O95067
PR
Gene name |
CCNB2 |
Protein name |
G2/mitotic-specific cyclin-B2 |
Names |
|
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:9133 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O95067
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O95067-F1 | Predicted | AlphaFoldDB |
337 variants for O95067
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA271776808 rs773160088 |
2 | A>E | No |
ClinGen Ensembl |
|
|
rs1181647609 CA392635698 |
5 | R>Q | No |
ClinGen gnomAD |
|
|
rs763932078 CA7588517 |
8 | T>M | No |
ClinGen ExAC gnomAD |
|
|
CA7588540 rs771676922 |
9 | V>E | No |
ClinGen ExAC gnomAD |
|
|
CA7588539 rs771676922 |
9 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs549586410 CA7588538 |
9 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs549586410 CA7588537 |
9 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA392635865 rs1466186488 |
10 | S>F | No |
ClinGen gnomAD |
|
|
rs1399354319 CA392635871 |
11 | S>I | No |
ClinGen gnomAD |
|
|
rs1301930519 CA392635866 |
11 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1399354319 CA392635870 |
11 | S>T | No |
ClinGen gnomAD |
|
|
CA392635875 rs1190805389 |
12 | D>N | No |
ClinGen TOPMed |
|
|
rs1445920601 CA392635893 |
14 | E>G | No |
ClinGen TOPMed |
|
|
rs760169940 CA392635897 |
15 | N>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760169940 CA7588541 |
15 | N>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA392635908 rs1300429324 |
16 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
CA7588542 rs768589001 |
18 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA392635922 rs768589001 |
18 | T>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768589001 CA392635923 |
18 | T>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776514242 CA7588543 |
19 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761620661 CA7588544 |
20 | V>F | No |
ClinGen ExAC gnomAD |
|
|
CA392635936 rs1314338481 |
21 | N>D | No |
ClinGen gnomAD |
|
|
rs1314338481 CA392635934 |
21 | N>H | No |
ClinGen gnomAD |
|
|
CA271777100 rs983351370 |
22 | S>P | No |
ClinGen gnomAD |
|
|
CA392635948 rs1255638779 |
23 | K>E | No |
ClinGen gnomAD |
|
|
CA392635951 rs1566955173 |
23 | K>R | No |
ClinGen Ensembl |
|
|
rs751848817 CA7588546 |
24 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs151299700 CA392635983 |
27 | H>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs767695563 CA7588548 |
28 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA392635989 rs1464425381 |
29 | T>P | No |
ClinGen gnomAD |
|
|
rs1399705642 CA392636005 |
31 | R>T | No |
ClinGen TOPMed |
|
|
CA7588549 rs752722691 |
32 | R>* | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 33 | T>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7588550 rs367803778 |
39 | G>A | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1174847062 CA392636078 |
42 | V>D | No |
ClinGen gnomAD |
|
|
CA7588552 rs778445498 |
43 | T>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA392636090 rs1320696326 |
44 | T>I | No |
ClinGen gnomAD |
|
|
rs140527154 CA7588553 |
45 | R>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7588554 rs150117081 |
46 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7588556 rs371888839 |
48 | Q>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA392636127 rs1300837527 |
50 | A>V | No |
ClinGen gnomAD |
|
|
rs138427426 CA7588582 |
53 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1406410155 CA392636168 |
54 | Q>H | No |
ClinGen gnomAD |
|
| TCGA novel | 55 | N>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs773159638 CA7588583 |
56 | T>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1394327238 CA392636184 |
57 | K>E | No |
ClinGen TOPMed |
|
|
rs1432033469 CA392636187 |
57 | K>R | No |
ClinGen gnomAD |
|
|
CA392636191 rs1425747871 |
58 | V>I | No |
ClinGen TOPMed |
|
|
CA392636192 rs1425747871 |
58 | V>L | No |
ClinGen TOPMed |
|
|
rs1350175101 CA392636199 |
59 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA392636211 rs1399646925 |
61 | Q>K | No |
ClinGen gnomAD |
|
|
rs866249126 CA271777135 |
62 | P>L | No |
ClinGen Ensembl |
|
|
CA392636219 rs1566955249 |
