Q6FHJ7
PR
Gene name |
SFRP4 (FRPHE) |
Protein name |
Secreted frizzled-related protein 4 |
Names |
sFRP-4, Frizzled protein, human endometrium, FrpHE |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:6424 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6FHJ7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6FHJ7-F1 | Predicted | AlphaFoldDB |
351 variants for Q6FHJ7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA4222939 rs758308395 RCV001271112 |
54 | A>D | Pyle metaphyseal dysplasia [ClinVar] | Yes |
ClinGen ClinVar ExAC dbSNP gnomAD |
|
RCV001271113 CA367220408 rs1344808304 |
125 | C>S | Pyle metaphyseal dysplasia [ClinVar] | Yes |
ClinGen ClinVar dbSNP gnomAD |
|
rs879253778 RCV000234974 |
161 | V>missing | Pyle metaphyseal dysplasia [ClinVar] | Yes |
ClinVar dbSNP |
|
rs879255603 RCV000234979 |
167 | D>missing | Pyle metaphyseal dysplasia [ClinVar] | Yes |
ClinVar dbSNP |
|
CA4222757 RCV000234991 rs755007671 |
232 | R>* | Pyle metaphyseal dysplasia Variant assessed as Somatic; 0.0 impact. [ClinVar, NCI-TCGA] | Yes |
ClinGen ClinVar ExAC NCI-TCGA dbSNP |
|
CA4222987 rs746008646 |
2 | F>C | No |
ClinGen ExAC gnomAD |
|
|
rs143943716 CA4222988 |
2 | F>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA367221402 rs200498112 |
3 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4222985 rs200498112 |
3 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs968890170 CA157155019 |
4 | S>F | No |
ClinGen TOPMed gnomAD |
|
|
rs1429283335 CA367221396 |
4 | S>T | No |
ClinGen gnomAD |
|
|
CA4222984 rs747377478 |
5 | I>L | No |
ClinGen ExAC |
|
|
CA4222983 COSM746974 rs778293050 |
5 | I>N | lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA157154995 rs981529571 |
6 | L>V | No |
ClinGen TOPMed |
|
|
rs1376302743 CA367221348 |
7 | V>A | No |
ClinGen TOPMed |
|
|
CA4222979 rs572680887 |
8 | A>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs149474737 CA4222980 |
8 | A>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs149474737 CA4222981 |
8 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA367221339 rs572680887 |
8 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4222976 rs757039656 |
9 | L>R | No |
ClinGen ExAC gnomAD |
|
|
rs751326708 CA4222975 |
10 | C>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762924097 CA4222973 |
12 | W>C | No |
ClinGen ExAC gnomAD |
|
|
rs1226204385 CA367221302 |
12 | W>S | No |
ClinGen TOPMed |
|
|
rs752828075 CA4222972 |
13 | L>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367221278 rs1225837945 |
14 | H>D | No |
ClinGen gnomAD |
|
|
CA4222970 rs369808742 |
16 | A>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA367221256 rs369808742 |
16 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs760978297 CA4222967 |
18 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs994051636 CA157154928 |
20 | R>H | No |
ClinGen TOPMed |
|
|
CA367221213 rs1372900624 |
20 | R>S | No |
ClinGen TOPMed gnomAD |
|
|
CA4222965 rs772584311 |
21 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA4222963 rs769250207 |
22 | A>E | No |
ClinGen ExAC gnomAD |
|
|
rs769250207 CA4222962 |
22 | A>V | Variant assessed as Somatic; 4.7e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA367221186 rs1478763521 |
23 | P>A | No |
ClinGen gnomAD |
|
|
CA367221179 rs1244442122 |
23 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs780735559 CA4222959 |
24 | C>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4222958 rs756881667 |
25 | E>* | No |
ClinGen ExAC gnomAD |
|
|
CA367221146 rs1406922555 |
26 | A>G | No |
ClinGen TOPMed |
|
|
CA4222957 rs751323190 |
27 | V>G | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 27 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
COSM1450598 rs555863176 CA367221124 |
28 | R>H | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs555863176 CA4222956 |
28 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1401111950 CA367221130 |
