AiPD: Autoinhibited Protein Database

Q9H2U1

Gene name	DHX36
Protein name	ATP-dependent DNA/RNA helicase DHX36
Names	DEAD/H box polypeptide 36, DEAH-box protein 36, G4-resolvase-1, G4R1, MLE-like protein 1, RNA helicase associated with AU-rich element protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:170506
EC number	3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-211 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-211 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q9H2U1

Entry ID	Method	Resolution	Chain	Position	Source
2N16	NMR	-	A	53-70	PDB
2N21	NMR	-	A	53-70	PDB
6Q6R	X-ray	150 A	E/F/G/H	53-81	PDB
AF-Q9H2U1-F1	Predicted				AlphaFoldDB

660 variants for Q9H2U1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1440204061 CA355120834	2	S>N		No	ClinGen gnomAD
rs370181315 CA2674428	3	Y>H		No	ClinGen ESP ExAC gnomAD
CA2674427 rs771686732	4	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1170756954 CA355120811	5	Y>C		No	ClinGen gnomAD
rs375589062 CA2674426	5	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs372982076 CA2674424	6	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs773934907 CA2674425	6	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2674423 rs748752789	7	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs777707368 CA2674422	8	N>D		No	ClinGen ExAC TOPMed gnomAD
rs756053986 CA2674421 CA355120790	8	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1181666717 CA355120777	10	G>D		No	ClinGen gnomAD
CA355120774 rs1576888682	11	R>S		No	ClinGen Ensembl
rs1329511191 CA355120749	14	G>D		No	ClinGen TOPMed gnomAD
TCGA novel CA355120750 rs1329511191	14	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed gnomAD NCI-TCGA
CA2674420 rs747936122	16	R>C		No	ClinGen ExAC gnomAD
rs745406144 CA2674419	16	R>H		No	ClinGen ExAC TOPMed gnomAD
CA2674418 rs758611003	17	S>N		No	ClinGen ExAC TOPMed gnomAD
CA355120735 rs758611003	17	S>T		No	ClinGen ExAC TOPMed gnomAD
CA355120727 rs1272470194	18	S>C		No	ClinGen gnomAD
CA355120730 rs1306010350	18	S>P		No	ClinGen gnomAD
rs750691599 CA355120721	19	G>A		No	ClinGen ExAC gnomAD
rs1247186254 CA355120723	19	G>S		No	ClinGen gnomAD
rs750691599 CA2674417	19	G>V		No	ClinGen ExAC gnomAD
rs1009578310 CA85784465	21	G>A		No	ClinGen TOPMed gnomAD
rs533475988 CA2674414	22	Y>S		No	ClinGen ExAC
rs753922693 CA2674413	24	G>R		No	ClinGen ExAC gnomAD
CA2674412 rs764748750	25	G>R		No	ClinGen ExAC gnomAD
rs1306964560 CA355120687	25	G>V		No	ClinGen gnomAD
rs759751451 CA2674407	26	P>R		No	ClinGen ExAC gnomAD
rs1559963470 CA355120684	26	P>S		No	ClinGen Ensembl
CA2674406 rs774020317	27	A>E		No	ClinGen ExAC gnomAD
rs770517246 CA2674405	28	G>E		No	ClinGen ExAC gnomAD
CA2674404 rs762496026	30	H>L		No	ClinGen ExAC TOPMed gnomAD
rs1479663687 CA355120653	31	G>E		No	ClinGen gnomAD
CA355120655 rs1479663687	31	G>V		No	ClinGen gnomAD
rs1576888584 CA355120650	32	G>C		No	ClinGen Ensembl
rs772676265 CA2674403	34	R>Q		No	ClinGen ExAC gnomAD
CA355120631 rs1223494155	35	G>A		No	ClinGen gnomAD
CA85784464 rs764811567	35	G>S		No	ClinGen Ensembl
CA2674401 rs748106524	37	G>E		No	ClinGen ExAC gnomAD
CA355120623 rs1290013457	37	G>R		No	ClinGen gnomAD
CA2674397 rs576957075	44	G>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs576957075 CA355120579	44	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1370526043 CA355120580	44	G>R		No	ClinGen gnomAD
rs576957075 CA355120578	44	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2674396 rs779300245	45	G>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	45	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs376557871 CA2674395	46	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs558792451 CA2674393	47	R>P		No	ClinGen 1000Genomes ExAC gnomAD
rs1345725102 CA355120556	49	G>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	49	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2674392 rs756088630	49	G>V		No	ClinGen ExAC gnomAD
rs1559963379 CA355120551	50	R>W		No	ClinGen Ensembl
CA2674390 rs753252393	51	G>S		No	ClinGen ExAC TOPMed gnomAD
CA2674389 rs376376653	52	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA355120519 rs1486365314	55	G>A		No	ClinGen gnomAD
CA355120522 rs200451346 CA2674387	55	G>R		No	ClinGen ExAC gnomAD
CA355120506 rs1314660044	57	L>R		No	ClinGen gnomAD
CA2674384 rs772770487	57	L>V		No	ClinGen ExAC gnomAD
CA355120494 rs1200601058	59	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1223544645 CA355120482	61	E>G		No	ClinGen gnomAD
rs769364061 CA2674383	61	E>K		No	ClinGen ExAC
rs1159039437 CA355120467	63	G>A		No	ClinGen TOPMed
rs1347047519 CA355120469	63	G>S		No	ClinGen TOPMed gnomAD
CA85784461 rs866694888 CA85784462	64	M>I		No	ClinGen TOPMed
CA2674382 rs761165750	64	M>L		No	ClinGen ExAC gnomAD
CA2674381 rs776661898	66	Y>F		No	ClinGen ExAC gnomAD
CA2674379 rs746851158	68	K>E		No	ClinGen ExAC gnomAD
rs1451511014 CA355120427	69	K>T		No	ClinGen gnomAD
CA355120394 rs1427488260	73	K>N		No	ClinGen TOPMed gnomAD
rs199746825 CA2674375	74	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2674376 rs749533653	74	N>S		No	ClinGen ExAC gnomAD
rs756248849 CA2674374	75	K>R		No	ClinGen ExAC gnomAD
rs767557562 CA2674373	76	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1185343876 CA355120368	77	A>G		No	ClinGen gnomAD
CA2674371 rs187165766	79	R>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1259848519 CA355120351	80	Q>E		No	ClinGen Ensembl
CA2674343 rs760194903	84	V>I		No	ClinGen ExAC gnomAD
rs1429562996 CA355120291	86	H>Q		No	ClinGen gnomAD
rs1386248260 CA355120284	87	M>I		No	ClinGen gnomAD
TCGA novel	87	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201423228 CA2674342	88	D>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs375298743 CA2674341	90	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA85783560 rs954292951	90	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA355120262 rs1186267485	91	R>*		No	ClinGen gnomAD
rs759420266 CA2674340	91	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs770117599 CA2674338	93	E>A		No	ClinGen ExAC gnomAD
