Q8IX18
PR
Gene name |
DHX40 (DDX40, ARG147) |
Protein name |
Probable ATP-dependent RNA helicase DHX40 |
Names |
DEAH box protein 40, Protein PAD |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:79665 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8IX18
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8IX18-F1 | Predicted | AlphaFoldDB |
384 variants for Q8IX18
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs773926655 CA8680369 |
2 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs745310098 CA8680370 |
3 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8680371 rs537021962 |
5 | P>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA400402821 rs940408919 |
9 | G>C | No |
ClinGen gnomAD |
|
|
CA292119038 rs940408919 |
9 | G>S | No |
ClinGen gnomAD |
|
|
rs1222980416 CA400402827 |
10 | R>K | No |
ClinGen gnomAD |
|
|
rs200846551 CA8680373 |
11 | A>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1282102465 CA400402837 |
12 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
rs143836506 CA8680375 |
12 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1282102465 CA400402838 |
12 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA400402851 rs1489756954 |
14 | R>Q | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 17 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs374800359 CA8680378 |
18 | G>S | No |
ClinGen ESP ExAC gnomAD |
|
|
CA400402888 rs1470889456 |
19 | E>* | No |
ClinGen gnomAD |
|
|
rs750517648 CA8680379 |
21 | S>L | No |
ClinGen ExAC |
|
|
CA400402925 rs762935870 |
23 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs888954549 CA292119071 |
23 | D>V | No |
ClinGen TOPMed |
|
|
rs1407960199 CA400402930 |
24 | L>F | No |
ClinGen gnomAD |
|
|
rs1407960199 CA400402933 |
24 | L>V | No |
ClinGen gnomAD |
|
|
CA400402975 rs1167436332 |
27 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
CA400402965 rs1406309999 |
27 | E>K | No |
ClinGen gnomAD |
|
|
CA400403008 rs1308890408 |
30 | S>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1440164378 CA400403025 |
32 | V>A | No |
ClinGen gnomAD |
|
|
rs1440164378 CA400403027 |
32 | V>G | No |
ClinGen gnomAD |
|
|
rs755438586 CA8680383 |
33 | C>F | No |
ClinGen ExAC gnomAD |
|
|
CA8680382 rs752038735 |
33 | C>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755438586 CA400403032 |
33 | C>S | No |
ClinGen ExAC gnomAD |
|
|
CA8680384 rs781559692 |
34 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1489714847 CA400403061 |
36 | D>H | No |
ClinGen TOPMed |
|
|
CA400403079 rs1304168983 |
37 | R>T | No |
ClinGen gnomAD |
|
|
rs759142376 CA292119684 |
39 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
| TCGA novel | 41 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8680404 rs778678371 |
42 | C>G | No |
ClinGen ExAC gnomAD |
|
|
rs1403896897 CA400403380 |
42 | C>Y | No |
ClinGen gnomAD |
|
| TCGA novel | 45 | Q>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA400403446 rs1297977658 |
47 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1323847826 CA400403470 |
49 | T>A | No |
ClinGen TOPMed |
|
|
CA400403490 rs1224730512 |
50 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1054542096 CA292119719 |
52 | T>S | No |
ClinGen TOPMed |
|
|
rs1269262884 CA400403529 |
53 | F>L | No |
ClinGen gnomAD |
|
| TCGA novel | 54 | P>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA400403545 rs1224870930 |
55 | I>V | No |
ClinGen gnomAD |
|
| TCGA novel | 56 | Q>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs779729021 CA8680407 |
56 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1393080749 CA400403574 |
57 | K>Q | No |
ClinGen TOPMed |
|
|
CA400403610 rs1461316255 |
59 | R>K | No |
ClinGen TOPMed gnomAD |
|
|
CA8680408 rs746457998 |
60 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1445655506 CA400403723 |
67 | R>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA8680410 rs372442650 |
