AiPD: Autoinhibited Protein Database

P30279

Gene name	CCND2
Protein name	G1/S-specific cyclin-D2
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:894
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

235-289 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

235-289 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for P30279

Entry ID	Method	Resolution	Chain	Position	Source
6EI2	X-ray	161 A	C	114-123	PDB
AF-P30279-F1	Predicted				AlphaFoldDB

179 variants for P30279

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV001267555 rs1864058731	198	P>R	Inborn genetic diseases [ClinVar]	Yes	ClinVar dbSNP
RCV000133496 rs587777619 CA170549	270	K>*	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
CA383413682 rs1477693311 RCV001266372	272	E>*	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar dbSNP gnomAD
RCV000133495 CA170548 COSM3764414 rs587777618 VAR_072370 RCV000623001	280	T>A	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 Variant assessed as Somatic; impact. central_nervous_system Inborn genetic diseases MPPH3 [ClinVar, NCI-TCGA, Cosmic, UniProt]	Yes	ClinGen cosmic curated ClinVar UniProt Ensembl NCI-TCGA dbSNP
rs587777620 RCV000824980 RCV002282386 CA6395339	280	T>I	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
VAR_072371 RCV001849314 rs587777620 RCV000133497 CA170551 RCV000264513 COSM1166668	280	T>N	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 haematopoietic_and_lymphoid_tissue MPPH3 [ClinVar, Cosmic, UniProt]	Yes	ClinGen cosmic curated ClinVar UniProt ExAC dbSNP gnomAD
RCV000623673 rs587777621 CA383413770	281	P>A	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP
rs587777622 RCV000133500 CA170555 VAR_072372	281	P>L	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 MPPH3 [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt TOPMed dbSNP
CA170554 RCV001384753 VAR_072373 RCV000133499 COSM96814 rs587777622	281	P>R	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 haematopoietic_and_lymphoid_tissue MPPH3 [ClinVar, Cosmic, UniProt]	Yes	ClinGen cosmic curated ClinVar UniProt TOPMed dbSNP
rs587777621 CA170552 RCV000133498 COSM301895	281	P>S	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 Variant assessed as Somatic; impact. central_nervous_system [ClinVar, NCI-TCGA, Cosmic]	Yes	ClinGen cosmic curated ClinVar NCI-TCGA TOPMed dbSNP
RCV000258931 VAR_072374 CA10602706 rs777786993	284	V>G	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 MPPH3 [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt ExAC TOPMed dbSNP gnomAD
CA383661436 rs1219274844	2	E>*		No	ClinGen gnomAD
rs1278580204 CA383661440	2	E>V		No	ClinGen gnomAD
CA383661444 rs904703881	3	L>V		No	ClinGen TOPMed
CA6395134 rs745641213	5	C>F		No	ClinGen ExAC gnomAD
CA383661453 rs1211080900	5	C>R		No	ClinGen gnomAD
rs775161299 CA6395136	6	H>Q		No	ClinGen ExAC gnomAD
TCGA novel	7	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6395137 rs370617608	8	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA383661483 rs1374564893	9	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6395139 rs776260684	9	D>Y		No	ClinGen ExAC gnomAD
CA6395140 rs200897111	10	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA383661516 rs1278982864	14	A>V		No	ClinGen gnomAD
rs1242864601 CA383661521	15	V>G		No	ClinGen gnomAD
CA383661519 rs1374736402	15	V>L		No	ClinGen gnomAD
CA383661518 rs1374736402	15	V>M		No	ClinGen gnomAD
CA6395144 rs535993641	18	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6395143 rs535993641	18	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6395145 rs753037343	18	R>H		No	ClinGen ExAC
rs778299007 CA6395147	22	R>G		No	ClinGen ExAC TOPMed gnomAD
COSM333234 CA6395148 rs556058578	22	R>Q	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA383661575 rs1232891371	24	D>E		No	ClinGen gnomAD
CA383661595 rs1418862467	28	Q>E		No	ClinGen TOPMed
rs1418862467 CA383661594	28	Q>K		No	ClinGen TOPMed
CA383661602 rs1368834606	29	N>H		No	ClinGen TOPMed
rs778986120 CA6395150	30	L>M		No	ClinGen ExAC TOPMed gnomAD
CA6395151 rs746043858	31	L>F		No	ClinGen ExAC
CA6395152 rs772187536	32	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1009356572 CA232171569	33	I>S		No	ClinGen TOPMed
rs956736880 CA232171567	33	I>V		No	ClinGen TOPMed
rs1565430722 CA383661637	35	E>K		No	ClinGen Ensembl
