 CA64007006	84	H>P		No	ClinGen Ensembl
TCGA novel	86	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2059463 rs368323286	91	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA350336444 rs1293935728	92	V>L		No	ClinGen TOPMed
CA64007029 rs745305774	93	Q>R		No	ClinGen Ensembl
CA350336457 rs1574985474	94	C>G		No	ClinGen Ensembl
CA2059465 rs769887663	96	P>A		No	ClinGen ExAC TOPMed gnomAD
CA2059466 rs780521635	96	P>L		No	ClinGen ExAC TOPMed gnomAD
CA350336470 rs769887663	96	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1401639507 CA350336477	97	E>G		No	ClinGen TOPMed
CA350336536 rs1360444754	105	M>I		No	ClinGen TOPMed gnomAD
CA350336532 rs1157551362	105	M>L		No	ClinGen TOPMed
CA350336542 rs1254206415	106	Y>C		No	ClinGen gnomAD
rs776377398 CA2059472	106	Y>N		No	ClinGen ExAC gnomAD
rs1470744219 CA350336557	108	P>L		No	ClinGen gnomAD
rs764888077 CA2059474	109	V>L		No	ClinGen ExAC TOPMed gnomAD
CA2059475 rs764888077	109	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs757076058 CA64007134	117	I>M		No	ClinGen ExAC gnomAD
rs751252031 CA2059478	117	I>V		No	ClinGen ExAC TOPMed gnomAD
CA64007154 rs893983948	118	P>Q		No	ClinGen TOPMed gnomAD
rs893983948 CA350336618	118	P>R		No	ClinGen TOPMed gnomAD
CA350336617 rs1466062224	118	P>S		No	ClinGen TOPMed
TCGA novel	120	C>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA64007158 rs1010905016	121	R>G		No	ClinGen TOPMed gnomAD
rs1010905016 CA350336635	121	R>S		No	ClinGen TOPMed gnomAD
CA64007159 COSM1293974 rs1020354758	122	S>C	cervix [Cosmic]	No	ClinGen cosmic curated TOPMed
CA350336644 rs1020354758	122	S>F		No	ClinGen TOPMed
rs781228423 CA2059481	123	L>V		No	ClinGen ExAC TOPMed gnomAD
CA350336656 rs1230100560	124	C>W		No	ClinGen TOPMed
CA350336652 rs1365417398	124	C>Y		No	ClinGen gnomAD
rs1448747662 CA350336666	126	R>G		No	ClinGen gnomAD
TCGA novel	127	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756159952 CA2059482	128	R>L		No	ClinGen ExAC gnomAD
rs749785666 CA350336682	129	Q>*		No	ClinGen ExAC gnomAD
rs749785666 CA2059484	129	Q>E		No	ClinGen ExAC gnomAD
CA64007187 rs964070574	130	G>D		No	ClinGen TOPMed
CA350336702 COSM3838316 rs1438604237	132	E>K	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1318881499 CA350336712	133	A>S		No	ClinGen TOPMed
rs748422280 CA2059487	134	L>R		No	ClinGen ExAC TOPMed gnomAD
CA350336734 rs1194851481	136	N>S		No	ClinGen gnomAD
rs1395850429 CA350336742	137	K>M		No	ClinGen TOPMed
CA350336751 rs1390081657	138	F>C		No	ClinGen gnomAD
rs776305663 CA2059489	142	W>*		No	ClinGen ExAC gnomAD
rs1029560195 CA64007211	144	E>D		No	ClinGen TOPMed gnomAD
rs1322672860 CA350336810	147	R>C		No	ClinGen TOPMed gnomAD
rs1304131500 CA350336826	149	E>G		No	ClinGen gnomAD
rs1450888277 CA350336830	150	N>Y		No	ClinGen TOPMed
rs1271936629 CA350336841	151	F>Y		No	ClinGen gnomAD
CA2059494 rs762562271	157	G>C		No	ClinGen ExAC gnomAD
rs1287956554 CA350336880	157	G>D		No	ClinGen gnomAD
rs1470150101 CA350336890	158	E>D		No	ClinGen gnomAD
rs763868554 CA2059495	159	I>N		No	ClinGen ExAC gnomAD
CA350336894 rs763868554	159	I>T		No	ClinGen ExAC gnomAD
rs1248026205 CA350336902	160	C>F		No	ClinGen gnomAD
rs1448135519 CA350336917	163	Q>*		No	ClinGen gnomAD
rs751543710 CA2059496	163	Q>P		No	ClinGen ExAC gnomAD
rs1475553188 CA350336937	165	T>M		No	ClinGen gnomAD
CA64007289 COSM1404552 rs185267840	166	S>L	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes NCI-TCGA TOPMed
CA350336953 rs1162322036	168	G>C		No	ClinGen gnomAD
rs566038011 CA64007292	170	G>R		No	ClinGen gnomAD
CA350336970 rs1215406293	171	G>D		No	ClinGen TOPMed
rs767389004 CA350336968	171	G>R		No	ClinGen ExAC TOPMed gnomAD