28 | R>S | No |
ClinGen TOPMed |
|
|
rs139103759 CA4222954 |
29 | I>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1312883273 CA367221102 |
30 | P>R | No |
ClinGen TOPMed |
|
|
CA4222953 rs765243688 |
31 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA367221067 rs759575847 |
33 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367221063 rs1278633805 |
33 | R>P | No |
ClinGen TOPMed |
|
|
rs759575847 CA4222952 |
33 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367221057 rs1410475769 |
34 | H>L | No |
ClinGen gnomAD |
|
| TCGA novel | 34 | H>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 35 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367221051 rs760896287 |
35 | M>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760896287 CA4222949 |
35 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs142701985 CA4222947 |
36 | P>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs142701985 CA4222948 |
36 | P>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA157154881 rs747919425 |
37 | W>R | No |
ClinGen Ensembl |
|
|
rs1050503407 CA157154879 |
39 | I>M | No |
ClinGen TOPMed |
|
|
CA367220975 rs1176387719 |
40 | T>M | No |
ClinGen gnomAD |
|
|
rs1415798667 CA367220969 |
41 | R>Q | No |
ClinGen gnomAD |
|
|
rs933340448 CA157154877 |
42 | M>I | No |
ClinGen Ensembl |
|
|
rs1583656721 CA367220947 |
43 | P>R | No |
ClinGen Ensembl |
|
|
CA4222946 rs762156391 |
44 | N>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 44 | N>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1175123689 CA367220936 |
45 | H>Y | No |
ClinGen gnomAD |
|
|
rs769162073 CA4222944 |
47 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
CA4222943 rs377374272 |
48 | H>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA367220899 rs1041957078 |
50 | T>M | No |
ClinGen gnomAD |
|
|
CA157154847 rs1041957078 |
50 | T>R | No |
ClinGen gnomAD |
|
|
CA4222941 rs770492825 |
51 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA4222942 rs776146633 |
51 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1262676862 CA367220888 |
52 | E>G | No |
ClinGen gnomAD |
|
|
CA4222938 rs758308395 |
54 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs778737132 CA4222936 |
57 | A>D | No |
ClinGen ExAC gnomAD |
|
|
rs1304983545 CA367220849 |
58 | I>M | No |
ClinGen TOPMed gnomAD |
|
|
CA4222934 CA367220843 rs753865207 |
59 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4222935 rs754903385 |
59 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA4222930 rs766508176 |
60 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
CA4222932 rs750706822 |
60 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA4222933 rs766422223 |
60 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs1583656658 CA367220832 |
61 | Y>C | No |
ClinGen Ensembl |
|
|
CA367220827 rs946302056 |
62 | E>K | No |
ClinGen gnomAD |
|
|
rs946302056 CA157154801 |
62 | E>Q | No |
ClinGen gnomAD |
|
|
rs767690874 CA4222929 |
65 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs373224073 CA367220796 |
66 | D>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1414396947 CA367220803 |
66 | D>N | No |
ClinGen gnomAD |
|
|
rs1242830697 CA367220792 |
67 | V>E | No |
ClinGen gnomAD |
|
|
CA367220793 rs1482121931 |
67 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
CA367220795 rs1482121931 |
67 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
CA4222926 rs141728432 |
69 | C>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA367220781 rs141728432 |
69 | C>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs571165714 CA4222925 |
69 | C>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1238358289 CA367220766 |
71 | A>P | No |
ClinGen gnomAD |
|
|
CA367220767 rs1238358289 |
71 | A>T | No |
ClinGen gnomAD |
|
|
CA157154782 rs367982958 |
71 | A>V | No |
ClinGen Ensembl |
|
|
rs1226976707 CA367220758 |
72 | V>A | No |
