P30280
PR
Gene name |
Ccnd2 |
Protein name |
G1/S-specific cyclin-D2 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12444 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P30280
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P30280-F1 | Predicted | AlphaFoldDB |
17 variants for P30280
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388869318 | 43 | F>Y | No | EVA | |
| rs3388861375 | 68 | E>D | No | EVA | |
| rs3388866320 | 76 | F>Y | No | EVA | |
| rs3388839713 | 102 | A>T | No | EVA | |
| rs3388864652 | 113 | E>* | No | EVA | |
| rs3388861411 | 148 | W>* | No | EVA | |
| rs3388857301 | 213 | L>R | No | EVA | |
| rs3397263723 | 214 | Q>H | No | EVA | |
| rs3397303896 | 215 | Q>H | No | EVA | |
| rs3397389588 | 216 | D>A | No | EVA | |
| rs3397488585 | 216 | D>H | No | EVA | |
| rs3388839689 | 220 | N>Y | No | EVA | |
| rs3388826810 | 222 | L>V | No | EVA | |
| rs13461862 | 229 | E>* | No | EVA | |
| rs3388857317 | 248 | Q>E | No | EVA | |
| rs241574610 | 252 | L>V | No | EVA | |
| rs219918406 | 267 | A>T | No | EVA |
No associated diseases with P30280
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cyclin D2-CDK4 complex | A protein complex consisting of cyclin D2 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. |
| cyclin-dependent protein kinase holoenzyme complex | Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
16 GO annotations of biological process
| Name | Definition |
|---|---|
| adult locomotory behavior | Locomotory behavior in a fully developed and mature organism. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| cellular response to X-ray | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). |
| G1/S transition of mitotic cell cycle | The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. |
| long-term memory | The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. |
| mitotic cell cycle phase transition | The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| negative regulation of cardiac muscle cell differentiation | Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation. |
| positive regulation of cardiac muscle cell proliferation | Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of cyclin-dependent protein serine/threonine kinase activity | Any process that activates or increases the frequency, rate or extent of CDK activity. |
| positive regulation of epithelial cell proliferation | Any process that activates or increases the rate or extent of epithelial cell proliferation. |
| positive regulation of G1/S transition of mitotic cell cycle | Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
| regulation of cyclin-dependent protein serine/threonine kinase activity | Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. |
18 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P20438 | CLN2 | G1/S-specific cyclin CLN2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P24869 | CLB2 | G2/mitotic-specific cyclin-2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P30279 | CCND2 | G1/S-specific cyclin-D2 | Homo sapiens (Human) | PR |
| Q61457 | Ccne1 | G1/S-specific cyclin-E1 | Mus musculus (Mouse) | PR |
| Q8WNW2 | CCND2 | G1/S-specific cyclin-D2 | Sus scrofa (Pig) | PR |
| Q10QA2 | CYCD5-3 | Cyclin-D5-3 | Oryza sativa subsp japonica (Rice) | PR |
| Q10PQ9 | SDS | Cyclin-SDS-like | Oryza sativa subsp japonica (Rice) | PR |
| Q0JIF2 | CYCB1-1 | Cyclin-B1-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q10Q62 | CYCF3-2 | Putative cyclin-F3-2 | Oryza sativa subsp japonica (Rice) | PR |
| Q9SN11 | CYCD3-3 | Cyclin-D3-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LZM0 | CYCD7-1 | Putative cyclin-D7-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LGA1 | CYCD4-1 | Cyclin-D4-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WQN9 | CYCD4-2 | Cyclin-D4-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O48790 | CYCB1-4 | Cyclin-B1-4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A0MEB5 | CYCA3-3 | Cyclin-A3-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FMH5 | CYCA3-1 | Putative cyclin-A3-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1PFW3 | SDS | Cyclin-SDS | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C6A9 | CYCA3-2 | Cyclin-A3-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELLCCEVDP | VRRAVPDRNL | LEDRVLQNLL | TIEERYLPQC | SYFKCVQKDI | QPYMRRMVAT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WMLEVCEEQK | CEEEVFPLAM | NYLDRFLAGV | PTPKTHLQLL | GAVCMFLASK | LKETIPLTAE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KLCIYTDNSV | KPQELLEWEL | VVLGKLKWNL | AAVTPHDFIE | HILRKLPQQK | EKLSLIRKHA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QTFIALCATD | FKFAMYPPSM | IATGSVGAAI | CGLQQDDEVN | TLTCDALTEL | LAKITHTDVD |
| 250 | 260 | 270 | 280 | ||
| CLKACQEQIE | ALLLNSLQQF | RQEQHNAGSK | SVEDPDQATT | PTDVRDVDL |