AiPD: Autoinhibited Protein Database

Q8N474

Gene name	SFRP1 (FRP, FRP1, SARP2)
Protein name	Secreted frizzled-related protein 1
Names	FRP-1, sFRP-1, Secreted apoptosis-related protein 2, SARP-2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6422
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

144-214 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

144-214 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8N474

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8N474-F1	Predicted				AlphaFoldDB

247 variants for Q8N474

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA176287895 rs62636770	2	G>D		No	ClinGen ExAC TOPMed gnomAD
CA176287896 rs1040811307	2	G>R		No	ClinGen TOPMed
CA4726041 rs62636770	2	G>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	3	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371173559 rs1375510729	3	I>S		No	ClinGen TOPMed
CA371173563 rs1296477652	3	I>V		No	ClinGen TOPMed
CA371173557 rs946005107 CA176287894	4	G>R		No	ClinGen gnomAD
CA371173549 rs1277033544	5	R>H		No	ClinGen gnomAD
rs1292519999 CA371173552	5	R>S		No	ClinGen TOPMed
CA371173540 rs1179730809	6	S>R		No	ClinGen gnomAD
rs1234845666 CA371173533	7	E>D		No	ClinGen TOPMed
rs910850635 CA176287893	7	E>K		No	ClinGen TOPMed
rs1436812585	9	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	9	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA176287892 rs978853823	9	G>V		No	ClinGen TOPMed gnomAD
CA371173518 rs1354207047	10	R>C		No	ClinGen gnomAD
CA4726039 rs774144452	10	R>L		No	ClinGen ExAC gnomAD
CA371173512 rs762804035	11	R>H		No	ClinGen ExAC gnomAD
rs762804035 CA4726037	11	R>L		No	ClinGen ExAC gnomAD
CA4726038 rs770845217	11	R>S		No	ClinGen ExAC
CA371173511 rs1286145742	12	G>W		No	ClinGen gnomAD
CA176287891 rs201843680	13	A>G		No	ClinGen Ensembl
CA371173505 rs1585525598	13	A>T		No	ClinGen Ensembl
CA371173497 rs1585525590	14	A>S		No	ClinGen Ensembl
rs768750338 CA4726034	17	V>L		No	ClinGen ExAC gnomAD
rs768750338 CA371173481	17	V>M		No	ClinGen ExAC gnomAD
rs1159160639 CA371173455	22	G>C		No	ClinGen TOPMed gnomAD
rs1159160639 CA371173456	22	G>S		No	ClinGen TOPMed gnomAD
CA371173446 rs1410024224	23	A>G		No	ClinGen gnomAD
rs1455462910 CA371173449	23	A>P		No	ClinGen gnomAD
rs1158754825 CA371173437	25	L>I		No	ClinGen gnomAD
CA371173433 rs1472127921	25	L>R		No	ClinGen gnomAD
rs1200745613 CA371173431	26	L>V		No	ClinGen gnomAD
CA176287889 rs927483508	27	A>D		No	ClinGen Ensembl
CA371173425 rs1449743976	27	A>S		No	ClinGen gnomAD
rs1205203867 CA371173420	28	V>L		No	ClinGen TOPMed gnomAD
CA371173422 rs1205203867	28	V>M		No	ClinGen TOPMed gnomAD
rs746183289 CA371173415	29	G>C		No	ClinGen ExAC TOPMed gnomAD
rs746183289 CA4726029	29	G>R		No	ClinGen ExAC TOPMed gnomAD
rs746183289 CA371173416	29	G>S		No	ClinGen ExAC TOPMed gnomAD
CA4726026 rs749835100	30	S>L		No	ClinGen ExAC TOPMed gnomAD
CA4726027 rs757738974	30	S>T		No	ClinGen ExAC gnomAD
COSM1552677 rs918864261 CA176287887 COSM1552676	31	A>D	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA371173405 rs1284545416	31	A>S		No	ClinGen TOPMed