68 | D>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8680412 rs369693869 |
70 | S>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 70 | S>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs773521950 CA8680413 |
72 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs559969785 CA8680414 |
73 | I>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1183430843 CA400403824 |
75 | T>A | No |
ClinGen TOPMed |
|
| TCGA novel | 79 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 79 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8680415 rs771127203 |
80 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs774421039 CA8680416 |
86 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs948789933 CA292119848 |
91 | Y>F | No |
ClinGen Ensembl |
|
| TCGA novel | 92 | E>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8680445 rs764600219 |
95 | F>V | No |
ClinGen ExAC gnomAD |
|
|
rs776860135 CA8680446 |
100 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762231558 CA8680447 |
103 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs141519169 CA400405532 |
105 | Q>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA400405545 rs1179083080 |
107 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA400405601 rs754573837 |
112 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8680450 rs754573837 |
112 | I>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1329025886 CA400405649 |
116 | Q>K | No |
ClinGen TOPMed |
|
|
CA8680453 rs150885026 |
122 | M>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA8680452 rs767165924 |
122 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs1386574596 CA400405727 |
125 | T>A | No |
ClinGen TOPMed |
|
|
rs777763519 CA8680455 |
125 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA400405726 rs1386574596 |
125 | T>P | No |
ClinGen TOPMed |
|
|
rs757026229 CA8680457 |
127 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs1310702257 CA400405747 |
128 | S>C | No |
ClinGen TOPMed gnomAD |
|
|
CA8680458 rs779149837 |
129 | K>I | No |
ClinGen ExAC gnomAD |
|
|
CA8680460 rs772237931 |
130 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA8680459 rs746124350 |
130 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs775441974 CA8680461 |
131 | G>R | No |
ClinGen ExAC |
|
| TCGA novel | 138 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs777179956 CA8680464 |
139 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
CA400405908 rs1248095512 |
141 | S>T | No |
ClinGen gnomAD |
|
|
rs922242973 CA292122694 |
142 | K>E | No |
ClinGen TOPMed gnomAD |
|
|
CA400406012 rs1486777882 |
143 | E>K | No |
ClinGen TOPMed |
|
|
CA292124354 rs139401056 |
145 | A>E | No |
ClinGen ESP |
|
|
CA8680478 rs778705834 |
145 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1216496001 CA400406049 |
146 | I>V | No |
ClinGen gnomAD |
|
|
rs1306957525 CA400406101 |
149 | M>I | No |
ClinGen gnomAD |
|
|
rs1462548564 CA400406167 |
156 | K>R | No |
ClinGen gnomAD |
|
|
CA400406216 rs1201709197 |
163 | N>S | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 166 | K>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1305641106 CA400406236 |
166 | K>R | No |
ClinGen TOPMed |
|
|
CA8680483 rs397843095 |
168 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8680484 rs781588633 |
170 | I>T | No |
ClinGen ExAC TOPMed |
|
|
rs925270330 CA292124393 |
176 | H>R | No |
ClinGen TOPMed |
|
| TCGA novel | 179 | T>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA292124599 rs796835899 |
183 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1402789874 CA400406611 |
185 | L>F | No |
ClinGen gnomAD |
|
|
rs1315689411 CA400406622 |
186 | F>C | No |
ClinGen gnomAD |
|
|
CA8680509 rs771298646 |
186 | F>L | No |
ClinGen ExAC TOPMed |
|
|
CA8680511 rs375856901 |
188 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 189 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs768140192 CA8680512 |