62 | P>S | No |
ClinGen Ensembl |
|
|
CA7588588 rs146926787 |
65 | T>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1021675271 CA271777138 |
65 | T>P | No |
ClinGen Ensembl |
|
|
CA392636246 rs1333981437 |
67 | N>H | No |
ClinGen gnomAD |
|
|
rs150253971 CA7588590 |
67 | N>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7588589 rs138232014 |
67 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs761914242 CA7588591 |
68 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA7588592 rs765697847 |
69 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200529135 CA7588593 |
70 | K>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs11548098 CA271777143 |
75 | T>A | No |
ClinGen Ensembl |
|
|
CA392636302 rs1211826519 |
75 | T>I | No |
ClinGen gnomAD |
|
|
CA7588594 rs144091405 |
77 | S>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs201051714 CA7588595 |
80 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA392636385 rs1383989423 |
81 | V>I | No |
ClinGen gnomAD |
|
|
rs1451713966 CA392636398 |
82 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
rs1451713966 CA392636394 |
82 | Q>K | No |
ClinGen TOPMed gnomAD |
|
|
CA392636425 rs1169668571 |
83 | M>T | No |
ClinGen gnomAD |
|
|
rs1374301768 CA392636416 |
83 | M>V | No |
ClinGen TOPMed |
|
| TCGA novel | 84 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1336437839 CA392636504 |
88 | P>S | No |
ClinGen gnomAD |
|
|
rs1359750427 CA392636521 |
89 | K>E | No |
ClinGen gnomAD |
|
|
rs777331417 CA7588619 |
90 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA7588622 rs778925803 |
93 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7588623 rs778925803 |
93 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1209837582 CA392637872 |
94 | T>S | No |
ClinGen gnomAD |
|
|
rs1445628854 CA392637892 |
97 | D>N | No |
ClinGen gnomAD |
|
|
CA7588626 rs748353573 |
98 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs139296509 CA7588630 |
100 | M>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7588628 rs773329622 |
100 | M>L | No |
ClinGen ExAC gnomAD |
|
|
CA7588629 rs16941036 VAR_022221 RCV000883792 |
100 | M>T | No |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA7588631 rs774800920 |
102 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs1457847652 CA392637925 |
102 | E>K | No |
ClinGen gnomAD |
|
|
CA271778787 TCGA novel rs749080700 |
103 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
NCI-TCGA ClinGen Ensembl |
|
CA7588632 rs759942264 |
103 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA271778789 rs550919161 |
104 | N>H | No |
ClinGen 1000Genomes |
|
| TCGA novel | 105 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs767834376 CA7588633 |
106 | C>F | No |
ClinGen ExAC gnomAD |
|
|
rs775189310 CA7588634 |
106 | C>W | No |
ClinGen ExAC gnomAD |
|
|
CA7588635 rs760361771 |
108 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs1330325494 CA392637963 |
108 | A>T | No |
ClinGen gnomAD |
|
|
rs865848383 CA271778793 |
109 | F>L | No |
ClinGen Ensembl |
|
|
CA392637972 rs1289843160 |
109 | F>S | No |
ClinGen gnomAD |
|
|
CA7588636 rs763591966 |
111 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA7588637 rs144226046 |
112 | A>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7588639 rs201147134 |
118 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1212173180 CA392638038 |
119 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1270741723 CA392638048 |
120 | I>T | No |
ClinGen TOPMed |
|
|
rs536661238 CA7588640 |
121 | D>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs758310424 CA392638064 |
122 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA392638066 rs1197466426 |
123 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
rs896571394 CA271778804 |
124 | D>G | No |
ClinGen TOPMed gnomAD |
|
|
CA7588642 rs779994699 |
124 | D>Y | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 126 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1404809792 CA392638100 |
127 | N>T | No |
ClinGen gnomAD |
|
| TCGA novel | 133 | D>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7588646 rs2306785 VAR_053052 |