CA371173403 rs918864261	31	A>V		No	ClinGen gnomAD
CA371173400 rs1319631327	32	S>G		No	ClinGen TOPMed gnomAD
CA371173401 rs1319631327	32	S>R		No	ClinGen TOPMed gnomAD
rs755723496 CA4726024	33	E>A		No	ClinGen ExAC TOPMed gnomAD
rs959862345 CA176287886	33	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA371173391 rs755723496	33	E>V		No	ClinGen ExAC TOPMed gnomAD
CA4726021 rs754601948	35	D>V		No	ClinGen ExAC TOPMed gnomAD
rs1476958923 CA371173366	36	Y>*		No	ClinGen gnomAD
TCGA novel	37	V>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371173361 rs1193874674	37	V>A		No	ClinGen TOPMed gnomAD
rs1376969223 CA371173365	37	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs141546086 CA176287884	38	S>N		No	ClinGen ESP TOPMed gnomAD
rs762832033 CA4726018	39	F>I		No	ClinGen ExAC gnomAD
CA371173349 rs1461443942	39	F>Y		No	ClinGen TOPMed gnomAD
CA4726017 rs773186629	41	S>L		No	ClinGen ExAC gnomAD
rs964980693 CA176287883	41	S>T		No	ClinGen Ensembl
rs1344797531 CA371173329	42	D>G		No	ClinGen gnomAD
rs866487203 CA176287882	44	G>D		No	ClinGen TOPMed gnomAD
CA371173313 rs1231189794	45	P>A		No	ClinGen TOPMed gnomAD
CA4726013 rs772267698	45	P>L		No	ClinGen ExAC TOPMed gnomAD
CA4726014 rs772267698	45	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1006637962 CA371173295 CA176287881	47	Q>H		No	ClinGen gnomAD
rs771249090 CA4726011	50	R>H		No	ClinGen ExAC gnomAD
rs771249090 CA4726010	50	R>P		No	ClinGen ExAC gnomAD
rs749781995 CA4726009	52	Y>S		No	ClinGen ExAC gnomAD
rs1451181965 CA371173257	53	T>S		No	ClinGen gnomAD
CA4726006 rs747605410	54	K>E		No	ClinGen ExAC gnomAD
CA4726005 rs780574104	54	K>N		No	ClinGen ExAC gnomAD
CA371173249 rs1238812519	55	P>S		No	ClinGen gnomAD
rs766178906 CA4726002	59	V>A		No	ClinGen ExAC gnomAD
rs751194586 CA4726003	59	V>L		No	ClinGen ExAC gnomAD
TCGA novel	60	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1340647494 CA371173201	62	P>A		No	ClinGen gnomAD
TCGA novel	63	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA371173189 rs1274637063	64	D>H		No	ClinGen gnomAD
CA371173176 rs1282525022	66	R>W		No	ClinGen gnomAD
rs1431460518 CA371173143	71	V>M		No	ClinGen gnomAD
rs767514199 CA4725996	73	Y>C		No	ClinGen ExAC gnomAD
CA176287879 rs866775064	75	K>R		No	ClinGen Ensembl
rs1585525370 CA371173104	76	M>I		No	ClinGen Ensembl
CA4725994 rs774476008	76	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA371173094 rs1415268484	78	L>V		No	ClinGen gnomAD
rs773726937 CA4725992	85	E>K		No	ClinGen ExAC TOPMed gnomAD
CA4725991 rs773726937	85	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA176287878 rs374492383	86	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA4725990 rs374492383	86	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA176287877 rs1057451989	90	V>A		No	ClinGen Ensembl
CA4725989 rs748698728	90	V>M		No	ClinGen ExAC TOPMed gnomAD
rs937435721 CA176287876	94	A>S		No	ClinGen gnomAD
rs768103490 CA4725987	95	S>I		No	ClinGen ExAC
rs1324063735 COSM454559 CA371172963	97	W>*	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