CA2674339 rs773983100	93	E>Q		No	ClinGen ExAC gnomAD
rs748303595 CA2674337	94	Q>K		No	ClinGen ExAC gnomAD
TCGA novel	95	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs976806523 CA85783559	95	I>V		No	ClinGen TOPMed
TCGA novel	96	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA355120226 rs1481761535	97	Q>E		No	ClinGen TOPMed
CA2674334 rs747055754	97	Q>R		No	ClinGen ExAC gnomAD
rs967186926 CA85783557	98	L>S		No	ClinGen Ensembl
rs780565013 CA2674333	99	L>V		No	ClinGen ExAC gnomAD
rs758881420 CA2674332	101	S>Y		No	ClinGen ExAC gnomAD
CA2674331 rs746285368	104	A>T		No	ClinGen ExAC gnomAD
CA2674330 rs372294393	104	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA85783556 rs142405159	105	K>R		No	ClinGen ESP TOPMed
CA355120170 rs1390675087	106	N>D		No	ClinGen gnomAD
CA355120156 rs1159630633	107	D>E		No	ClinGen gnomAD
rs1412003608 CA355120161	107	D>Y		No	ClinGen TOPMed
rs572056315 CA2674327	110	S>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1164733878 CA355120139	110	S>A		No	ClinGen TOPMed
rs572056315 CA355120135	110	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA355120128 rs1472066814	111	E>D		No	ClinGen gnomAD
rs1022716866 CA85783555	113	Q>R		No	ClinGen TOPMed
rs777526815 CA2674326	114	I>V		No	ClinGen ExAC gnomAD
rs1449604463 CA355120104	115	S>Y		No	ClinGen gnomAD
rs755707305 CA2674325	116	W>S		No	ClinGen ExAC gnomAD
rs369663360 CA2674324	117	F>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2674323 rs767599231	118	A>V		No	ClinGen ExAC TOPMed gnomAD
rs759383912 CA2674322	119	P>S		No	ClinGen ExAC TOPMed gnomAD
CA355120071 rs1381688056	120	E>V		No	ClinGen TOPMed
CA2674321 rs377209125	122	H>Y		No	ClinGen ESP ExAC gnomAD
CA2674320 rs766104286	123	G>E		No	ClinGen ExAC TOPMed
CA2674294 rs138481688	124	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1412418114 CA355120017	127	E>K		No	ClinGen gnomAD
rs374481403 CA2674292	130	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA2674291 rs759618376	130	T>I		No	ClinGen ExAC gnomAD
rs1454421554 CA355119981	132	N>S		No	ClinGen TOPMed
rs774738637 CA2674290	133	T>A		No	ClinGen ExAC TOPMed gnomAD
CA355119972 rs1388301072	134	P>T		No	ClinGen gnomAD
CA2674289 rs771442180	135	C>Y		No	ClinGen ExAC gnomAD
CA2674288 rs749710536	137	E>K		No	ClinGen ExAC TOPMed gnomAD
CA355119934 rs1404600321	139	K>R		No	ClinGen TOPMed
rs1225542681 CA355119926	140	L>P		No	ClinGen gnomAD
CA355119915 rs1284140683	142	I>V		No	ClinGen TOPMed
rs566031900 CA2674286	143	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA355119896 rs1559959785	144	E>D		No	ClinGen Ensembl
CA355119898 rs1221856437	144	E>G		No	ClinGen TOPMed
rs1221856437 CA355119897	144	E>V		No	ClinGen TOPMed
rs1306274182 CA355119893	145	K>E		No	ClinGen TOPMed
rs747815107 COSM1040209 CA2674285	145	K>N	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs945630937 CA355119874	147	L>F		No	ClinGen TOPMed gnomAD
CA355119869 rs1234893253	148	I>K		No	ClinGen gnomAD
rs367855835 CA2674283	148	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	149	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1304088085 CA355119860	149	N>K		No	ClinGen gnomAD
rs1445125300 CA355119857	150	Q>E		No	ClinGen gnomAD
rs1445125300 CA355119858	150	Q>K		No	ClinGen gnomAD
rs879119392 CA85783470	150	Q>P		No	ClinGen gnomAD
CA85783469 rs879119392	150	Q>R		No	ClinGen gnomAD
rs779905545 CA2674281	151	E>D		No	ClinGen ExAC gnomAD
rs1058299 VAR_027140 CA2674282	151	E>K		No	ClinGen UniProt ExAC dbSNP gnomAD
CA355119843 rs1319877362	152	K>T		No	ClinGen gnomAD
CA85783468 rs923207712	153	K>N		No	ClinGen TOPMed
rs373108427	154	M>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA2674280 rs758329623	154	M>L		No	ClinGen ExAC gnomAD
rs1393934825 CA355119817	155	F>L		No	ClinGen gnomAD
CA2674277 rs750288689	156	R>G		No	ClinGen ExAC gnomAD
CA355119797 rs1445178962	156	R>T		No	ClinGen TOPMed gnomAD
rs1053785889 CA85783467	160	R>G		No	ClinGen Ensembl
CA2674276 rs756991329	160	R>S		No	ClinGen ExAC TOPMed gnomAD
CA2674274 rs752946103	161	S>T		No	ClinGen ExAC TOPMed
rs746768660 CA85783466	162	Y>C		No	ClinGen Ensembl
CA85783465 rs1015561990	163	I>V		No	ClinGen TOPMed
rs766862291 CA2674270	165	R>Q		No	ClinGen ExAC
CA355119669 rs1482315163	166	D>V		No	ClinGen gnomAD
CA2674269 rs763540594	167	S>F		No	ClinGen ExAC gnomAD
rs1383483307 CA355119363	172	Q>P		No	ClinGen TOPMed
CA2674267 rs770285464	173	E>G		No	ClinGen ExAC gnomAD
rs748486094 CA2674266	175	E>G		No	ClinGen ExAC gnomAD
CA355119342 rs1559959675	175	E>K		No	ClinGen Ensembl
rs1424065620 CA355119336	176	P>S		No	ClinGen TOPMed
CA355119327 rs1226167723	177	D>G		No	ClinGen gnomAD
CA355119325 rs1226167723	177	D>V		No	ClinGen gnomAD
rs1559959664 CA355119316	179	T>P		No	ClinGen Ensembl
rs776171731 CA2674265	180	L>S		No	ClinGen ExAC TOPMed gnomAD
rs768333798 CA2674264	184	L>F		No	ClinGen ExAC TOPMed gnomAD
rs746541770 CA2674263	185	L>W		No	ClinGen ExAC
CA355119267 rs1368257371	186	E>K		No	ClinGen gnomAD
CA2674262 rs779616243	188	L>V		No	ClinGen ExAC TOPMed gnomAD
CA355119234 rs1351565397	189	Q>K		No	ClinGen gnomAD
TCGA novel	193	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs61757215 CA2674259 CA2674260	194	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1408797895 CA355119152	194	D>G		No	ClinGen gnomAD
CA355119145 rs1471738542	195	L>F		No	ClinGen gnomAD
CA355119135 rs757064717	196	R>G		No	ClinGen ExAC TOPMed gnomAD
COSM1420116 rs370724025 CA2674257	196	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
COSM23511 rs757064717 CA2674258	196	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs571544760 CA2674255	199	E>G		No	ClinGen 1000Genomes ExAC gnomAD
CA355119105 rs1221472102	199	E>Q		No	ClinGen gnomAD
rs970803871 CA85783463	200	M>I		No	ClinGen TOPMed gnomAD
CA85783099 rs963787216	202	H>Y		No	ClinGen TOPMed gnomAD
rs770821327 CA2674239	205	E>G		No	ClinGen ExAC gnomAD
CA2674238 rs749100005	207	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA2674237 rs777610388 COSM1040207	209	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA2674236 rs755806882	210	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA355118226 rs1416615950	212	M>I		No	ClinGen TOPMed