135 | V>I | No |
ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
rs2306785 CA271778813 |
135 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA392638168 rs1364661031 |
136 | K>N | No |
ClinGen gnomAD |
|
|
rs1163806606 CA392638165 |
136 | K>R | No |
ClinGen gnomAD |
|
|
CA392638173 rs1370825940 |
137 | D>E | No |
ClinGen gnomAD |
|
|
rs534109952 CA7588648 |
137 | D>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1422533351 CA392638169 |
137 | D>N | No |
ClinGen gnomAD |
|
|
CA7588647 rs534109952 |
137 | D>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs140205864 CA7588649 |
139 | Y>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7588650 rs772482349 |
140 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
CA7588651 rs775841822 |
140 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs1403060049 CA392638227 |
141 | Y>H | No |
ClinGen TOPMed |
|
|
CA7588652 rs760877193 |
144 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA392638286 rs1400116822 |
144 | Q>R | No |
ClinGen Ensembl |
|
|
rs776096009 CA7588654 |
145 | L>Q | No |
ClinGen ExAC gnomAD |
|
|
CA7588655 rs761438863 |
146 | E>D | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 147 | V>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs766450641 CA7588676 |
147 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs143904498 CA7588677 |
148 | L>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA392638445 rs767211640 |
150 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7588679 rs767211640 |
150 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs979385275 CA271778881 |
152 | N>K | No |
ClinGen Ensembl |
|
|
rs200052341 CA392638492 |
153 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA7588681 rs200052341 |
153 | P>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs779036918 CA7588683 |
154 | H>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779036918 CA7588682 |
154 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1488779179 CA392638496 |
154 | H>Y | No |
ClinGen gnomAD |
|
|
CA271778887 rs770999254 |
156 | L>V | No |
ClinGen Ensembl |
|
|
rs1188492078 CA392638552 |
157 | D>Y | No |
ClinGen gnomAD |
|
|
CA392638581 rs1451048568 |
159 | R>G | No |
ClinGen gnomAD |
|
|
CA392638608 rs758420783 |
160 | D>A | No |
ClinGen ExAC gnomAD |
|
|
rs937993546 CA271778891 |
160 | D>E | No |
ClinGen gnomAD |
|
|
rs758420783 CA7588684 |
160 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs148986291 CA7588685 |
161 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA392638631 rs1293701356 |
162 | N>D | No |
ClinGen gnomAD |
|
|
CA7588686 rs747445408 |
162 | N>K | No |
ClinGen ExAC gnomAD |
|
|
COSM1373809 rs144432316 CA7588687 |
164 | R>C | large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA7588689 rs748469810 |
165 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA7588690 COSM1373810 rs759811496 |
166 | R>C | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA7588691 rs772960032 |
166 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7588692 rs762576167 |
167 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759377590 CA7588695 |
170 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770327276 CA7588693 CA7588694 |
170 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA271778919 rs949483720 |
171 | D>H | No |
ClinGen TOPMed |
|
|
CA392638795 rs1279835665 |
172 | W>* | No |
ClinGen TOPMed |
|
|
rs200615810 CA7588697 |
174 | V>G | No |
ClinGen ExAC gnomAD |
|
|
CA392638812 COSM470890 rs1433361474 |
174 | V>I | kidney Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs1433361474 CA392638814 |
174 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
rs765464570 CA7588699 |
175 | Q>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA392638818 rs765464570 |
175 | Q>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1161989994 CA392638825 |
176 | V>I | No |
ClinGen gnomAD |
|
|
CA271778927 rs370067045 |
179 | K>* | No |
ClinGen ESP |
|
|
CA392638883 rs1346382113 |
179 | K>M | No |
ClinGen gnomAD |
|
|
rs781621511 CA271778930 |
180 | F>L | No |
ClinGen Ensembl |
|
|
CA392638923 rs1453464199 |
181 | R>S | No |