CA4725985 rs779643083	102	N>D		No	ClinGen ExAC gnomAD
CA176287875 rs75563193	104	N>T		No	ClinGen Ensembl
rs1585525327 CA371172905	106	H>D		No	ClinGen Ensembl
TCGA novel	106	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1585525323 CA371172904	106	H>P		No	ClinGen Ensembl
TCGA novel	106	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750147715 CA4725983	107	A>D		No	ClinGen ExAC gnomAD
CA4725984 rs370348984	107	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs750147715 CA176287874	107	A>V		No	ClinGen ExAC gnomAD
rs1162079487 CA371172863	112	F>L		No	ClinGen gnomAD
rs137876408 CA176287873	113	L>F		No	ClinGen ESP gnomAD
rs1245539217 CA371172787	124	R>L		No	ClinGen gnomAD
rs535023429 CA4725979	124	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	126	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4725977 rs572275992	127	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs918768957 CA176287872	128	P>R		No	ClinGen Ensembl
CA371172749 rs1328783831	130	R>H		No	ClinGen gnomAD
CA371172710 rs1393341218	136	V>M		No	ClinGen TOPMed
rs762360499 CA4725972	139	S>L		No	ClinGen ExAC gnomAD
rs1209491334 CA371172676	141	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs768211131 CA4725970	142	P>R		No	ClinGen ExAC gnomAD
rs746562361 CA4725969	143	V>L		No	ClinGen ExAC TOPMed
CA4725968 rs779616580	145	Q>R		No	ClinGen ExAC gnomAD
rs1563369238 CA371172626	148	G>R		No	ClinGen Ensembl
CA4725967 rs771668038	149	F>L		No	ClinGen ExAC gnomAD
rs745540217 CA4725966	150	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1443018881 CA371172613	150	Y>H		No	ClinGen gnomAD
rs985557782 CA176287868	153	E>*		No	ClinGen Ensembl
CA371172571 rs1439671267	155	L>R		No	ClinGen TOPMed
rs1300715645 CA371172569	156	K>E		No	ClinGen TOPMed
rs1450662153 CA371172549	158	D>G		No	ClinGen gnomAD
CA371172554 rs1191173756	158	D>N		No	ClinGen gnomAD
rs538888138 CA4725965	160	F>L		No	ClinGen 1000Genomes ExAC gnomAD
rs757083203 CA4725964	161	P>S		No	ClinGen ExAC TOPMed gnomAD
rs569409498 CA4725963	162	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA371172525 rs1275968065	162	E>Q		No	ClinGen TOPMed
CA176287867 rs367671655	163	G>R		No	ClinGen ESP TOPMed
rs777629927 CA4725962	163	G>V		No	ClinGen ExAC
rs756090145 CA371172515	164	D>N		No	ClinGen ExAC gnomAD
rs756090145 CA4725961	164	D>Y		No	ClinGen ExAC gnomAD
rs766598576 CA4725959	167	I>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs763220830 CA4725957	168	A>S		No	ClinGen ExAC TOPMed gnomAD
rs750724569 CA4725956	169	M>I		No	ClinGen ExAC gnomAD
rs1203574222 CA371172481	169	M>L		No	ClinGen TOPMed gnomAD
rs1203574222 CA371172482	169	M>V		No	ClinGen TOPMed gnomAD
rs1365846317 CA371172474	170	T>A		No	ClinGen gnomAD
TCGA novel	170	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762154768 CA4725954	171	P>L		No	ClinGen ExAC TOPMed gnomAD
CA4725955 rs374023983	171	P>S		No	ClinGen ESP ExAC gnomAD
CA371172454 rs1467880705	173	N>K		No	ClinGen gnomAD
CA176287865 rs988681383	173	N>S		No	ClinGen TOPMed
CA4725952 rs768990544	174	A>T		No	ClinGen ExAC gnomAD
