P43329

PR
Gene name
hrpA (b1413, JW5905)
Protein name
ATP-dependent RNA helicase HrpA
Names
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b1413
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-101 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P43329

Entry ID Method Resolution Chain Position Source
6ZWW X-ray 316 A A/C/E/G 1-783 PDB
6ZWX X-ray 270 A A 1-756 PDB
7AKP X-ray 259 A A 1-783 PDB
AF-P43329-F1 Predicted AlphaFoldDB

No variants for P43329

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P43329

No associated diseases with P43329

6 regional properties for P43329

Type Name Position InterPro Accession
domain Helicase, C-terminal 540 - 735 IPR001650
conserved_site DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site 468 - 477 IPR002464
domain Helicase-associated domain 756 - 846 IPR007502
domain DEAD/DEAH box helicase domain 357 - 511 IPR011545
domain DEAD-box helicase, OB fold 903 - 980 IPR011709
domain Helicase superfamily 1/2, ATP-binding domain 348 - 535 IPR014001

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically.

19 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P20095 PRP2 Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P36009 DHR2 Probable ATP-dependent RNA helicase DHR2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P15938 PRP16 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
O46072 kz Probable ATP-dependent RNA helicase kurz Drosophila melanogaster (Fruit fly) PR
O60231 DHX16 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 Homo sapiens (Human) PR
Q8IX18 DHX40 Probable ATP-dependent RNA helicase DHX40 Homo sapiens (Human) PR
Q7L7V1 DHX32 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 Homo sapiens (Human) PR
O43143 DHX15 ATP-dependent RNA helicase DHX15 Homo sapiens (Human) PR
Q6P158 DHX57 Putative ATP-dependent RNA helicase DHX57 Homo sapiens (Human) PR
Q9H2U1 DHX36 ATP-dependent DNA/RNA helicase DHX36 Homo sapiens (Human) PR
Q8IY37 DHX37 Probable ATP-dependent RNA helicase DHX37 Homo sapiens (Human) PR
Q8NG08 HELB DNA helicase B Homo sapiens (Human) PR
Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 Homo sapiens (Human) PR
Q14BI7 Tdrd9 ATP-dependent RNA helicase TDRD9 Mus musculus (Mouse) PR
Q8VHK9 Dhx36 ATP-dependent DNA/RNA helicase DHX36 Mus musculus (Mouse) PR
Q6NVF4 Helb DNA helicase B Mus musculus (Mouse) PR
Q9BKQ8 ddx-35 Probable ATP-dependent RNA helicase DHX35 homolog Caenorhabditis elegans PR
P34305 rha-2 Putative ATP-dependent RNA helicase rha-2 Caenorhabditis elegans PR
P34498 mog-1 Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 Caenorhabditis elegans PR
10 20 30 40 50 60
MTEQQKLTFT ALQQRLDSLM LRDRLRFSRR LHGVKKVKNP DAQQAIFQEM AKEIDQAAGK
70 80 90 100 110 120
VLLREAARPE ITYPDNLPVS QKKQDILEAI RDHQVVIVAG ETGSGKTTQL PKICMELGRG
130 140 150 160 170 180
IKGLIGHTQP RRLAARTVAN RIAEELKTEP GGCIGYKVRF SDHVSDNTMV KLMTDGILLA
190 200 210 220 230 240
EIQQDRLLMQ YDTIIIDEAH ERSLNIDFLL GYLKELLPRR PDLKIIITSA TIDPERFSRH
250 260 270 280 290 300
FNNAPIIEVS GRTYPVEVRY RPIVEEADDT ERDQLQAIFD AVDELSQESH GDILIFMSGE
310 320 330 340 350 360
REIRDTADAL NKLNLRHTEI LPLYARLSNS EQNRVFQSHS GRRIVLATNV AETSLTVPGI
370 380 390 400 410 420
KYVIDPGTAR ISRYSYRTKV QRLPIEPISQ ASANQRKGRC GRVSEGICIR LYSEDDFLSR
430 440 450 460 470 480
PEFTDPEILR TNLASVILQM TALGLGDIAA FPFVEAPDKR NIQDGVRLLE ELGAITTDEQ
490 500 510 520 530 540
ASAYKLTPLG RQLSQLPVDP RLARMVLEAQ KHGCVREAMI ITSALSIQDP RERPMDKQQA
550 560 570 580 590 600
SDEKHRRFHD KESDFLAFVN LWNYLGEQQK ALSSNAFRRL CRTDYLNYLR VREWQDIYTQ
610 620 630 640 650 660
LRQVVKELGI PVNSEPAEYR EIHIALLTGL LSHIGMKDAD KQEYTGARNA RFSIFPGSGL
670 680 690 700 710 720
FKKPPKWVMV AELVETSRLW GRIAARIDPE WVEPVAQHLI KRTYSEPHWE RAQGAVMATE
730 740 750 760 770 780
KVTVYGLPIV AARKVNYSQI DPALCRELFI RHALVEGDWQ TRHAFFRENL KLRAEVEELE
790 800 810 820 830 840
HKSRRRDILV DDETLFEFYD QRISHDVISA RHFDSWWKKV SRETPDLLNF EKSMLIKEGA
850 860 870 880 890 900
EKISKLDYPN FWHQGNLKLR LSYQFEPGAD ADGVTVHIPL PLLNQVEESG FEWQIPGLRR
910 920 930 940 950 960
ELVIALIKSL PKPVRRNFVP APNYAEAFLG RVKPLELPLL DSLERELRRM TGVTVDREDW
970 980 990 1000 1010 1020
HWDQVPDHLK ITFRVVDDKN KKLKEGRSLQ DLKDALKGKV QETLSAVADD GIEQSGLHIW
1030 1040 1050 1060 1070 1080
SFGQLPESYE QKRGNYKVKA WPALVDERDS VAIKLFDNPL EQKQAMWNGL RRLLLLNIPS
1090 1100 1110 1120 1130 1140
PIKYLHEKLP NKAKLGLYFN PYGKVLELID DCISCGVDKL IDANGGPVWT EEGFAALHEK
1150 1160 1170 1180 1190 1200
VRAELNDTVV DIAKQVEQIL TAVFNINKRL KGRVDMTMAL GLSDIKAQMG GLVYRGFVTG
1210 1220 1230 1240 1250 1260
NGFKRLGDTL RYLQAIEKRL EKLAVDPHRD RAQMLKVENV QQAWQQWINK LPPARREDED
1270 1280 1290
VKEIRWMIEE LRVSYFAQQL GTPYPISDKR ILQAMEQISG