CA355118223 rs1293330018	213	Q>*		No	ClinGen TOPMed
rs1337710062 CA355118221	213	Q>R		No	ClinGen TOPMed gnomAD
CA355118196 rs1576877593	215	E>K		No	ClinGen Ensembl
rs760885157 CA2674220	218	N>D		No	ClinGen ExAC gnomAD
CA85782900 rs896783106	220	I>T		No	ClinGen TOPMed
CA2674219 rs775242605	220	I>V		No	ClinGen ExAC gnomAD
rs565024141 CA2674218	222	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2674217 rs759083962	224	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs149886314 CA2674214	226	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA2674213 rs777503457	228	I>V		No	ClinGen ExAC gnomAD
CA2674212 rs769660438	229	S>N		No	ClinGen ExAC gnomAD
rs747851403 CA2674211	229	S>R		No	ClinGen ExAC gnomAD
rs193282907 CA2674209	231	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA355118074 rs1227183820	233	G>A		No	ClinGen TOPMed
CA355118078 rs1410646805	233	G>S		No	ClinGen gnomAD
TCGA novel	233	G>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs866037055 CA85782897	235	G>D		No	ClinGen Ensembl
CA2674208 rs758663359	246	D>V		No	ClinGen ExAC gnomAD
rs750597793 CA2674207	248	Y>C		No	ClinGen ExAC gnomAD
CA2674206 rs779126431	249	I>V		No	ClinGen ExAC gnomAD
rs764470095 CA2674203	258	R>T		No	ClinGen ExAC TOPMed gnomAD
CA355117899 rs761148618	259	I>L		No	ClinGen ExAC TOPMed gnomAD
CA355117897 rs1231169493	259	I>T		No	ClinGen gnomAD
CA2674202 rs761148618	259	I>V		No	ClinGen ExAC TOPMed gnomAD
CA85782896 rs917090818	260	V>I		No	ClinGen TOPMed gnomAD
rs188272051 CA85782895	262	T>P		No	ClinGen 1000Genomes
CA2674200 rs767220511	266	R>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2674183 rs778381631	272	V>I		No	ClinGen ExAC TOPMed gnomAD
CA355117354 rs778381631	272	V>L		No	ClinGen ExAC TOPMed gnomAD
rs756572280 CA2674182	273	A>T		No	ClinGen ExAC gnomAD
CA355117336 rs1297009891	273	A>V		No	ClinGen gnomAD
CA355117329 rs1332804295	274	E>G		No	ClinGen TOPMed
rs560624516 CA2674179	278	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs751242466 CA2674178	280	R>K		No	ClinGen ExAC gnomAD
CA2674176 rs762575010	282	E>*		No	ClinGen ExAC gnomAD
rs545178351 CA2674174	283	S>F		No	ClinGen 1000Genomes ExAC gnomAD
rs1399763825 CA355117218	284	C>F		No	ClinGen gnomAD
rs200760394 CA85782519	286	S>R		No	ClinGen Ensembl
CA2674172 rs776656161	288	N>S		No	ClinGen ExAC gnomAD
rs761644070 CA2674173	288	N>Y		No	ClinGen ExAC gnomAD
rs768580381 CA2674171	290	T>A		No	ClinGen ExAC TOPMed gnomAD
CA2674169 rs774740694	294	I>V		No	ClinGen ExAC gnomAD
CA355117144 rs1466359277	295	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs771024580 CA2674168	298	S>G		No	ClinGen ExAC gnomAD
rs189057829 CA2674153	299	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs761343968 CA2674154	299	R>W		No	ClinGen ExAC gnomAD
rs764076484 CA2674152	302	R>K		No	ClinGen ExAC gnomAD
CA2674151 rs760599389	303	K>R		No	ClinGen ExAC gnomAD
CA355117078 rs1279467174	304	Q>K		No	ClinGen TOPMed
CA85782402 rs899176569	304	Q>R		No	ClinGen TOPMed gnomAD
CA355117072 rs1207652992	305	G>S		No	ClinGen gnomAD
CA355117062 rs1265052384	306	S>C		No	ClinGen Ensembl
CA85782401 rs1037895319	307	I>V		No	ClinGen TOPMed gnomAD
rs1274484799 CA355117046	309	Y>H		No	ClinGen TOPMed gnomAD
rs771239703 CA2674149	312	T>I		No	ClinGen ExAC gnomAD
rs1305700904 CA355116980	318	W>*		No	ClinGen gnomAD
CA355116959 rs1308443938	321	S>L		No	ClinGen gnomAD
rs769794924 CA2674146	321	S>T		No	ClinGen ExAC gnomAD
CA2674145 rs375675104	322	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs781700028 CA2674144	323	P>L		No	ClinGen ExAC TOPMed gnomAD
CA2674127 rs769979088	324	Y>C		No	ClinGen ExAC gnomAD
rs1235949164 CA355116912	327	S>G		No	ClinGen TOPMed
CA2674125 rs776689416	329	S>G		No	ClinGen ExAC TOPMed gnomAD
CA2674124 rs371491624	331	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1459672619 CA355116879	332	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA85782395 rs867608114	335	E>*		No	ClinGen Ensembl
CA85782394 rs536261791	344	D>G		No	ClinGen gnomAD
CA355116773 rs1467614875	347	M>V		No	ClinGen gnomAD
rs557690427 CA85782393	348	T>A		No	ClinGen 1000Genomes gnomAD
rs780544054 CA2674122	349	V>L		No	ClinGen ExAC gnomAD
CA355127321 rs1326571872	352	D>G		No	ClinGen gnomAD
CA85782391 rs3172334	354	L>I		No	ClinGen Ensembl
CA2674120 rs772357295	355	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1219544180 CA355127302	355	N>S		No	ClinGen gnomAD
rs746199451 COSM1566636 CA2674119	357	R>*	large_intestine Variant assessed as Somatic; 4.64e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA2674118 rs151135113	357	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs753453392 CA2674116	362	V>A		No	ClinGen ExAC gnomAD
CA2674114 rs142114460	363	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1419677023 CA355127243	364	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs767440112 CA2674112	364	L>M		No	ClinGen ExAC TOPMed gnomAD
CA355127246 rs1387383019	364	L>S		No	ClinGen TOPMed
rs1484707168 CA355127183	373	K>E		No	ClinGen gnomAD
rs762011011 CA2674108	376	E>K		No	ClinGen ExAC gnomAD
rs991112283 CA85782389	378	F>L		No	ClinGen Ensembl
rs1372997889 CA355127118	380	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA2674094 rs781031768	381	C>R		No	ClinGen ExAC TOPMed gnomAD
CA2674093 rs754937391	383	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA355127089 rs1299934150	384	I>T		No	ClinGen TOPMed
CA2674092 rs139842779	385	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA355127074 rs1324648858	386	I>M		No	ClinGen gnomAD
rs766175399 CA2674091	386	I>T		No	ClinGen ExAC gnomAD
rs1425220907 CA355127077	386	I>V		No	ClinGen gnomAD
CA355127069 rs1388826508	387	P>L		No	ClinGen gnomAD
CA2674090 rs758123951	387	P>S		No	ClinGen ExAC gnomAD
rs1210480391 CA355127065	388	G>A		No	ClinGen TOPMed
TCGA novel	390	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1483245039 CA355127039	392	P>A		No	ClinGen gnomAD