ClinGen gnomAD |
|
|
rs770542595 CA4222923 |
72 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746487383 CA4222922 |
73 | L>R | No |
ClinGen ExAC gnomAD |
|
|
rs773048077 CA4222921 |
74 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs771800349 COSM1240164 CA4222920 |
74 | R>H | oesophagus [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA4222916 rs778897623 |
80 | M>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367220710 rs1166818773 |
80 | M>T | No |
ClinGen gnomAD |
|
|
CA157154756 rs778897623 |
80 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4222915 rs779848423 |
81 | Y>C | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 81 | Y>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs756223201 CA157154745 |
82 | A>P | No |
ClinGen ExAC gnomAD |
|
|
rs756223201 CA4222914 |
82 | A>T | No |
ClinGen ExAC gnomAD |
|
|
COSM346898 rs1562852039 CA367220697 |
82 | A>V | lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
rs1246378644 CA367220676 |
85 | C>F | No |
ClinGen gnomAD |
|
|
rs1246378644 CA367220677 |
85 | C>Y | No |
ClinGen gnomAD |
|
|
CA157154716 rs971060232 |
86 | T>I | No |
ClinGen Ensembl |
|
|
rs1267814222 CA367220637 |
91 | H>L | No |
ClinGen gnomAD |
|
|
rs1488814149 CA367220640 |
91 | H>Y | No |
ClinGen gnomAD |
|
|
CA367220630 rs1583656582 |
92 | D>A | No |
ClinGen Ensembl |
|
| TCGA novel | 92 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367220602 rs1219996012 |
96 | P>Q | No |
ClinGen gnomAD |
|
|
rs763224100 CA4222908 |
97 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
CA367220591 rs1583656579 |
98 | K>E | No |
ClinGen Ensembl |
|
|
CA4222907 rs753289011 |
99 | S>* | No |
ClinGen ExAC gnomAD |
|
|
CA4222906 rs765640507 COSM421459 |
100 | V>L | Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
| TCGA novel | 103 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1021785125 CA157154698 |
103 | R>S | No |
ClinGen TOPMed gnomAD |
|
|
CA4222904 rs201127378 |
104 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
COSM3431583 CA367220546 rs1583656567 |
105 | R>C | large_intestine [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
rs773860267 CA4222901 |
106 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs768560715 CA4222900 |
108 | C>* | No |
ClinGen ExAC gnomAD |
|
|
rs780084181 CA4222899 |
109 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780084181 CA4222898 |
109 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367220506 rs1192727541 |
111 | L>F | No |
ClinGen gnomAD |
|
|
CA157154678 rs1016795843 |
111 | L>R | No |
ClinGen Ensembl |
|
|
rs1190026429 CA367220501 |
112 | M>L | No |
ClinGen gnomAD |
|
|
rs1190026429 CA367220503 |
112 | M>V | No |
ClinGen gnomAD |
|
|
rs1474139768 CA367220490 |
113 | K>R | No |
ClinGen TOPMed |
|
|
rs1166740874 CA367220480 |
114 | M>I | No |
ClinGen TOPMed |
|
|
rs375379770 CA4222896 |
115 | Y>C | No |
ClinGen ESP ExAC gnomAD |
|
|
CA367220466 rs1207763237 |
116 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
CA4222894 rs757317955 |
117 | H>N | No |
ClinGen ExAC gnomAD |
|
|
rs1392694048 CA367220449 |
118 | S>R | No |
ClinGen TOPMed |
|
|
rs149152949 CA157154665 |
119 | W>C | No |
ClinGen ESP TOPMed |
|
|
CA4222893 rs368945306 |
119 | W>R | No |
ClinGen ESP ExAC gnomAD |
|
|
CA4222890 rs367610039 |
121 | E>G | No |
ClinGen ESP ExAC gnomAD |
|
| TCGA novel | 124 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367220395 rs1411490949 |
126 | D>V | No |
ClinGen gnomAD |
|
|
CA367220400 COSM3942207 rs1308499091 |
126 | D>Y | oesophagus [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs964161713 CA157154616 |
129 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA4222886 rs749966042 |
129 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1225880645 CA367220374 |
130 | V>I | No |
ClinGen TOPMed |
|
|
CA4222885 rs375398740 |
132 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367220354 rs1480119945 |