rs1430879330 CA371172432	177	A>T		No	ClinGen gnomAD
rs555751360 CA176287864	178	S>F		No	ClinGen gnomAD
COSM1099826 CA4725950 COSM1099825 rs200639526	179	K>N	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA176287863 rs966502256	179	K>R		No	ClinGen gnomAD
rs745486439 CA4725948	180	P>L		No	ClinGen ExAC TOPMed gnomAD
CA176287862 rs745486439	180	P>R		No	ClinGen ExAC TOPMed gnomAD
rs771616794 CA4725949	180	P>S		No	ClinGen ExAC gnomAD
rs774055361 CA176287861	181	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs774055361 CA4725947	181	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs777718042 CA4725878	183	T>I		No	ClinGen ExAC TOPMed gnomAD
CA4725877 rs146935086	184	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs565294570 CA4725876	185	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1289794231 CA371172078	186	C>*		No	ClinGen gnomAD
TCGA novel	188	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781514683 CA4725875	188	P>S		No	ClinGen ExAC gnomAD
rs1166811978 CA371172062	189	C>Y		No	ClinGen gnomAD
rs370594120 CA4725874	191	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1185856105 CA371172040	192	E>*		No	ClinGen gnomAD
CA4725871 rs758844432	196	E>G		No	ClinGen ExAC gnomAD
rs1336169928 CA371172001	197	A>V		No	ClinGen TOPMed
rs112168565 CA176287289	198	I>V		No	ClinGen Ensembl
CA4725868 rs141186016	199	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA4725867 rs753580176	202	L>V		No	ClinGen ExAC
CA4725864 rs775159542	206	E>G		No	ClinGen ExAC gnomAD
COSM1099824 CA4725865 rs199552867 COSM1099823	206	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA371171932 rs1197332351	207	F>L		No	ClinGen TOPMed
TCGA novel	210	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4725818 rs762885491	211	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1563357161 CA371171893	211	M>V		No	ClinGen Ensembl
CA176282687 rs181850396	215	E>A		No	ClinGen 1000Genomes gnomAD
rs1433160063 CA371171832	219	E>*		No	ClinGen gnomAD
TCGA novel	219	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs937511666 CA176282686	221	G>D		No	ClinGen gnomAD
rs937511666 CA371171814	221	G>V		No	ClinGen gnomAD
rs140852585 CA4725816	222	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA371171785 rs1461581988	225	I>M		No	ClinGen gnomAD
rs760933254 CA4725815	225	I>T		No	ClinGen ExAC gnomAD
CA4725814 rs375541809	227	P>A		No	ClinGen ESP ExAC gnomAD
CA176282685 rs375541809	227	P>S		No	ClinGen ESP ExAC gnomAD
rs930950453 CA176282684	228	K>E		No	ClinGen Ensembl
CA371171766 rs1167121153	229	K>E		No	ClinGen gnomAD
CA371171761 rs1474369734	229	K>N		No	ClinGen gnomAD
CA4725812 rs759759230	230	K>R		No	ClinGen ExAC gnomAD
CA371171752 rs1186978741	231	K>Q		No	ClinGen gnomAD
CA4725811 rs151006069	231	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4725810 rs151006069	231	K>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4725809 rs749833439	232	P>A		No	ClinGen ExAC TOPMed gnomAD
CA4725806 rs769227722	232	P>H		No	ClinGen ExAC gnomAD
rs769227722 CA4725807	232	P>L		No	ClinGen ExAC gnomAD
