Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q10QA2

Entry ID Method Resolution Chain Position Source
AF-Q10QA2-F1 Predicted AlphaFoldDB

No variants for Q10QA2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q10QA2

No associated diseases with Q10QA2

3 regional properties for Q10QA2

Type Name Position InterPro Accession
domain Cyclin, C-terminal domain 199 - 291 IPR004367
domain Cyclin, N-terminal 97 - 195 IPR006671
domain Cyclin-like domain 105 - 189 IPR013763

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.

3 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
mitotic cell cycle phase transition The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.
regulation of cyclin-dependent protein serine/threonine kinase activity Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P30279 CCND2 G1/S-specific cyclin-D2 Homo sapiens (Human) PR
Q6ZMN8 CCNI2 Cyclin-I2 Homo sapiens (Human) PR
P30280 Ccnd2 G1/S-specific cyclin-D2 Mus musculus (Mouse) PR
Q8WNW2 CCND2 G1/S-specific cyclin-D2 Sus scrofa (Pig) PR
Q10PQ9 SDS Cyclin-SDS-like Oryza sativa subsp japonica (Rice) PR
Q0JIF2 CYCB1-1 Cyclin-B1-1 Oryza sativa subsp japonica (Rice) PR
Q10Q62 CYCF3-2 Putative cyclin-F3-2 Oryza sativa subsp japonica (Rice) PR
Q9SN11 CYCD3-3 Cyclin-D3-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LZM0 CYCD7-1 Putative cyclin-D7-1 Arabidopsis thaliana (Mouse-ear cress) PR
Q0WQN9 CYCD4-2 Cyclin-D4-2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LGA1 CYCD4-1 Cyclin-D4-1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGDASASTSA PATPTSTLIC REDGNDLFSA DPADDDGGGG SGGDWELSIA DDDHVLLMDR
70 80 90 100 110 120
DDEYLALMLS KERCAGGGGG GERGDEEEEE MVEEWMKNAR AWCVGWIVKT NAGFRFSLKT
130 140 150 160 170 180
AYVAVTYLDR FLARRCVDRD KEWALQLLSV ACLSLAAKVE ERRPPRLPEF KLDMYDCASL
190 200 210 220 230 240
MRMELLVLTT LKWQMITETP FSYLNCFTAK FRHDERKAIV LRAIECIFAS IKVISSVGYQ
250 260 270 280 290 300
PSTIALAAIL IARNKETAPN LDELKSVVGS LWQQLDTGHV YSCYNKMMIQ EDRSMQSTTE
310 320 330 340
VASSGVSVAH IGGSEDSAMG GANNATTLEA TPDKKRKRLH SPQRQ