CA2059498 rs767389004	171	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1344501190 CA350336976	172	P>L		No	ClinGen TOPMed
CA350336999 rs1326327915	176	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs750610497 CA2059499	177	T>A		No	ClinGen ExAC gnomAD
rs886860070 CA64007307	177	T>N		No	ClinGen Ensembl
CA350337012 rs1432750092	178	A>V		No	ClinGen gnomAD
rs1574985611 CA350337016	179	Y>S		No	ClinGen Ensembl
CA64007337 rs909683952	180	P>S		No	ClinGen TOPMed gnomAD
CA2059502 rs753849552	182	A>T		No	ClinGen ExAC gnomAD
CA350337034 rs1337223448	182	A>V		No	ClinGen gnomAD
rs768746616 CA350337040	183	P>L		No	ClinGen ExAC gnomAD
rs768746616 CA2059504	183	P>R		No	ClinGen ExAC gnomAD
CA2059503 rs755082967	183	P>S		No	ClinGen ExAC gnomAD
CA2059506 rs758658014	185	L>P		No	ClinGen ExAC gnomAD
CA2059505 rs748736397	185	L>V		No	ClinGen ExAC gnomAD
rs778267383 CA2059507	187	D>E		No	ClinGen ExAC gnomAD
rs745501154 CA2059508	189	P>L		No	ClinGen ExAC TOPMed gnomAD
CA2059509 rs769510212	191	T>I		No	ClinGen ExAC TOPMed gnomAD
rs769510212 CA350337087	191	T>S		No	ClinGen ExAC TOPMed gnomAD
CA350337090 rs1170465228	192	A>S		No	ClinGen TOPMed
CA2059511 rs748764354	194	P>S		No	ClinGen ExAC TOPMed gnomAD
CA350337105 rs1332197379	195	P>A		No	ClinGen gnomAD
rs1357614849 CA350337109	195	P>L		No	ClinGen gnomAD
VAR_033941 CA2059514 rs34908164 RCV000949888	196	G>E		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2059513 rs774128163	196	G>R		No	ClinGen ExAC TOPMed gnomAD
rs774128163 CA64007401	196	G>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	197	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767207672 CA2059515	197	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1344920415 CA350337117	197	A>V		No	ClinGen gnomAD
rs1574985660 CA350337140	201	R>K		No	ClinGen Ensembl
CA350337152 rs1188265651	203	R>C		No	ClinGen TOPMed gnomAD
CA350337153 rs1188265651	203	R>G		No	ClinGen TOPMed gnomAD
CA2059519 rs762005854	203	R>H		No	ClinGen ExAC TOPMed gnomAD
CA2059521 rs765396513	204	P>A		No	ClinGen ExAC gnomAD
rs753137612 CA2059522	204	P>H		No	ClinGen ExAC gnomAD
CA350337157 rs765396513	204	P>S		No	ClinGen ExAC gnomAD
TCGA novel	205	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759000866 CA2059523	205	A>V		No	ClinGen ExAC TOPMed gnomAD
CA2059524 rs769617465	206	F>L		No	ClinGen ExAC TOPMed gnomAD
rs757723607 CA2059526	208	F>Y		No	ClinGen ExAC gnomAD
rs1331049297 CA350337196	210	C>F		No	ClinGen gnomAD
rs1308072780 CA350337192	210	C>G		No	ClinGen gnomAD
TCGA novel	212	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA350337207 rs1434026386	212	R>G		No	ClinGen TOPMed gnomAD
rs748991312 CA2059528	212	R>H		No	ClinGen ExAC TOPMed gnomAD
CA350337211 rs1349481688	213	Q>E		No	ClinGen gnomAD
CA2059529 rs768050210	213	Q>H		No	ClinGen ExAC gnomAD
rs773973498 CA2059530	215	K>R		No	ClinGen ExAC gnomAD
CA2059531 rs747629174	216	V>M		No	ClinGen ExAC gnomAD
CA350337240 rs1367439438	217	P>L		No	ClinGen TOPMed
CA350337237 rs1250906059	217	P>S		No	ClinGen gnomAD
CA350337245 rs1396791730	218	P>L		No	ClinGen TOPMed gnomAD
CA350337243 rs1396791730	218	P>Q		No	ClinGen TOPMed gnomAD
COSM26302 rs773165797 CA2059533	218	P>S	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA350337262 rs1352985249	221	G>D		No	ClinGen gnomAD
rs1368373758 CA350337269	222	Y>F		No	ClinGen TOPMed
rs1299122672 CA350337275	223	R>C		No	ClinGen gnomAD
rs561680999 CA64007608	223	R>P		No	ClinGen Ensembl
CA350337322 rs1306993536	230	C>Y		No	ClinGen TOPMed
rs776801836 CA2059536	232	A>S		No	ClinGen ExAC gnomAD
rs373396669 CA2059537	233	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1206130077 CA350337349	234	C>*		No	ClinGen gnomAD
TCGA novel	235	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA350337353 rs1251500958	235	E>Q		No	ClinGen gnomAD