ClinGen gnomAD |
|
| TCGA novel | 184 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7588700 rs750619117 |
185 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA392638995 rs1361552374 |
186 | T>A | No |
ClinGen gnomAD |
|
|
rs779995640 CA392639036 |
188 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
rs1343702396 CA392639059 |
189 | M>I | No |
ClinGen gnomAD |
|
|
rs752169210 CA7588703 |
189 | M>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1316318221 CA392639091 |
191 | V>A | No |
ClinGen gnomAD |
|
|
CA7588705 rs781678337 |
191 | V>I | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 192 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA392639123 rs1375249891 |
193 | I>S | No |
ClinGen TOPMed |
|
|
CA392639144 rs1366327766 |
194 | M>I | No |
ClinGen gnomAD |
|
|
rs770234668 CA7588707 |
194 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA7588708 rs528221556 |
196 | R>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA392639168 rs528221556 |
196 | R>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs770530308 COSM963416 CA7588710 |
196 | R>Q | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs1566956593 CA392639189 |
197 | F>C | No |
ClinGen Ensembl |
|
|
CA271778949 rs1048672738 |
199 | Q>E | No |
ClinGen gnomAD |
|
|
rs1383496240 CA392640327 |
200 | V>A | No |
ClinGen gnomAD |
|
|
rs1418290201 CA392640332 |
201 | Q>R | No |
ClinGen TOPMed |
|
|
rs1312589425 CA392640338 |
202 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
CA392640339 rs1312589425 |
202 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA392640347 rs1193933897 |
203 | V>D | No |
ClinGen TOPMed |
|
|
rs201177056 CA7588733 |
203 | V>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1211667325 CA392640353 |
204 | S>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA7588736 rs750922699 |
205 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM700835 rs369137460 CA7588735 |
205 | R>W | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA271779413 rs1055013442 |
206 | K>R | No |
ClinGen TOPMed |
|
|
CA392640372 rs1208472102 |
208 | L>F | No |
ClinGen TOPMed |
|
|
CA392640398 rs1283258181 |
211 | V>G | No |
ClinGen TOPMed |
|
|
CA392640402 rs1227439754 |
212 | G>V | No |
ClinGen TOPMed |
|
|
rs1419163021 CA392640401 |
212 | G>W | No |
ClinGen gnomAD |
|
|
CA392640419 rs150170652 |
215 | A>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7588739 rs150170652 |
215 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs774584434 CA7588740 |
215 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs759584289 CA392640422 |
216 | L>M | No |
ClinGen ExAC gnomAD |
|
|
rs759584289 CA7588741 |
216 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA392640437 rs1434276500 |
218 | L>F | No |
ClinGen TOPMed |
|
|
rs1367074440 CA392640447 |
220 | S>A | No |
ClinGen TOPMed gnomAD |
|
|
CA392640445 rs1367074440 |
220 | S>T | No |
ClinGen TOPMed gnomAD |
|
|
CA7588742 rs767674929 |
223 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA392640495 rs1325260353 |
226 | F>S | No |
ClinGen TOPMed |
|
|
CA392640504 rs1403420055 |
227 | S>F | No |
ClinGen TOPMed |
|
|
rs868377459 CA271779422 |
228 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA392640511 rs1566956992 |
229 | N>D | No |
ClinGen Ensembl |
|
|
CA392640513 rs1220618453 |
229 | N>T | No |
ClinGen gnomAD |
|
|
CA7588745 rs138629566 |
230 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs756700202 CA7588744 |
230 | I>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 231 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7588746 rs370687594 |
231 | E>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
COSM963417 rs531597901 CA7588747 |
232 | D>Y | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs778475417 CA7588748 |
233 | F>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA271779436 rs371204713 |
235 | Y>* | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA7588752 rs779529323 |
236 | I>V | No |
ClinGen ExAC |
|
|
rs746467746 CA7588753 |
237 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA271779442 rs951118216 |
