Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q10PQ9

Entry ID Method Resolution Chain Position Source
AF-Q10PQ9-F1 Predicted AlphaFoldDB

No variants for Q10PQ9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q10PQ9

No associated diseases with Q10PQ9

4 regional properties for Q10PQ9

Type Name Position InterPro Accession
domain Cyclin, C-terminal domain 378 - 464 IPR004367
domain Cyclin, N-terminal 274 - 373 IPR006671
domain Cyclin-like domain 281 - 368 IPR013763-1
domain Cyclin-like domain 381 - 462 IPR013763-2

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.

5 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
homologous chromosome pairing at meiosis The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete.
homologous chromosome segregation The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets.
mitotic cell cycle phase transition The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.
regulation of cyclin-dependent protein serine/threonine kinase activity Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

18 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P20438 CLN2 G1/S-specific cyclin CLN2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P24869 CLB2 G2/mitotic-specific cyclin-2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P39963 CCNB3 G2/mitotic-specific cyclin-B3 Gallus gallus (Chicken) PR
Q6ZMN8 CCNI2 Cyclin-I2 Homo sapiens (Human) PR
O95067 CCNB2 G2/mitotic-specific cyclin-B2 Homo sapiens (Human) PR
P41002 CCNF Cyclin-F Homo sapiens (Human) PR
P30279 CCND2 G1/S-specific cyclin-D2 Homo sapiens (Human) PR
P24864 CCNE1 G1/S-specific cyclin-E1 Homo sapiens (Human) PR
Q61457 Ccne1 G1/S-specific cyclin-E1 Mus musculus (Mouse) PR
P30280 Ccnd2 G1/S-specific cyclin-D2 Mus musculus (Mouse) PR
Q8WNW2 CCND2 G1/S-specific cyclin-D2 Sus scrofa (Pig) PR
Q8K4F8 Ccnf Cyclin-F Rattus norvegicus (Rat) PR
Q10QA2 CYCD5-3 Cyclin-D5-3 Oryza sativa subsp japonica (Rice) PR
Q0JIF2 CYCB1-1 Cyclin-B1-1 Oryza sativa subsp japonica (Rice) PR
Q10Q62 CYCF3-2 Putative cyclin-F3-2 Oryza sativa subsp japonica (Rice) PR
O48790 CYCB1-4 Cyclin-B1-4 Arabidopsis thaliana (Mouse-ear cress) PR
Q1PFW3 SDS Cyclin-SDS Arabidopsis thaliana (Mouse-ear cress) PR
P47794 ccne1 G1/S-specific cyclin-E1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MPPTMLASVP TRPRSHPFRR RRGAAAAAPP LLPDQIAAAA AAAAKRPAES STSASSCFHS
70 80 90 100 110 120
EVISATSTTC PTSLAAAQRP EKRPRYQDVD EEQPAASECS EIIGGARPRA AEVEVSESSC
130 140 150 160 170 180
LASVLESYLA CPEQLANDAE TTAYSSARED LTLSETEEEE EEEEVRSGPC ICTDCSFSPL
190 200 210 220 230 240
HESSSSSDDD NAVPSPTFSL FLALAEQFVP FTHPKTPTAT DVALQAGEGK RFEDLDNEVS
250 260 270 280 290 300
YERFRRRERR GVVARDYIEV YSSMLGSYGR AVVEQRVVMV NWIMEHSQAM KLQPETVFMG
310 320 330 340 350 360
IGLMDRFLTR GYVKGSRNLQ LLGIACTTLA TRIEENQPYN CILQKAFKVG INTYSRSEVV
370 380 390 400 410 420
AMEWLVQEVL DFQCFVTTTH HFLWFYLKAA NADDRVEDLA KYLALLSLLD HKHLSFWPST
430 440 450 460
VAAAVVALAC LATNNESSCH LVMETHMRTK NDDLPECLMS LEWLTNYAS