CA2059541 rs762942182	236	P>L		No	ClinGen ExAC
CA2059543 rs752131418	238	R>C		No	ClinGen ExAC gnomAD
TCGA novel	238	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA350337376 rs1432587635	239	A>T		No	ClinGen TOPMed
CA2059546 rs370505613	242	L>P		No	ClinGen ESP ExAC gnomAD
rs1219913507 CA350337406	243	M>I		No	ClinGen gnomAD
CA2059548 rs778438593	246	K>E		No	ClinGen ExAC
TCGA novel	247	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA350337436 rs1368102077	247	E>G		No	ClinGen gnomAD
CA350337433 rs747655093	247	E>K		No	ClinGen ExAC gnomAD
rs747655093 CA2059549	247	E>Q		No	ClinGen ExAC gnomAD
rs1328263001 CA350337440	248	E>K		No	ClinGen TOPMed gnomAD
rs1319336726 CA350337454	249	E>D		No	ClinGen gnomAD
rs1434945843 CA350337448	249	E>K		No	ClinGen gnomAD
CA64007735 rs374592078	250	R>G		No	ClinGen ESP TOPMed
CA350337478 rs1208459790	253	A>S		No	ClinGen TOPMed
rs1295925810 CA350337479	253	A>V		No	ClinGen gnomAD
CA64007750 rs868385707	254	R>H		No	ClinGen Ensembl
CA2059553 rs140897513	255	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs776466891 CA2059554	256	W>C		No	ClinGen ExAC gnomAD
CA2059555 rs759263156	257	V>M		No	ClinGen ExAC gnomAD
CA2059556 rs769990859	259	V>L		No	ClinGen ExAC gnomAD
CA2059557 rs769990859	259	V>M		No	ClinGen ExAC gnomAD
rs1486923501 CA350337518	260	W>*		No	ClinGen gnomAD
rs369157584 CA350337570	268	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA2059563 rs369157584	268	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA350337576 rs1559184457	269	L>F		No	ClinGen Ensembl
rs1300922220 CA350337589	271	T>A		No	ClinGen TOPMed
CA350337592 rs371541002	271	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA2059564 rs371541002	271	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
COSM340636 CA350337594 rs778579874	272	V>F	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
COSM1014990 CA2059565 rs778579874	272	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1412486458 CA350337609	274	T>I		No	ClinGen gnomAD
rs757874303 CA2059567	277	V>A		No	ClinGen ExAC gnomAD
rs375789778 CA2059568	279	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs11546413 CA64007817	282	F>L		No	ClinGen Ensembl
rs955853592 CA64007820	283	S>T		No	ClinGen Ensembl
CA350337682 COSM1565150 rs1181462221	285	P>L	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs267599158 CA64007836 COSM24315	285	P>S	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
CA64007854 rs1039747640	287	R>Q		No	ClinGen TOPMed
CA2059569 rs746933869	288	P>R		No	ClinGen ExAC
CA2059571 rs781110747	289	I>M		No	ClinGen ExAC TOPMed gnomAD
rs112587415 CA64007874	289	I>V		No	ClinGen gnomAD
rs982963006 CA64007880	290	I>M		No	ClinGen TOPMed gnomAD
CA350337706 rs1180531030	290	I>V		No	ClinGen TOPMed
CA350337747 rs1451395018	296	Y>S		No	ClinGen gnomAD
CA350337763 rs1159226499	298	M>T		No	ClinGen gnomAD
rs763122149 CA2059575	298	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1341945140 COSM3933509 CA350337801	303	H>Y	urinary_tract [Cosmic]	No	ClinGen cosmic curated TOPMed
CA350337828 rs1559184502	305	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	309	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1038142339 CA64007988	309	L>V		No	ClinGen TOPMed
CA2059579 rs201306518	310	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1193536366 CA350337865	310	E>K		No	ClinGen gnomAD
CA350337883 rs1300462405	311	D>E		No	ClinGen gnomAD
rs766695859 CA2059582	311	D>G		No	ClinGen ExAC gnomAD
rs761079277 CA2059581	311	D>N		No	ClinGen ExAC TOPMed gnomAD
rs766695859 CA64008016	311	D>V		No	ClinGen ExAC gnomAD
