P34305

PR
Gene name
rha-2 (C06E1.10)
Protein name
Putative ATP-dependent RNA helicase rha-2
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C06E1.10
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

8-189 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P34305

Entry ID Method Resolution Chain Position Source
AF-P34305-F1 Predicted AlphaFoldDB

No variants for P34305

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P34305

No associated diseases with P34305

6 regional properties for P34305

Type Name Position InterPro Accession
domain Helicase, C-terminal 463 - 703 IPR001650
conserved_site DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site 350 - 359 IPR002464
domain Helicase-associated domain 723 - 836 IPR007502
domain DEAD/DEAH box helicase domain 246 - 398 IPR011545
domain DEAD-box helicase, OB fold 903 - 989 IPR011709
domain Helicase superfamily 1/2, ATP-binding domain 234 - 425 IPR014001

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
developmental process A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
reproductive process A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P43329 hrpA ATP-dependent RNA helicase HrpA Escherichia coli (strain K12) PR
O46072 kz Probable ATP-dependent RNA helicase kurz Drosophila melanogaster (Fruit fly) PR
Q8IY37 DHX37 Probable ATP-dependent RNA helicase DHX37 Homo sapiens (Human) PR
P34498 mog-1 Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 Caenorhabditis elegans PR
Q9BKQ8 ddx-35 Probable ATP-dependent RNA helicase DHX35 homolog Caenorhabditis elegans PR
10 20 30 40 50 60
MGKRKTKEDN ASEDYDANEL MIVPGEKRKK LEKSGEKSAT GGKKNRNFAK EKEVAKLTKQ
70 80 90 100 110 120
AKRKLAAVQS RKALKQTQEE LFAGLAEFQL DPSKLCQLSS STKLSKEPEK APVFPEKLKV
130 140 150 160 170 180
FSGKTKTEAK RTQQDYYPTD DESSSEEEEE EEEGDNDIED AGNTVEVKIE PIDLDDVDEA
190 200 210 220 230 240
IDGNPETNLD QIVVKREDDE ESDNEDILAL PTTTVINRKK VIVERSKEIQ KSRAELPIFA
250 260 270 280 290 300
EEMRIVEAIN ENLVTVVCGE TGSGKTTQIP QFLYEAGYAS EGELIGITEP RRVAAIAMAQ
310 320 330 340 350 360
RVGVELAKPD EVSYQIRYEG TRSETTNILF MTDGVLMKEM EQDVMLKKYS VILIDEAHER
370 380 390 400 410 420
SMYSDVLIGM LSRIVPLRSK TARPLRLVIM SATLRLDDFT HKKLFPLLTP KVIKVDARQF
430 440 450 460 470 480
PVSVHFEKRT PDDYIASAFR KTCRIHETLP PGAILVFVTG QHEVKQLITK LKKRYPVVYE
490 500 510 520 530 540
TDKNGEVLVK GTKEWKEKKV EAAKSIKLED FKEETPETED FEDVDDGLMD GDDMNERGAA
550 560 570 580 590 600
EAFDDYEEFE NGDGDLSDGK VENSIGAPPA DCEPLYCLPL YSLLSMGKQR RVFDETPAGM
610 620 630 640 650 660
RLCVISTNVA ETSLTIPGVK YVIDGGFEKR RLYDSITGVS RFAVCRISQA SGDQRAGRAG
670 680 690 700 710 720
RISAGHAYRL YSSAVYQDFV KFADPEILSK PADQLVLHLK SMNIVKVVNF PFPSAPDEQM
730 740 750 760 770 780
LESAEKRLCR LGALSESTKN GKTEARITKL GKTLAVFPLA PSYAKFIAMA DQHNLMSHAI
790 800 810 820 830 840
LLISLLSVRE PLIPVSSLRG DTPEETKELM KNVLKERRRW CSHTGARRLG DLKVLMHAAS
850 860 870 880 890 900
VAEQIKYNAR ECEKVGLRVK ALVEARKLRQ QLTNIVNASC KKEHAAALDS DLPPPTDQQA
910 920 930 940 950 960
QLLRQMVVAS FSDRLARRVD RSVGQEEVQK GAYETTLIKG HVFIDPCSVV FTEEPEFVIY
970 980 990 1000 1010 1020
QELVQVNEKK LMTSVCAVDK EWLSRLAESY CNYGEQDKNQ EPIYDPVKDM VVKTVKVTFG
1030 1040 1050 1060 1070 1080
PLNWELPNEN RSVPHDIMMY RYFALFLLDG LVFEKLKEYT PKLLAPPSTM VKSWAKLQKR
1090 1100 1110 1120 1130 1140
TEMLLNKLIE KEVTTRSSLK EQWLKNENWL LEEYLEWVPE SVHQQISLMW PPLEDHEKTI
KMGRNKKY