133 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA367220352 rs1480119945 |
133 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1184968478 CA367220348 |
134 | G>S | No |
ClinGen gnomAD |
|
|
rs997519734 CA157154599 |
135 | V>L | No |
ClinGen Ensembl |
|
|
CA367220335 rs1234184204 |
136 | C>G | No |
ClinGen TOPMed gnomAD |
|
|
rs774089133 CA4222883 |
138 | S>L | No |
ClinGen ExAC gnomAD |
|
|
CA4222882 rs768168729 |
140 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1182234084 CA367220294 |
142 | I>N | No |
ClinGen gnomAD |
|
|
rs1345320766 CA367220289 |
143 | V>F | No |
ClinGen gnomAD |
|
|
CA367220291 rs1345320766 |
143 | V>I | No |
ClinGen gnomAD |
|
|
CA367220290 rs1345320766 |
143 | V>L | No |
ClinGen gnomAD |
|
|
CA367220282 rs1257326476 |
144 | T>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs887087560 CA367220261 |
147 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs887087560 CA157154567 |
147 | P>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs769740096 CA4222879 |
148 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1476129427 CA367220256 |
148 | E>G | No |
ClinGen TOPMed |
|
|
CA367220252 rs1230116365 |
149 | D>H | No |
ClinGen gnomAD |
|
|
rs1444769435 CA367220057 |
150 | V>I | No |
ClinGen gnomAD |
|
|
CA367220042 rs1562851171 |
152 | W>R | No |
ClinGen Ensembl |
|
|
rs374657153 CA367220034 |
153 | I>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA367220030 rs1322652370 |
153 | I>T | No |
ClinGen gnomAD |
|
|
rs374657153 CA4222853 |
153 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA157153535 rs763627035 |
154 | D>G | No |
ClinGen Ensembl |
|
|
CA4222851 rs780724990 |
159 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs199977774 CA4222850 |
162 | Q>* | No |
ClinGen ESP ExAC gnomAD |
|
| TCGA novel | 162 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367219964 rs1329734204 |
163 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA4222849 CA4222848 rs201887265 |
164 | R>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs954464010 CA367219951 |
165 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
rs954464010 CA157153471 |
165 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1428789399 CA367219944 |
166 | L>F | No |
ClinGen gnomAD |
|
|
rs1032419220 CA157153464 |
166 | L>R | No |
ClinGen Ensembl |
|
|
CA367219940 rs1325924983 |
167 | D>H | No |
ClinGen gnomAD |
|
|
CA4222846 rs752388443 |
169 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs764850380 CA4222845 |
170 | C>S | No |
ClinGen ExAC gnomAD |
|
|
rs764850380 CA367219917 |
170 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
CA4222844 COSM270132 rs140561432 |
172 | R>C | Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
COSM3715795 rs140561432 CA367219904 |
172 | R>G | upper_aerodigestive_tract [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA4222842 rs372088978 |
172 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs372088978 CA4222843 |
172 | R>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA367219894 rs1313738957 |
174 | S>N | No |
ClinGen TOPMed |
|
| rs546060485 | 175 | P>= | Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367219887 rs1187904199 |
175 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs773185976 CA4222840 |
175 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774209318 CA4222806 |
176 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs146871972 CA4222838 |
176 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs755909350 CA4222805 |
177 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750181342 CA4222803 |
177 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs755909350 COSM3431582 CA4222804 |
177 | R>W | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs1334387832 CA367219863 |
178 | C>R | No |
ClinGen gnomAD |
|
|
rs1470709427 CA367219848 |
180 | C>R | No |
ClinGen gnomAD |
|
|