CA350337898 COSM1404555 rs1458457825	313	A>T	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA350337903 rs1213097813	313	A>V		No	ClinGen gnomAD
CA350337931 rs1171032851	316	V>A		No	ClinGen TOPMed gnomAD
CA350337932 rs1171032851	316	V>G		No	ClinGen TOPMed gnomAD
CA350337925 COSM1014992 rs1202884817	316	V>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs962532274 CA64008028	318	R>P		No	ClinGen TOPMed gnomAD
rs376375888 CA350337982	321	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA2059586 rs201094355 COSM3391398	322	D>Y	pancreas [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA2059587 rs756791088	323	G>V		No	ClinGen ExAC gnomAD
CA2059590 rs755903607	326	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA350338030 rs755903607	326	T>R		No	ClinGen ExAC TOPMed gnomAD
CA64008096 rs373015204	328	A>E		No	ClinGen ESP TOPMed
rs1399375323 CA350338043	328	A>S		No	ClinGen gnomAD
TCGA novel	330	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1356099942 CA350338109	334	E>G		No	ClinGen gnomAD
CA350338115 rs1263109646	335	G>S		No	ClinGen TOPMed
rs981229079 CA64008121	335	G>V		No	ClinGen TOPMed gnomAD
CA2059595 COSM719737 rs768936211	338	I>V	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs748190045 CA2059597	339	L>F		No	ClinGen ExAC TOPMed gnomAD
CA350338156 rs748190045	339	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	340	F>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2059601 rs766751333	347	G>R		No	ClinGen ExAC TOPMed gnomAD
CA2059602 rs776802145	348	M>T		No	ClinGen ExAC TOPMed gnomAD
CA64008179 rs964122959	349	A>G		No	ClinGen TOPMed gnomAD
CA350338267 rs964122959	349	A>V		No	ClinGen TOPMed gnomAD
rs996855105 CA64008184	352	I>M		No	ClinGen Ensembl
CA350338316 rs1395116969	353	W>C		No	ClinGen gnomAD
CA2059606 rs751230509	355	V>A		No	ClinGen ExAC TOPMed gnomAD
rs763695398 CA2059605	355	V>I		No	ClinGen ExAC
CA350338365 rs1165837627	358	S>F		No	ClinGen gnomAD
TCGA novel	358	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1421184136 CA350338391	361	W>C		No	ClinGen gnomAD
CA64008196 rs1052627983	361	W>G		No	ClinGen TOPMed gnomAD
CA350338417 rs144653732	364	A>E		No	ClinGen ESP TOPMed gnomAD
rs144653732 CA64008216	364	A>V		No	ClinGen ESP TOPMed gnomAD
CA2059608 rs766972889	366	G>D		No	ClinGen ExAC gnomAD
CA350338449 rs1208720088	367	M>I		No	ClinGen TOPMed
CA350338441 rs1326702622	367	M>L		No	ClinGen gnomAD
rs1559184602 CA350338502	372	E>V		No	ClinGen Ensembl
rs1483210850 COSM4139188 CA350338525	375	E>*	ovary [Cosmic]	No	ClinGen cosmic curated TOPMed
CA350338531 rs1272206298	376	A>T		No	ClinGen gnomAD
CA350338538 rs1340237363	377	N>D		No	ClinGen gnomAD
CA350338537 rs1340237363	377	N>H		No	ClinGen gnomAD
CA350338546 rs1271603959	378	S>P		No	ClinGen gnomAD
rs1574985957 CA350338578	382	H>P		No	ClinGen Ensembl
rs749054651 CA2059613	383	L>V		No	ClinGen ExAC gnomAD
CA2059614 rs754845922	384	A>S		No	ClinGen ExAC TOPMed gnomAD
CA2059616 rs202180353	385	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1163977982 CA350338612	388	V>M		No	ClinGen TOPMed gnomAD
COSM70843 CA2059619 rs747123860	390	A>T	ovary Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA350338666 rs1380670871	393	T>S		No	ClinGen TOPMed gnomAD
rs149352549 CA2059621	394	I>V		No	ClinGen ESP ExAC gnomAD
CA350338679 rs1327270604	395	T>A		No	ClinGen gnomAD
CA350338687 rs1291635079	396	I>L		No	ClinGen TOPMed gnomAD
rs1291635079 CA350338689	396	I>V		No	ClinGen TOPMed gnomAD
rs1376413817 CA350338718	399	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA2059626 rs767037777	400	G>D		No	ClinGen ExAC gnomAD
rs760267744 CA2059628	401	Q>H		No	ClinGen ExAC gnomAD
CA2059627 rs749838885	401	Q>L		No	ClinGen ExAC gnomAD
CA2059629 rs766182243	403	D>E		No	ClinGen ExAC gnomAD
