Q5BL72
PR
Gene name |
fzd7 |
Protein name |
Frizzled-7 |
Names |
Frz7, Fz-7 |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:549495 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5BL72
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5BL72-F1 | Predicted | AlphaFoldDB |
No variants for Q5BL72
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5BL72 | |||||
No associated diseases with Q5BL72
4 regional properties for Q5BL72
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome membrane | The lipid bilayer surrounding an endosome. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| syndecan binding | Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells. |
| Wnt receptor activity | Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| Wnt-protein binding | Binding to a Wnt-protein, a secreted growth factor involved in signaling. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| canonical Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. |
| convergent extension involved in gastrulation | The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. |
| dorsal/ventral axis specification | The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. |
| mesoderm formation | The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
| tissue morphogenesis | The process in which the anatomical structures of a tissue are generated and organized. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O19116 | SFRP1 | Secreted frizzled-related protein 1 | Bos taurus (Bovine) | PR |
| Q9DEQ4 | SFRP1 | Secreted frizzled-related protein 1 | Gallus gallus (Chicken) | PR |
| O57328 | FZD1 | Frizzled-1 | Gallus gallus (Chicken) | PR |
| Q9IA96 | SFRP2 | Secreted frizzled-related protein 2 | Gallus gallus (Chicken) | PR |
| Q8N474 | SFRP1 | Secreted frizzled-related protein 1 | Homo sapiens (Human) | PR |
| Q9ULW2 | FZD10 | Frizzled-10 | Homo sapiens (Human) | PR |
| Q96HF1 | SFRP2 | Secreted frizzled-related protein 2 | Homo sapiens (Human) | PR |
| Q9UP38 | FZD1 | Frizzled-1 | Homo sapiens (Human) | PR |
| Q14332 | FZD2 | Frizzled-2 | Homo sapiens (Human) | PR |
| O00144 | FZD9 | Frizzled-9 | Homo sapiens (Human) | PR |
| O60353 | FZD6 | Frizzled-6 | Homo sapiens (Human) | PR |
| Q6FHJ7 | SFRP4 | Secreted frizzled-related protein 4 | Homo sapiens (Human) | PR |
| O75084 | FZD7 | Frizzled-7 | Homo sapiens (Human) | PR |
| Q9Z1N6 | Sfrp4 | Secreted frizzled-related sequence protein 4 | Mus musculus (Mouse) | PR |
| P97299 | Sfrp2 | Secreted frizzled-related protein 2 | Mus musculus (Mouse) | PR |
| Q8C4U3 | Sfrp1 | Secreted frizzled-related protein 1 | Mus musculus (Mouse) | PR |
| O70421 | Fzd1 | Frizzled-1 | Mus musculus (Mouse) | PR |
| Q9JIP6 | Fzd2 | Frizzled-2 | Mus musculus (Mouse) | PR |
| Q61090 | Fzd7 | Frizzled-7 | Mus musculus (Mouse) | PR |
| Q08463 | Fzd1 | Frizzled-1 | Rattus norvegicus (Rat) | PR |
| Q9JLS4 | Sfrp4 | Secreted frizzled-related protein 4 | Rattus norvegicus (Rat) | PR |
| Q08464 | Fzd2 | Frizzled-2 | Rattus norvegicus (Rat) | PR |
| Q7YRN1 | SFRP4 | Secreted frizzled-related protein 4 | Macaca mulatta (Rhesus macaque) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFATVSLLFC | LLLQPSPSAQ | QYHGEKGISV | PDHGFCQPIS | IPLCTDIAYN | QTIMPNLLGH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TNQEDAGLEV | HQFYPLVKVQ | CSPELRFFLC | SMYAPVCTVL | EQAIPPCRSL | CERARQGCEA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LMNKFGFQWP | ERLRCENFPV | HGAGEICVGQ | NTSDNSPSGP | TARPTPYLPD | SITFHPHPNR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DFTCPRQLKV | PPYLGYRFLG | EKDCGAPCEP | GKANGLMYFK | EEEVRFARLW | VGIWAILCGI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| STLFTVLTYL | VDMRRFSYPE | RPIIFLSGCY | FMVAVAYTAG | FLLEERGVCV | ERFSEDSYRT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VAQGTKKEGC | TILFMILYFF | GMASSIWWVI | LSLTWFLAAG | MKWGHEAIEA | NSQYFHLAAW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AVPAVKTITI | LAMGQVDGDI | LSGVCYVGIN | SVDSLRGFVL | APLFVYLFIG | TSFLLAGFVS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LFRIRTIMKH | DGTKTEKLEK | LMVRIGVFSV | MYTVPATIVL | ACYFYEQAFR | DTWEKTWLVQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TCKGFAVPCP | NYNFAPMSPD | FTVFMIKYLM | TMIVGITSSF | WIWSGKTLQS | WRRFYHRLSN |
| GGKGETAV |