CA367219845 rs1426548120 |
180 | C>Y | No |
ClinGen gnomAD |
|
|
CA367219821 rs1410018965 |
183 | V>A | No |
ClinGen gnomAD |
|
|
rs767383357 CA4222801 |
183 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367219811 rs1175268995 |
185 | P>T | No |
ClinGen gnomAD |
|
|
rs751532588 CA4222799 |
186 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs761773096 CA4222800 |
186 | T>P | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 188 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4222798 rs149860855 |
189 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA367219764 rs1262618169 |
192 | S>I | No |
ClinGen gnomAD |
|
|
rs1170146047 CA367219760 |
193 | K>E | No |
ClinGen TOPMed |
|
|
rs1209399275 CA367219746 |
194 | N>K | No |
ClinGen gnomAD |
|
|
rs775627840 CA4222796 |
195 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA157153246 rs112054297 |
196 | S>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs759851892 CA4222794 |
196 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs1324234401 CA367219731 |
197 | Y>H | No |
ClinGen TOPMed |
|
|
CA367219618 rs1350361678 |
202 | K>I | No |
ClinGen gnomAD |
|
|
rs1165249599 CA367219609 |
203 | I>V | No |
ClinGen gnomAD |
|
|
rs201281505 CA157152317 |
206 | V>M | No |
ClinGen 1000Genomes |
|
|
CA4222771 rs773755392 |
207 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs1000289110 CA157152311 |
208 | R>K | No |
ClinGen TOPMed |
|
|
CA157152309 rs889433110 |
209 | S>N | No |
ClinGen TOPMed |
|
|
CA367219536 rs1321227498 |
209 | S>R | No |
ClinGen TOPMed |
|
|
rs1185954370 CA367219520 |
210 | G>D | No |
ClinGen gnomAD |
|
|
rs748777856 CA4222769 |
210 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA4222768 rs199701204 |
211 | C>W | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1271599596 CA367219471 |
214 | V>F | No |
ClinGen gnomAD |
|
|
rs1583654731 CA367219470 |
214 | V>G | No |
ClinGen Ensembl |
|
|
CA4222767 rs769341984 |
216 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367219447 rs745604736 |
216 | T>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs745604736 CA4222766 |
216 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA367219433 rs1583654722 |
217 | V>G | No |
ClinGen Ensembl |
|
|
CA367219422 rs1583654715 |
218 | V>G | No |
ClinGen Ensembl |
|
|
rs746754945 CA4222763 COSM601153 |
218 | V>M | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA4222760 rs758346872 |
219 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA367219410 rs1248957536 |
219 | D>G | No |
ClinGen gnomAD |
|
|
rs1248957536 CA367219412 |
219 | D>V | No |
ClinGen gnomAD |
|
|
CA367219387 rs1304864884 |
221 | K>T | No |
ClinGen TOPMed gnomAD |
|
|
TCGA novel CA367219371 rs752732854 |
222 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
NCI-TCGA ClinGen ExAC TOPMed gnomAD |
|
CA367219376 rs1176173165 |
222 | E>G | No |
ClinGen TOPMed |
|
|
rs746099302 CA157152269 |
222 | E>Q | No |
ClinGen Ensembl |
|
|
CA4222758 rs765416338 |
223 | I>L | No |
ClinGen ExAC gnomAD |
|
|
CA367219360 rs1416680970 |
223 | I>N | No |
ClinGen TOPMed |
|
| TCGA novel | 225 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1463933859 CA367219338 |
225 | K>T | No |
ClinGen gnomAD |
|
|
rs1562850239 CA367219330 |
226 | S>P | No |
ClinGen Ensembl |
|
|
CA367219295 rs1299011407 |
228 | S>L | No |
ClinGen gnomAD |
|
|
rs1265128302 CA367219282 |
229 | P>L | No |
ClinGen gnomAD |
|
|
rs1463740379 CA367219267 |
231 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs766014536 CA4222756 COSM258002 |
232 | R>Q | large_intestine endometrium skin [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA4222755 rs766564289 |
233 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1210884709 CA367219251 |
233 | T>P | No |
ClinGen gnomAD |
|
| TCGA novel | 234 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 235 | V>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4222753 rs773522363 |