195 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs1305225341 CA400406757 |
197 | S>A | No |
ClinGen gnomAD |
|
|
rs2523371 COSM3403066 CA8680515 |
198 | P>A | central_nervous_system [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
rs1260703533 CA400406793 |
200 | R>K | No |
ClinGen gnomAD |
|
|
CA400406829 rs1374056579 |
203 | H>D | No |
ClinGen gnomAD |
|
|
rs184751983 CA8680516 |
203 | H>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8680517 rs762694128 |
206 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA400406868 rs762694128 |
206 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1222720870 CA400406887 |
208 | V>G | No |
ClinGen gnomAD |
|
|
rs139789772 CA8680518 |
208 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1280247401 CA400406892 |
209 | M>T | No |
ClinGen TOPMed |
|
| TCGA novel | 211 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1204842858 CA400406911 |
212 | T>S | No |
ClinGen TOPMed gnomAD |
|
|
rs751262139 CA8680519 |
213 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA292124630 rs1000425024 |
216 | A>G | No |
ClinGen TOPMed gnomAD |
|
|
CA292124632 rs1000425024 |
216 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1421689004 CA400406986 |
218 | L>F | No |
ClinGen TOPMed |
|
|
rs752883417 CA8680522 |
218 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1445664156 CA400407005 |
220 | A>T | No |
ClinGen gnomAD |
|
|
rs1364009731 CA400407066 |
225 | C>Y | No |
ClinGen gnomAD |
|
|
CA400407074 rs749845728 |
226 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1329549961 CA400407078 |
226 | P>R | No |
ClinGen gnomAD |
|
|
CA8680525 rs749845728 |
226 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779351905 CA8680527 |
231 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs779351905 CA400407126 |
231 | P>T | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 233 | R>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1375836842 CA627144966 |
234 | L>* | No |
ClinGen gnomAD |
|
|
rs1598143214 CA400407193 |
236 | P>L | No |
ClinGen Ensembl |
|
|
rs1230644744 CA400407196 |
237 | V>F | No |
ClinGen TOPMed |
|
| TCGA novel | 243 | N>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA400407276 rs1316698702 |
243 | N>S | No |
ClinGen gnomAD |
|
|
rs1273043297 CA400407300 |
245 | I>T | No |
ClinGen gnomAD |
|
|
CA8680529 rs768417749 |
245 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1178628984 CA400407326 |
248 | R>G | No |
ClinGen TOPMed |
|
|
rs776249309 CA400407329 |
248 | R>P | No |
ClinGen ExAC gnomAD |
|
|
CA8680530 rs776249309 |
248 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs769259657 CA8680532 |
251 | E>A | No |
ClinGen ExAC gnomAD |
|
|
rs1275446854 CA400407368 |
251 | E>D | No |
ClinGen TOPMed |
|
|
rs772666485 CA8680533 |
254 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA8680535 rs766169136 |
255 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA400407436 rs1472559220 |
258 | A>T | No |
ClinGen gnomAD |
|
|
rs774201074 CA8680536 |
258 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1373875506 CA400407591 |
266 | I>V | No |
ClinGen gnomAD |
|
|
CA400407644 rs1358191087 |
269 | N>K | No |
ClinGen TOPMed |
|
|
rs973959557 CA292124788 |
278 | F>Y | No |
ClinGen TOPMed |
|
|
rs1303173249 CA400408331 |
286 | E>D | No |
ClinGen TOPMed |
|
|
rs774132500 CA8680558 |
294 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs1417430250 CA400408474 |
295 | M>K | No |
ClinGen gnomAD |
|
|
rs1386886990 CA400408468 |
295 | M>V | No |
ClinGen gnomAD |
|
|
rs1297234973 CA400408503 |
296 | A>V | No |
ClinGen gnomAD |
|
|
CA400408549 rs1345560072 |
299 | V>I | No |
ClinGen gnomAD |
|
|
rs1331102900 CA400408588 |
301 | Y>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1299804475 CA400408582 |
301 | Y>D | No |
ClinGen TOPMed gnomAD |
|
|
CA8680559 rs759414152 |
302 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA400408674 rs1271253165 |
