Q6NVF4
PR
Gene name |
Helb |
Protein name |
DNA helicase B |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:117599 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6NVF4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6NVF4-F1 | Predicted | AlphaFoldDB |
86 variants for Q6NVF4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389134329 | 6 | R>S | No | EVA | |
| rs263453960 | 35 | E>D | No | EVA | |
| rs239700109 | 36 | E>* | No | EVA | |
| rs226965982 | 36 | E>A | No | EVA | |
| rs3401760000 | 45 | C>* | No | EVA | |
| rs3389128132 | 68 | K>* | No | EVA | |
| rs3389117092 | 105 | P>T | No | EVA | |
| rs30955366 | 111 | V>A | No | EVA | |
| rs3389069626 | 125 | F>L | No | EVA | |
| rs3389127719 | 140 | L>* | No | EVA | |
| rs263599931 | 189 | E>K | No | EVA | |
| rs3389105589 | 190 | K>I | No | EVA | |
| rs215274735 | 202 | Q>R | No | EVA | |
| rs3389117064 | 216 | R>P | No | EVA | |
| rs51147175 | 235 | D>E | No | EVA | |
| rs263942495 | 236 | V>I | No | EVA | |
| rs3389131733 | 243 | K>N | No | EVA | |
| rs30963666 | 264 | T>A | No | EVA | |
| rs239630253 | 271 | S>L | No | EVA | |
| rs3389134360 | 288 | S>Y | No | EVA | |
| rs3389130848 | 295 | R>K | No | EVA | |
| rs228744531 | 325 | A>E | No | EVA | |
| rs228744531 | 325 | A>V | No | EVA | |
| rs30962952 | 339 | Y>C | No | EVA | |
| rs3389131744 | 340 | V>D | No | EVA | |
| rs3389120836 | 346 | Y>F | No | EVA | |
| rs244220559 | 384 | N>H | No | EVA | |
| rs3389101048 | 391 | A>E | No | EVA | |
| rs3389134355 | 407 | S>G | No | EVA | |
| rs30962950 | 409 | L>F | No | EVA | |
| rs3389134310 | 419 | R>K | No | EVA | |
| rs30962948 | 423 | E>K | No | EVA | |
| rs30962946 | 429 | E>A | No | EVA | |
| rs3389131772 | 431 | N>Y | No | EVA | |
| rs222561327 | 432 | D>N | No | EVA | |
| rs237538761 | 437 | Q>R | No | EVA | |
| rs254116543 | 450 | A>S | No | EVA | |
| rs30962944 | 473 | M>V | No | EVA | |
| rs3389120879 | 482 | Q>L | No | EVA | |
| rs256768235 | 493 | E>G | No | EVA | |
| rs3389117040 | 498 | W>C | No | EVA | |
| rs3389138572 | 509 | V>E | No | EVA | |
| rs3389138599 | 536 | A>T | No | EVA | |
| rs255473053 | 551 | T>M | No | EVA | |
| rs3389101042 | 552 | K>N | No | EVA | |
| rs3401707391 | 557 | K>E | No | EVA | |
| rs3389101012 | 558 | P>L | No | EVA | |
| rs3389124291 | 570 | D>E | No | EVA | |
| rs3389140804 | 570 | D>G | No | EVA | |
| rs212731854 | 585 | Q>K | No | EVA | |
| rs255201472 | 586 | L>S | No | EVA | |
| rs221822813 | 603 | R>K | No | EVA | |
| rs3389120868 | 606 | P>S | No | EVA | |
| rs3389120880 | 613 | M>L | No | EVA | |
| rs3389120827 | 620 | T>A | No | EVA | |
| rs3389127515 | 620 | T>N | No | EVA | |
| rs262126937 | 624 | R>K | No | EVA | |
| rs3401787585 | 627 | A>V | No | EVA | |
| rs3389131765 | 632 | T>K | No | EVA | |
| rs3389130849 | 642 | V>A | No | EVA | |
| rs3389101071 | 704 | V>L | No | EVA | |
| rs245264110 | 740 | C>S | No | EVA | |
| rs3389124316 | 763 | I>V | No | EVA | |
| rs3389101046 | 766 | T>I | No | EVA | |
| rs3389130850 | 782 | A>V | No | EVA | |
| rs3389131738 | 784 | G>V | No | EVA | |
| rs3389120797 | 785 | K>S | No | EVA | |
| rs3389128451 | 787 | Y>N | No | EVA | |
| rs3389131787 | 845 | S>G | No | EVA | |
| rs3389127548 | 885 | Q>H | No | EVA | |
| rs224574690 | 911 | T>I | No | EVA | |
| rs3389130889 | 916 | F>S | No | EVA | |
| rs3389138553 | 927 | Q>L | No | EVA | |
| rs245059401 | 948 | R>P | No | EVA | |
| rs245916193 | 961 | H>Y | No | EVA | |
| rs3389117079 | 964 | R>* | No | EVA | |
| rs226664297 | 984 | A>T | No | EVA | |
| rs262731232 | 992 | T>M | No | EVA | |
| rs3389128518 | 998 | Q>* | No | EVA | |
| rs3389095108 | 1027 | P>S | No | EVA | |
| rs30948456 | 1034 | Q>E | No | EVA | |