CA2674089 rs754091943	392	P>L		No	ClinGen ExAC TOPMed gnomAD
rs760718691 CA2674087	396	Y>C		No	ClinGen ExAC gnomAD
rs775613115 CA2674086	397	L>V		No	ClinGen ExAC gnomAD
rs999621606 CA85782248	398	L>V		No	ClinGen TOPMed gnomAD
CA355126983 rs529965388	400	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA355126989 rs1332986759	400	D>N		No	ClinGen gnomAD
rs1410870522 CA355126981	401	V>I		No	ClinGen TOPMed gnomAD
rs1176396180 CA355126968	403	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1362514485 CA355126949	405	I>K		No	ClinGen gnomAD
rs146498505 CA2674084	406	R>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs146498505 CA2674083	406	R>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA355126943 rs146498505	406	R>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2674065 rs759492179	407	Y>C		No	ClinGen ExAC gnomAD
rs1200907512 CA355126914	409	P>S		No	ClinGen gnomAD
CA2674058 rs761541315	414	H>Q		No	ClinGen ExAC gnomAD
CA2674059 rs769389381	414	H>R		No	ClinGen ExAC
rs543903099 CA2674060	414	H>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA355126871 rs1204957832	415	R>K		No	ClinGen gnomAD
CA2674057 rs9438 VAR_027141	416	S>C		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs9438 CA355126863	416	S>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746474123 CA2674055	423	M>T		No	ClinGen ExAC TOPMed gnomAD
CA355126815 rs1254892200	423	M>V		No	ClinGen gnomAD
rs1302098656 CA355126790	426	H>R		No	ClinGen gnomAD
CA2674052 rs745734355	427	V>A		No	ClinGen ExAC gnomAD
rs1010043030 CA85781992	428	N>H		No	ClinGen Ensembl
CA2674051 rs778759805	428	N>S		No	ClinGen ExAC gnomAD
rs201175580 CA2674050	429	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA2674049 rs752990736	431	E>G		No	ClinGen ExAC gnomAD
rs1432822056 CA355126743	433	E>A		No	ClinGen gnomAD
CA2674048 rs781220404	434	E>G		No	ClinGen ExAC gnomAD
rs1189351206 CA355126724	435	K>N		No	ClinGen gnomAD
rs755131401 CA2674047	437	A>V		No	ClinGen ExAC TOPMed
CA2674043 rs763540777	438	I>M		No	ClinGen ExAC gnomAD
CA355126707 rs751657520	438	I>R		No	ClinGen ExAC gnomAD
CA2674045 rs751657520	438	I>T		No	ClinGen ExAC gnomAD
CA355126701 rs1186038497	439	Y>C		No	ClinGen TOPMed
CA2674042 rs750902113	440	K>E		No	ClinGen ExAC gnomAD
rs765639976 CA2674041	442	R>C		No	ClinGen ExAC gnomAD
CA2674040 rs762046431	442	R>H		No	ClinGen ExAC TOPMed gnomAD
rs765639976 CA355126681	442	R>S		No	ClinGen ExAC gnomAD
CA355126659 rs1347815111	445	D>G		No	ClinGen TOPMed gnomAD
CA355126650 rs1405076107	446	Y>F		No	ClinGen TOPMed
CA2674037 rs149315263	449	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs149315263 CA355126631	449	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs774980712 CA2674036	451	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs191495075 CA2674034	452	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	452	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA355126610 rs1340631917	453	R>K		No	ClinGen gnomAD
TCGA novel	454	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2674024 rs758486477	455	S>F		No	ClinGen ExAC TOPMed gnomAD
rs371713336 CA355126579	456	A>S		No	ClinGen ESP gnomAD
CA85781964 rs371713336	456	A>T		No	ClinGen ESP gnomAD
CA2674023 rs750970956	456	A>V		No	ClinGen ExAC gnomAD
CA2674022 rs111899617	457	S>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	458	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1032424652 CA85781963	459	V>I		No	ClinGen TOPMed gnomAD
CA355126554 rs1444301834	460	D>G		No	ClinGen gnomAD
CA355126558 rs1308350099	460	D>N		No	ClinGen gnomAD
CA355126553 rs1444301834	460	D>V		No	ClinGen gnomAD
rs1352654246 CA355126550	461	V>I		No	ClinGen gnomAD
rs763875729 CA2674019	462	I>T		No	ClinGen ExAC gnomAD
CA355126529 rs1389639064	464	M>V		No	ClinGen TOPMed gnomAD
CA2674018 rs201400534	465	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	468	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2674016 rs775068749	470	V>A		No	ClinGen ExAC gnomAD
rs1179249482 CA355126472	471	D>G		No	ClinGen gnomAD
CA355126466 rs1395012777	472	L>Q		No	ClinGen TOPMed
rs112262409 CA85781961	473	N>D		No	ClinGen Ensembl
rs758993869 CA85781960	476	V>I		No	ClinGen ExAC gnomAD
CA2674014 rs758993869	476	V>L		No	ClinGen ExAC gnomAD
rs536514494 CA85781959	478	L>V		No	ClinGen Ensembl
rs1274726510 CA355126424	479	I>T		No	ClinGen gnomAD
rs1036399719 CA85781958	479	I>V		No	ClinGen Ensembl
CA2674013 rs774393087	480	R>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	481	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA355126417 rs1450721317	481	Y>N		No	ClinGen TOPMed
TCGA novel	481	Y>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770740239 CA2674012	483	V>I		No	ClinGen ExAC TOPMed gnomAD
rs749172236 CA2674011	485	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs762811159 CA2673993	488	D>V		No	ClinGen ExAC gnomAD
COSM728641 CA2673992 rs773134906	490	A>V	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1055041069 CA85781887	491	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA355126320 rs1452157323	494	F>L		No	ClinGen gnomAD
CA85781886 rs867985484	496	P>S		No	ClinGen Ensembl
rs1437163102 CA355126298	497	G>A		No	ClinGen gnomAD
rs1191263664 CA355126270	501	I>V		No	ClinGen gnomAD
rs775904709 CA2673989	502	S>N		No	ClinGen ExAC TOPMed gnomAD
CA355126233 rs1559952988	506	D>A		No	ClinGen Ensembl
TCGA novel	508	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA85781885 rs1045735686	509	M>V		No	ClinGen TOPMed gnomAD
rs746029389 CA2673987	510	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1259931668 CA355126196	511	Q>H		No	ClinGen gnomAD
rs916682162 CA85781884	512	V>I		No	ClinGen Ensembl
TCGA novel	519	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA355126116 rs1478788728	520	L>F		No	ClinGen TOPMed
CA2673954 rs761830719	521	I>V		No	ClinGen ExAC gnomAD
CA355126097 rs1395162267	523	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs776349643 CA2673952	523	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs774482192 CA2673950	528	M>I		No	ClinGen ExAC gnomAD
