Q1PFW3

PR
Gene name
SDS (At1g14750, F10B6.15)
Protein name
Cyclin-SDS
Names
Protein SOLO DANCERS
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G14750
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-388 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1PFW3

Entry ID Method Resolution Chain Position Source
AF-Q1PFW3-F1 Predicted AlphaFoldDB

39 variants for Q1PFW3

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_5082411_C_G 5 A>P No 1000Genomes
tmp_1_5082399_A_G 9 S>P No 1000Genomes
ENSVATH00023805 20 G>R No 1000Genomes
ENSVATH04578001 23 L>P No 1000Genomes
ENSVATH04578000 24 R>Q No 1000Genomes
ENSVATH04577999 29 R>H No 1000Genomes
tmp_1_5082326_G_A 33 A>V No 1000Genomes
tmp_1_5082315_G_A 37 P>S No 1000Genomes
tmp_1_5082258_C_T 56 V>I No 1000Genomes
ENSVATH01051995 60 S>Y No 1000Genomes
ENSVATH04577995 61 D>N No 1000Genomes
tmp_1_5082196_C_G 76 E>D No 1000Genomes
ENSVATH04577993 77 K>N No 1000Genomes
tmp_1_5082170_A_C 85 L>R No 1000Genomes
ENSVATH04577991 109 R>M No 1000Genomes
ENSVATH11227797 115 S>F No 1000Genomes
ENSVATH13897979 125 E>K No 1000Genomes
ENSVATH11227796 159 S>Y No 1000Genomes
ENSVATH11227795 165 V>M No 1000Genomes
tmp_1_5081918_C_T 169 G>E No 1000Genomes
ENSVATH11227754 183 N>D No 1000Genomes
ENSVATH11227753 189 V>A No 1000Genomes
tmp_1_5081816_C_G 203 S>T No 1000Genomes
tmp_1_5081767_G_C 219 S>R No 1000Genomes
ENSVATH01051992 224 A>P No 1000Genomes
tmp_1_5081637_C_A 263 D>Y No 1000Genomes
tmp_1_5081510_G_T 305 P>H No 1000Genomes
ENSVATH00023800 306 I>T No 1000Genomes
tmp_1_5081210_A_T 342 L>Q No 1000Genomes
tmp_1_5080715_A_T 424 F>Y No 1000Genomes
tmp_1_5080314_T_C 459 T>A No 1000Genomes
tmp_1_5080274_G_C 472 A>G No 1000Genomes
tmp_1_5080251_C_T 480 V>I No 1000Genomes
ENSVATH01051981 481 L>F No 1000Genomes
tmp_1_5080209_A_C 494 L>V No 1000Genomes
tmp_1_5080094_C_T 503 A>T No 1000Genomes
ENSVATH04577982 546 K>E No 1000Genomes
tmp_1_5079963_T_A 546 K>N No 1000Genomes
tmp_1_5079686_C_A 575 L>F No 1000Genomes

No associated diseases with Q1PFW3

1 regional properties for Q1PFW3

Type Name Position InterPro Accession
domain YqgF/RNase H-like domain 4 - 104 IPR006641

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.

5 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
chiasma assembly The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids.
double-strand break repair via homologous recombination The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
mitotic cell cycle phase transition The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.
regulation of cyclin-dependent protein serine/threonine kinase activity Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

23 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P20438 CLN2 G1/S-specific cyclin CLN2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P24869 CLB2 G2/mitotic-specific cyclin-2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P39963 CCNB3 G2/mitotic-specific cyclin-B3 Gallus gallus (Chicken) PR
Q6ZMN8 CCNI2 Cyclin-I2 Homo sapiens (Human) PR
O95067 CCNB2 G2/mitotic-specific cyclin-B2 Homo sapiens (Human) PR
P24864 CCNE1 G1/S-specific cyclin-E1 Homo sapiens (Human) PR
P41002 CCNF Cyclin-F Homo sapiens (Human) PR
P30279 CCND2 G1/S-specific cyclin-D2 Homo sapiens (Human) PR
Q61457 Ccne1 G1/S-specific cyclin-E1 Mus musculus (Mouse) PR
P30280 Ccnd2 G1/S-specific cyclin-D2 Mus musculus (Mouse) PR
Q8WNW2 CCND2 G1/S-specific cyclin-D2 Sus scrofa (Pig) PR
Q8K4F8 Ccnf Cyclin-F Rattus norvegicus (Rat) PR
Q0JIF2 CYCB1-1 Cyclin-B1-1 Oryza sativa subsp japonica (Rice) PR
Q10PQ9 SDS Cyclin-SDS-like Oryza sativa subsp japonica (Rice) PR
O48790 CYCB1-4 Cyclin-B1-4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C6A9 CYCA3-2 Cyclin-A3-2 Arabidopsis thaliana (Mouse-ear cress) PR
A0MEB5 CYCA3-3 Cyclin-A3-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FMH5 CYCA3-1 Putative cyclin-A3-1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SN11 CYCD3-3 Cyclin-D3-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LZM0 CYCD7-1 Putative cyclin-D7-1 Arabidopsis thaliana (Mouse-ear cress) PR
Q0WQN9 CYCD4-2 Cyclin-D4-2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LGA1 CYCD4-1 Cyclin-D4-1 Arabidopsis thaliana (Mouse-ear cress) PR
P47794 ccne1 G1/S-specific cyclin-E1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MKEIAMRNSK RKPEPTPFAG KKLRSTRLRR KRAQISPVLV QSPLWSKQIG VSAASVDSCS
70 80 90 100 110 120
DLLADDNVSC GSSRVEKSSN PKKTLIEEVE VSKPGYNVKE TIGDSKFRRI TRSYSKLHKE
130 140 150 160 170 180
KEGDEIEVSE SSCVDSNSGA GLRRLNVKGN KINDNDEISF SRSDVTFAGH VSNSRSLNFE
190 200 210 220 230 240
SENKESDVVS VISGVEYCSK FGSVTGGADN EEIEISKPSS FVEADSSLGS AKELKPELEI
250 260 270 280 290 300
VGCVSDLACS EKFSEEVSDS LDDESSEQRS EIYSQYSDFD YSDYTPSIFF DSGSEFSEKS
310 320 330 340 350 360
SSDSPISHSR SLYLQFKEQF CRSTIPNDFG SSCEEEIHSE LLRFDDEEVE ESYLRLRERE
370 380 390 400 410 420
RSHAYMRDCA KAYCSRMDNT GLIPRLRSIM VQWIVKQCSD MGLQQETLFL GVGLLDRFLS
430 440 450 460 470 480
KGSFKSERTL ILVGIASLTL ATRIEENQPY NSIRKRNFTI QNLRYSRHEV VAMEWLVQEV
490 500 510 520 530 540
LNFKCFTPTI FNFLWFYLKA ARANPEVERK AKSLAVTSLS DQTQLCFWPS TVAAALVVLA
550 560 570
CIEHNKISAY QRVIKVHVRT TDNELPECVK SLDWLLGQ