P34498

PR
Gene name
mog-1 (K03H1.2)
Protein name
Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1
Names
Masculinization of germline protein 1, Sex determination protein mog-1
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_K03H1.2
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-306 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P34498

Entry ID Method Resolution Chain Position Source
AF-P34498-F1 Predicted AlphaFoldDB

No variants for P34498

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P34498

No associated diseases with P34498

1 regional properties for P34498

Type Name Position InterPro Accession
domain AP2/ERF domain 45 - 111 IPR001471

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
spliceosomal complex Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
feminization of hermaphroditic germ-line The determination of female sex and sexual phenotype in the germ-line of the hermaphrodite.
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P36009 DHR2 Probable ATP-dependent RNA helicase DHR2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P15938 PRP16 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P43329 hrpA ATP-dependent RNA helicase HrpA Escherichia coli (strain K12) PR
Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 Homo sapiens (Human) PR
P34305 rha-2 Putative ATP-dependent RNA helicase rha-2 Caenorhabditis elegans PR
Q9BKQ8 ddx-35 Probable ATP-dependent RNA helicase DHX35 homolog Caenorhabditis elegans PR
10 20 30 40 50 60
MSDKRADGRL EGTSDTFGGL VIKKKKVEGD SKPTEPSGKS LLGLDRLAST KREHARKRLE
70 80 90 100 110 120
DDDDRGVTES VRKGIEKVHE KHRDRDDRGM KYKSRDDDRR RDRDRSERRE PSSRRGWKDR
130 140 150 160 170 180
SGDQTPRFKV PDTPSRMSWD QDDREGSSRK RNSWDMPTPR GERDRKRYMD SERSISSAWR
190 200 210 220 230 240
SERRNRDDEK RRRHRKPEDS VRSVKEEKAE PTFHDDEERA QWEEEQKNLD REWYDNEGAF
250 260 270 280 290 300
DDEYNPFNKV SDEFVEKREK QWQEKTQKPR LTVKQQAIKR ENELWENNRL HRSGVVAMAD
310 320 330 340 350 360
ELSSIFEDET DENRVTILVQ NIVPPFLDGR IVFTKQAQPI IPVVDTTCDM AVSAARGSVA
370 380 390 400 410 420
VRKRREVEDR KKAQDKHWEL AGSKLGNLMG VKEKKDETAD PEDDDSGNYK ESHQFASHMK
430 440 450 460 470 480
DNEAVSDFAM EKSIKQQREY LPVFACRQKM MNVIRENNVV IIVGETGSGK TTQLAQYLLE
490 500 510 520 530 540
DGFGDSGLIG CTQPRRVAAM SVARRVADEM GVDLGQDVGY AIRFEDCTSE KTIIKYMTDG
550 560 570 580 590 600
ILLRECLGDG SLDQYSAIIM DEAHERSLNT DVLFGLLREV IAKRADLKLI VTSATMDADK
610 620 630 640 650 660
FADFFGGNCP TFTIPGRTFP VELFHARTPV EDYVDAAVKQ AVTIHLGGMD GDILIFMPGQ
670 680 690 700 710 720
EDIECTCEMI KEKLGELDEA PPLAVLPIYS QLPSDLQAKI FQRAPGGMRK AIVATNIAET
730 740 750 760 770 780
SLTVDGILFV IDPGFCKMKV YNPRIGMDAL SIFPVSQASA NQRTGRAGRT GPGQCYRLYT
790 800 810 820 830 840
ERQFKDELLK STVPEIQRTN LANVVLLLKS LGVDDLLKFH FMDAPPQDNM LNSMYQLWTL
850 860 870 880 890 900
GALDNTGQLT PMGRKMVEFP LDPTLSKMLI MSAEMGCSDE VLTIVSMLSV PAIFFRPKGR
910 920 930 940 950 960
EEEADAKKEK FQVPESDHLT FLNVYIQWRT HKYSAKWCAD NYLHVKALKK VREVRAQLKE
970 980 990 1000 1010 1020
IMQDLKLPLI SNGSEWDIVR KCICSAYFHN AARLKGIGEY VNVRTGIPCF LHPTSALFGM
1030 1040 1050 1060 1070 1080
GFMPDYVVYH ELIMTAKEYM QCVTAVDAIW LAELGPMFYS IKESKQSRKE LKMESVRTVE
1090 1100 1110 1120 1130
TMEAEMREAQ KEMERRKEES DKAFKRPESS RRVVEVGSKS ARSERRKLWG L