rs201995049 CA2673948	530	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA355126020 rs1365536357	535	Q>*		No	ClinGen gnomAD
rs766565110 CA355125967	540	T>I		No	ClinGen ExAC gnomAD
rs766565110 CA2673929	540	T>N		No	ClinGen ExAC gnomAD
CA2673927 rs773354597	543	G>R		No	ClinGen ExAC gnomAD
rs773354597 CA2673928	543	G>S		No	ClinGen ExAC gnomAD
CA85781246 rs143919087	545	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2673925 rs143919087	545	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs370292953 CA2673926	545	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA355125934 rs1486405293	547	I>V		No	ClinGen TOPMed
CA2673922 rs376255288	548	V>A		No	ClinGen ESP ExAC gnomAD
CA2673921 rs775911753	549	I>V		No	ClinGen ExAC gnomAD
rs555040815 CA2673919	554	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2673881 rs769129846	560	I>M		No	ClinGen ExAC gnomAD
CA2673882 rs777343688	560	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	561	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749806167 COSM3004427 CA2673880	562	D>G	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1204653300 CA355125817	563	V>I		No	ClinGen gnomAD
rs754807929 CA355125810	564	V>F		No	ClinGen ExAC TOPMed gnomAD
rs754807929 CA2673878	564	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2673877 rs751332755	565	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA2673876 rs779164052	570	G>A		No	ClinGen ExAC gnomAD
CA2673875 rs375099457	572	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs911524805 CA85781118	575	T>M		No	ClinGen TOPMed gnomAD
CA355125735 rs1231204154	575	T>S		No	ClinGen gnomAD
CA355125732 rs1300923973	576	H>N		No	ClinGen TOPMed
CA85781117 rs934434664	576	H>R		No	ClinGen gnomAD
CA2673872 rs760620287	582	N>S		No	ClinGen ExAC TOPMed gnomAD
CA85781116 VAR_027142 rs17853513	583	I>N		No	ClinGen UniProt Ensembl dbSNP
rs1405027474 CA355125679	583	I>V		No	ClinGen TOPMed
rs747991225 CA2673871	584	S>C		No	ClinGen ExAC gnomAD
rs747991225 CA85781115	584	S>G		No	ClinGen ExAC gnomAD
CA2673870 rs768102537	585	T>I		No	ClinGen ExAC gnomAD
rs774855423 CA2673868	586	M>L		No	ClinGen ExAC TOPMed gnomAD
rs1405105096 CA355125661	586	M>T		No	ClinGen gnomAD
rs774855423 CA85781114	586	M>V		No	ClinGen ExAC TOPMed gnomAD
CA2673866 rs762683262	588	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1469002134 CA355125646	588	A>V		No	ClinGen gnomAD
CA355125630 rs1468682616	590	W>C		No	ClinGen gnomAD
CA2673864 rs769378583	597	K>E		No	ClinGen ExAC gnomAD
rs778305476	599	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA2673861 rs781157437	600	K>R		No	ClinGen ExAC TOPMed gnomAD
CA355125550 rs1223273053	602	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	602	R>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1576864462 CA355125532	605	R>K		No	ClinGen Ensembl
CA2673843 rs763189600	606	V>I		No	ClinGen ExAC TOPMed gnomAD
CA2673842 rs772959037	607	Q>H		No	ClinGen ExAC gnomAD
CA2673841 rs764775767	608	P>A		No	ClinGen ExAC TOPMed gnomAD
CA355125501 rs1576862260	608	P>R		No	ClinGen Ensembl
TCGA novel	609	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761444991 CA2673840	610	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA355125474 rs1374135662	612	Y>C		No	ClinGen TOPMed
TCGA novel	615	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1429025334 CA355125447	616	N>D		No	ClinGen gnomAD
rs1314010717 CA355125417	620	A>G		No	ClinGen gnomAD
rs1396372358 CA355125396	624	D>H		No	ClinGen gnomAD
rs775355206 CA2673836	626	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs371829924 CA85780788	631	I>N		No	ClinGen ESP
rs771930327 CA2673835	633	R>T		No	ClinGen ExAC gnomAD
CA2673834 rs745616345	634	T>I		No	ClinGen ExAC gnomAD
rs143189936 CA2673833	637	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	638	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1262462940 CA355125285	640	C>Y		No	ClinGen gnomAD
CA355125261 rs1211525526	643	I>T		No	ClinGen gnomAD
CA355125254 rs1233159297	644	K>R		No	ClinGen TOPMed
rs535950163 CA2673814	647	R>K		No	ClinGen 1000Genomes ExAC gnomAD
rs755150998 CA2673812	649	G>A		No	ClinGen ExAC gnomAD
CA2673813 rs755150998	649	G>D		No	ClinGen ExAC gnomAD
rs2666194 CA355125213	649	G>R		No	ClinGen gnomAD
rs2666194 CA85780729	649	G>S		No	ClinGen gnomAD
rs747063807 CA2673810	650	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1057155848 CA85780727	651	I>T		No	ClinGen Ensembl
CA2673809 rs374959754	652	A>S		No	ClinGen ESP ExAC gnomAD
CA355125190 rs1463763987	653	Y>C		No	ClinGen gnomAD
TCGA novel	655	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs908638366 CA85780726	659	M>T		No	ClinGen TOPMed gnomAD
CA85780725 rs984168279	661	P>A		No	ClinGen TOPMed gnomAD
rs984168279 CA355125135	661	P>S		No	ClinGen TOPMed gnomAD
rs984168279 CA85780724	661	P>T		No	ClinGen TOPMed gnomAD
TCGA novel	663	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA355125112 rs1419530710	664	N>K		No	ClinGen gnomAD
rs765531803 CA2673806	667	V>E		No	ClinGen ExAC TOPMed gnomAD
CA355125097 rs1247490947	667	V>M		No	ClinGen TOPMed
CA355125089 rs1176799059	668	L>S		No	ClinGen gnomAD
rs1576861615 CA355125083	669	L>F		No	ClinGen Ensembl
rs1274013189 CA355125074	670	S>F		No	ClinGen gnomAD
CA85780722 rs201582480	671	I>M		No	ClinGen 1000Genomes TOPMed gnomAD
CA2673803 rs763701497	671	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA355125055 rs1240396068	673	H>Q		No	ClinGen gnomAD
CA2673786 rs746382604	678	N>Y		No	ClinGen ExAC gnomAD
rs757655851 CA2673784	679	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA355124971 rs149205201	684	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs149205201 CA2673782	684	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs773557405	685	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	685	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA85780292 rs1023547104	687	T>I		No	ClinGen TOPMed
CA355124943 rs1382539365	688	P>A		No	ClinGen gnomAD
rs1382539365 CA355124942	688	P>S		No	ClinGen gnomAD