rs769227722 CA371171744	232	P>R		No	ClinGen ExAC gnomAD
rs749833439 CA371171745	232	P>S		No	ClinGen ExAC TOPMed gnomAD
CA4725804 rs142720509	233	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4725803 rs754674465	234	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA176282682 rs764816163	234	K>R		No	ClinGen Ensembl
CA371171728 rs1332223558	235	L>F		No	ClinGen gnomAD
rs1293000885 CA371171722	236	G>A		No	ClinGen gnomAD
rs758287049 CA4725800	238	I>T		No	ClinGen ExAC gnomAD
rs148909390 CA176282680	238	I>V		No	ClinGen ESP gnomAD
CA4725798 rs764207675	240	K>E		No	ClinGen ExAC
rs1206663823 CA371171681	242	D>A		No	ClinGen gnomAD
rs1460022173 CA371171658	245	K>N		No	ClinGen gnomAD
CA371171655 rs1193869527	246	L>F		No	ClinGen TOPMed
CA371171636 rs1585501876	249	Y>S		No	ClinGen Ensembl
CA4725796 rs752829505	254	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA371171597 rs1585501858	255	D>A		No	ClinGen Ensembl
CA371171581 rs1255052319	257	P>L		No	ClinGen gnomAD
CA4725794 rs560765379	263	N>K		No	ClinGen 1000Genomes ExAC gnomAD
CA371171538 rs1585501848	263	N>T		No	ClinGen Ensembl
rs774818490 CA4725793	266	H>N		No	ClinGen ExAC gnomAD
CA371171519 rs774818490	266	H>Y		No	ClinGen ExAC gnomAD
CA371171507 rs1419662937	267	H>Q		No	ClinGen TOPMed
RCV000486865 rs1064796559 CA16618634	271	M>I		No	ClinGen ClinVar Ensembl dbSNP
CA371171483 rs1272199243	271	M>L		No	ClinGen gnomAD
CA371171476 rs1585501830	272	G>S		No	ClinGen Ensembl
CA4725789 rs769341807	273	R>C		No	ClinGen ExAC gnomAD
rs1259368868 CA371171443	277	S>G		No	ClinGen gnomAD
rs761465184 CA4725787	282	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1370482202 CA371171394	284	I>V		No	ClinGen gnomAD
CA176282675 rs1032233346	285	H>Y		No	ClinGen Ensembl
CA4725784 rs779789689	286	K>N		No	ClinGen ExAC
rs368345836 CA4725785	286	K>R		No	ClinGen ESP ExAC TOPMed
CA176282674 rs1001220796	288	D>E		No	ClinGen Ensembl
rs758234202 CA4725783	289	K>T		No	ClinGen ExAC gnomAD
CA4725782 rs750360179	290	K>E		No	ClinGen ExAC gnomAD
CA371171350 rs1386818382	290	K>R		No	ClinGen gnomAD
CA176282673 rs904508437	292	K>E		No	ClinGen Ensembl
rs1378188494 CA371171311	295	K>R		No	ClinGen gnomAD
CA371171300 rs1227785642	296	N>K		No	ClinGen gnomAD
COSM1728163 CA4725780 COSM1728162 rs778653065	297	F>L	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA371171297 rs1460724002	297	F>V		No	ClinGen TOPMed
rs757235545 CA4725779	298	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA371171289 rs1452083798	298	M>T		No	ClinGen TOPMed gnomAD
CA4725778 rs752673340	299	K>*		No	ClinGen ExAC gnomAD
CA4725777 rs539940272	300	K>I		No	ClinGen 1000Genomes ExAC gnomAD
CA371171273 rs539940272	300	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1020339177 CA176282672	301	M>V		No	ClinGen Ensembl
CA4725776 rs755220954	303	N>I		No	ClinGen ExAC gnomAD
CA371171189 rs765603358	312	V>L		No	ClinGen ExAC TOPMed gnomAD
COSM3834713 COSM3834712 CA4725771 rs765603358	312	V>M	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA371171184 rs1401538679	313	F>I		No	ClinGen gnomAD

