Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q08463

Entry ID Method Resolution Chain Position Source
AF-Q08463-F1 Predicted AlphaFoldDB

No variants for Q08463

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q08463

No associated diseases with Q08463

3 regional properties for Q08463

Type Name Position InterPro Accession
domain Frizzled/Smoothened, transmembrane domain 303 - 634 IPR000539
domain GPCR, family 2-like, transmembrane domain 311 - 623 IPR017981
domain Frizzled domain 106 - 226 IPR020067

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cell surface The external part of the cell wall and/or plasma membrane.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

9 GO annotations of molecular function

Name Definition
frizzled binding Binding to a frizzled (fz) receptor.
G protein-coupled receptor activity Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
identical protein binding Binding to an identical protein or proteins.
PDZ domain binding Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
protein homodimerization activity Binding to an identical protein to form a homodimer.
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
Wnt receptor activity Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
Wnt-protein binding Binding to a Wnt-protein, a secreted growth factor involved in signaling.

30 GO annotations of biological process

Name Definition
astrocyte-dopaminergic neuron signaling Cell-cell signaling that mediates the transfer of information from an astrocyte to a dopaminergic neuron.
autocrine signaling Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type.
canonical Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in mesenchymal stem cell differentiation.
canonical Wnt signaling pathway involved in osteoblast differentiation The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in osteoblast differentiation.
cell-cell signaling Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
cellular response to growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
cellular response to peptide hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
cellular response to vitamin D Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.
endothelial cell differentiation The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
hard palate development The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes.
lung alveolus development The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
membranous septum morphogenesis The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.
muscular septum morphogenesis The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.
negative regulation of BMP signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
negative regulation of canonical Wnt signaling pathway Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of oxidative stress-induced neuron death Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death.
outflow tract morphogenesis The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
planar cell polarity pathway involved in neural tube closure The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure.
positive regulation of DNA-binding transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of neuron projection development Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
regulation of osteoblast differentiation Any process that modulates the frequency, rate or extent of osteoblast differentiation.
regulation of presynapse assembly Any process that modulates the frequency, rate or extent of presynapse assembly.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
ventricular septum morphogenesis The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

23 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O19116 SFRP1 Secreted frizzled-related protein 1 Bos taurus (Bovine) PR
Q9DEQ4 SFRP1 Secreted frizzled-related protein 1 Gallus gallus (Chicken) PR
Q9IA96 SFRP2 Secreted frizzled-related protein 2 Gallus gallus (Chicken) PR
O57328 FZD1 Frizzled-1 Gallus gallus (Chicken) PR
Q8N474 SFRP1 Secreted frizzled-related protein 1 Homo sapiens (Human) PR
Q9ULW2 FZD10 Frizzled-10 Homo sapiens (Human) PR
Q96HF1 SFRP2 Secreted frizzled-related protein 2 Homo sapiens (Human) PR
O75084 FZD7 Frizzled-7 Homo sapiens (Human) PR
Q14332 FZD2 Frizzled-2 Homo sapiens (Human) PR
O00144 FZD9 Frizzled-9 Homo sapiens (Human) PR
O60353 FZD6 Frizzled-6 Homo sapiens (Human) PR
Q6FHJ7 SFRP4 Secreted frizzled-related protein 4 Homo sapiens (Human) PR
Q9UP38 FZD1 Frizzled-1 Homo sapiens (Human) PR
Q9Z1N6 Sfrp4 Secreted frizzled-related sequence protein 4 Mus musculus (Mouse) PR
P97299 Sfrp2 Secreted frizzled-related protein 2 Mus musculus (Mouse) PR
Q8C4U3 Sfrp1 Secreted frizzled-related protein 1 Mus musculus (Mouse) PR
Q9JIP6 Fzd2 Frizzled-2 Mus musculus (Mouse) PR
Q61090 Fzd7 Frizzled-7 Mus musculus (Mouse) PR
O70421 Fzd1 Frizzled-1 Mus musculus (Mouse) PR
Q08464 Fzd2 Frizzled-2 Rattus norvegicus (Rat) PR
Q9JLS4 Sfrp4 Secreted frizzled-related protein 4 Rattus norvegicus (Rat) PR
Q7YRN1 SFRP4 Secreted frizzled-related protein 4 Macaca mulatta (Rhesus macaque) PR
Q5BL72 fzd7 Frizzled-7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MAEEAVPSES RAAGRPSLEL CAVALPGRRE EVGHQDTAGH RRPRAHSRCW ARGLLLLLWL
70 80 90 100 110 120
LEAPLLLGVR AQPAGQVSGP GQQRPPPPQP QQGGQQYNGE RGISIPDHGY CQPISIPLCT
130 140 150 160 170 180
DIAYNQTIMP NLLGHTNQED AGLEVHQFYP LVKVQCSAEL KFFLCSMYAP VCTVLEQALP
190 200 210 220 230 240
PCRSLCERAQ GCEALMNKFG FQWPDTLKCE KFPVHGAGEL CVGQNTSDKG TPTPSLLPEF
250 260 270 280 290 300
WTSNPQHGGG GYRGGYPGGA GPVERGKFSC PRALRVPSYL NYHFLGEKDC GAPCEPTKVY
310 320 330 340 350 360
GLMYFGPEEL RFSRTWIGIW SVLCCASTLF TVLTYLVDMR RFSYPERPII FLSGCYTAVA
370 380 390 400 410 420
VAYIAGFLLE DRVVCNDKFA EDGARTVAQG TKKEGCTILF MMLYFFSMAS SIWWVILSLT
430 440 450 460 470 480
WFLAAGMKWG HEAIEANSQY FHLAAWAVPA IKTITILALG QVDGDVLSGV CFVGLNNVDA
490 500 510 520 530 540
LRGFVLAPLF VYLFIGTSFL LAGFVSLFRI RTIMKHDGTK TEKLEKLMVR IGVFSVLYTV
550 560 570 580 590 600
PATIVIACYF YEQAFRDQWE RSWVAQSCKS YAIPCPHLQG GGGVPPHPPM SPDFTVFMIK
610 620 630 640
YLMTLIVGIT SGFWIWSGKT LNSWRKFYTR LTNSKQGETT V