Q14BI7
PR
Gene name |
Tdrd9 |
Protein name |
ATP-dependent RNA helicase TDRD9 |
Names |
Tudor domain-containing protein 9 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:74691 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q14BI7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q14BI7-F1 | Predicted | AlphaFoldDB |
58 variants for Q14BI7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs253325853 | 53 | T>M | No | EVA | |
| rs3389235506 | 71 | T>A | No | EVA | |
| rs249151287 | 73 | G>V | No | EVA | |
| rs225848228 | 73 | G>W | No | EVA | |
| rs48294427 | 99 | I>T | No | EVA | |
| rs3389262208 | 121 | V>L | No | EVA | |
| rs3389259180 | 130 | K>N | No | EVA | |
| rs3389262138 | 140 | K>E | No | EVA | |
| rs3389257927 | 163 | K>N | No | EVA | |
| rs3389262184 | 207 | W>R | No | EVA | |
| rs3389277291 | 232 | M>I | No | EVA | |
| rs3389229945 | 242 | V>L | No | EVA | |
| rs3389270566 | 290 | A>V | No | EVA | |
| rs240656616 | 299 | D>G | No | EVA | |
| rs29140496 | 299 | D>N | No | EVA | |
| rs3403925581 | 306 | Q>L | No | EVA | |
| rs3389261774 | 354 | Y>F | No | EVA | |
| rs3389259151 | 368 | D>V | No | EVA | |
| rs3389229949 | 409 | M>L | No | EVA | |
| rs226550582 | 505 | Y>H | No | EVA | |
| rs3389229941 | 549 | A>V | No | EVA | |
| rs3389261799 | 572 | E>V | No | EVA | |
| rs3389270590 | 586 | N>S | No | EVA | |
| rs219353946 | 683 | R>H | No | EVA | |
| rs3389261805 | 788 | L>P | No | EVA | |
| rs3389257965 | 825 | F>L | No | EVA | |
| rs216263397 | 879 | T>A | No | EVA | |
| rs3389255372 | 893 | P>H | No | EVA | |
| rs3389247717 | 896 | V>D | No | EVA | |
| rs3389272340 | 989 | H>Q | No | EVA | |
| rs261558184 | 993 | D>N | No | EVA | |
| rs263095500 | 1043 | G>S | No | EVA | |
| rs3389265031 | 1050 | K>M | No | EVA | |
| rs3389263962 | 1071 | D>V | No | EVA | |
| rs3389263896 | 1091 | S>Y | No | EVA | |
| rs3403926931 | 1125 | E>L | No | EVA | |
| rs3403730814 | 1130 | R>Q | No | EVA | |
| rs3403074123 | 1131 | I>N | No | EVA | |
| rs3403754374 | 1132 | L>P | No | EVA | |
| rs3403850949 | 1133 | L>* | No | EVA | |
| rs255997289 | 1138 | S>A | No | EVA | |
| rs241838208 | 1143 | A>T | No | EVA | |
| rs3389272309 | 1175 | I>V | No | EVA | |
| rs3389235512 | 1177 | K>E | No | EVA | |
| rs3389247778 | 1221 | H>R | No | EVA | |
| rs3389263951 | 1229 | L>F | No | EVA | |
| rs3389229956 | 1236 | V>M | No | EVA | |
| rs3389270558 | 1241 | V>D | No | EVA | |
| rs3403664629 | 1251 | V>G | No | EVA | |
| rs3403730783 | 1254 | G>S | No | EVA | |
| rs3389235480 | 1293 | A>D | No | EVA | |
| rs3389221877 | 1296 | K>R | No | EVA | |
| rs3389255312 | 1298 | V>A | No | EVA | |
| rs3389235434 | 1299 | C>S | No | EVA | |
| rs3389235455 | 1299 | C>Y | No | EVA | |
| rs3389265069 | 1319 | N>K | No | EVA | |
| rs3402369101 | 1327 | L>W | No | EVA | |
| rs3389259437 | 1367 | G>R | No | EVA |
No associated diseases with Q14BI7
6 regional properties for Q14BI7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase, C-terminal | 378 - 545 | IPR001650 |
| domain | Tudor domain | 905 - 1014 | IPR002999 |
| domain | Helicase-associated domain | 565 - 666 | IPR007502 |
| domain | DEAD/DEAH box helicase domain | 139 - 296 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 132 - 327 | IPR014001 |
| domain | Tudor domain-containing protein 9, Tudor domain | 906 - 1006 | IPR047384 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| piP-body | A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| DNA methylation involved in gamete generation | The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete. |
| fertilization | The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). |
| gene silencing by RNA | A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. |