305 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
CA400408745 rs1349009559 |
308 | T>I | No |
ClinGen gnomAD |
|
|
rs2523376 CA292125120 |
309 | T>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA400408767 rs1358090474 |
310 | L>V | No |
ClinGen TOPMed |
|
|
CA292125133 rs546867586 |
311 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1182466887 CA400408988 |
318 | C>W | No |
ClinGen gnomAD |
|
|
rs761789387 CA8680565 |
319 | Y>C | No |
ClinGen ExAC |
|
|
rs1598145273 CA400409016 |
320 | G>* | No |
ClinGen Ensembl |
|
|
CA8680566 rs765826060 |
320 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs758865205 CA8680568 |
322 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs371749406 CA8680627 |
326 | Q>E | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs371749406 CA8680626 |
326 | Q>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA400409442 rs1416896861 |
327 | Q>R | No |
ClinGen TOPMed |
|
|
rs1250451565 CA400409454 |
328 | R>K | No |
ClinGen TOPMed |
|
|
CA400409474 rs1320553273 |
329 | R>S | No |
ClinGen gnomAD |
|
|
rs1157802165 CA400409493 |
331 | F>V | No |
ClinGen gnomAD |
|
|
CA400409520 rs767998768 |
333 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775781471 CA8680629 |
333 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA8680628 rs767998768 |
333 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1318395244 CA400409534 |
334 | P>S | No |
ClinGen gnomAD |
|
|
rs750074222 CA8680632 |
335 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs1209757854 CA400409553 |
336 | P>T | No |
ClinGen TOPMed |
|
|
rs1168499599 CA400409564 |
337 | G>A | No |
ClinGen gnomAD |
|
|
CA8680633 rs138939353 |
338 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8680634 rs766012505 |
343 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1399233957 CA400409622 |
346 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
rs751058166 CA8680635 |
348 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
CA400409649 rs1335765079 |
350 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA8680637 rs574737069 |
354 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA400409680 rs1343700143 |
355 | D>V | No |
ClinGen TOPMed |
|
| TCGA novel | 356 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 356 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8680638 rs752493564 |
357 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA400410002 rs1346624765 |
359 | Y>* | No |
ClinGen gnomAD |
|
|
CA400410003 rs1222735980 |
360 | V>M | No |
ClinGen TOPMed |
|
|
rs1310832495 CA400410023 |
363 | G>S | No |
ClinGen TOPMed |
|
| TCGA novel | 366 | V>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 366 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs752649524 CA8680657 |
366 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA400410095 rs1487341276 |
373 | P>T | No |
ClinGen gnomAD |
|
|
rs755954717 CA8680658 |
374 | R>I | No |
ClinGen ExAC gnomAD |
|
|
CA400410121 rs1224599456 |
377 | L>V | No |
ClinGen gnomAD |
|
|
rs1288923271 CA400410130 |
378 | D>A | No |
ClinGen TOPMed |
|
|
rs777557974 CA8680659 |
382 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA400410173 rs1411529649 |
385 | I>V | No |
ClinGen TOPMed |
|
|
CA400410183 rs1200953377 |
386 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1250408090 CA400410327 |
406 | F>V | No |
ClinGen TOPMed |
|
|
CA400410462 rs1213236935 |
424 | P>T | No |
ClinGen TOPMed |
|
|
rs572053476 CA292126550 |
426 | I>L | No |
ClinGen 1000Genomes |
|
|
CA400410536 rs1598150911 |
435 | V>I | No |
ClinGen Ensembl |
|
|
CA400410669 rs1332580983 |
452 | L>S | No |
ClinGen TOPMed |
|
|
rs1444948876 CA400410683 |
454 | P>A | No |
ClinGen TOPMed |
|
|
CA8680678 rs757021826 |
460 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA400410755 rs1199223011 |
465 | K>E | No |
ClinGen gnomAD |
|
|
rs1598156799 CA400410763 |
466 | Q>K | No |
ClinGen Ensembl |
|
|
rs1456304506 CA400410789 |
