P36009
PR
Gene name |
DHR2 (YKL078W, YKL408) |
Protein name |
Probable ATP-dependent RNA helicase DHR2 |
Names |
DEAH box RNA helicase DHR2, Helicase JA2 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YKL078W |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P36009
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P36009-F1 | Predicted | AlphaFoldDB |
7 variants for P36009
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s11-288571 | 28 | T>M | No | SGRP | |
| s11-288625 | 46 | G>V | No | SGRP | |
| s11-288672 | 62 | L>V | No | SGRP | |
| s11-289063 | 192 | S>N | No | SGRP | |
| s11-289503 | 339 | A>P | No | SGRP | |
| s11-289984 | 499 | Q>R | No | SGRP | |
| s11-290497 | 670 | S>Y | No | SGRP |
No associated diseases with P36009
6 regional properties for P36009
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase, C-terminal | 262 - 456 | IPR001650 |
| conserved_site | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site | 198 - 207 | IPR002464 |
| domain | Helicase-associated domain | 476 - 570 | IPR007502 |
| domain | DEAD/DEAH box helicase domain | 88 - 243 | IPR011545 |
| domain | DEAD-box helicase, OB fold | 646 - 721 | IPR011709 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 79 - 266 | IPR014001 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| identical protein binding | Binding to an identical protein or proteins. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of SSU-rRNA | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. |
| maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| positive regulation of transcription by RNA polymerase I | Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I. |
| ribosome biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P20095 | PRP2 | Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P15938 | PRP16 | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P43329 | hrpA | ATP-dependent RNA helicase HrpA | Escherichia coli (strain K12) | PR |
| Q92620 | DHX38 | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 | Homo sapiens (Human) | PR |
| P34498 | mog-1 | Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAANSNSRVA | SNHTSKKQKV | RRNIHPFTNN | TRIKRASKIV | KFNDSGEGDH | VSDQRSNKEN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLTYKSLKSR | ASDLLKMRET | LPVYQHKREI | MSYIESNPVT | VLIGETGSGK | STQIPQFVLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KLYDTKKHGS | IAVTQPRRVA | AINLATRVAQ | EHGCKLGEQV | GYSVRFDNTT | TTRTRLKYLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DGMLLRELMM | NSDLREYSVI | VIDEAHERTV | LTDLILGFLK | SLIQGPRPDL | RIIVMSATLQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AEKFSEFFNN | APILFVEGRK | FDVKQYYLKA | PTDDIVDAVI | RCCIQINQGE | ELGDILCFLP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GQEEIDKAVT | IMEKIAKYVS | DEAPVPLIVP | YPLYAALPAV | QQSLVFAPIK | GFKRKVVFST |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NIAETSVTIS | GVKFVVDSGL | RKVKVWRHQL | GLATLLTVPI | SQASAMQRSG | RAGRESEGKS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FRLYCESDYV | KLPKQSEPEI | ARSDVTSPVL | MLKRYGVDDL | LNWTWFENPG | KEAIVMGLQE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LYELGALDTR | GKITKRGQQM | ALLPLQPHLS | SVLIKASEVG | CLSQVIDIVS | CLSVENLLLN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PSPEERDEVN | ERRLSLCNAG | KRYGDLIMLK | ELFDIYFYEL | GKSQDASSER | NDWCKGLCIS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IRGFKNVIRV | RDQLRVYCKR | LFSSISEEDE | ESKKIGEDGE | LISKILKCFL | TGFIKNTAIG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MPDRSYRTVS | TGEPISIHPS | SMLFMNKSCP | GIMYTEYVFT | TKGYARNVSR | IELSWLQEVV |
| 730 | |||||
| TNAAAVAKQK | VSDSK |