rs1488988626 CA350338760	403	D>G		No	ClinGen gnomAD
CA64008382 rs868238478	405	D>N		No	ClinGen Ensembl
rs138410404 CA350338786	406	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs138410404 CA2059630	406	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs754790390 CA2059631	407	L>R		No	ClinGen ExAC gnomAD
rs778919951 CA2059632	408	S>G		No	ClinGen ExAC TOPMed gnomAD
CA2059634 rs376228466 CA64008403	409	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC gnomAD NCI-TCGA
rs747019981 CA2059636	410	V>A		No	ClinGen ExAC TOPMed gnomAD
CA350338826 rs747019981	410	V>G		No	ClinGen ExAC TOPMed gnomAD
rs1377495934 CA350338849	412	Y>*		No	ClinGen gnomAD
CA350338842 rs1351203371	412	Y>H		No	ClinGen TOPMed
CA350338867 rs1415784012	414	G>A		No	ClinGen gnomAD
CA2059639 rs139393561	417	S>C		No	ClinGen ESP ExAC gnomAD
CA2059641 rs775888500	420	A>G		No	ClinGen ExAC gnomAD
rs770136662 CA2059640	420	A>S		No	ClinGen ExAC TOPMed gnomAD
rs763382154 CA2059642	422	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2059643 rs771586697	425	V>L		No	ClinGen ExAC gnomAD
rs139806141 CA64008443	431	V>I		No	ClinGen ESP TOPMed
CA2059646 rs765955164	432	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs753824459 CA2059647	433	L>F		No	ClinGen ExAC gnomAD
CA2059648 rs759605888	434	F>L		No	ClinGen ExAC gnomAD
rs945271936 CA64008455	435	I>M		No	ClinGen TOPMed
CA2059649 rs559202385	435	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	436	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1171767397 CA350339061	437	T>P		No	ClinGen gnomAD
TCGA novel	438	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	440	L>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	441	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2059653 rs777808101	446	S>C		No	ClinGen ExAC TOPMed gnomAD
CA2059652 rs777808101	446	S>F		No	ClinGen ExAC TOPMed gnomAD
CA350339171 rs1370906276	447	L>F		No	ClinGen gnomAD
rs1559184707 CA350339188	448	F>L		No	ClinGen Ensembl
CA2059655 rs781312452	449	R>H		No	ClinGen ExAC gnomAD
CA350339205 rs1237684776	450	I>S		No	ClinGen TOPMed
CA2059656 rs746357590	451	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1233571370 CA350339215	452	T>S		No	ClinGen gnomAD
rs1209287192 CA350339232	454	M>T		No	ClinGen TOPMed
CA64008585 rs146693247	458	G>V		No	ClinGen ESP
rs780572956 CA2059658	461	T>I		No	ClinGen ExAC TOPMed gnomAD
rs780572956 CA64008590	461	T>N		No	ClinGen ExAC TOPMed gnomAD
CA2059659 rs749570044	462	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	464	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	465	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	468	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA350339339 rs1574986084	469	V>G		No	ClinGen Ensembl
CA64008616 rs772230105	469	V>M		No	ClinGen Ensembl
TCGA novel	471	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	473	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201191053 CA350339360	473	V>I		No	ClinGen 1000Genomes ExAC gnomAD
rs201191053 CA2059660	473	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA2059661 rs772709570	475	S>C		No	ClinGen ExAC gnomAD
TCGA novel	482	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA350339428 rs1168789891	483	T>I		No	ClinGen gnomAD
rs776225705 CA2059664	484	I>M		No	ClinGen ExAC gnomAD
CA2059663 rs770553279	484	I>V		No	ClinGen ExAC gnomAD
CA2059665 rs759120037	486	L>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA350339442 rs1226633427	486	L>P		No	ClinGen TOPMed
CA64008634 VAR_033942 rs35600847	487	A>V		No	ClinGen UniProt Ensembl dbSNP
rs1350289407 CA350339452	488	C>Y		No	ClinGen TOPMed
CA350339461 rs1284972017	489	Y>C		No	ClinGen TOPMed