No associated diseases with Q8N474

4 regional properties for Q8N474

Type	Name	Position	InterPro Accession
domain	Netrin domain	180 - 300	IPR001134
domain	Netrin module, non-TIMP type	193 - 294	IPR018933
domain	Frizzled domain	47 - 165	IPR020067
domain	SFRP1, cysteine-rich domain	46 - 169	IPR041760

Functions

		Description
EC Number
Subcellular Localization	Secreted	Cell membrane or extracellular matrix-associated Released by heparin-binding
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cell surface	The external part of the cell wall and/or plasma membrane.
collagen-containing extracellular matrix	An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name	Definition
cysteine-type endopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
frizzled binding	Binding to a frizzled (fz) receptor.
heparin binding	Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
identical protein binding	Binding to an identical protein or proteins.
Wnt-protein binding	Binding to a Wnt-protein, a secreted growth factor involved in signaling.

85 GO annotations of biological process

Name	Definition
BMP signaling pathway	The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
bone trabecula formation	The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod.
canonical Wnt signaling pathway	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
cellular response to BMP stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus.
cellular response to estradiol stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
cellular response to estrogen stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
cellular response to fibroblast growth factor stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.
cellular response to growth factor stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
cellular response to heparin	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus.
cellular response to hypoxia	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
cellular response to interleukin-1	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
cellular response to prostaglandin E stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
cellular response to starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
cellular response to transforming growth factor beta stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
cellular response to tumor necrosis factor	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
cellular response to vitamin D	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.
cellular response to X-ray	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).
convergent extension involved in somitogenesis	The morphogenetic process in which a presomitic mesoderm narrows along the left-right axis and lengthens in the rostral-caudal axis contributing to somitogenesis.
digestive tract morphogenesis	The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.
dopaminergic neuron differentiation	The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
dorsal/ventral axis specification	The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
extrinsic apoptotic signaling pathway	The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
female gonad development	The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.
hematopoietic progenitor cell differentiation	The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
hematopoietic stem cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
male gonad development	The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
negative regulation of androgen receptor signaling pathway	Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of B cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation.
negative regulation of BMP signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
negative regulation of bone remodeling	Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling.
negative regulation of canonical Wnt signaling pathway	Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation	Any process that stops, prevents, or reduces the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation.
negative regulation of cell growth	Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
negative regulation of cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of epithelial cell proliferation	Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
negative regulation of epithelial to mesenchymal transition	Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
negative regulation of fibroblast apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process.
negative regulation of fibroblast proliferation	Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
negative regulation of gene expression	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of insulin secretion	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
negative regulation of JUN kinase activity	Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.
negative regulation of ossification	Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
negative regulation of osteoblast differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.
negative regulation of osteoblast proliferation	Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation.
negative regulation of osteoclast differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.
negative regulation of peptidyl-tyrosine phosphorylation	Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
negative regulation of planar cell polarity pathway involved in axis elongation	Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in axis elongation.
negative regulation of Wnt signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification.
neural crest cell fate commitment	The process in which a cell becomes committed to become a neural crest cell.
osteoblast differentiation	The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
osteoclast differentiation	The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
planar cell polarity pathway involved in axis elongation	The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation.
planar cell polarity pathway involved in neural tube closure	The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure.
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of canonical Wnt signaling pathway	Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of cell growth	Any process that activates or increases the frequency, rate, extent or direction of cell growth.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of cell-matrix adhesion	Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of epithelial cell proliferation	Any process that activates or increases the rate or extent of epithelial cell proliferation.
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
positive regulation of fat cell differentiation	Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
positive regulation of fibroblast apoptotic process	Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process.
positive regulation of focal adhesion assembly	Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
positive regulation of GTPase activity	Any process that activates or increases the activity of a GTPase.
positive regulation of non-canonical Wnt signaling pathway	Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway.
positive regulation of smoothened signaling pathway	Any process that activates or increases the frequency, rate or extent of smoothened signaling.
positive regulation of stress fiber assembly	Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
positive regulation of Wnt signaling pathway	Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini.
regulation of angiogenesis	Any process that modulates the frequency, rate or extent of angiogenesis.
regulation of branching involved in prostate gland morphogenesis	Any process that modulates the rate, frequency, or extent of prostate gland branching, the process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem.
regulation of cell cycle process	Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
regulation of midbrain dopaminergic neuron differentiation	Any process that modulates the frequency, rate or extent of midbrain dopaminergic neuron differentiation.
regulation of neuron projection development	Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
response to organic cyclic compound	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
somatic stem cell population maintenance	Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
stromal-epithelial cell signaling involved in prostate gland development	The process of transferring information from a stromal cell to an epithelial cell where it is received and interpreted, as part of prostate gland development.
ureteric bud development	The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.
Wnt signaling pathway involved in somitogenesis	The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis.