236 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA157152254 rs924433228 |
236 | P>S | No |
ClinGen Ensembl |
|
|
CA4222751 rs762319538 |
237 | L>I | No |
ClinGen ExAC gnomAD |
|
|
rs1300183105 CA367219197 |
239 | T>S | No |
ClinGen TOPMed |
|
|
rs769390624 CA4222749 |
241 | S>P | No |
ClinGen ExAC gnomAD |
|
|
CA4222748 rs745353091 |
245 | C>R | No |
ClinGen ExAC gnomAD |
|
|
rs1249204548 CA367219122 |
245 | C>W | No |
ClinGen gnomAD |
|
|
rs915273110 CA157152236 |
246 | P>L | No |
ClinGen Ensembl |
|
|
rs946772320 COSM3950488 CA157152238 |
246 | P>S | lung [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs866588308 CA157152234 |
247 | H>Y | No |
ClinGen gnomAD |
|
|
CA367219096 rs1323621779 |
248 | I>V | No |
ClinGen gnomAD |
|
| TCGA novel | 251 | H>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA157152232 rs151082049 COSM1698584 |
251 | H>Y | skin [Cosmic] | No |
ClinGen cosmic curated ESP gnomAD |
|
rs377005166 CA4222746 |
254 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1329329111 CA367219019 |
255 | L>F | No |
ClinGen gnomAD |
|
|
CA367219007 rs1392848476 |
256 | I>T | No |
ClinGen gnomAD |
|
|
rs777655694 CA4222744 |
257 | M>V | No |
ClinGen ExAC TOPMed |
|
|
rs1470380717 CA367218962 |
260 | E>K | No |
ClinGen gnomAD |
|
|
COSM1089454 CA4222742 rs748182253 |
262 | R>H | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA4222716 rs147388554 |
264 | R>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA157146999 rs144196534 |
265 | M>L | No |
ClinGen ESP |
|
|
CA4222714 rs751834775 |
267 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs764670979 CA4222713 |
268 | L>I | No |
ClinGen ExAC gnomAD |
|
|
rs1357940715 CA367218759 |
269 | E>* | No |
ClinGen TOPMed |
|
|
rs1227034616 CA367218754 |
269 | E>D | No |
ClinGen TOPMed |
|
|
CA367218740 rs1267591810 |
271 | C>F | No |
ClinGen TOPMed |
|
|
rs753245114 CA4222711 |
274 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA367218698 rs1384823755 |
277 | R>K | No |
ClinGen TOPMed gnomAD |
|
|
CA367218686 rs1554369743 |
278 | D>E | No |
ClinGen Ensembl |
|
|
rs1164610145 CA367218685 |
279 | Q>K | No |
ClinGen gnomAD |
|
|
CA4222710 rs766055041 |
280 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA157146991 rs868460292 |
283 | R>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA4222709 rs760229761 |
283 | R>K | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 284 | S>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs780669813 CA367218647 |
284 | S>F | No |
ClinGen gnomAD |
|
|
rs780669813 CA157146978 |
284 | S>Y | No |
ClinGen gnomAD |
|
|
CA4222693 rs778056562 |
286 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs758831650 CA4222692 |
287 | W>R | No |
ClinGen ExAC gnomAD |
|
|
CA4222691 rs753298451 |
288 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 289 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367218567 rs1317368256 |
294 | Q>R | No |
ClinGen gnomAD |
|
|
rs568754305 COSM1089452 CA4222688 |
295 | R>Q | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs765815507 CA4222689 COSM3703220 |
295 | R>W | liver [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs1344120415 CA367218556 |
296 | R>I | No |
ClinGen TOPMed gnomAD |
|
|
CA367218537 rs1195835329 |
299 | Q>R | No |
ClinGen TOPMed |
|
|
rs1443297650 CA367218528 |
300 | D>V | No |
ClinGen gnomAD |
|
|
rs1415557538 CA367218524 |
301 | K>E | No |
ClinGen TOPMed |
|
|
CA4222687 rs749861176 |
301 | K>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 301 | K>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 302 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 302 | K>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367218499 rs1407752621 |
304 | T>R | No |
ClinGen gnomAD |
|
| TCGA novel | 305 | A>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4222684 rs774036745 |