rs1362459799 CA355124918	692	H>Y		No	ClinGen gnomAD
CA2673780 rs755754972	695	R>*		No	ClinGen ExAC gnomAD
rs752340783 CA2673779	695	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs766960645 CA2673778	697	P>L		No	ClinGen ExAC
rs375447310 CA2673776	698	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs773137935 CA2673773	701	H>R		No	ClinGen ExAC TOPMed gnomAD
CA355124863 rs1449445667	701	H>Y		No	ClinGen gnomAD
CA355124856 rs1357657536	702	I>F		No	ClinGen TOPMed
CA355124854 rs1168794447	702	I>T		No	ClinGen gnomAD
CA355124814 rs1222257475	708	F>L		No	ClinGen TOPMed
rs1424691368 CA355124796	710	A>V		No	ClinGen gnomAD
CA85780289 rs372524615	712	F>L		No	ClinGen Ensembl
rs1261405159 CA355124781	713	C>G		No	ClinGen TOPMed gnomAD
TCGA novel	717	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA355124742 rs1249904189	718	V>A		No	ClinGen TOPMed
rs1194332211 CA355124746	718	V>I		No	ClinGen TOPMed
CA85780287 rs998897815	720	T>A		No	ClinGen TOPMed gnomAD
rs1280443240 CA355124728	721	I>V		No	ClinGen gnomAD
CA355124709 rs1383306234	724	S>G		No	ClinGen TOPMed
CA2673770 rs775729954	724	S>T		No	ClinGen ExAC gnomAD
rs199954319 CA85780285	725	L>F		No	ClinGen Ensembl
rs1342485127 CA355124699	725	L>R		No	ClinGen gnomAD
CA355124697 rs1443734599	726	S>G		No	ClinGen TOPMed
TCGA novel	727	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768176187 CA2673769	728	K>R		No	ClinGen ExAC gnomAD
rs370305174 CA2673767	732	V>I		No	ClinGen ESP ExAC gnomAD
rs370305174 CA85780284	732	V>L		No	ClinGen ESP ExAC gnomAD
rs1043187850 CA85780283	733	I>V		No	ClinGen TOPMed
TCGA novel	737	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA85780276 rs1006752629	738	E>G		No	ClinGen Ensembl
CA355124579 rs1467398968	741	A>V		No	ClinGen gnomAD
rs1432551622 CA355124578	742	D>N		No	ClinGen Ensembl
CA85780275 rs889193975	743	A>G		No	ClinGen TOPMed
CA2673749 rs759590228	743	A>S		No	ClinGen ExAC gnomAD
CA85780274 rs889193975	743	A>V		No	ClinGen TOPMed
TCGA novel	745	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1173603513 CA355124549	746	K>R		No	ClinGen TOPMed
CA2673748 rs774480904	749	A>T		No	ClinGen ExAC gnomAD
CA2673747 rs763254140	751	D>N		No	ClinGen ExAC TOPMed gnomAD
CA355124516 rs763254140	751	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs1472720050 CA355124479	756	H>D		No	ClinGen gnomAD
CA2673745 rs773671514	760	V>A		No	ClinGen ExAC gnomAD
rs773260677 CA2673744	762	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	767	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1465022762 CA355124068	768	E>G		No	ClinGen TOPMed
CA2673708 rs753647774	771	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
CA2673707 rs777634590	771	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM728643 CA2673706 rs755829356	772	R>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs751823753 CA2673705	772	R>H		No	ClinGen ExAC TOPMed gnomAD
CA2673704 rs766568571	774	F>C		No	ClinGen ExAC gnomAD
CA355124009 rs1477564808	775	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1263556631 CA355124004	775	R>S		No	ClinGen gnomAD
COSM1420110 CA355123989 rs1487247381	777	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs983909341 CA85780009	779	D>N		No	ClinGen TOPMed
CA355123909 rs1211664222	783	E>G		No	ClinGen gnomAD
CA2673701 rs765164564	784	Y>F		No	ClinGen ExAC gnomAD
rs762396977 CA2673700	789	N>D		No	ClinGen ExAC gnomAD
rs776953926 CA2673699	790	T>I		No	ClinGen ExAC gnomAD
CA85779999 rs952113824	792	Q>R		No	ClinGen TOPMed
rs146446831 CA2673682	796	N>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA355123686 rs1398242873	796	N>K		No	ClinGen gnomAD
CA355123679 rs1484180595	797	M>T		No	ClinGen TOPMed
rs1185888771 CA355123659	799	G>R		No	ClinGen TOPMed
CA2673681 rs530250010	799	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1300529451 CA355123620	802	A>T		No	ClinGen gnomAD
rs1164939005 CA355123545	809	G>A		No	ClinGen TOPMed
CA2673679 rs754409173	812	S>R		No	ClinGen ExAC gnomAD
rs1172611926 CA355123473	816	P>A		No	ClinGen gnomAD
rs1463863908 CA355123471	816	P>H		No	ClinGen gnomAD
CA355123448 rs1165415483	818	D>G		No	ClinGen gnomAD
CA355123417 rs1425443544	821	S>Y		No	ClinGen gnomAD
rs756689810 CA2673656	826	D>A		No	ClinGen ExAC gnomAD
rs112204498 CA85779429	828	E>G		No	ClinGen Ensembl
rs1265369789 CA355123295	829	K>T		No	ClinGen gnomAD
rs762931017 CA85779427	835	I>V		No	ClinGen TOPMed gnomAD
CA85779422 rs766398981	836	C>F		No	ClinGen ExAC TOPMed gnomAD
CA2673655 rs766398981	836	C>S		No	ClinGen ExAC TOPMed gnomAD
rs768012758 CA2673654	841	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA355123162 rs1391845027	842	K>R		No	ClinGen TOPMed
CA355123136 rs1334781429	844	A>G		No	ClinGen gnomAD
CA355123106 rs1324011744	847	R>Q		No	ClinGen TOPMed gnomAD
rs527309363 CA85779410	849	N>K		No	ClinGen gnomAD
rs1158088108 CA355123085	850	L>M		No	ClinGen TOPMed gnomAD
rs1388559804 CA355123072	851	G>D		No	ClinGen gnomAD
rs1388559804 CA355123069	851	G>V		No	ClinGen gnomAD
rs1035914470 CA85779407	853	K>N		No	ClinGen Ensembl
CA85778787 rs1033707683	856	M>I		No	ClinGen Ensembl
CA2673653 rs199890757	856	M>T		No	ClinGen 1000Genomes ExAC gnomAD
rs753284230 CA2673634	858	K>N		No	ClinGen ExAC
CA355122147 rs1195502919	858	K>R		No	ClinGen TOPMed
rs768118881 CA355122131	860	Y>D		No	ClinGen ExAC gnomAD
rs768118881 CA2673633	860	Y>H		No	ClinGen ExAC gnomAD
CA355122091 rs751870066	864	D>H		No	ClinGen ExAC TOPMed gnomAD
CA2673631 rs751870066	864	D>N		No	ClinGen ExAC TOPMed gnomAD
CA2673630 rs766702613	867	V>A		No	ClinGen ExAC gnomAD
CA355121988 rs1319449725	878	Q>E		No	ClinGen TOPMed
rs761280991 CA2673627	880	D>H		No	ClinGen ExAC gnomAD
rs761280991 CA2673626	880	D>Y		No	ClinGen ExAC gnomAD
rs776597389 CA2673625	882	H>N		No	ClinGen ExAC gnomAD
COSM1040187 CA2673624 rs372465114	884	N>S	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA2673623 rs760584736	885	W>C		No	ClinGen ExAC gnomAD
TCGA novel	886	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA355121914 rs1429870397	888	Y>C		No	ClinGen gnomAD
