Q7YRN1
Gene name |
SFRP4 |
Protein name |
Secreted frizzled-related protein 4 |
Names |
B-cell surface antigen CD40, CD40L receptor, sFRP-4 |
Species |
Macaca mulatta (Rhesus macaque) |
KEGG Pathway |
mcc:574393 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7YRN1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7YRN1-F1 | Predicted | AlphaFoldDB |
No variants for Q7YRN1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7YRN1 | |||||
No associated diseases with Q7YRN1
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| Wnt-protein binding | Binding to a Wnt-protein, a secreted growth factor involved in signaling. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| bone morphogenesis | The process in which bones are generated and organized. |
| canonical Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| negative regulation of canonical Wnt signaling pathway | Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| negative regulation of non-canonical Wnt signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway. |
| regulation of BMP signaling pathway | Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway. |
| regulation of developmental process | Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O19116 | SFRP1 | Secreted frizzled-related protein 1 | Bos taurus (Bovine) | PR |
| Q9DEQ4 | SFRP1 | Secreted frizzled-related protein 1 | Gallus gallus (Chicken) | PR |
| O57328 | FZD1 | Frizzled-1 | Gallus gallus (Chicken) | PR |
| Q9IA96 | SFRP2 | Secreted frizzled-related protein 2 | Gallus gallus (Chicken) | PR |
| Q8N474 | SFRP1 | Secreted frizzled-related protein 1 | Homo sapiens (Human) | PR |
| Q9ULW2 | FZD10 | Frizzled-10 | Homo sapiens (Human) | PR |
| Q96HF1 | SFRP2 | Secreted frizzled-related protein 2 | Homo sapiens (Human) | PR |
| O75084 | FZD7 | Frizzled-7 | Homo sapiens (Human) | PR |
| Q9UP38 | FZD1 | Frizzled-1 | Homo sapiens (Human) | PR |
| Q14332 | FZD2 | Frizzled-2 | Homo sapiens (Human) | PR |
| O00144 | FZD9 | Frizzled-9 | Homo sapiens (Human) | PR |
| O60353 | FZD6 | Frizzled-6 | Homo sapiens (Human) | PR |
| Q6FHJ7 | SFRP4 | Secreted frizzled-related protein 4 | Homo sapiens (Human) | PR |
| P97299 | Sfrp2 | Secreted frizzled-related protein 2 | Mus musculus (Mouse) | PR |
| Q8C4U3 | Sfrp1 | Secreted frizzled-related protein 1 | Mus musculus (Mouse) | PR |
| O70421 | Fzd1 | Frizzled-1 | Mus musculus (Mouse) | PR |
| Q9JIP6 | Fzd2 | Frizzled-2 | Mus musculus (Mouse) | PR |
| Q61090 | Fzd7 | Frizzled-7 | Mus musculus (Mouse) | PR |
| Q9Z1N6 | Sfrp4 | Secreted frizzled-related sequence protein 4 | Mus musculus (Mouse) | PR |
| Q08463 | Fzd1 | Frizzled-1 | Rattus norvegicus (Rat) | PR |
| Q08464 | Fzd2 | Frizzled-2 | Rattus norvegicus (Rat) | PR |
| Q9JLS4 | Sfrp4 | Secreted frizzled-related protein 4 | Rattus norvegicus (Rat) | PR |
| Q5BL72 | fzd7 | Frizzled-7 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFLSILVALC | LWLHLALGVR | GAPCEAVRIP | MCRHMPWNIT | RMPNHLHHST | QENAILAIEQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YEELVDVNCS | SVLRFFLCAM | YAPICTLEFL | HDPIKPCKSV | CQRARDDCEP | LMKMYNHSWP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ESLACDELPV | YDRGVCISPE | AIVTDLPEDV | KWIDITPDMM | VQERPLDVDC | KRLSPDRCKC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KKVKPTLATY | LSKNCSYVIH | AKIKAVQRSG | CNEVTTVVDV | KEIFKSSSPI | PRTQVPLITN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSCQCPHILP | HQDVLIMCYE | WRSRMMLLEN | CLVEKWRDQL | SKRSIQWEER | LREQRRTIQD |
| 310 | 320 | 330 | 340 | ||
| KKKTAGRTSR | SNPPKPKGKP | PAPKPASPKK | NIKTRSAQKK | TNPKKV |