469 | Q>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1177596134 CA400410805 |
471 | D>G | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA400410816 rs1256486682 |
473 | I>V | No |
ClinGen gnomAD |
|
|
CA400410828 rs1444032361 |
474 | D>E | No |
ClinGen TOPMed |
|
|
CA400410822 rs1161765432 |
474 | D>N | No |
ClinGen TOPMed |
|
|
CA400410832 rs1425036141 |
475 | R>K | No |
ClinGen gnomAD |
|
|
CA8680708 rs766509574 |
478 | H>R | No |
ClinGen ExAC |
|
|
rs1361217454 CA400411134 |
478 | H>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs1401983648 CA400411154 |
479 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1401983648 CA400411152 |
479 | V>D | No |
ClinGen TOPMed gnomAD |
|
|
CA8680709 rs751720073 |
482 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA400411248 rs1451471225 |
487 | V>M | No |
ClinGen TOPMed |
|
| TCGA novel | 488 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA400411255 rs1285408687 |
488 | E>Q | No |
ClinGen TOPMed |
|
|
CA400411271 rs1301657350 |
490 | P>A | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA400411273 rs1313769565 |
490 | P>L | No |
ClinGen gnomAD |
|
|
rs781774662 CA8680711 |
494 | H>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 497 | C>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs778203917 CA8680714 |
498 | A>P | No |
ClinGen ExAC gnomAD |
|
|
rs778203917 CA400411366 |
498 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA8680715 rs749609122 |
499 | V>I | No |
ClinGen ExAC |
|
|
rs1248117371 CA400411393 |
500 | I>R | No |
ClinGen gnomAD |
|
|
CA8680716 rs562694135 |
504 | S>F | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs774979768 CA8680717 |
506 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA400411547 rs1224336136 |
512 | L>F | No |
ClinGen TOPMed |
|
|
rs1369896411 CA400411563 |
513 | P>L | No |
ClinGen TOPMed |
|
|
rs768181823 CA8680719 |
515 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8680720 rs776066618 |
515 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs769555475 CA8680723 |
517 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA8680721 rs761755655 |
517 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1267686357 CA400411635 |
519 | S>C | No |
ClinGen gnomAD |
|
|
CA400411633 rs1296355691 |
519 | S>P | No |
ClinGen gnomAD |
|
|
rs1598159773 CA400411697 |
523 | V>G | No |
ClinGen Ensembl |
|
|
CA400411691 rs1429887231 |
523 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs766674022 CA8680726 |
525 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1333169805 CA400411744 |
528 | V>A | No |
ClinGen TOPMed |
|
|
rs1200886600 CA400411730 |
528 | V>F | No |
ClinGen gnomAD |
|
|
CA8680743 rs773001666 |
530 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA400411760 rs1166703461 |
531 | E>Q | No |
ClinGen gnomAD |
|
|
rs1444280918 CA400411780 |
533 | Q>R | No |
ClinGen TOPMed |
|
|
rs1598174082 CA400411821 |
539 | R>G | No |
ClinGen Ensembl |
|
|
CA292131954 rs932638334 |
541 | R>* | No |
ClinGen TOPMed |
|
|
rs1205611360 CA400411838 |
541 | R>Q | No |
ClinGen TOPMed |
|
| TCGA novel | 542 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs762847650 CA8680744 |
542 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA8680746 rs774240093 |
545 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8680748 rs767847178 |
551 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs376151196 CA8680750 |
557 | A>V | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1046601854 CA292132143 |
567 | G>E | No |
ClinGen TOPMed |
|
|
CA8680772 rs762234654 |
570 | A>G | No |
ClinGen ExAC |
|
|
rs776713218 CA8680771 |
570 | A>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 572 | W>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8680774 rs750849571 |
575 | K>T | No |
ClinGen ExAC gnomAD |
|
|
CA400412410 rs1165876568 |
579 | H>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1395532928 CA400412417 |
