P47794
Gene name |
ccne1 (ccne, cyce) |
Protein name |
G1/S-specific cyclin-E1 |
Names |
|
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:30188 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P47794
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P47794-F1 | Predicted | AlphaFoldDB |
No variants for P47794
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P47794 | |||||
No associated diseases with P47794
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cyclin E1-CDK2 complex | A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. |
| cyclin-dependent protein kinase holoenzyme complex | Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
| kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| G1/S transition of mitotic cell cycle | The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. |
| mitotic cell cycle phase transition | The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase. |
| regulation of cyclin-dependent protein serine/threonine kinase activity | Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P20438 | CLN2 | G1/S-specific cyclin CLN2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P24869 | CLB2 | G2/mitotic-specific cyclin-2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P24864 | CCNE1 | G1/S-specific cyclin-E1 | Homo sapiens (Human) | PR |
| Q61457 | Ccne1 | G1/S-specific cyclin-E1 | Mus musculus (Mouse) | PR |
| Q10PQ9 | SDS | Cyclin-SDS-like | Oryza sativa subsp japonica (Rice) | PR |
| Q0JIF2 | CYCB1-1 | Cyclin-B1-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q10Q62 | CYCF3-2 | Putative cyclin-F3-2 | Oryza sativa subsp japonica (Rice) | PR |
| O48790 | CYCB1-4 | Cyclin-B1-4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A0MEB5 | CYCA3-3 | Cyclin-A3-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FMH5 | CYCA3-1 | Putative cyclin-A3-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1PFW3 | SDS | Cyclin-SDS | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C6A9 | CYCA3-2 | Cyclin-A3-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPSKKVLQTE | HINTTDEAPK | TTSVRPRKRK | ADVAIHLQDP | DEEVTEMTRK | KQCASQACWN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PDTGYTSPCR | RIPTPDEVEE | PVAFGSVGFT | QYASESIFIT | PTRSTPLPAL | CWASKDEVWN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NLLGKDKLYL | RDTRVMERHP | NLQPKMRAIL | LDWLMEVCEV | YKLHRETFYL | GQDYFDRFMA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TQENVLKTTL | QLIGISCLFI | AAKMEEIYPP | KVHQFAYVTD | GACTEDDILS | MEIIIMKELN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WSLSPLTPVA | WLNIYMQMAY | LKETAEVLTA | QYPQATFVQI | AELLDLCILD | VRSLEFSYSL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LAASALFHFS | SLELVIKVSG | LKWCDLEECV | RWMVPFAMSI | REAGSSALKT | FKGIAADDMH |
| 370 | 380 | 390 | 400 | ||
| NIQTHVPYLE | WLGKVHSYQL | VDIESSQRSP | VPTGVLTPPP | SSEKPESTIS |