AiPD: Autoinhibited Protein Database

Gene name	CYCD3-3 (At3g50070, F3A4.150)
Protein name	Cyclin-D3-3
Names	G1/S-specific cyclin-D3-3, CycD33
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT3G50070
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

260-361 (Predicted disordered autoinhibitory region) PR

260-361 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9SN11-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_3_18566665_G_T	2	A>D	No	1000Genomes
tmp_3_18566637_G_C	11	N>K	No	1000Genomes
tmp_3_18566632_G_T	13	P>Q	No	1000Genomes
ENSVATH06283914	15	C>G	No	1000Genomes
ENSVATH06283913	19	G>C	No	1000Genomes
ENSVATH14411926	19	G>D	No	1000Genomes
ENSVATH12675845	21	F>Y	No	1000Genomes
ENSVATH12675844	23	E>Q	No	1000Genomes
tmp_3_18566593_C_A	26	S>I	No	1000Genomes
ENSVATH12675843	31	Q>E	No	1000Genomes
tmp_3_18566567_A_T	35	C>S	No	1000Genomes
ENSVATH12675842	40	E>K	No	1000Genomes
ENSVATH06283911	46	N>Y	No	1000Genomes
ENSVATH06283910	71	C>Y	No	1000Genomes
ENSVATH14411925	72	L>I	No	1000Genomes
tmp_3_18566392_A_G	93	I>T	No	1000Genomes
tmp_3_18566388_A_T	94	F>L	No	1000Genomes
tmp_3_18566389_A_T	94	F>Y	No	1000Genomes
tmp_3_18566384_C_A	96	V>L	No	1000Genomes
tmp_3_18566378_A_T	98	S>T	No	1000Genomes
tmp_3_18566373_A_C	99	H>Q	No	1000Genomes
tmp_3_18566356_A_G	105	L>S	No	1000Genomes
ENSVATH06283909	112	N>S	No	1000Genomes
ENSVATH06283908	138	C>S	No	1000Genomes
tmp_3_18566242_G_A	143	A>V	No	1000Genomes
ENSVATH12675838	175	L>F	No	1000Genomes
ENSVATH06283905	220	L>F	No	1000Genomes
ENSVATH14411914	225	D>E	No	1000Genomes
ENSVATH12675823	262	T>S	No	1000Genomes
ENSVATH14411913	277	L>I	No	1000Genomes
tmp_3_18565544_C_T	288	M>I	No	1000Genomes
tmp_3_18565525_G_T	295	P>T	No	1000Genomes
tmp_3_18565438_A_T	324	S>T	No	1000Genomes
tmp_3_18565396_C_T	338	V>M	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	EF-hand domain	105 - 245	IPR002048
binding_site	EF-Hand 1, calcium-binding site	175 - 187	IPR018247-1
binding_site	EF-Hand 1, calcium-binding site	223 - 235	IPR018247-2

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
cyclin-dependent protein serine/threonine kinase regulator activity	Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.

Name	Definition
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
guard mother cell differentiation	The process in which a meristemoid acquires the specialized features of a guard mother cell.
mitotic cell cycle phase transition	The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.
regulation of cyclin-dependent protein serine/threonine kinase activity	Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
seed development	The process whose specific outcome is the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P30279	CCND2	G1/S-specific cyclin-D2	Homo sapiens (Human)	PR
Q6ZMN8	CCNI2	Cyclin-I2	Homo sapiens (Human)	PR
P30280	Ccnd2	G1/S-specific cyclin-D2	Mus musculus (Mouse)	PR
Q8WNW2	CCND2	G1/S-specific cyclin-D2	Sus scrofa (Pig)	PR
Q10QA2	CYCD5-3	Cyclin-D5-3	Oryza sativa subsp japonica (Rice)	PR
Q0WQN9	CYCD4-2	Cyclin-D4-2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LZM0	CYCD7-1	Putative cyclin-D7-1	Arabidopsis thaliana (Mouse-ear cress)	PR
O48790	CYCB1-4	Cyclin-B1-4	Arabidopsis thaliana (Mouse-ear cress)	PR
A0MEB5	CYCA3-3	Cyclin-A3-3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FMH5	CYCA3-1	Putative cyclin-A3-1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8LGA1	CYCD4-1	Cyclin-D4-1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9C6A9	CYCA3-2	Cyclin-A3-2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q1PFW3	SDS	Cyclin-SDS	Arabidopsis thaliana (Mouse-ear cress)	PR