Q8LGA1
Gene name |
CYCD4-1 (CYCD4.1, At5g65420, MNA5.15) |
Protein name |
Cyclin-D4-1 |
Names |
G1/S-specific cyclin-D4-1, CycD41 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G65420 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8LGA1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8LGA1-F1 | Predicted | AlphaFoldDB |
31 variants for Q8LGA1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH03478794 | 13 | T>A | No | 1000Genomes | |
| tmp_5_26143690_C_T | 21 | G>S | No | 1000Genomes | |
| ENSVATH00752975 | 34 | P>R | No | 1000Genomes | |
| tmp_5_26143651_G_A | 34 | P>S | No | 1000Genomes | |
| ENSVATH12940723 | 52 | E>K | No | 1000Genomes | |
| ENSVATH07483707 | 58 | L>F | No | 1000Genomes | |
| ENSVATH00752974 | 59 | P>S | No | 1000Genomes | |
| ENSVATH07483706 | 60 | S>N | No | 1000Genomes | |
| ENSVATH07483705 | 69 | S>R | No | 1000Genomes | |
| ENSVATH07483704 | 74 | L>S | No | 1000Genomes | |
| ENSVATH12940722 | 78 | R>S | No | 1000Genomes | |
| tmp_5_26143149_A_G | 99 | F>S | No | 1000Genomes | |
| ENSVATH07483695 | 141 | E>K | No | 1000Genomes | |
| tmp_5_26142770_G_A | 161 | S>L | No | 1000Genomes | |
| ENSVATH00752970 | 172 | K>R | No | 1000Genomes | |
| ENSVATH07483693 | 188 | Y>H | No | 1000Genomes | |
| ENSVATH07483693 | 188 | Y>N | No | 1000Genomes | |
| tmp_5_26142658_T_G | 198 | Q>H | No | 1000Genomes | |
| ENSVATH12940716 | 205 | I>L | No | 1000Genomes | |
| tmp_5_26142635_G_C | 206 | S>C | No | 1000Genomes | |
| tmp_5_26142612_T_A | 214 | S>C | No | 1000Genomes | |
| tmp_5_26142611_C_A | 214 | S>I | No | 1000Genomes | |
| ENSVATH03478788 | 224 | F>V | No | 1000Genomes | |
| ENSVATH14649542 | 227 | S>F | No | 1000Genomes | |
| ENSVATH07483681 | 283 | N>I | No | 1000Genomes | |
| ENSVATH07483678 | 303 | S>T | No | 1000Genomes | |
| ENSVATH07483677 | 304 | Y>D | No | 1000Genomes | |
| ENSVATH07483676 | 307 | L>H | No | 1000Genomes | |
| tmp_5_26141596_G_A | 308 | S>F | No | 1000Genomes | |
| ENSVATH09164296 | 309 | S>L | No | 1000Genomes | |
| tmp_5_26141592_T_TC,A | 309 | S>Y | No | 1000Genomes |
No associated diseases with Q8LGA1
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cyclin-dependent protein kinase holoenzyme complex | Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| mitotic cell cycle phase transition | The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase. |
| regulation of cyclin-dependent protein serine/threonine kinase activity | Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P30279 | CCND2 | G1/S-specific cyclin-D2 | Homo sapiens (Human) | PR |
| Q6ZMN8 | CCNI2 | Cyclin-I2 | Homo sapiens (Human) | PR |
| P30280 | Ccnd2 | G1/S-specific cyclin-D2 | Mus musculus (Mouse) | PR |
| Q8WNW2 | CCND2 | G1/S-specific cyclin-D2 | Sus scrofa (Pig) | PR |
| Q10QA2 | CYCD5-3 | Cyclin-D5-3 | Oryza sativa subsp japonica (Rice) | PR |
| Q0WQN9 | CYCD4-2 | Cyclin-D4-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LZM0 | CYCD7-1 | Putative cyclin-D7-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SN11 | CYCD3-3 | Cyclin-D3-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O48790 | CYCB1-4 | Cyclin-B1-4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A0MEB5 | CYCA3-3 | Cyclin-A3-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C6A9 | CYCA3-2 | Cyclin-A3-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FMH5 | CYCA3-1 | Putative cyclin-A3-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1PFW3 | SDS | Cyclin-SDS | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEENLELSL | LCTESNVDDE | GMIVDETPIE | ISIPQMGFSQ | SESEEIIMEM | VEKEKQHLPS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DDYIKRLRSG | DLDLNVGRRD | ALNWIWKACE | VHQFGPLCFC | LAMNYLDRFL | SVHDLPSGKG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WILQLLAVAC | LSLAAKIEET | EVPMLIDLQV | GDPQFVFEAK | SVQRMELLVL | NKLKWRLRAI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TPCSYIRYFL | RKMSKCDQEP | SNTLISRSLQ | VIASTTKGID | FLEFRPSEVA | AAVALSVSGE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LQRVHFDNSS | FSPLFSLLQK | ERVKKIGEMI | ESDGSDLCSQ | TPNGVLEVSA | CCFSFKTHDS |
| SSSYTHLS |