580 | W>R | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 581 | R>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA400412461 rs1335825273 |
586 | A>T | No |
ClinGen gnomAD |
|
|
rs200066612 CA292132187 COSM982068 |
588 | R>C | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs200066612 CA8680777 |
588 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA8680778 rs755745082 |
588 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA400412477 rs755745082 |
588 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748825947 CA8680780 |
592 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs748825947 CA400412499 |
592 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
rs1346203679 CA400412505 |
593 | L>I | No |
ClinGen gnomAD |
|
| TCGA novel | 593 | L>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8680782 rs368453009 |
594 | R>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs745697239 CA8680783 |
594 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA292132215 rs899098144 |
595 | E>K | No |
ClinGen TOPMed |
|
|
rs1265441121 CA400412564 |
602 | Q>* | No |
ClinGen gnomAD |
|
|
rs1265441121 CA400412563 |
602 | Q>E | No |
ClinGen gnomAD |
|
|
CA400412650 rs1328070464 |
603 | Q>R | No |
ClinGen TOPMed gnomAD |
|
|
CA292133913 rs979431618 |
613 | G>A | No |
ClinGen Ensembl |
|
|
CA292133921 rs369046977 |
614 | P>L | No |
ClinGen ESP ExAC gnomAD |
|
|
rs369046977 CA8680812 |
614 | P>R | No |
ClinGen ESP ExAC gnomAD |
|
|
rs925288813 CA292133929 |
615 | K>E | No |
ClinGen Ensembl |
|
|
rs774634392 CA8680813 |
616 | H>L | No |
ClinGen ExAC gnomAD |
|
|
CA400412837 rs1239696455 |
617 | E>G | No |
ClinGen gnomAD |
|
|
rs759920447 CA8680814 |
617 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA400412841 rs1180384917 |
618 | V>I | No |
ClinGen gnomAD |
|
|
CA400412853 rs1181373006 |
620 | R>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA400412854 rs1368558325 COSM191919 |
620 | R>Q | Variant assessed as Somatic; 0.0 impact. large_intestine prostate [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs1459859609 CA400412873 |
623 | L>V | No |
ClinGen gnomAD |
|
|
rs763694059 CA8680815 |
624 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1472936136 CA400412889 |
625 | A>G | No |
ClinGen TOPMed |
|
|
rs1466521808 CA400412895 |
626 | G>A | No |
ClinGen gnomAD |
|
|
CA400412901 rs1567900203 |
627 | Y>C | No |
ClinGen Ensembl |
|
|
CA8680818 rs764848896 |
629 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs991055636 CA292133955 |
633 | R>G | No |
ClinGen Ensembl |
|
| TCGA novel | 636 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA292105829 rs1049932971 |
639 | T>M | No |
ClinGen TOPMed |
|
|
rs1303693959 CA400413992 |
639 | T>P | No |
ClinGen TOPMed gnomAD |
|
|
CA400413994 rs1303693959 |
639 | T>S | No |
ClinGen TOPMed gnomAD |
|
|
rs539150022 CA8680832 |
643 | M>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8680833 rs772508336 |
646 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8680834 rs753352443 |
646 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs1265614378 CA400414045 |
647 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA400414072 rs1213804101 |
651 | H>D | No |
ClinGen TOPMed |
|
|
CA8680836 rs148552104 |
652 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 653 | H>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1226209145 CA400414092 |
653 | H>Q | No |
ClinGen gnomAD |
|
|
rs766271992 CA8680839 |
657 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1256222916 CA400414115 |
657 | A>V | No |
ClinGen gnomAD |
|
|
rs1027915064 CA292106174 |
663 | T>S | No |
ClinGen Ensembl |
|
|
rs759522523 CA8680858 |
669 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA8680859 rs767352983 |
672 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA400414239 rs1164649184 |
673 | V>L | No |
ClinGen gnomAD |
|
|
CA400414248 rs1213394835 |
674 | L>W | No |
ClinGen TOPMed |