CA2673622 rs368518294	889	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	889	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA355121894 rs1284270899	891	K>R		No	ClinGen TOPMed
rs1405581806 CA355121862	895	S>R		No	ClinGen gnomAD
rs1394534782 CA355121864	895	S>T		No	ClinGen gnomAD
CA2673606 rs199866859	898	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1166071480 CA355121796 COSM1203546	903	T>A	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1384021500 CA355121785	904	E>D		No	ClinGen gnomAD
CA2673604 rs760538965	905	V>I		No	ClinGen ExAC gnomAD
CA355121754 rs1203534130	909	C>S		No	ClinGen gnomAD
CA85778551 rs757479472	910	L>F		No	ClinGen Ensembl
rs1207928464 CA355121700	917	I>F		No	ClinGen TOPMed gnomAD
CA85778547 rs866726380	920	Q>K		No	ClinGen Ensembl
CA355121653 rs377323319	923	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs998150992 CA355121649	924	D>A		No	ClinGen TOPMed
rs998150992 CA85778542	924	D>G		No	ClinGen TOPMed
CA2673598 rs151188512	924	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA85778539 rs902108724	926	E>K		No	ClinGen TOPMed
rs781438310 CA2673597	926	E>V		No	ClinGen ExAC gnomAD
CA355121613 rs1279376763	929	A>V		No	ClinGen gnomAD
CA355121602 rs1200671964	931	D>G		No	ClinGen TOPMed gnomAD
CA355121601 rs1200671964	931	D>V		No	ClinGen TOPMed gnomAD
rs750771753 CA2673592	933	W>*		No	ClinGen ExAC gnomAD
CA355121541 rs1364444849	940	A>T		No	ClinGen gnomAD
TCGA novel	942	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	943	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753427207 CA2673589	944	H>Q		No	ClinGen ExAC gnomAD
CA2673590 rs756907366	944	H>R		No	ClinGen ExAC TOPMed gnomAD
rs142222613 CA2673591	944	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA355121446 rs1559942446	952	E>K		No	ClinGen Ensembl
CA355121439 rs1479521182	953	L>V		No	ClinGen TOPMed
rs144256684 CA85778421	955	I>M		No	ClinGen ESP gnomAD
rs779262363 CA2673572	955	I>T		No	ClinGen ExAC gnomAD
rs1196984514 CA355121426	955	I>V		No	ClinGen gnomAD
CA2673570 rs748967470	959	E>G		No	ClinGen ExAC gnomAD
rs777448506 CA355121392	960	K>M		No	ClinGen ExAC gnomAD
CA2673569 rs777448506	960	K>R		No	ClinGen ExAC gnomAD
CA355121385 rs1576852179	961	I>T		No	ClinGen Ensembl
CA2673568 rs755625188	962	E>Q		No	ClinGen ExAC gnomAD
rs752250569 CA2673567	965	H>Y		No	ClinGen ExAC gnomAD
CA355121352 rs1277011065	966	P>S		No	ClinGen TOPMed gnomAD
rs766874499 CA2673566	967	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
rs1223249933 CA355121337	968	D>E		No	ClinGen gnomAD
rs1441179765 CA355121342	968	D>H		No	ClinGen TOPMed
CA355121328 rs1319294505	969	W>*		No	ClinGen gnomAD
CA2673565 rs377213039	970	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs866209660 CA85778410	972	T>A		No	ClinGen Ensembl
CA85778407 rs1032662220	975	R>G		No	ClinGen TOPMed gnomAD
rs1424792297 CA355121278	977	C>S		No	ClinGen TOPMed
CA355121274 rs1287727041	977	C>S		No	ClinGen TOPMed gnomAD
CA355121275 rs1287727041	977	C>Y		No	ClinGen TOPMed gnomAD
CA2673563 rs766309241	979	V>I		No	ClinGen ExAC gnomAD
rs777044563 CA2673561	983	I>V		No	ClinGen ExAC gnomAD
rs1297969330 CA355121231	984	I>M		No	ClinGen TOPMed
rs905581871 CA85778400	984	I>V		No	ClinGen TOPMed
TCGA novel	985	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA85778397 rs201136651	990	Q>L		No	ClinGen Ensembl
TCGA novel	992	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2673560 rs555450521	994	T>P		No	ClinGen 1000Genomes ExAC gnomAD
rs372847714 CA2673559	996	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1426624053 CA355120930	997	N>S		No	ClinGen gnomAD
CA355120917 rs1261160680	999	P>A		No	ClinGen gnomAD
CA2673558 rs147970714	999	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA85778389 rs894924455	1000	P>T		No	ClinGen TOPMed
CA2673556 rs143454337	1001	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs140010768 CA2673555	1001	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA355120882 rs1260348335	1004	D>E		No	ClinGen gnomAD
rs147479799 CA2673554	1005	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA85778382 rs867399225	1006	Y>C		No	ClinGen gnomAD
CA2673552 rs61757598	1008	S>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1009	S>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1009	S>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q9H2U1

6 regional properties for Q9H2U1

Type	Name	Position	InterPro Accession
domain	Helicase, C-terminal	477 - 647	IPR001650
conserved_site	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site	329 - 338	IPR002464
domain	Helicase-associated domain	669 - 760	IPR007502
domain	DEAD/DEAH box helicase domain	212 - 372	IPR011545
domain	DEAD-box helicase, OB fold	831 - 917	IPR011709
domain	Helicase superfamily 1/2, ATP-binding domain	205 - 396	IPR014001

Functions

		Description
EC Number	3.6.4.12	Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization	Nucleus Cytoplasm Cytoplasm, cytosol Cytoplasm, Stress granule Nucleus speckle Chromosome, telomere Mitochondrion Perikaryon Cell projection, dendrite Cell projection, axon	Predominantly localized in the nucleus (PubMed:18279852) Colocalizes with SRSF2 in nuclear speckles (PubMed:18279852) Colocalizes with DDX5 in nucleolar caps upon transcription inhibition (PubMed:18279852) Accumulates and colocalized with TIA1 in cytoplasmic stress granules (SGs) in an arsenite-, heat shock- and RNA-binding-dependent manner (PubMed:18854321) Shuttles into and out of SGs in an ATPase-dependent manner (PubMed:18854321) Colocalizes in the cytosol with the multi-helicase-TICAM1 complex that translocates to the mitochondria upon poly(I:C) RNA ligand stimulation (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

12 GO annotations of cellular component

Name	Definition
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
chromosome, telomeric region	The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule	A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perikaryon	The portion of the cell soma (neuronal cell body) that excludes the nucleus.

