P24869
PR
Gene name |
CLB2 (YPR119W, P9642.6) |
Protein name |
G2/mitotic-specific cyclin-2 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YPR119W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P24869
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P24869-F1 | Predicted | AlphaFoldDB |
6 variants for P24869
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s16-771721 | 24 | Q>R | No | SGRP | |
| s16-771859 | 70 | S>N | No | SGRP | |
| s16-771932 | 94 | N>K | No | SGRP | |
| s16-772066 | 139 | I>N | No | SGRP | |
| s16-772257 | 203 | D>N | No | SGRP | |
| s16-772911 | 421 | D>H | No | SGRP |
No associated diseases with P24869
4 regional properties for P24869
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclin, C-terminal domain | 359 - 474 | IPR004367 |
| domain | Cyclin, N-terminal | 232 - 357 | IPR006671 |
| domain | Cyclin-like domain | 266 - 350 | IPR013763-1 |
| domain | Cyclin-like domain | 363 - 445 | IPR013763-2 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cellular bud neck | The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding. |
| cyclin-dependent protein kinase holoenzyme complex | Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
| spindle pole body | The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| G2/M transition of mitotic cell cycle | The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. |
| mitotic cell cycle phase transition | The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase. |
| negative regulation of protein dephosphorylation | Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein. |
| positive regulation of cyclin-dependent protein serine/threonine kinase activity | Any process that activates or increases the frequency, rate or extent of CDK activity. |
| positive regulation of mitotic spindle pole body separation | Any process that increases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. |
| regulation of cyclin-dependent protein serine/threonine kinase activity | Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. |
| regulation of mitotic spindle elongation | Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle. |
19 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P20438 | CLN2 | G1/S-specific cyclin CLN2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P39963 | CCNB3 | G2/mitotic-specific cyclin-B3 | Gallus gallus (Chicken) | PR |
| O95067 | CCNB2 | G2/mitotic-specific cyclin-B2 | Homo sapiens (Human) | PR |
| P30279 | CCND2 | G1/S-specific cyclin-D2 | Homo sapiens (Human) | PR |
| P41002 | CCNF | Cyclin-F | Homo sapiens (Human) | PR |
| P24864 | CCNE1 | G1/S-specific cyclin-E1 | Homo sapiens (Human) | PR |
| P30280 | Ccnd2 | G1/S-specific cyclin-D2 | Mus musculus (Mouse) | PR |
| Q61457 | Ccne1 | G1/S-specific cyclin-E1 | Mus musculus (Mouse) | PR |
| Q8WNW2 | CCND2 | G1/S-specific cyclin-D2 | Sus scrofa (Pig) | PR |
| Q8K4F8 | Ccnf | Cyclin-F | Rattus norvegicus (Rat) | PR |
| Q10PQ9 | SDS | Cyclin-SDS-like | Oryza sativa subsp japonica (Rice) | PR |
| Q0JIF2 | CYCB1-1 | Cyclin-B1-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q10Q62 | CYCF3-2 | Putative cyclin-F3-2 | Oryza sativa subsp japonica (Rice) | PR |
| O48790 | CYCB1-4 | Cyclin-B1-4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1PFW3 | SDS | Cyclin-SDS | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A0MEB5 | CYCA3-3 | Cyclin-A3-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C6A9 | CYCA3-2 | Cyclin-A3-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FMH5 | CYCA3-1 | Putative cyclin-A3-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P47794 | ccne1 | G1/S-specific cyclin-E1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNPIENTEN | SQNTSSSRFL | RNVQRLALNN | VTNTTFQKSN | ANNPALTNFK | STLNSVKKEG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SRIPQFTRES | VSRSTAAQEE | KRTLKENGIQ | LPKNNLLDDK | ENQDPSSQQF | GALTSIKEGR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AELPANISLQ | ESSSAKEIIQ | HDPLKGVGSS | TEVVHNSVEN | EKLHPARSQL | QVRNTESETD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SGKKRPISTI | VEQELPKKFK | VCDENGKEEY | EWEDLDAEDV | NDPFMVSEYV | NDIFEYLHQL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EVITLPKKED | LYQHRNIHQN | RDILVNWLVK | IHNKFGLLPE | TLYLAINIMD | RFLGKELVQL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DKLQLVGTSC | LFIASKYEEV | YSPSIKHFAS | ETDGACTEDE | IKEGEKFILK | TLKFNLNYPN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PMNFLRRISK | ADDYDIQSRT | LAKFLLEISL | VDFRFIGILP | SLCAAAAMFM | SRKMLGKGKW |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DGNLIHYSGG | YTKEELAPVC | HMIMDYLVSP | IVHDEFHRKY | QSRRFMKASI | ISVQWALKVR |
| 490 | |||||
| KNGYDIMTLH | E |