rs746820501 CA6395154	37	Y>H		No	ClinGen ExAC gnomAD
TCGA novel	40	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383661680 rs1215532509	41	C>G		No	ClinGen TOPMed
rs1401047935 CA383661691	42	S>C		No	ClinGen gnomAD
rs1449067414 CA383661726	47	V>L		No	ClinGen gnomAD
TCGA novel	49	K>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383661755 rs1247566214	51	I>V		No	ClinGen TOPMed
rs61731957 CA232171576	57	R>G		No	ClinGen TOPMed gnomAD
CA6395158 rs769290616	58	M>T		No	ClinGen ExAC gnomAD
rs1234478843 CA383661854	65	E>Q		No	ClinGen gnomAD
rs780412072	66	V>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA383661891 rs1591643829	68	E>G		No	ClinGen Ensembl
rs1349838711 CA383661887	68	E>K		No	ClinGen gnomAD
CA383661899 rs1591643835	69	E>G		No	ClinGen Ensembl
rs1591643836 COSM361653 CA383661903	70	Q>K	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
TCGA novel	75	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383661955 rs1475640917	76	V>G		No	ClinGen TOPMed
TCGA novel	76	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6395194 rs747983314	81	M>V		No	ClinGen ExAC gnomAD
CA383662040 rs1441700094	89	A>T		No	ClinGen TOPMed
TCGA novel	92	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383662066 rs1189680723	93	T>S		No	ClinGen gnomAD
CA232172076 COSM939325 rs1019910889	94	P>L	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA6395202 rs776929300	114	E>G		No	ClinGen ExAC gnomAD
CA6395203 rs762132499	115	T>S		No	ClinGen ExAC gnomAD
rs765770986 CA6395204	116	S>N		No	ClinGen ExAC TOPMed gnomAD
CA6395205 rs773652105	116	S>R		No	ClinGen ExAC gnomAD
rs867376054 CA232172087	117	P>L		No	ClinGen Ensembl
rs766500677 CA6395207	118	L>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	120	A>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383662241 rs1345554353	120	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA383662298 rs1483674458	128	D>E		No	ClinGen gnomAD
CA6395212 rs755925937	129	N>H		No	ClinGen ExAC gnomAD
rs777749450 CA6395213	129	N>S		No	ClinGen ExAC gnomAD
rs1006222339 CA232172107	133	P>L		No	ClinGen TOPMed gnomAD
TCGA novel	134	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	134	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1178548785 CA383662336	134	Q>R		No	ClinGen gnomAD
CA6395214 rs368616285	136	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	137	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1380307234 CA383662370	138	E>Q		No	ClinGen gnomAD
CA6395238 rs757962346	144	L>M		No	ClinGen ExAC gnomAD
rs1219347646 CA383662417	145	G>E		No	ClinGen gnomAD
CA232172706 rs866439707	149	W>*		No	ClinGen Ensembl
rs1221557392 CA383662460	151	L>V		No	ClinGen gnomAD
RCV000994779 rs199719393 CA6395241	152	A>E		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA232172710 rs907637736	155	T>A		No	ClinGen TOPMed
CA383662521 rs1262048964	160	I>M		No	ClinGen gnomAD
CA6395243 rs182823354	160	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771536354 CA6395244	161	E>D		No	ClinGen ExAC gnomAD
TCGA novel	161	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383662550 rs1414949152	164	L>F		No	ClinGen gnomAD
rs775067994 CA6395245 COSM2067078	165	R>C	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs759672856 CA6395246	165	R>H		No	ClinGen ExAC gnomAD
CA6395250 rs764397997	169	Q>P		No	ClinGen ExAC gnomAD
rs1400766897 CA383662582	170	Q>E		No	ClinGen TOPMed gnomAD
CA6395251 rs367874736	171	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6395252 rs367874736	171	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA232172717 rs975747044	171	R>W		No	ClinGen TOPMed gnomAD
CA383662595 rs765154003	172	E>G		No	ClinGen ExAC gnomAD
rs765154003 CA6395253	172	E>V		No	ClinGen ExAC gnomAD
CA383662600 rs1323984296	173	K>E		No	ClinGen gnomAD
rs1361440169 CA383662609	174	L>P		No	ClinGen gnomAD
rs143681287 RCV000897099 CA6395254 RCV000603208	175	S>C		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA6395255 rs143681287	175	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1344939362 CA383662624	177	I>T		No	ClinGen TOPMed
rs1488421614 CA383662628	178	R>C		No	ClinGen gnomAD
rs1218408329 CA383662630	178	R>H		No	ClinGen gnomAD
rs779391624 CA6395256	181	A>T		No	ClinGen ExAC gnomAD
rs1165955980 CA383662677	185	I>V		No	ClinGen TOPMed
CA383662688 rs1472201110	186	A>V		No	ClinGen gnomAD
