O46072

PR
Gene name
kz (CG3228)
Protein name
Probable ATP-dependent RNA helicase kurz
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG3228
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

154-245 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O46072

Entry ID Method Resolution Chain Position Source
AF-O46072-F1 Predicted AlphaFoldDB

No variants for O46072

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O46072

No associated diseases with O46072

14 regional properties for O46072

Type Name Position InterPro Accession
domain C2 domain 1071 - 1194 IPR000008
domain Phosphatidylinositol-specific phospholipase C, X domain 320 - 465 IPR000909
domain SH2 domain 548 - 657 IPR000980-1
domain SH2 domain 666 - 756 IPR000980-2
domain SH3 domain 791 - 851 IPR001452
domain Phospholipase C, phosphatidylinositol-specific, Y domain 953 - 1070 IPR001711
domain Pleckstrin homology domain 27 - 144 IPR001849-1
domain Pleckstrin homology domain 489 - 680 IPR001849-2
domain Pleckstrin homology domain 804 - 933 IPR001849-3
domain EF-hand domain 152 - 187 IPR002048
binding_site EF-Hand 1, calcium-binding site 165 - 177 IPR018247
domain PLC-gamma, C-terminal SH2 domain 663 - 765 IPR035023
domain PLC-gamma, N-terminal SH2 domain 545 - 649 IPR035024
domain 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain 791 - 850 IPR035724

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
reproductive process A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P43329 hrpA ATP-dependent RNA helicase HrpA Escherichia coli (strain K12) PR
Q8IY37 DHX37 Probable ATP-dependent RNA helicase DHX37 Homo sapiens (Human) PR
P34305 rha-2 Putative ATP-dependent RNA helicase rha-2 Caenorhabditis elegans PR
10 20 30 40 50 60
MGKKVHNAKA RQNPQTIVDN SAVKKIQIDV DAVAGGNQVG YDEANALVLP SEKRATKIKV
70 80 90 100 110 120
DKVQHVKILS KKQRKHLQAI VDKKKKKEGR AQLLGDLAAV QIPEEELQQY TSISQVQTVG
130 140 150 160 170 180
LKRLPTLDEY LAKKKERQAQ VLAEKSSASG LRVNAIKGSK RKLLVEEEEE LQAKRKNPNV
190 200 210 220 230 240
ISVEEDDEDS SSSDEDDEEA PAQSAPIAIP TPVSIAPPQI AVKPPIKKLK PEPNPPACIH
250 260 270 280 290 300
QTVYVPVHRT TEVQNARLRL PILAEEQQVM ETINENPIVI VAGETGSGKT TQLPQFLYEA
310 320 330 340 350 360
GYAQHKMIGV TEPRRVAAIA MSKRVAHEMN LPESEVSYLI RFEGNVTPAT RIKFMTDGVL
370 380 390 400 410 420
LKEIETDFLL SKYSVIILDE AHERSVYTDI LVGLLSRIVP LRHKRGQPLK LIIMSATLRV
430 440 450 460 470 480
SDFTENTRLF KIPPPLLKVE ARQFPVTIHF QKRTPDDYVA EAYRKTLKIH NKLPEGGILI
490 500 510 520 530 540
FVTGQQEVNQ LVRKLRRTFP YHHAPTKDVA KNGKVSEEEK EETIDDAAST VEDPKELEFD
550 560 570 580 590 600
MKRVIRNIRK SKKKFLAQMA LPKINLDDYK LPGDDTEADM HEQPDEDDEQ EGLEEDNDDE
610 620 630 640 650 660
LGLEDESGMG SGQRQPLWVL PLYSLLSSEK QNRIFLPVPD GCRLCVVSTN VAETSLTIPH
670 680 690 700 710 720
IKYVVDCGRQ KTRLYDKLTG VSAFVVTYTS KASADQRAGR AGRISAGHCY RLYSSAVYND
730 740 750 760 770 780
CFEDFSQPDI QKKPVEDLML QMRCMGIDRV VHFPFPSPPD QVQLQAAERR LIVLGALEVA
790 800 810 820 830 840
KTENTDLPPA VTRLGHVISR FPVAPRFGKM LALSHQQNLL PYTVCLVAAL SVQEVLIETG
850 860 870 880 890 900
VQRDEDVAPG ANRFHRKRQS WAASGNYQLL GDPMVLLRAV GAAEYAGSQG RLPEFCAANG
910 920 930 940 950 960
LRQKAMSEVR KLRVQLTNEI NLNVSDVELG VDPELKPPTD AQARFLRQIL LAGMGDRVAR
970 980 990 1000 1010 1020
KVPLADIADK EERRRLKYAY NCADMEEPAF LHVSSVLRQK APEWVIYQEA YELQNGDSTK
1030 1040 1050 1060 1070 1080
MFIRGITAIE PEWLLLYVPL LCNIREVRED PAPRFDKTSG KIFCHVDATF GKSGWELPLG
1090 1100 1110 1120 1130 1140
EVEMPLSEKA CCYFGMFLLD GEVCSRLADF RSKLKSTPAS VIKSWSSMNN KVLRFKRALI
1150 1160 1170 1180 1190
TKQIHNRQAL IDQWNSDPHF LLEEYQNLLY DVALSELTPL WPPVDKKEPQ RQ