238 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs200252030 CA271779445 |
239 | N>D | No |
ClinGen 1000Genomes |
|
|
rs768589002 CA7588754 |
240 | A>G | No |
ClinGen ExAC gnomAD |
|
|
CA7588755 rs143578095 |
242 | T>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA7588757 rs547706416 |
244 | S>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA392640625 rs1197137745 |
246 | I>T | No |
ClinGen TOPMed |
|
|
rs774478257 CA7588758 |
247 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759801780 CA7588759 |
247 | R>L | No |
ClinGen ExAC gnomAD |
|
|
rs759801780 CA271779455 |
247 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs566348759 CA7588760 |
249 | M>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs775714532 CA7588761 |
250 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs764720101 CA7588763 |
255 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1261808656 CA392640690 |
256 | E>V | No |
ClinGen gnomAD |
|
|
CA392640695 rs1206250461 |
257 | L>* | No |
ClinGen gnomAD |
|
|
CA392640720 rs1445972349 |
260 | E>A | No |
ClinGen gnomAD |
|
|
rs754343842 CA7588764 |
260 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs762120507 CA7588765 |
261 | L>* | No |
ClinGen ExAC gnomAD |
|
|
CA392640727 rs1269924233 |
261 | L>F | No |
ClinGen gnomAD |
|
|
CA392640723 rs1445664193 |
261 | L>M | No |
ClinGen gnomAD |
|
|
rs1566957027 CA392640735 |
263 | R>* | No |
ClinGen Ensembl |
|
|
rs1480149587 CA392640737 |
263 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA7588766 rs765627677 |
265 | L>S | No |
ClinGen ExAC gnomAD |
|
|
CA7588768 rs552125926 |
266 | P>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA392640753 rs552125926 |
266 | P>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1227099806 CA392640764 |
268 | H>N | No |
ClinGen TOPMed |
|
|
CA392640785 rs1566957042 |
271 | R>G | No |
ClinGen Ensembl |
|
|
rs754439548 CA7588771 |
272 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA7588772 rs781157452 |
272 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1402535052 CA392640808 |
275 | K>E | No |
ClinGen gnomAD |
|
|
CA7588775 rs373918972 |
277 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7588777 rs772453266 |
278 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA271779537 rs990575775 |
280 | D>N | No |
ClinGen Ensembl |
|
|
CA392640876 rs1596331978 |
283 | Q>R | No |
ClinGen Ensembl |
|
|
rs768913561 CA7588798 |
285 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748536373 CA271779541 |
285 | T>S | No |
ClinGen Ensembl |
|
|
CA7588799 rs776783136 |
286 | L>* | No |
ClinGen ExAC gnomAD |
|
|
rs776783136 CA392640894 |
286 | L>S | No |
ClinGen ExAC gnomAD |
|
|
rs1337987761 CA392640941 |
292 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
rs1394694184 CA392640954 |
295 | L>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1423995104 CA392640961 |
296 | I>F | No |
ClinGen TOPMed |
|
|
rs763357025 CA7588803 |
296 | I>S | No |
ClinGen ExAC gnomAD |
|
|
CA392640960 rs1423995104 |
296 | I>V | No |
ClinGen TOPMed |
|
|
rs774061171 CA7588806 |
297 | D>H | No |
ClinGen ExAC gnomAD |
|
|
rs774061171 CA7588805 |
297 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs752279669 CA7588808 |
298 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA392640973 rs1179559522 |
298 | Y>H | No |
ClinGen TOPMed |
|
|
CA7588809 rs368620705 |
300 | M>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs201814723 CA7588810 |
301 | V>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA392641004 rs1267225857 |
302 | H>R | No |
ClinGen TOPMed |
|
|
rs1323681249 CA392641020 |
304 | H>R | No |
ClinGen TOPMed |
|
|
CA392641055 rs1430731195 |
309 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1227748139 CA392641073 |
312 | A>V | No |
ClinGen TOPMed |
|
|
rs1177745022 CA392641099 |
316 | S>C | No |
ClinGen gnomAD |
|
|
CA271779556 rs372870051 |
317 | Q>E | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA392641121 rs1596332022 |
319 | V>G | No |
ClinGen Ensembl |
|
| TCGA novel | 320 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1283438623 CA392641125 |
320 | L>P | No |
ClinGen TOPMed gnomAD |
|
|
rs745599085 CA392641122 |