19 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent activity, acting on DNA	Catalytic activity that acts to modify DNA, driven by ATP hydrolysis.
DNA helicase activity	Unwinding of a DNA helix, driven by ATP hydrolysis.
double-stranded RNA binding	Binding to double-stranded RNA.
G-quadruplex DNA binding	Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome.
G-quadruplex RNA binding	Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad.
histone deacetylase binding	Binding to histone deacetylase.
magnesium ion binding	Binding to a magnesium (Mg) ion.
mRNA 3'-UTR AU-rich region binding	Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs.
mRNA 3'-UTR binding	Binding to a 3' untranslated region of an mRNA molecule.
mRNA 5'-UTR binding	Binding to an mRNA molecule at its 5' untranslated region.
pre-miRNA binding	Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA.
RNA binding	Binding to an RNA molecule or a portion thereof.
RNA helicase activity	Unwinding of an RNA helix, driven by ATP hydrolysis.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
single-stranded DNA binding	Binding to single-stranded DNA.
telomerase RNA binding	Binding to the telomerase RNA template.
transcription cis-regulatory region binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

32 GO annotations of biological process

Name	Definition
3'-UTR-mediated mRNA destabilization	An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cellular response to arsenite ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus.
cellular response to heat	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
cellular response to UV	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
defense response to virus	Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
G-quadruplex DNA unwinding	The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
negative regulation of translation	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
ossification	The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
positive regulation of cardioblast differentiation	Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
positive regulation of cytoplasmic translation	Any process that activates or increases the frequency, rate or extent of cytoplasmic translation.
positive regulation of dendritic spine morphogenesis	Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of hematopoietic progenitor cell differentiation	Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation.
positive regulation of I-kappaB kinase/NF-kappaB signaling	Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
positive regulation of interferon-alpha production	Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
positive regulation of intracellular mRNA localization	Any process that activates or increases the frequency, rate or extent of intracellular mRNA localization.
positive regulation of mRNA 3'-end processing	Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing.
positive regulation of myeloid dendritic cell cytokine production	Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production.
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.
positive regulation of telomere maintenance	Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
positive regulation of telomere maintenance via telomere lengthening	Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of transcription initiation by RNA polymerase II	Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.
regulation of embryonic development	Any process that modulates the frequency, rate or extent of embryonic development.
regulation of mRNA stability	Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
regulation of transcription by RNA polymerase III	Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III.
response to exogenous dsRNA	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
RNA secondary structure unwinding	The process in which a secondary structure of RNA are broken or 'melted'.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
telomerase RNA stabilization	Prevention of degradation of telomerase RNA (TERC) molecules.

10 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P43329	hrpA	ATP-dependent RNA helicase HrpA	Escherichia coli (strain K12)	PR
O60231	DHX16	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16	Homo sapiens (Human)	PR
Q8IX18	DHX40	Probable ATP-dependent RNA helicase DHX40	Homo sapiens (Human)	PR
Q6P158	DHX57	Putative ATP-dependent RNA helicase DHX57	Homo sapiens (Human)	PR
Q7L7V1	DHX32	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32	Homo sapiens (Human)	PR
O43143	DHX15	ATP-dependent RNA helicase DHX15	Homo sapiens (Human)	PR
Q8IY37	DHX37	Probable ATP-dependent RNA helicase DHX37	Homo sapiens (Human)	PR
Q92620	DHX38	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16	Homo sapiens (Human)	PR
Q14BI7	Tdrd9	ATP-dependent RNA helicase TDRD9	Mus musculus (Mouse)	PR
Q8VHK9	Dhx36	ATP-dependent DNA/RNA helicase DHX36	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSYDYHQNWG	RDGGPRSSGG	GYGGGPAGGH	GGNRGSGGGG	GGGGGGRGGR	GRHPGHLKGR
70	80	90	100	110	120
EIGMWYAKKQ	GQKNKEAERQ	ERAVVHMDER	REEQIVQLLN	SVQAKNDKES	EAQISWFAPE
130	140	150	160	170	180
DHGYGTEVST	KNTPCSENKL	DIQEKKLINQ	EKKMFRIRNR	SYIDRDSEYL	LQENEPDGTL
190	200	210	220	230	240
DQKLLEDLQK	KKNDLRYIEM	QHFREKLPSY	GMQKELVNLI	DNHQVTVISG	ETGCGKTTQV
250	260	270	280	290	300
TQFILDNYIE	RGKGSACRIV	CTQPRRISAI	SVAERVAAER	AESCGSGNST	GYQIRLQSRL
310	320	330	340	350	360
PRKQGSILYC	TTGIILQWLQ	SDPYLSSVSH	IVLDEIHERN	LQSDVLMTVV	KDLLNFRSDL
370	380	390	400	410	420
KVILMSATLN	AEKFSEYFGN	CPMIHIPGFT	FPVVEYLLED	VIEKIRYVPE	QKEHRSQFKR
430	440	450	460	470	480
GFMQGHVNRQ	EKEEKEAIYK	ERWPDYVREL	RRRYSASTVD	VIEMMEDDKV	DLNLIVALIR
490	500	510	520	530	540
YIVLEEEDGA	ILVFLPGWDN	ISTLHDLLMS	QVMFKSDKFL	IIPLHSLMPT	VNQTQVFKRT
550	560	570	580	590	600
PPGVRKIVIA	TNIAETSITI	DDVVYVIDGG	KIKETHFDTQ	NNISTMSAEW	VSKANAKQRK
610	620	630	640	650	660
GRAGRVQPGH	CYHLYNGLRA	SLLDDYQLPE	ILRTPLEELC	LQIKILRLGG	IAYFLSRLMD
670	680	690	700	710	720
PPSNEAVLLS	IRHLMELNAL	DKQEELTPLG	VHLARLPVEP	HIGKMILFGA	LFCCLDPVLT
730	740	750	760	770	780
IAASLSFKDP	FVIPLGKEKI	ADARRKELAK	DTRSDHLTVV	NAFEGWEEAR	RRGFRYEKDY
790	800	810	820	830	840
CWEYFLSSNT	LQMLHNMKGQ	FAEHLLGAGF	VSSRNPKDPE	SNINSDNEKI	IKAVICAGLY
850	860	870	880	890	900
PKVAKIRLNL	GKKRKMVKVY	TKTDGLVAVH	PKSVNVEQTD	FHYNWLIYHL	KMRTSSIYLY
910	920	930	940	950	960
DCTEVSPYCL	LFFGGDISIQ	KDNDQETIAV	DEWIVFQSPA	RIAHLVKELR	KELDILLQEK
970	980	990	1000
IESPHPVDWN	DTKSRDCAVL	SAIIDLIKTQ	EKATPRNFPP	RFQDGYYS