|
|
rs752547846 CA8680860 |
676 | T>N | No |
ClinGen ExAC gnomAD |
|
|
CA400414286 rs1343292001 |
680 | Y>C | No |
ClinGen gnomAD |
|
|
rs1372964175 CA400414293 |
681 | A>G | No |
ClinGen gnomAD |
|
|
rs754081507 CA8680863 COSM982078 |
681 | A>T | Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs865960853 CA292106219 |
684 | V>G | No |
ClinGen Ensembl |
|
|
rs369320452 CA8680864 |
684 | V>I | No |
ClinGen ESP ExAC gnomAD |
|
| TCGA novel | 686 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs745927262 CA8680866 |
687 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA8680867 rs770146463 |
688 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770146463 CA400414334 |
688 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM191921 CA8680868 rs780681873 |
688 | R>H | pancreas large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs559169845 CA400414344 |
689 | Y>* | No |
ClinGen gnomAD |
|
| TCGA novel | 689 | Y>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA400414349 rs1467456682 |
690 | E>G | No |
ClinGen gnomAD |
|
|
CA400414347 rs1275408603 |
690 | E>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA8680869 rs747421171 |
692 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs777091523 CA8680871 |
697 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1407381086 CA400414435 |
702 | F>Y | No |
ClinGen gnomAD |
|
|
CA400414448 rs1451915328 |
704 | A>T | No |
ClinGen gnomAD |
|
|
rs1567904447 CA400414458 |
705 | H>R | No |
ClinGen Ensembl |
|
|
rs1418400037 CA400414456 |
705 | H>Y | No |
ClinGen gnomAD |
|
|
CA400414507 rs1324974939 |
712 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs141945224 COSM982084 CA8680876 |
713 | R>C | endometrium [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA292106307 rs374274847 |
713 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs374274847 CA8680877 |
713 | R>P | No |
ClinGen ExAC gnomAD |
|
|
rs529784000 CA292106324 |
719 | A>G | No |
ClinGen Ensembl |
|
|
CA400414575 rs879331825 |
722 | R>S | No |
ClinGen TOPMed |
|
|
rs1229374111 CA400414578 |
723 | W>R | No |
ClinGen gnomAD |
|
|
CA8680879 rs763889511 |
726 | K>* | No |
ClinGen ExAC |
|
|
rs146141913 CA8680880 |
727 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs757563128 CA8680881 |
731 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1213388102 CA400414655 |
734 | D>N | No |
ClinGen gnomAD |
|
|
rs1443346410 CA400414681 |
736 | I>V | No |
ClinGen gnomAD |
|
|
rs544885439 CA400414690 |
737 | S>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA8680912 rs544885439 |
737 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA8680915 rs372012056 |
739 | D>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 739 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA8680916 rs746504742 |
740 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768625906 CA8680917 |
742 | K>E | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 742 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 745 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA400414785 rs1250681055 |
750 | D>G | No |
ClinGen gnomAD |
|
|
rs769501766 CA8680920 |
752 | S>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA400414805 rs1181838221 |
753 | I>K | No |
ClinGen gnomAD |
|
|
CA400414806 rs1181838221 |
753 | I>T | No |
ClinGen gnomAD |
|
|
CA400414813 rs1329474534 |
754 | S>C | No |
ClinGen gnomAD |
|
|
CA8680923 rs766704902 |
757 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8680922 rs763276276 |
757 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs751747695 CA8680924 |
758 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA8680925 rs759667190 |
759 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA400414851 rs1567906912 |
761 | L>F | No |
ClinGen Ensembl |
|
| TCGA novel | 764 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs368343588 CA8680926 |
764 | K>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA8680927 rs753164187 |