| rs260703467 | 1036 | M>L | No | EVA | |
| rs30948454 | 1041 | L>F | No | EVA | |
| rs3389117047 | 1053 | Q>* | No | EVA | |
| rs242954623 | 1053 | Q>P | No | EVA | |
| rs223009957 | 1066 | D>E | No | EVA |
No associated diseases with Q6NVF4
1 regional properties for Q6NVF4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EGF-like domain | 35 - 73 | IPR000742 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| DNA replication factor A complex | A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| site of double-strand break | A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5'-3' DNA helicase activity | Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
| protein-containing complex binding | Binding to a macromolecular complex. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| single-stranded DNA helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| DNA replication, synthesis of RNA primer | The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis. |
| DNA-templated DNA replication | A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. |
| maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| negative regulation of double-strand break repair via homologous recombination | Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination. |
| regulation of DNA double-strand break processing | Any process that modulates the frequency, rate or extent of DNA double-strand break processing. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARQDRLREL | LGPLHPYKSD | DEEEDCAQEE | EGEQEEEFVD | AEELCSGGIK | AGSLPGRARV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SIPDEYTKEK | CTVYGRFPLK | GPWWRVKVQV | LKPQRSRSYQ | VQGFPAYFLQ | VDMSPPDQKQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ICSLFLKECN | LASERIQEFL | KWVEKVSSFE | NLHFENLWET | LRLFYRETEK | KDKKLSTPRE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QQGEEMRVEK | SFAFISAMVA | LQFPKVMEFL | PSLFPRHFKR | LISSSSDWVL | GCIEDVLGTQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PWKLGFRRIT | YREMKLVRCE | ASWTAFSQCP | SLLQLMTPLQ | KNALVIYSKL | RQTCREDGHT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YIEVKDLTSG | LSEHMSFEEA | CQSLAFLKDI | DVVIYEKDYV | FLSELYEAEQ | DIASSICELM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SRPPWHLKVD | VKNVLASIRG | AKPNDPGSAE | AVEGSKPEEV | GSEQGDSVLD | AQDGDDHVRS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NGEHVANAEI | NDVPLDQDQV | VALETICANA | VTVLSGKGGC | GKTTIVSRLF | KHMEHLEETE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VQQACEDFEQ | DQEASEEWLD | CPKQSPAGVD | KAVEVLLTAP | TGKAAGLLRQ | RTDLPAYTLC |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QVNYSFYMWK | TKNEVDKPWK | FSTVRVLVVD | EGSLVSVGIF | KSVLQLLCKH | SKLSKLIILG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DVRQLPSIEP | GNMLQDVFET | LKSRQCAIEL | KTNHRTESQL | IVDNATRISR | RQFPKFDAEL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NICGNPTLPL | SIQDKTFIFV | RLPEEDSRSQ | SSKGEHRSNL | YTAVKTLLQG | KDFCSFESSK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TSQFIAFRRQ | DCDLINDCCC | KHYTGHLIKD | HEKKLIFAVG | DKICCTRNAY | LSDLLPDKDQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EAEGKGYGDA | PDDDAKIKQD | FESSTRLCNG | EIFFITRDVT | DVTFKRKRLL | TINNEAGLEV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TVDFSKLMAN | CQIKHAWART | IHTFQGSEEN | TVVYVVGKAG | RQHWQHVYTA | VTRGRSRVYI |
| 910 | 920 | 930 | 940 | 950 | 960 |
| IAQESELRSA | TRKRGFPRQT | RLKHFLQKKL | SGSCAPSTGF | ASQPSSPRVG | GRPDTQPPAS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| HLCRTPDNKA | TADSARGDER | WLSASVNDDV | DTDEESAQLR | GSKRIGDGFP | FDEESPSKFR |
| 1030 | 1040 | 1050 | 1060 | 1070 | |
| MVEAPSPQVS | SVFQNMRLNT | LTPRQLFKPT | DNQDTGTAGV | ADDANDPSNQ | EMEM |