Q8VHK9

PR
Gene name
Dhx36
Protein name
ATP-dependent DNA/RNA helicase DHX36
Names
DEAD/H box polypeptide 36, DEAH box protein 36, MLE-like protein 1, RNA helicase associated with AU-rich element ARE
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:72162
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q8VHK9

Entry ID Method Resolution Chain Position Source
6UP2 X-ray 197 A A 153-982 PDB
6UP3 X-ray 269 A A 153-982 PDB
6UP4 X-ray 240 A A 153-982 PDB
AF-Q8VHK9-F1 Predicted AlphaFoldDB

27 variants for Q8VHK9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs218967670 11 R>C No EVA
rs233234300 17 G>A No EVA
rs224043268 160 S>T No EVA
rs265181789 240 N>D No EVA
rs3388625108 299 S>F No EVA
rs3388613653 306 G>R No EVA
rs3388626815 315 D>Y No EVA
rs3388619775 418 G>D No EVA
rs3388627150 453 D>Y No EVA
rs3388628741 493 N>K No EVA
rs3388634717 502 M>K No EVA
rs3388625096 528 Q>P No EVA
rs47785188 543 A>T No EVA
rs3388634653 576 I>N No EVA
rs3388634016 576 I>V No EVA
rs3388626763 578 T>I No EVA
rs3388632757 624 I>N No EVA
rs213872523 656 S>T No EVA
rs3388630675 670 L>* No EVA
rs3388626811 673 L>W No EVA
rs3388630716 696 G>R No EVA
rs3388636507 731 E>D No EVA
rs3388630717 732 K>R No EVA
rs3388630671 735 D>Y No EVA
rs3388631356 758 G>S No EVA
rs3388634713 912 I>L No EVA
rs3388634643 988 P>L No EVA

No associated diseases with Q8VHK9

4 regional properties for Q8VHK9

Type Name Position InterPro Accession
repeat Leucine-rich repeat 66 - 87 IPR001611-1
repeat Leucine-rich repeat 88 - 109 IPR001611-2
repeat Leucine-rich repeat 110 - 131 IPR001611-3
repeat Leucine-rich repeat 132 - 153 IPR001611-4

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Cytoplasm, cytosol
  • Cytoplasm, Stress granule
  • Nucleus speckle
  • Chromosome, telomere
  • Mitochondrion
  • Perikaryon
  • Cell projection, dendrite
  • Cell projection, axon
  • Predominantly localized in the nucleus
  • Colocalizes with SRSF2 in nuclear speckles
  • Colocalizes with DDX5 in nucleolar caps upon transcription inhibition
  • Accumulates and colocalized with TIA1 in cytoplasmic stress granules (SGs) in an arsenite-, heat shock- and RNA-binding-dependent manner
  • Shuttles into and out of SGs in an ATPase-dependent manner (By similarity)
  • Colocalizes in the cytosol with the multi-helicase-TICAM1 complex that translocates to the mitochondria upon poly(I:C) stimulation (PubMed:21703541)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

11 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.

19 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent activity, acting on DNA Catalytic activity that acts to modify DNA, driven by ATP hydrolysis.
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
double-stranded RNA binding Binding to double-stranded RNA.
G-quadruplex DNA binding Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome.
G-quadruplex RNA binding Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad.
histone deacetylase binding Binding to histone deacetylase.
magnesium ion binding Binding to a magnesium (Mg) ion.
mRNA 3'-UTR AU-rich region binding Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs.
mRNA 3'-UTR binding Binding to a 3' untranslated region of an mRNA molecule.
mRNA 5'-UTR binding Binding to an mRNA molecule at its 5' untranslated region.
pre-miRNA binding Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
single-stranded DNA binding Binding to single-stranded DNA.
telomerase RNA binding Binding to the telomerase RNA template.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