rs1415898009 CA383662702	189	A>T		No	ClinGen gnomAD
rs1417189054 CA383662705	189	A>V		No	ClinGen TOPMed gnomAD
COSM3384352 rs754567300 CA6395258	190	T>I	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs758807595 CA6395281	195	A>S		No	ClinGen ExAC gnomAD
COSM939344 rs780649921 CA6395282	195	A>V	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA383412158 rs1219387853	196	M>T		No	ClinGen gnomAD
CA231738811 rs61755286	204	T>A		No	ClinGen Ensembl
rs1565435266 CA383412216	205	G>R		No	ClinGen Ensembl
TCGA novel	206	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6395287 rs770027846	206	S>I		No	ClinGen ExAC gnomAD
rs932643313 CA231738830	209	A>T		No	ClinGen Ensembl
rs202056442 CA6395288	210	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs199882809 CA231738835	212	C>R		No	ClinGen Ensembl
CA383412315 rs1288782951	219	E>D		No	ClinGen TOPMed
rs762849458 CA6395289	222	S>L		No	ClinGen ExAC gnomAD
CA231738856 rs1012989280	227	A>V		No	ClinGen TOPMed
rs759408487 CA6395292	231	L>V		No	ClinGen ExAC gnomAD
CA383412422 rs1467582311	236	T>S		No	ClinGen gnomAD
TCGA novel	237	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6395297 rs750783951	240	V>A		No	ClinGen ExAC gnomAD
rs373099767 CA6395296	240	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA383413486 rs1323809351	242	C>Y		No	ClinGen gnomAD
TCGA novel	243	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1466024683 CA383413501	244	K>R		No	ClinGen gnomAD
rs149961693 CA231747141	249	Q>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs1370660631 CA383413548	250	I>M		No	ClinGen TOPMed
rs781695497 CA231747147	252	A>G		No	ClinGen ExAC TOPMed gnomAD
CA6395322 rs781695497	252	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA231747166 rs76269597	254	L>V		No	ClinGen Ensembl
RCV000519841 CA383413572 rs1555089162	255	L>I		No	ClinGen ClinVar Ensembl dbSNP
CA383413582 rs1331853855	256	N>S		No	ClinGen gnomAD
rs1565438867 CA383413589	257	S>N		No	ClinGen Ensembl
rs1400185708 CA383413602	259	Q>R		No	ClinGen Ensembl
CA383413607 rs1445439577	260	Q>K		No	ClinGen TOPMed
CA6395325 rs777848359 COSM3954764	262	R>C	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs142170178 RCV000437731 CA6395326	262	R>H		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA383413629 rs1199884235	263	Q>*		No	ClinGen gnomAD
CA6395327 rs771085906	264	D>G		No	ClinGen ExAC gnomAD
TCGA novel	264	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
RCV001093119 rs1864224611	265	Q>*		No	ClinVar dbSNP
CA383413652 rs1487732338	266	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs778716956 CA6395329	266	R>H		No	ClinGen ExAC TOPMed gnomAD
rs778716956 CA383413653	266	R>L		No	ClinGen ExAC TOPMed gnomAD
rs778716956 CA6395328	266	R>P		No	ClinGen ExAC TOPMed gnomAD
CA6395331 rs199959738	267	D>E		No	ClinGen ExAC TOPMed gnomAD
rs772100759 CA6395330	267	D>H		No	ClinGen ExAC gnomAD
rs564008627 CA231747210	267	D>V		No	ClinGen Ensembl
COSM693972 VAR_018820 CA6395333 CA383413659 rs3217921	268	G>R	lung [Cosmic]	No	ClinGen cosmic curated UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA231747234 rs886804797	269	S>F		No	ClinGen TOPMed
rs888439350 CA231747259	270	K>R		No	ClinGen gnomAD
rs776036883 CA383413678	271	S>*		No	ClinGen ExAC TOPMed gnomAD
rs776036883 CA6395334	271	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs776036883 CA383413679	271	S>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	272	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6395335 rs761478437	273	D>E		No	ClinGen ExAC TOPMed gnomAD
CA231747280 rs777751484	274	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA383413698 rs1162222406	274	E>V		No	ClinGen TOPMed
rs1864225645 RCV001268523	277	Q>*		No	ClinVar dbSNP
CA6395336 rs764849326	279	S>G		No	ClinGen ExAC gnomAD
CA6395337 rs751922391	279	S>N		No	ClinGen ExAC TOPMed gnomAD
rs777786993 CA6395342	284	V>A		No	ClinGen ExAC TOPMed gnomAD
CA6395341 rs746964971	284	V>M		No	ClinGen ExAC TOPMed gnomAD
CA383413806 rs1199912313 RCV000994780	285	R>G		No	ClinGen ClinVar TOPMed dbSNP
rs753881524 CA6395343	285	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA383413808 rs1199912313 COSM939348	285	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
TCGA novel	286	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383413832 rs1261984704	288	D>N		No	ClinGen gnomAD

