P20438

PR
Gene name
CLN2 (YPL256C)
Protein name
G1/S-specific cyclin CLN2
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPL256C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

199-284 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P20438

Entry ID Method Resolution Chain Position Source
AF-P20438-F1 Predicted AlphaFoldDB

12 variants for P20438

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-65919 232 Q>H No SGRP
s16-65735 294 F>L No SGRP
s16-65713 301 T>I No SGRP
s16-65680 312 P>Q No SGRP
s16-65676 313 M>I No SGRP
s16-65675 314 T>S No SGRP
s16-65394 407 M>I No SGRP
s16-65377 413 L>H No SGRP
s16-65188 476 T>I No SGRP
s16-65122 498 A>V No SGRP
s16-65066 517 P>S No SGRP
s16-65039 526 G>S No SGRP

No associated diseases with P20438

2 regional properties for P20438

Type Name Position InterPro Accession
domain Cyclin, N-terminal 43 - 195 IPR006671
domain Cyclin-like domain 79 - 188 IPR013763

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.

6 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
mitotic cell cycle phase transition The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.
re-entry into mitotic cell cycle after pheromone arrest The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae.
regulation of cell cycle G1/S phase transition Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.
regulation of cyclin-dependent protein serine/threonine kinase activity Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
traversing start control point of mitotic cell cycle A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity.

19 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P24869 CLB2 G2/mitotic-specific cyclin-2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P39963 CCNB3 G2/mitotic-specific cyclin-B3 Gallus gallus (Chicken) PR
O95067 CCNB2 G2/mitotic-specific cyclin-B2 Homo sapiens (Human) PR
P30279 CCND2 G1/S-specific cyclin-D2 Homo sapiens (Human) PR
P41002 CCNF Cyclin-F Homo sapiens (Human) PR
P24864 CCNE1 G1/S-specific cyclin-E1 Homo sapiens (Human) PR
P30280 Ccnd2 G1/S-specific cyclin-D2 Mus musculus (Mouse) PR
Q61457 Ccne1 G1/S-specific cyclin-E1 Mus musculus (Mouse) PR
Q8WNW2 CCND2 G1/S-specific cyclin-D2 Sus scrofa (Pig) PR
Q8K4F8 Ccnf Cyclin-F Rattus norvegicus (Rat) PR
Q10PQ9 SDS Cyclin-SDS-like Oryza sativa subsp japonica (Rice) PR
Q0JIF2 CYCB1-1 Cyclin-B1-1 Oryza sativa subsp japonica (Rice) PR
Q10Q62 CYCF3-2 Putative cyclin-F3-2 Oryza sativa subsp japonica (Rice) PR
O48790 CYCB1-4 Cyclin-B1-4 Arabidopsis thaliana (Mouse-ear cress) PR
Q1PFW3 SDS Cyclin-SDS Arabidopsis thaliana (Mouse-ear cress) PR
A0MEB5 CYCA3-3 Cyclin-A3-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C6A9 CYCA3-2 Cyclin-A3-2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FMH5 CYCA3-1 Putative cyclin-A3-1 Arabidopsis thaliana (Mouse-ear cress) PR
P47794 ccne1 G1/S-specific cyclin-E1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MASAEPRPRM GLVINAKPDY YPIELSNAEL LSHFEMLQEY HQEISTNVIA QSCKFKPNPK
70 80 90 100 110 120
LIDQQPEMNP VETRSNIITF LFELSVVTRV TNGIFFHSVR LYDRYCSKRI VLRDQAKLVV
130 140 150 160 170 180
ATCLWLAAKT WGGCNHIINN VVIPTGGRFY GPNPRARIPR LSELVHYCGD GQVFDESMFL
190 200 210 220 230 240
QMERHILDTL NWNIYEPMIN DYVLNVDENC LMQYELYENQ VTYDKQCSEK RQSQLSQDSD
250 260 270 280 290 300
ATVDERPYQN EEEEEEDLKL KIKLINLKKF LIDVSAWQYD LLRYELFEVS HGIFSIINQF
310 320 330 340 350 360
TNQDHGPFLM TPMTSESKNG EILSTLMNGI VSIPNSLMEV YKTVNGVLPF INQVKEYHLD
370 380 390 400 410 420
LQRKLQIASN LNISRKLTIS TPSCSFENSN STSIPSPASS SQSHTPMRNM SSLSDNSVFS
430 440 450 460 470 480
RNMEQSSPIT PSMYQFGQQQ SNSICGSTVS VNSLVNTNNK QRIYEQITGP NSNNATNDYI
490 500 510 520 530 540
DLLNLNESNK ENQNPATAHY LNGGPPKTSF INHGMFPSPT GTINSGKSSS ASSLISFGMG
NTQVI