Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q0JIF2

Entry ID Method Resolution Chain Position Source
AF-Q0JIF2-F1 Predicted AlphaFoldDB

No variants for Q0JIF2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0JIF2

No associated diseases with Q0JIF2

9 regional properties for Q0JIF2

Type Name Position InterPro Accession
domain Oxidoreductase FAD/NAD(P)-binding 181 - 288 IPR001433
domain Flavoprotein pyridine nucleotide cytochrome reductase 96 - 103 IPR001709-1
domain Flavoprotein pyridine nucleotide cytochrome reductase 128 - 137 IPR001709-2
domain Flavoprotein pyridine nucleotide cytochrome reductase 180 - 199 IPR001709-3
domain Flavoprotein pyridine nucleotide cytochrome reductase 218 - 229 IPR001709-4
domain Flavoprotein pyridine nucleotide cytochrome reductase 250 - 266 IPR001709-5
domain Flavoprotein pyridine nucleotide cytochrome reductase 274 - 282 IPR001709-6
domain Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain 50 - 155 IPR008333
domain FAD-binding domain, ferredoxin reductase-type 44 - 156 IPR017927

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.

3 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
mitotic cell cycle phase transition The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.
regulation of cyclin-dependent protein serine/threonine kinase activity Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

18 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P20438 CLN2 G1/S-specific cyclin CLN2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P24869 CLB2 G2/mitotic-specific cyclin-2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P39963 CCNB3 G2/mitotic-specific cyclin-B3 Gallus gallus (Chicken) PR
Q6ZMN8 CCNI2 Cyclin-I2 Homo sapiens (Human) PR
O95067 CCNB2 G2/mitotic-specific cyclin-B2 Homo sapiens (Human) PR
P24864 CCNE1 G1/S-specific cyclin-E1 Homo sapiens (Human) PR
P41002 CCNF Cyclin-F Homo sapiens (Human) PR
P30279 CCND2 G1/S-specific cyclin-D2 Homo sapiens (Human) PR
Q61457 Ccne1 G1/S-specific cyclin-E1 Mus musculus (Mouse) PR
P30280 Ccnd2 G1/S-specific cyclin-D2 Mus musculus (Mouse) PR
Q8WNW2 CCND2 G1/S-specific cyclin-D2 Sus scrofa (Pig) PR
Q8K4F8 Ccnf Cyclin-F Rattus norvegicus (Rat) PR
Q10PQ9 SDS Cyclin-SDS-like Oryza sativa subsp japonica (Rice) PR
Q10Q62 CYCF3-2 Putative cyclin-F3-2 Oryza sativa subsp japonica (Rice) PR
Q10QA2 CYCD5-3 Cyclin-D5-3 Oryza sativa subsp japonica (Rice) PR
Q1PFW3 SDS Cyclin-SDS Arabidopsis thaliana (Mouse-ear cress) PR
O48790 CYCB1-4 Cyclin-B1-4 Arabidopsis thaliana (Mouse-ear cress) PR
P47794 ccne1 G1/S-specific cyclin-E1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MATRSQNVAA APQPPQNRGN VAALGKQKAV VAGRPDAKNR RALGEIGNVM NVRLPEGKPL
70 80 90 100 110 120
QQAPAGRTAN FGAQLLKNAQ ANAAANKQNA VAPAAVARPA QRQARKAPVK PAPPPPEHVI
130 140 150 160 170 180
EISSDSDQSM RQQSEGSASS VRKCSRKKVI NTLTSVLTAR SKVACGITDK PREVIEDIDK
190 200 210 220 230 240
LDGDNELAVV DYIEDIYKFY KVAENECRPC DYIDTQVEIN SKMRAILADW IIEVHHKFEL
250 260 270 280 290 300
MPETLYLSMY VIDRYLSMQQ VQRRELQLVG VSAMLIACKY EEIWAPEVND FILISDSAYT
310 320 330 340 350 360
REQILAMEKG ILNKLQWNLT VPTAYVFIMR YLKAGASADN KSDKEMEHMA FFFAELALMQ
370 380 390 400 410 420
YGLVASLPSK VAASAVYAAR LTLKKSPLWT DTLKHHTGFT ESQLLDSAKL LVTSHSTAPE
430 440
SKLRVVYKKY SSEQLGGVAL RSPAVELCK