No associated diseases with P30279

5 regional properties for P30279

Type	Name	Position	InterPro Accession
conserved_site	Calsequestrin, conserved site	20 - 34	IPR018233-1
conserved_site	Calsequestrin, conserved site	357 - 376	IPR018233-2
domain	Calsequestrin, middle TRX-fold domain	145 - 246	IPR041858
domain	Calsequestrin, N-terminal TRX-fold domain	24 - 143	IPR041859
domain	Calsequestrin, C-terminal TRX-fold domain	247 - 366	IPR041860

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm Nucleus membrane	Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cyclin D2-CDK4 complex	A protein complex consisting of cyclin D2 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.
cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
cyclin-dependent protein serine/threonine kinase regulator activity	Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

12 GO annotations of biological process

Name	Definition
adult locomotory behavior	Locomotory behavior in a fully developed and mature organism.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cellular response to X-ray	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).
G1/S transition of mitotic cell cycle	The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
long-term memory	The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
mitotic cell cycle phase transition	The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of cyclin-dependent protein serine/threonine kinase activity	Any process that activates or increases the frequency, rate or extent of CDK activity.
positive regulation of G1/S transition of mitotic cell cycle	Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
regulation of cyclin-dependent protein serine/threonine kinase activity	Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

21 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P20438	CLN2	G1/S-specific cyclin CLN2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P24869	CLB2	G2/mitotic-specific cyclin-2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P24864	CCNE1	G1/S-specific cyclin-E1	Homo sapiens (Human)	PR
P41002	CCNF	Cyclin-F	Homo sapiens (Human)	PR
O95067	CCNB2	G2/mitotic-specific cyclin-B2	Homo sapiens (Human)	PR
Q6ZMN8	CCNI2	Cyclin-I2	Homo sapiens (Human)	PR
P30280	Ccnd2	G1/S-specific cyclin-D2	Mus musculus (Mouse)	PR
Q8WNW2	CCND2	G1/S-specific cyclin-D2	Sus scrofa (Pig)	PR
Q10QA2	CYCD5-3	Cyclin-D5-3	Oryza sativa subsp japonica (Rice)	PR
Q10PQ9	SDS	Cyclin-SDS-like	Oryza sativa subsp japonica (Rice)	PR
Q0JIF2	CYCB1-1	Cyclin-B1-1	Oryza sativa subsp japonica (Rice)	PR
Q10Q62	CYCF3-2	Putative cyclin-F3-2	Oryza sativa subsp japonica (Rice)	PR
Q9SN11	CYCD3-3	Cyclin-D3-3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LZM0	CYCD7-1	Putative cyclin-D7-1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8LGA1	CYCD4-1	Cyclin-D4-1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0WQN9	CYCD4-2	Cyclin-D4-2	Arabidopsis thaliana (Mouse-ear cress)	PR
O48790	CYCB1-4	Cyclin-B1-4	Arabidopsis thaliana (Mouse-ear cress)	PR
A0MEB5	CYCA3-3	Cyclin-A3-3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FMH5	CYCA3-1	Putative cyclin-A3-1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q1PFW3	SDS	Cyclin-SDS	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9C6A9	CYCA3-2	Cyclin-A3-2	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MELLCHEVDP	VRRAVRDRNL	LRDDRVLQNL	LTIEERYLPQ	CSYFKCVQKD	IQPYMRRMVA
70	80	90	100	110	120
TWMLEVCEEQ	KCEEEVFPLA	MNYLDRFLAG	VPTPKSHLQL	LGAVCMFLAS	KLKETSPLTA
130	140	150	160	170	180
EKLCIYTDNS	IKPQELLEWE	LVVLGKLKWN	LAAVTPHDFI	EHILRKLPQQ	REKLSLIRKH
190	200	210	220	230	240
AQTFIALCAT	DFKFAMYPPS	MIATGSVGAA	ICGLQQDEEV	SSLTCDALTE	LLAKITNTDV
250	260	270	280
DCLKACQEQI	EAVLLNSLQQ	YRQDQRDGSK	SEDELDQAST	PTDVRDIDL