rs1372601818 CA350339457	489	Y>N		No	ClinGen gnomAD
rs765225022 CA2059666	490	F>L		No	ClinGen ExAC gnomAD
rs201452450 CA64008662	491	Y>H		No	ClinGen Ensembl
CA2059667 rs775589753	493	Q>H		No	ClinGen ExAC gnomAD
CA2059668 rs762632983	494	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1436477460 CA350339499	495	F>L		No	ClinGen TOPMed
CA350339523 rs1258416034	498	H>Y		No	ClinGen TOPMed gnomAD
CA350339546 rs1334110194	501	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1029625624 CA64008755	509	K>E		No	ClinGen Ensembl
CA350339622 rs1356408833	511	Y>*		No	ClinGen gnomAD
rs751432827 CA2059675	511	Y>*		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	511	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs541873049 CA2059677	512	A>D		No	ClinGen 1000Genomes ExAC gnomAD
CA2059676 rs541873049	512	A>G		No	ClinGen 1000Genomes ExAC gnomAD
CA350339638 rs1188964012	514	P>L		No	ClinGen TOPMed
rs1287718003 CA350339647	516	P>A		No	ClinGen gnomAD
CA350339652 rs1253159878	516	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1213783275 CA350339658	517	P>L		No	ClinGen TOPMed
CA350339664 rs1278406659	518	G>D		No	ClinGen gnomAD
CA2059685 rs775255613	519	H>Q		No	ClinGen ExAC gnomAD
rs769473710 CA2059684	519	H>R		No	ClinGen ExAC gnomAD
rs946938708 CA64008847	520	F>L		No	ClinGen TOPMed
rs763013166 CA2059686	520	F>L		No	ClinGen ExAC gnomAD
CA64008875 rs891140187	521	P>R		No	ClinGen TOPMed gnomAD
rs1322184413 CA350339679	521	P>S		No	ClinGen gnomAD
CA2059687 rs763782149	523	M>V		No	ClinGen ExAC gnomAD
rs1486871073 CA350339699	524	S>N		No	ClinGen gnomAD
rs1211876804 CA350339706	525	P>A		No	ClinGen gnomAD
rs774136031 CA2059688	526	D>N		No	ClinGen ExAC gnomAD
CA350339729 rs1237694457	528	T>S		No	ClinGen TOPMed gnomAD
CA2059690 rs767678664	530	F>L		No	ClinGen ExAC gnomAD
COSM221671 rs1190426799 CA350339750 CA350339749	531	M>I	skin [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA64008936 rs140867221	531	M>V		No	ClinGen ESP
CA2059691 rs750694306	533	K>N		No	ClinGen ExAC gnomAD
rs1415169873 CA350339763	533	K>R		No	ClinGen gnomAD
rs756155956 CA2059692	536	M>I		No	ClinGen ExAC gnomAD
rs1342968635 CA350339788	537	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	538	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766517331 CA2059693	538	M>T		No	ClinGen ExAC gnomAD
rs1420967138 CA350339793	538	M>V		No	ClinGen gnomAD
rs368139563 CA64008947	539	I>T		No	ClinGen ESP TOPMed gnomAD
CA2059694 rs754291190	540	V>I		No	ClinGen ExAC gnomAD
rs1176490445 CA350339818	542	I>F		No	ClinGen gnomAD
CA2059697 rs748503156	543	T>I		No	ClinGen ExAC gnomAD
rs1403313159 CA350339834	544	T>I		No	ClinGen TOPMed
CA2059699 rs528874438	545	G>A		No	ClinGen ExAC TOPMed gnomAD
rs1574986206 CA350339836	545	G>S		No	ClinGen Ensembl
rs769424376 CA2059701	547	W>*		No	ClinGen ExAC gnomAD
rs748759824 CA2059703	548	I>N		No	ClinGen ExAC gnomAD
CA2059702 rs372045596	548	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs768569299 CA2059704	550	S>L		No	ClinGen ExAC TOPMed gnomAD
rs774179533 CA2059705	552	K>N		No	ClinGen ExAC gnomAD
CA350339921 rs1574986229	557	W>C		No	ClinGen Ensembl
CA350339923 COSM1404559 rs1480494909	558	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA350339933 rs1410790493	559	R>H		No	ClinGen TOPMed gnomAD
rs761575550 CA2059706	559	R>S		No	ClinGen ExAC gnomAD
rs1441079594 CA350339937	560	F>L		No	ClinGen gnomAD
CA2059707 rs771894898	562	H>R		No	ClinGen ExAC gnomAD
rs1394116238 CA350339959	563	R>G		No	ClinGen gnomAD
rs773419766 CA2059708	563	R>S		No	ClinGen ExAC gnomAD
rs1015839962 CA64009055	564	L>F		No	ClinGen Ensembl
CA2059709 rs565714072	565	S>G		No	ClinGen ExAC
CA350339972 rs1489938804	565	S>N		No	ClinGen TOPMed