23 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O19116	SFRP1	Secreted frizzled-related protein 1	Bos taurus (Bovine)	PR
O57328	FZD1	Frizzled-1	Gallus gallus (Chicken)	PR
Q9IA96	SFRP2	Secreted frizzled-related protein 2	Gallus gallus (Chicken)	PR
Q9DEQ4	SFRP1	Secreted frizzled-related protein 1	Gallus gallus (Chicken)	PR
O00144	FZD9	Frizzled-9	Homo sapiens (Human)	PR
O75084	FZD7	Frizzled-7	Homo sapiens (Human)	PR
Q14332	FZD2	Frizzled-2	Homo sapiens (Human)	PR
Q6FHJ7	SFRP4	Secreted frizzled-related protein 4	Homo sapiens (Human)	PR
Q96HF1	SFRP2	Secreted frizzled-related protein 2	Homo sapiens (Human)	PR
Q9ULW2	FZD10	Frizzled-10	Homo sapiens (Human)	PR
Q9UP38	FZD1	Frizzled-1	Homo sapiens (Human)	PR
O60353	FZD6	Frizzled-6	Homo sapiens (Human)	PR
Q9Z1N6	Sfrp4	Secreted frizzled-related sequence protein 4	Mus musculus (Mouse)	PR
O70421	Fzd1	Frizzled-1	Mus musculus (Mouse)	PR
Q9JIP6	Fzd2	Frizzled-2	Mus musculus (Mouse)	PR
Q61090	Fzd7	Frizzled-7	Mus musculus (Mouse)	PR
P97299	Sfrp2	Secreted frizzled-related protein 2	Mus musculus (Mouse)	PR
Q8C4U3	Sfrp1	Secreted frizzled-related protein 1	Mus musculus (Mouse)	PR
Q08463	Fzd1	Frizzled-1	Rattus norvegicus (Rat)	PR
Q9JLS4	Sfrp4	Secreted frizzled-related protein 4	Rattus norvegicus (Rat)	PR
Q08464	Fzd2	Frizzled-2	Rattus norvegicus (Rat)	PR
Q7YRN1	SFRP4	Secreted frizzled-related protein 4	Macaca mulatta (Rhesus macaque)	PR
Q5BL72	fzd7	Frizzled-7	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MGIGRSEGGR	RGAALGVLLA	LGAALLAVGS	ASEYDYVSFQ	SDIGPYQSGR	FYTKPPQCVD
70	80	90	100	110	120
IPADLRLCHN	VGYKKMVLPN	LLEHETMAEV	KQQASSWVPL	LNKNCHAGTQ	VFLCSLFAPV
130	140	150	160	170	180
CLDRPIYPCR	WLCEAVRDSC	EPVMQFFGFY	WPEMLKCDKF	PEGDVCIAMT	PPNATEASKP
190	200	210	220	230	240
QGTTVCPPCD	NELKSEAIIE	HLCASEFALR	MKIKEVKKEN	GDKKIVPKKK	KPLKLGPIKK
250	260	270	280	290	300
KDLKKLVLYL	KNGADCPCHQ	LDNLSHHFLI	MGRKVKSQYL	LTAIHKWDKK	NKEFKNFMKK
310
MKNHECPTFQ	SVFK