765 | Q>L | No |
ClinGen ExAC |
|
|
CA400414890 rs1392206922 |
766 | Q>R | No |
ClinGen gnomAD |
|
|
CA8680929 rs764369751 |
768 | T>N | No |
ClinGen ExAC gnomAD |
|
|
rs1260727438 CA400414914 |
770 | D>H | No |
ClinGen gnomAD |
|
|
rs1567907018 CA400414918 |
770 | D>V | No |
ClinGen Ensembl |
|
|
rs1326263616 CA400414923 |
771 | H>Y | No |
ClinGen gnomAD |
|
|
CA400414930 rs1416402005 |
772 | S>G | No |
ClinGen Ensembl |
|
|
rs1413933429 CA400414943 |
773 | D>E | No |
ClinGen TOPMed |
|
|
rs964476548 CA292107479 |
773 | D>H | No |
ClinGen Ensembl |
|
|
rs143165826 CA8680931 |
775 | R>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 775 | R>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA292107483 rs922991360 |
777 | E>G | No |
ClinGen Ensembl |
|
|
rs954769716 CA292107484 |
779 | G>V | No |
ClinGen gnomAD |
No associated diseases with Q8IX18
6 regional properties for Q8IX18
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase, C-terminal | 263 - 442 | IPR001650 |
| conserved_site | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site | 168 - 177 | IPR002464 |
| domain | Helicase-associated domain | 462 - 557 | IPR007502 |
| domain | DEAD/DEAH box helicase domain | 60 - 216 | IPR011545 |
| domain | DEAD-box helicase, OB fold | 619 - 698 | IPR011709 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 47 - 240 | IPR014001 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43329 | hrpA | ATP-dependent RNA helicase HrpA | Escherichia coli (strain K12) | PR |
| O60231 | DHX16 | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 | Homo sapiens (Human) | PR |
| Q6P158 | DHX57 | Putative ATP-dependent RNA helicase DHX57 | Homo sapiens (Human) | PR |
| Q7L7V1 | DHX32 | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 | Homo sapiens (Human) | PR |
| O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | Homo sapiens (Human) | PR |
| Q9H2U1 | DHX36 | ATP-dependent DNA/RNA helicase DHX36 | Homo sapiens (Human) | PR |
| Q8IY37 | DHX37 | Probable ATP-dependent RNA helicase DHX37 | Homo sapiens (Human) | PR |
| Q92620 | DHX38 | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 | Homo sapiens (Human) | PR |
| Q9BKQ8 | ddx-35 | Probable ATP-dependent RNA helicase DHX35 homolog | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRFPAVAGR | APRRQEEGER | SRDLQEERLS | AVCIADREEK | GCTSQEGGTT | PTFPIQKQRK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KIIQAVRDNS | FLIVTGNTGS | GKTTQLPKYL | YEAGFSQHGM | IGVTQPRKVA | AISVAQRVAE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EMKCTLGSKV | GYQVRFDDCS | SKETAIKYMT | DGCLLKHILG | DPNLTKFSVI | ILDEAHERTL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TTDILFGLLK | KLFQEKSPNR | KEHLKVVVMS | ATMELAKLSA | FFGNCPIFDI | PGRLYPVREK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FCNLIGPRDR | ENTAYIQAIV | KVTMDIHLNE | MAGDILVFLT | GQFEIEKSCE | LLFQMAESVD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YDYDVQDTTL | DGLLILPCYG | SMTTDQQRRI | FLPPPPGIRK | CVISTNISAT | SLTIDGIRYV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VDGGFVKQLN | HNPRLGLDIL | EVVPISKSEA | LQRSGRAGRT | SSGKCFRIYS | KDFWNQCMPD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HVIPEIKRTS | LTSVVLTLKC | LAIHDVIRFP | YLDPPNERLI | LEALKQLYQC | DAIDRSGHVT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RLGLSMVEFP | LPPHLTCAVI | KAASLDCEDL | LLPIAAMLSV | ENVFIRPVDP | EYQKEAEQRH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RELAAKAGGF | NDFATLAVIF | EQCKSSGAPA | SWCQKHWIHW | RCLFSAFRVE | AQLRELIRKL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KQQSDFPKET | FEGPKHEVLR | RCLCAGYFKN | VARRSVGRTF | CTMDGRGSPV | HIHPSSALHE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QETKLEWIIF | HEVLVTTKVY | ARIVCPIRYE | WVRDLLPKLH | EFNAHDLSSV | ARREVREDAR |
| 730 | 740 | 750 | 760 | 770 | |
| RRWTNKENVK | QLKDGISKDV | LKKMQRRNDD | KSISDARARF | LERKQQRTQD | HSDTRKETG |