CA2059710 rs766526311	565	S>R		No	ClinGen ExAC gnomAD
rs1359574039 CA350340004	569	K>R		No	ClinGen gnomAD
rs1296448475 CA350340008	570	G>R		No	ClinGen gnomAD
rs1378933730 CA350340015	571	E>*		No	ClinGen gnomAD
CA2059713 rs765723806	571	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1574986256 CA350340036	574	V>A		No	ClinGen Ensembl
rs974234940 CA64009100	574	V>I		No	ClinGen Ensembl

No associated diseases with O75084

4 regional properties for O75084

Type	Name	Position	InterPro Accession
domain	Frizzled/Smoothened, transmembrane domain	243 - 567	IPR000539
domain	GPCR, family 2-like, transmembrane domain	253 - 556	IPR017981
domain	Frizzled domain	44 - 165	IPR020067
domain	Frizzled-7, cysteine-rich Wnt-binding domain	45 - 169	IPR042742

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein Endosome membrane ; Multi-pass membrane protein	Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) Localized in recycling endosomes in other conditions
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
recycling endosome membrane	The lipid bilayer surrounding a recycling endosome.

6 GO annotations of molecular function

Name	Definition
frizzled binding	Binding to a frizzled (fz) receptor.
G protein-coupled receptor activity	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
PDZ domain binding	Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.
phosphatidylinositol-4,5-bisphosphate binding	Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
Wnt receptor activity	Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
Wnt-protein binding	Binding to a Wnt-protein, a secreted growth factor involved in signaling.

20 GO annotations of biological process

Name	Definition
canonical Wnt signaling pathway	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
cellular response to retinoic acid	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
mesenchymal to epithelial transition	A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell.
negative regulation of cardiac muscle cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation.
negative regulation of cell-substrate adhesion	Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
negative regulation of ectodermal cell fate specification	Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell.
neuron differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neuron.
non-canonical Wnt signaling pathway via JNK cascade	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the JNK cascade.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of epithelial cell proliferation involved in wound healing	Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury.
positive regulation of JNK cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
positive regulation of phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.
regulation of canonical Wnt signaling pathway	Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	Any process by which the number of skeletal muscle satellite cells in a skeletal muscle is maintained during muscle regeneration. There are at least three mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. Some adult skeletal muscle myoblasts (descendants of activated satellite cells) can develop back into quiescent satellite cells, replenishing the overall pool of satellite cells.
somatic stem cell division	The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line.
stem cell population maintenance	The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
substrate adhesion-dependent cell spreading	The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
T cell differentiation in thymus	The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.