320 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA392641128 rs1290939024 |
321 | G>R | No |
ClinGen gnomAD |
|
|
rs1363094792 CA392641135 |
322 | Q>* | No |
ClinGen gnomAD |
|
|
rs773532612 CA271779562 |
322 | Q>R | No |
ClinGen Ensembl |
|
|
CA7588815 rs768741504 |
324 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA392641158 rs1351218014 |
325 | W>L | No |
ClinGen TOPMed |
|
|
CA7588839 rs777819950 |
326 | N>T | No |
ClinGen ExAC gnomAD |
|
|
rs1481339663 CA392641431 |
329 | Q>E | No |
ClinGen TOPMed gnomAD |
|
|
rs771434890 CA7588841 |
329 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA392641433 rs1596333515 |
329 | Q>R | No |
ClinGen Ensembl |
|
|
rs779341862 CA271785169 CA7588842 |
330 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA392641440 rs1409399562 |
330 | Q>R | No |
ClinGen gnomAD |
|
|
rs186770064 CA7588843 |
331 | Y>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA7588844 rs772289710 |
334 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs1425498580 CA392641481 |
336 | T>I | No |
ClinGen gnomAD |
|
|
rs1425498580 CA392641479 |
336 | T>K | No |
ClinGen gnomAD |
|
|
CA271785172 rs973715494 |
337 | E>K | No |
ClinGen Ensembl |
|
|
rs760230293 CA7588846 |
339 | E>* | No |
ClinGen ExAC gnomAD |
|
|
rs953851175 CA271785183 |
344 | M>T | No |
ClinGen gnomAD |
|
|
rs1372594385 CA392641539 |
345 | Q>E | No |
ClinGen gnomAD |
|
|
rs776284953 CA7588848 |
345 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA7588850 rs765290264 |
350 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA392641604 rs1208773224 |
350 | N>K | No |
ClinGen TOPMed |
|
|
rs1483745600 CA392641613 |
351 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1244721563 CA392641608 |
351 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1356703121 CA392641665 |
355 | N>I | No |
ClinGen TOPMed |
|
|
CA271785186 rs985187794 |
358 | L>V | No |
ClinGen Ensembl |
|
|
CA7588852 rs750364693 |
359 | T>I | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 365 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs766285505 CA7588873 |
365 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs1383670267 CA392643126 |
366 | N>S | No |
ClinGen TOPMed |
|
|
rs1338763357 CA392643176 |
369 | A>V | No |
ClinGen gnomAD |
|
|
rs1269283031 CA392643186 |
370 | S>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA392643197 rs1450230493 |
371 | S>C | No |
ClinGen TOPMed |
|
|
CA392643222 rs1337733276 |
372 | K>T | No |
ClinGen TOPMed gnomAD |
|
|
rs764347481 CA7588876 |
373 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1324824176 CA392643249 |
374 | L>R | No |
ClinGen gnomAD |
|
|
rs146077987 CA7588877 |
374 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7588878 rs757391426 |
375 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA271785810 rs1041356717 |
375 | K>R | No |
ClinGen Ensembl |
|
|
rs750459393 CA392643271 |
376 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs1276896131 CA392643269 |
376 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
CA392643277 rs1216738148 |
377 | S>I | No |
ClinGen gnomAD |
|
|
rs1476877578 CA392643287 |
378 | M>I | No |
ClinGen gnomAD |
|
|
CA7588882 rs376467552 |
379 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs747355242 CA7588883 |
381 | Q>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA392643309 rs1217984500 |
382 | L>V | No |
ClinGen gnomAD |
|
|
CA392643328 rs1409865422 |
385 | K>E | No |
ClinGen TOPMed gnomAD |
|
|
CA7588886 rs747798834 |
387 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA7588887 rs747798834 |
387 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA271785858 rs1024183249 |
388 | K>E | No |
ClinGen Ensembl |
|
|
CA392643348 rs1358299264 |
388 | K>I | No |
ClinGen gnomAD |
|
|
CA392643355 rs1596333889 |
389 | D>A | No |
ClinGen Ensembl |
|
|
rs770807962 CA7588890 |
391 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA7588891 rs774319575 |
392 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs774319575 CA392643374 |
392 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
CA392643381 rs1406587710 |
393 | P>L | No |
