Q8K4F8

PR
Gene name
Ccnf
Protein name
Cyclin-F
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:117524
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

661-744 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8K4F8

Entry ID Method Resolution Chain Position Source
AF-Q8K4F8-F1 Predicted AlphaFoldDB

No variants for Q8K4F8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8K4F8

No associated diseases with Q8K4F8

16 regional properties for Q8K4F8

Type Name Position InterPro Accession
ptm EGF-type aspartate/asparagine hydroxylation site 595 - 606 IPR000152-1
ptm EGF-type aspartate/asparagine hydroxylation site 750 - 761 IPR000152-2
domain EGF-like domain 579 - 620 IPR000742-1
domain EGF-like domain 738 - 775 IPR000742-2
domain CUB domain 354 - 466 IPR000859-1
domain CUB domain 467 - 579 IPR000859-2
domain CUB domain 623 - 735 IPR000859-3
domain CUB domain 779 - 891 IPR000859-4
domain CUB domain 892 - 1008 IPR000859-5
domain Peptidase M12A 153 - 352 IPR001506
domain EGF-like calcium-binding domain 579 - 620 IPR001881-1
domain EGF-like calcium-binding domain 735 - 775 IPR001881-2
domain Peptidase, metallopeptidase 158 - 300 IPR006026
conserved_site EGF-like calcium-binding, conserved site 579 - 604 IPR018097-1
conserved_site EGF-like calcium-binding, conserved site 735 - 759 IPR018097-2
domain Tolloid/BMP1 peptidase domain 153 - 352 IPR034036

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm, perinuclear region
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
  • Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles
  • Localization to centrosomes is not dependent on CP110
  • Localizes to the nucleus in G2 phase
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
centriole A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
SCF ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

3 GO annotations of molecular function

Name Definition
anaphase-promoting complex binding Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis.
cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

10 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
mitotic cell cycle phase transition The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.
negative regulation of centrosome duplication Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
placenta development The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
re-entry into mitotic cell cycle The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.
regulation of cyclin-dependent protein serine/threonine kinase activity Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
response to organic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P20438 CLN2 G1/S-specific cyclin CLN2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P24869 CLB2 G2/mitotic-specific cyclin-2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P41002 CCNF Cyclin-F Homo sapiens (Human) PR
Q10PQ9 SDS Cyclin-SDS-like Oryza sativa subsp japonica (Rice) PR
Q10Q62 CYCF3-2 Putative cyclin-F3-2 Oryza sativa subsp japonica (Rice) PR
Q0JIF2 CYCB1-1 Cyclin-B1-1 Oryza sativa subsp japonica (Rice) PR
A0MEB5 CYCA3-3 Cyclin-A3-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FMH5 CYCA3-1 Putative cyclin-A3-1 Arabidopsis thaliana (Mouse-ear cress) PR
O48790 CYCB1-4 Cyclin-B1-4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C6A9 CYCA3-2 Cyclin-A3-2 Arabidopsis thaliana (Mouse-ear cress) PR
Q1PFW3 SDS Cyclin-SDS Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGSGGVIHCR CAKCFCYPTK RRIKRRPRNL TILSLPEDVL FHILKWLSVG DILAVRAVHS
70 80 90 100 110 120
HLKYLVDNHA SVWASASFQE LWPSPQNLKL FERAAEKGNF EAAVKLGIAY LYNEGLSVSD
130 140 150 160 170 180
EACAEVNGLK ASRFFSMAER LNTGSDPFIW LFIRPPWSVS GSCCKAVVHD SLRAECQLQR
190 200 210 220 230 240
SHKASILHCL GRVLNLFEDE EKRKQAHNLF EESAHQGCLA SSYLLWESDR KVDMSDPGRC
250 260 270 280 290 300
LHSFRKLRDY AAKGCWEAQL ALAKACAGGS QLGLEGKACS ESVCQLFQAS QAVNKQQIFS
310 320 330 340 350 360
VQKGLSDTMR YILIDWLVEV ATMKDFTSLC LHLTVECVDR YLRRRLVPRY KLQLLGIACM
370 380 390 400 410 420
VICTRFISKE ILTIREAVWL TDNTYKYEDL VRVMGEIISA LEGKIRIPTV VDYKEVLLTL
430 440 450 460 470 480
VPVAPRTQHL CSFLCELTLL HTSLSVYAPA RLASAALLLA RLMHGHTQPW TTQLWDLTGF
490 500 510 520 530 540
SYSDLTPCVL SLHKKCFHDD APKDYRQVSL TAVKQRFEDK CYEEISQEEV LSYAELCSAL
550 560 570 580 590 600
GVKQESPEPP SFPSSGEIHT FLSSPSGRRS KRKRENSLQE DRGSFVTTPT AELSNQEETL
610 620 630 640 650 660
LGSLLDWSLD CCSGYEGDQE SEGEKEGDVT APSGLLDVTV VYLNPEEHCC QESSDEEVWP
670 680 690 700 710 720
EDKSHPTPGT QAPPASAPWP LPCNRGDPGK DVTTSGYSSV SSSSPISSLD GGMVGSPRST
730 740 750 760 770
SVLSVGSHSS TKPCYHQAKK SCLQCRPPNP PESGAHQQPV KRQNLSVHSD EDTNLGFLKL