Wnt signaling pathway, planar cell polarity pathway	The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity.

23 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O19116	SFRP1	Secreted frizzled-related protein 1	Bos taurus (Bovine)	PR
Q9DEQ4	SFRP1	Secreted frizzled-related protein 1	Gallus gallus (Chicken)	PR
O57328	FZD1	Frizzled-1	Gallus gallus (Chicken)	PR
Q9IA96	SFRP2	Secreted frizzled-related protein 2	Gallus gallus (Chicken)	PR
O00144	FZD9	Frizzled-9	Homo sapiens (Human)	PR
Q14332	FZD2	Frizzled-2	Homo sapiens (Human)	PR
Q6FHJ7	SFRP4	Secreted frizzled-related protein 4	Homo sapiens (Human)	PR
Q8N474	SFRP1	Secreted frizzled-related protein 1	Homo sapiens (Human)	PR
Q96HF1	SFRP2	Secreted frizzled-related protein 2	Homo sapiens (Human)	PR
Q9ULW2	FZD10	Frizzled-10	Homo sapiens (Human)	PR
Q9UP38	FZD1	Frizzled-1	Homo sapiens (Human)	PR
O60353	FZD6	Frizzled-6	Homo sapiens (Human)	PR
Q9Z1N6	Sfrp4	Secreted frizzled-related sequence protein 4	Mus musculus (Mouse)	PR
P97299	Sfrp2	Secreted frizzled-related protein 2	Mus musculus (Mouse)	PR
Q8C4U3	Sfrp1	Secreted frizzled-related protein 1	Mus musculus (Mouse)	PR
O70421	Fzd1	Frizzled-1	Mus musculus (Mouse)	PR
Q9JIP6	Fzd2	Frizzled-2	Mus musculus (Mouse)	PR
Q61090	Fzd7	Frizzled-7	Mus musculus (Mouse)	PR
Q08463	Fzd1	Frizzled-1	Rattus norvegicus (Rat)	PR
Q9JLS4	Sfrp4	Secreted frizzled-related protein 4	Rattus norvegicus (Rat)	PR
Q08464	Fzd2	Frizzled-2	Rattus norvegicus (Rat)	PR
Q7YRN1	SFRP4	Secreted frizzled-related protein 4	Macaca mulatta (Rhesus macaque)	PR
Q5BL72	fzd7	Frizzled-7	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MRDPGAAAPL	SSLGLCALVL	ALLGALSAGA	GAQPYHGEKG	ISVPDHGFCQ	PISIPLCTDI
70	80	90	100	110	120
AYNQTILPNL	LGHTNQEDAG	LEVHQFYPLV	KVQCSPELRF	FLCSMYAPVC	TVLDQAIPPC
130	140	150	160	170	180
RSLCERARQG	CEALMNKFGF	QWPERLRCEN	FPVHGAGEIC	VGQNTSDGSG	GPGGGPTAYP
190	200	210	220	230	240
TAPYLPDLPF	TALPPGASDG	RGRPAFPFSC	PRQLKVPPYL	GYRFLGERDC	GAPCEPGRAN
250	260	270	280	290	300
GLMYFKEEER	RFARLWVGVW	SVLCCASTLF	TVLTYLVDMR	RFSYPERPII	FLSGCYFMVA
310	320	330	340	350	360
VAHVAGFLLE	DRAVCVERFS	DDGYRTVAQG	TKKEGCTILF	MVLYFFGMAS	SIWWVILSLT
370	380	390	400	410	420
WFLAAGMKWG	HEAIEANSQY	FHLAAWAVPA	VKTITILAMG	QVDGDLLSGV	CYVGLSSVDA
430	440	450	460	470	480
LRGFVLAPLF	VYLFIGTSFL	LAGFVSLFRI	RTIMKHDGTK	TEKLEKLMVR	IGVFSVLYTV
490	500	510	520	530	540
PATIVLACYF	YEQAFREHWE	RTWLLQTCKS	YAVPCPPGHF	PPMSPDFTVF	MIKYLMTMIV
550	560	570
GITTGFWIWS	GKTLQSWRRF	YHRLSHSSKG	ETAV