| male meiosis I | A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline. |
| male meiotic nuclear division | A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline. |
| negative regulation of transposition | Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites. |
| piRNA metabolic process | The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43329 | hrpA | ATP-dependent RNA helicase HrpA | Escherichia coli (strain K12) | PR |
| Q6P158 | DHX57 | Putative ATP-dependent RNA helicase DHX57 | Homo sapiens (Human) | PR |
| Q9H2U1 | DHX36 | ATP-dependent DNA/RNA helicase DHX36 | Homo sapiens (Human) | PR |
| Q8VHK9 | Dhx36 | ATP-dependent DNA/RNA helicase DHX36 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLRKLTVDQI | NDWFTIGKTV | TNVELLGLPP | AFPAEAPREE | VQRSEEVPNE | DPTAQAQVPV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KATAPARPAS | TSGRSLSQRS | SEMEYINKYR | QLEEQELDIY | GQDQPPSGPG | LRSPLAKLSN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VACIPETTYK | YPDLPINRCK | EEVISLIESN | SVVIIHGATG | SGKSTQLPQY | VLDHYTQRSA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FCNIVVTQPR | KIGASSIARW | ISKERSWTLG | GLVGYQVGLE | KIATEDTRLI | YMTTGVLLQK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IVSAKSLMEF | THIFIDEVHE | RTEEMDFLLL | VVRKLLRTNS | RFVKVVLMSA | TINCKQFADY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FAVPVQNKMN | PAYVFEVEGK | PHAIEEYYLN | DLGHIYHSGL | PYRLEEPVIT | KDVYEVAVSL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IQMFDDLDMK | ESGNKTWSGA | QFVSERSSVL | VFLPGLGEIN | YMHELLTNMI | HKRLQVYPLH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SSVTLEEQNN | VFLSPVPGYR | KIILSTNIAE | SSVTVPDVKY | VIDFCLTRTL | VCDEDTNYQS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LRLSWASKTS | CDQRKGRAGR | VSKGYCYRLI | PRDFWDSAIP | DHVVPEMLRC | PLGSTILKVK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LLDMGEPRAL | LATALSPPSL | SDIERTILLL | KEVGALAVSG | QREDENPHDG | ELTFLGRVLA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QLPVSQQLGK | LVVLGHVFGC | LDECLIIAAA | LSLKNFFTMP | FRQHLDGYRN | KVHFSGSSRS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DCLALVEAFR | AWQACRQRGE | LRRPKDELDW | GRLNYIQIKR | IREVAELYEE | LKNRISQFNM |
| 730 | 740 | 750 | 760 | 770 | 780 |
| FVGPHHPVLD | QEYPYKQRFI | LQVVLAGAFY | PNYFTFGQPD | EEMAVRELAG | KDPKTTVVLK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| HIPPYGFLYY | KQLQSLFRQC | GQVKSIVFDG | AKAFVEFSRN | PTERFKTLPA | VNLAVKMSQL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KVSLELSVHA | AEEIEGKVQG | GSVSKLRNTR | VNVDFQKQTV | DPMQVSFNTL | DRPRTVADLL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LTIDVTEVVE | VGHFWGYRID | ERNAELLKQL | TAEINRLELV | PLPIHPHPDL | VCLAPFTDYN |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KESYFRAQIL | YVSGNSAEVF | FVDYGNRSHV | DLDLLREIPC | QFLELPFQAL | EFKICKMRPS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| AKSLICGEHW | SGGAHGRFAA | LVGGCPLLVK | VFSIVHSVLH | VDVYRYSGAQ | DAVNVRDVLI |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| REGYAELAEE | SYESKQSYEV | LKGFFAKSVD | TMPDGSVSSP | LKDDEKHLLR | ILLESFASNR |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| LGAPNCKAVL | HGPFNPYELK | CHSLTRISKF | RCVWIEKESI | NSVVISDSPA | DLHQRMLVAA |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| SLSVNETGST | MLLRETSLMP | HIPGLPALLS | MLFAPVMELR | VDREGKCYTG | VLCGLGWNSA |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| TEAPILPEHD | IELAFDVRLN | VEDIVEINIL | RAAINKLVCD | GPNGSKYLGP | ERIAQLQENA |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| RQKLLGLFCR | LKPREKITPQ | WHEKPYEWNQ | VDPRLIMEQA | EPEGSPGKST | SLYQLHTPVV |
| LSP |