305 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762703116 CA4222682 |
306 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775432602 CA4222681 COSM1569001 |
307 | R>C | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs769681617 CA367218484 |
307 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4222680 rs769681617 |
307 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1345036398 CA367218482 |
308 | T>P | No |
ClinGen TOPMed |
|
|
CA4222678 rs776519995 |
310 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs776519995 CA4222679 |
310 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs771031038 CA4222677 |
310 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs750688162 CA157146141 |
313 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs1314804498 CA367218447 |
313 | P>H | No |
ClinGen gnomAD |
|
|
rs750688162 CA4222676 |
313 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs778026259 CA4222675 |
314 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs748472179 CA4222673 |
315 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4222674 rs758881962 |
315 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs147145122 CA4222672 |
316 | P>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
VAR_051964 CA4222670 rs1802073 |
320 | P>T | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1470639043 CA367218397 |
321 | P>H | No |
ClinGen gnomAD |
|
|
CA4222667 rs756785202 |
322 | A>V | No |
ClinGen ExAC |
|
|
rs375203218 CA4222664 |
323 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA gnomAD |
|
CA4222665 rs763690982 |
323 | P>T | No |
ClinGen ExAC |
|
|
CA4222661 rs765176497 |
324 | K>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 324 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs775203383 CA4222662 |
324 | K>T | No |
ClinGen ExAC gnomAD |
|
|
CA367218371 rs759451084 |
326 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759451084 CA4222659 |
326 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 330 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1222351443 CA367218324 |
333 | K>E | No |
ClinGen TOPMed |
|
|
CA4222658 rs776627017 |
334 | T>I | No |
ClinGen ExAC TOPMed |
|
|
CA367218312 rs1185513124 |
335 | R>G | No |
ClinGen gnomAD |
|
|
rs867831044 CA157146093 |
335 | R>K | No |
ClinGen Ensembl |
|
|
rs770958824 CA4222657 |
337 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA367218279 rs1237455127 |
339 | K>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1802074 CA4222656 VAR_051965 |
340 | R>K | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs773327141 CA4222655 |
341 | T>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 342 | N>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA367218264 rs1282641028 |
342 | N>Y | No |
ClinGen gnomAD |
|
|
rs150761426 CA4222654 |
343 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 343 | P>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1239793031 CA367218256 |
343 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA157146067 rs1020154016 |
344 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
CA4222653 rs748527273 |
345 | R>T | No |
ClinGen ExAC TOPMed |
|
|
rs375649904 CA157146058 |
346 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs375649904 CA4222651 |
346 | V>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1372332587 CA367218232 |
347 | V>L | No |
ClinGen Ensembl |
|
|
rs1302239298 CA367218235 |
347 | V>R | No |
ClinGen gnomAD |
1 associated diseases with Q6FHJ7
[MIM: 265900]: Pyle disease (PYL)
A disorder characterized by cortical-bone thinning, limb deformity, bone fragility and fractures. {ECO:0000269|PubMed:27355534}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- A disorder characterized by cortical-bone thinning, limb deformity, bone fragility and fractures. {ECO:0000269|PubMed:27355534}. Note=The disease is caused by variants affecting the gene represented in this entry.