ClinGen TOPMed |
|
|
CA7588893 rs201360503 |
394 | L>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA392643388 rs1566958778 |
395 | I>L | No |
ClinGen Ensembl |
|
|
CA7588895 rs762035387 |
395 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs28383563 RCV000962510 VAR_022222 CA7588894 |
395 | I>T | No |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1225047849 CA392643392 |
396 | G>E | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs765376803 CA7588897 CA7588896 |
396 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA392643404 rs1451161940 |
398 | S>P | No |
ClinGen gnomAD |
No associated diseases with O95067
4 regional properties for O95067
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclin, C-terminal domain | 264 - 382 | IPR004367 |
| domain | Cyclin, N-terminal | 137 - 261 | IPR006671 |
| domain | Cyclin-like domain | 171 - 255 | IPR013763-1 |
| domain | Cyclin-like domain | 268 - 349 | IPR013763-2 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cyclin-dependent protein kinase holoenzyme complex | Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| microtubule cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cadherin binding | Binding to cadherin, a type I membrane protein involved in cell adhesion. |
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| G2/MI transition of meiotic cell cycle | The cell cycle process in which a cell progresses from meiotic G2 phase to M phase of meiosis I. |
| in utero embryonic development | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. |
| mitotic cell cycle phase transition | The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase. |
| regulation of cyclin-dependent protein serine/threonine kinase activity | Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. |
| regulation of growth | Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. |
| spindle assembly involved in female meiosis I | The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster. |
| T cell homeostasis | The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. |
| thymus development | The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P20438 | CLN2 | G1/S-specific cyclin CLN2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P24869 | CLB2 | G2/mitotic-specific cyclin-2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P39963 | CCNB3 | G2/mitotic-specific cyclin-B3 | Gallus gallus (Chicken) | PR |
| P41002 | CCNF | Cyclin-F | Homo sapiens (Human) | PR |
| P24864 | CCNE1 | G1/S-specific cyclin-E1 | Homo sapiens (Human) | PR |
| P30279 | CCND2 | G1/S-specific cyclin-D2 | Homo sapiens (Human) | PR |
| Q6ZMN8 | CCNI2 | Cyclin-I2 | Homo sapiens (Human) | PR |
| Q10PQ9 | SDS | Cyclin-SDS-like | Oryza sativa subsp japonica (Rice) | PR |
| Q0JIF2 | CYCB1-1 | Cyclin-B1-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q10Q62 | CYCF3-2 | Putative cyclin-F3-2 | Oryza sativa subsp japonica (Rice) | PR |
| O48790 | CYCB1-4 | Cyclin-B1-4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A0MEB5 | CYCA3-3 | Cyclin-A3-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FMH5 | CYCA3-1 | Putative cyclin-A3-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1PFW3 | SDS | Cyclin-SDS | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C6A9 | CYCA3-2 | Cyclin-A3-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALLRRPTVS | SDLENIDTGV | NSKVKSHVTI | RRTVLEEIGN | RVTTRAAQVA | KKAQNTKVPV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QPTKTTNVNK | QLKPTASVKP | VQMEKLAPKG | PSPTPEDVSM | KEENLCQAFS | DALLCKIEDI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DNEDWENPQL | CSDYVKDIYQ | YLRQLEVLQS | INPHFLDGRD | INGRMRAILV | DWLVQVHSKF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RLLQETLYMC | VGIMDRFLQV | QPVSRKKLQL | VGITALLLAS | KYEEMFSPNI | EDFVYITDNA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YTSSQIREME | TLILKELKFE | LGRPLPLHFL | RRASKAGEVD | VEQHTLAKYL | MELTLIDYDM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VHYHPSKVAA | AASCLSQKVL | GQGKWNLKQQ | YYTGYTENEV | LEVMQHMAKN | VVKVNENLTK |
| 370 | 380 | 390 | |||
| FIAIKNKYAS | SKLLKISMIP | QLNSKAVKDL | ASPLIGRS |