33 GO annotations of biological process

Name Definition
3'-UTR-mediated mRNA destabilization An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cellular response to arsenite ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus.
cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
cellular response to UV Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
G-quadruplex DNA unwinding The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
negative regulation of translation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
positive regulation of cardioblast differentiation Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
positive regulation of cytoplasmic translation Any process that activates or increases the frequency, rate or extent of cytoplasmic translation.
positive regulation of dendritic spine morphogenesis Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of hematopoietic progenitor cell differentiation Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation.
positive regulation of I-kappaB kinase/NF-kappaB signaling Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
positive regulation of interferon-alpha production Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
positive regulation of intracellular mRNA localization Any process that activates or increases the frequency, rate or extent of intracellular mRNA localization.
positive regulation of mRNA 3'-end processing Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing.
positive regulation of myeloid dendritic cell cytokine production Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production.
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.
positive regulation of telomere maintenance Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
positive regulation of telomere maintenance via telomere lengthening Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of transcription initiation by RNA polymerase II Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.
regulation of embryonic development Any process that modulates the frequency, rate or extent of embryonic development.
regulation of mRNA stability Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
regulation of transcription by RNA polymerase III Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III.
response to exogenous dsRNA Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
response to virus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
RNA secondary structure unwinding The process in which a secondary structure of RNA are broken or 'melted'.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
telomerase RNA stabilization Prevention of degradation of telomerase RNA (TERC) molecules.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P43329 hrpA ATP-dependent RNA helicase HrpA Escherichia coli (strain K12) PR
Q6P158 DHX57 Putative ATP-dependent RNA helicase DHX57 Homo sapiens (Human) PR
Q9H2U1 DHX36 ATP-dependent DNA/RNA helicase DHX36 Homo sapiens (Human) PR
Q14BI7 Tdrd9 ATP-dependent RNA helicase TDRD9 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSYDYHQSWS RDGGPRGSGQ GSSGGGGGGS RGSGGGGGGR GGRGRHPAHL KGREIGLWYA
70 80 90 100 110 120
KKQTQKNKEA ERQERAVVHM DERREEQIVQ LLNSVQAKTD KDSEAQISWF APEDHGYGTE
130 140 150 160 170 180
VSSEKKINSE KKLDNQEKKL LNQEKKTFRI TDKSYIDRDS EYLLQENEPN LSLDQHLLED
190 200 210 220 230 240
LQRKKTDPRY IEMQRFRKKL PSYGMQKELV NLINNHQVTV ISGETGCGKT TQVTQFILDN
250 260 270 280 290 300
YIERGKGSAC RIVCTQPRRI SAISVAERVA TERAESCGNG NSTGYQIRLQ SRLPRKQGSI
310 320 330 340 350 360
LYCTTGIILQ WLQSDSRLSS VSHIVLDEIH ERNLQSDVLM TVIKDLLHFR SDLKVILMSA
370 380 390 400 410 420
TLNAEKFSEY FGNCPMIHIP GFTFPVVEYL LEDIIEKIRY VPDQKEHRSQ FKRGFMQGHV
430 440 450 460 470 480
NRQEKEEKEA IYKERWPAYI KELRTRYSAS TVDVLQMMDD DKVDLNLIAA LIRYIVLEEE
490 500 510 520 530 540
DGAILVFLPG WDNISTLHDL LMSQVMFKSD KFLIIPLHSL MPTVNQTQVF KKTPPGVRKI
550 560 570 580 590 600
VIATNIAETS ITIDDVVYVI DGGKIKETHF DTQNNISTMS AEWVSKANAK QRKGRAGRVQ
610 620 630 640 650 660
PGHCYHLYNG LRASLLDDYQ LPEILRTPLE ELCLQIKILR LGGIAYFLSR LMDPPSNEAV
670 680 690 700 710 720
VLSIKHLMEL SALDKQEELT PLGVHLARLP VEPHIGKMIL FGALFCCLDP VLTIAASLSF
730 740 750 760 770 780
KDPFVIPLGK EKIADARRKE LAKETRSDHL TVVNAFEGWE EAKRRGFRYE KDYCWEYFLS
790 800 810 820 830 840
SNTLQMLHNM KGQFAEHLLG AGFVSSRSPK DPKANINSDN EKIIKAVICA GLYPKVAKIR
850 860 870 880 890 900
LNLGKKRKMV KVHTKSDGLV SIHPKSVNVE QTDFHYNWLI YHLKMRTSSI YLYDCTEVSP
910 920 930 940 950 960
YCLLFFGGDI SIQKDKDQEI IAVDEWIVFQ SPERIAHLVK GLRKELDSLL QEKIESPHPV
970 980 990 1000
DWDDTKSRDC AVLSAILDLI KTQEKATPRN LPPRSQDGYY S