AiPD: Autoinhibited Protein Database

Gene name	CYCD4-2 (At5g10440, F12B17.210)
Protein name	Cyclin-D4-2
Names	G1/S-specific cyclin-D4-2, CycD42
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT5G10440
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

220-298 (Predicted disordered autoinhibitory region) PR

220-298 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q0WQN9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH13981489	40	R>S	No	1000Genomes
ENSVATH13981488	41	E>K	No	1000Genomes
ENSVATH06948240	53	D>E	No	1000Genomes
ENSVATH06948239	54	D>N	No	1000Genomes
tmp_5_3282117_T_A	76	I>F	No	1000Genomes
ENSVATH00614899	108	S>N	No	1000Genomes
ENSVATH06948237	131	T>S	No	1000Genomes
ENSVATH00614898	138	Q>H	No	1000Genomes
tmp_5_3281605_C_T	147	V>M	No	1000Genomes
ENSVATH06948235	162	N>T	No	1000Genomes
tmp_5_3281556_A_G	163	V>A	No	1000Genomes
tmp_5_3281437_T_G	203	I>L	No	1000Genomes
ENSVATH06948232	214	E>K	No	1000Genomes
ENSVATH00614895	229	S>C	No	1000Genomes
tmp_5_3281212_C_T	231	E>K	No	1000Genomes
ENSVATH13981374	232	H>L	No	1000Genomes
ENSVATH06948230	234	D>E	No	1000Genomes
ENSVATH06948231	234	D>N	No	1000Genomes
tmp_5_3281181_G_A	241	S>F	No	1000Genomes
tmp_5_3281182_A_G	241	S>P	No	1000Genomes
ENSVATH10681825	243	S>T	No	1000Genomes
tmp_5_3280754_T_A	252	K>*	No	1000Genomes
ENSVATH13981373	254	G>S	No	1000Genomes
tmp_5_3280744_T_G	255	E>A	No	1000Genomes
tmp_5_3280705_G_A	268	T>I	No	1000Genomes
tmp_5_3280702_G_A	269	P>L	No	1000Genomes
ENSVATH10681821	278	S>T	No	1000Genomes
tmp_5_3280666_T_A	281	Y>F	No	1000Genomes
ENSVATH10681820	283	H>R	No	1000Genomes
ENSVATH06948226	287	T>S	No	1000Genomes
ENSVATH06948225	289	S>F	No	1000Genomes

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q0WQN9

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
cyclin-dependent protein serine/threonine kinase regulator activity	Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.

Name	Definition
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
mitotic cell cycle phase transition	The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.
regulation of cyclin-dependent protein serine/threonine kinase activity	Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
stomatal lineage progression	The process in which an unspecialized epidermal cell progresses through a series of divisions that culminate in the production of a stomatal complex.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P30279	CCND2	G1/S-specific cyclin-D2	Homo sapiens (Human)	PR
Q6ZMN8	CCNI2	Cyclin-I2	Homo sapiens (Human)	PR
P30280	Ccnd2	G1/S-specific cyclin-D2	Mus musculus (Mouse)	PR
Q8WNW2	CCND2	G1/S-specific cyclin-D2	Sus scrofa (Pig)	PR
Q10QA2	CYCD5-3	Cyclin-D5-3	Oryza sativa subsp japonica (Rice)	PR
Q9LZM0	CYCD7-1	Putative cyclin-D7-1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SN11	CYCD3-3	Cyclin-D3-3	Arabidopsis thaliana (Mouse-ear cress)	PR
O48790	CYCB1-4	Cyclin-B1-4	Arabidopsis thaliana (Mouse-ear cress)	PR
A0MEB5	CYCA3-3	Cyclin-A3-3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FMH5	CYCA3-1	Putative cyclin-A3-1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8LGA1	CYCD4-1	Cyclin-D4-1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9C6A9	CYCA3-2	Cyclin-A3-2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q1PFW3	SDS	Cyclin-SDS	Arabidopsis thaliana (Mouse-ear cress)	PR