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| Wnt-protein binding | Binding to a Wnt-protein, a secreted growth factor involved in signaling. |
18 GO annotations of biological process
| Name | Definition |
|---|---|
| bone morphogenesis | The process in which bones are generated and organized. |
| canonical Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| negative regulation of canonical Wnt signaling pathway | Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| negative regulation of DNA-binding transcription factor activity | Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
| negative regulation of non-canonical Wnt signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway. |
| negative regulation of sodium-dependent phosphate transport | Any process that stops, prevents, or reduces the frequency, rate or extent of sodium-dependent phosphate transport. |
| negative regulation of Wnt signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway. |
| phosphate ion homeostasis | Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell. |
| positive regulation of apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of canonical Wnt signaling pathway | Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| positive regulation of epidermal cell differentiation | Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of keratinocyte apoptotic process | Any process that activates or increases the frequency, rate or extent of keratinocyte apoptotic process. |
| positive regulation of receptor internalization | Any process that activates or increases the frequency, rate or extent of receptor internalization. |
| regulation of BMP signaling pathway | Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway. |
| response to hormone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O19116 | SFRP1 | Secreted frizzled-related protein 1 | Bos taurus (Bovine) | PR |
| Q9DEQ4 | SFRP1 | Secreted frizzled-related protein 1 | Gallus gallus (Chicken) | PR |
| O57328 | FZD1 | Frizzled-1 | Gallus gallus (Chicken) | PR |
| Q9IA96 | SFRP2 | Secreted frizzled-related protein 2 | Gallus gallus (Chicken) | PR |
| O00144 | FZD9 | Frizzled-9 | Homo sapiens (Human) | PR |
| O75084 | FZD7 | Frizzled-7 | Homo sapiens (Human) | PR |
| Q14332 | FZD2 | Frizzled-2 | Homo sapiens (Human) | PR |
| Q8N474 | SFRP1 | Secreted frizzled-related protein 1 | Homo sapiens (Human) | PR |
| Q96HF1 | SFRP2 | Secreted frizzled-related protein 2 | Homo sapiens (Human) | PR |
| Q9ULW2 | FZD10 | Frizzled-10 | Homo sapiens (Human) | PR |
| Q9UP38 | FZD1 | Frizzled-1 | Homo sapiens (Human) | PR |
| O60353 | FZD6 | Frizzled-6 | Homo sapiens (Human) | PR |
| P97299 | Sfrp2 | Secreted frizzled-related protein 2 | Mus musculus (Mouse) | PR |
| Q8C4U3 | Sfrp1 | Secreted frizzled-related protein 1 | Mus musculus (Mouse) | PR |
| O70421 | Fzd1 | Frizzled-1 | Mus musculus (Mouse) | PR |
| Q9JIP6 | Fzd2 | Frizzled-2 | Mus musculus (Mouse) | PR |
| Q61090 | Fzd7 | Frizzled-7 | Mus musculus (Mouse) | PR |
| Q9Z1N6 | Sfrp4 | Secreted frizzled-related sequence protein 4 | Mus musculus (Mouse) | PR |
| Q08463 | Fzd1 | Frizzled-1 | Rattus norvegicus (Rat) | PR |
| Q08464 | Fzd2 | Frizzled-2 | Rattus norvegicus (Rat) | PR |
| Q9JLS4 | Sfrp4 | Secreted frizzled-related protein 4 | Rattus norvegicus (Rat) | PR |
| Q7YRN1 | SFRP4 | Secreted frizzled-related protein 4 | Macaca mulatta (Rhesus macaque) | PR |
| Q5BL72 | fzd7 | Frizzled-7 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFLSILVALC | LWLHLALGVR | GAPCEAVRIP | MCRHMPWNIT | RMPNHLHHST | QENAILAIEQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YEELVDVNCS | AVLRFFLCAM | YAPICTLEFL | HDPIKPCKSV | CQRARDDCEP | LMKMYNHSWP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ESLACDELPV | YDRGVCISPE | AIVTDLPEDV | KWIDITPDMM | VQERPLDVDC | KRLSPDRCKC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KKVKPTLATY | LSKNYSYVIH | AKIKAVQRSG | CNEVTTVVDV | KEIFKSSSPI | PRTQVPLITN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSCQCPHILP | HQDVLIMCYE | WRSRMMLLEN | CLVEKWRDQL | SKRSIQWEER | LQEQRRTVQD |
| 310 | 320 | 330 | 340 | ||
| KKKTAGRTSR | SNPPKPKGKP | PAPKPASPKK | NIKTRSAQKR | TNPKRV |