Q9BKQ8

PR
Gene name
ddx-35
Protein name
Probable ATP-dependent RNA helicase DHX35 homolog
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_Y67D2.6
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-102 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9BKQ8

Entry ID Method Resolution Chain Position Source
AF-Q9BKQ8-F1 Predicted AlphaFoldDB

No variants for Q9BKQ8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9BKQ8

No associated diseases with Q9BKQ8

6 regional properties for Q9BKQ8

Type Name Position InterPro Accession
domain Coagulation factor 5/8 C-terminal domain 272 - 422 IPR000421-1
domain Coagulation factor 5/8 C-terminal domain 428 - 581 IPR000421-2
domain CUB domain 25 - 139 IPR000859-1
domain CUB domain 145 - 263 IPR000859-2
domain MAM domain 639 - 811 IPR000998
domain Neuropilin, C-terminal 847 - 923 IPR022579

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
catalytic step 2 spliceosome A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
developmental process A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
reproductive process A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P43329 hrpA ATP-dependent RNA helicase HrpA Escherichia coli (strain K12) PR
Q8IX18 DHX40 Probable ATP-dependent RNA helicase DHX40 Homo sapiens (Human) PR
P34305 rha-2 Putative ATP-dependent RNA helicase rha-2 Caenorhabditis elegans PR
P34498 mog-1 Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 Caenorhabditis elegans PR
10 20 30 40 50 60
MSYHPGHGHR QEPRKGAGAR RGFARPDDSA DAPRTGPLIF EERSTENAGA APPIEEQLKV
70 80 90 100 110 120
HNNPYASLNI QQQRIRLPIF KNRGHILYMC ERYRTIIIVG ETGCGKSTQV PQFLLEAGWA
130 140 150 160 170 180
ADGRQIVITQ PRRVAVVTLA TRVAEEKDCI LGHDVGYTVR FDDVSDKDTK VKFMTDGLLL
190 200 210 220 230 240
REILADPLLS KYSIIMIDEA HERSCNTDIL LGLLRKIIQI RNDLRIIVSS ATLDAELFKD
250 260 270 280 290 300
FFEMNETGNS DKDTAGIISV EGRTHPVAVH HTKTSVPDYC QSAVDTVINI HKHENPGDIL
310 320 330 340 350 360
VFLTGQDEVE DVCEKLRELA GNLKNCDRLW VVPCYGALPA REQMKAFDST PHGTRKVVVA
370 380 390 400 410 420
TNIAEASITI PGICYVIDTG YVKLRAQHAA NGVETLMRVT VSKASAEQRA GRAGRIRPGK
430 440 450 460 470 480
CYRLYPESEF ERFAEGTVPE IQRCQMASTI LQLKALGVQN VHRFHYLSPP PSWAMINGLE
490 500 510 520 530 540
LLYALGAIDE TSQLTSPLGL QMAEFPLPPM HSKCLLKSAE FGCSTEMVTI VAMMQIQDVF
550 560 570 580 590 600
ITPYRQRHQA DVIRKKFAVE EGDHMTMLNV FTKFVENGRS KKWCSDHFVN YRGLMRADNV
610 620 630 640 650 660
RSQLVRLLKR FEIEKVSSRG LINCSENIRQ CLVTGFFSQA AQYHYTGKYM TVKESFPFNM
670 680 690 700 710 720
YKGSSIMFKK DYPKWVIFTE VMQDSIRDVT VIEPEWLYEL APHYYEFGTE GELAEKRMRG
730
PAATSAAADD DY