Q9Z306
PR
Gene name |
Slc22a4 (Octn1) |
Protein name |
Solute carrier family 22 member 4 |
Names |
Organic cation/carnitine transporter 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:30805 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Z306
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z306-F1 | Predicted | AlphaFoldDB |
26 variants for Q9Z306
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389094826 | 14 | W>* | No | EVA | |
| rs264178755 | 61 | S>A | No | EVA | |
| rs3389158843 | 86 | L>V | No | EVA | |
| rs3389154198 | 99 | P>S | No | EVA | |
| rs219097071 | 112 | S>T | No | EVA | |
| rs8264486 | 123 | I>V | No | EVA | |
| rs3389150050 | 142 | T>K | No | EVA | |
| rs3389158850 | 146 | T>A | No | EVA | |
| rs3412988765 | 162 | Q>* | No | EVA | |
| rs3389131586 | 188 | I>N | No | EVA | |
| rs3389120033 | 224 | K>N | No | EVA | |
| rs3389144701 | 228 | I>F | No | EVA | |
| rs3389156686 | 255 | D>Y | No | EVA | |
| rs256841425 | 336 | R>K | No | EVA | |
| rs214226403 | 347 | A>S | No | EVA | |
| rs3389094750 | 369 | H>Y | No | EVA | |
| rs3389131518 | 395 | R>* | No | EVA | |
| rs3389156680 | 410 | G>* | No | EVA | |
| rs3389154185 | 414 | L>F | No | EVA | |
| rs26943476 | 428 | S>C | No | EVA | |
| rs3389150063 | 429 | I>T | No | EVA | |
| rs3389167146 | 473 | G>C | No | EVA | |
| rs3389094769 | 474 | S>N | No | EVA | |
| rs3389144676 | 493 | I>N | No | EVA | |
| rs26943504 | 533 | G>W | No | EVA | |
| rs48450683 | 545 | S>N | No | EVA |
No associated diseases with Q9Z306
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| amino acid transmembrane transporter activity | Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| carnitine transmembrane transporter activity | Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. |
| organic cation transmembrane transporter activity | Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. |
| PDZ domain binding | Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. |
| quaternary ammonium group transmembrane transporter activity | Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. |
| symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| amino acid import across plasma membrane | The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol. |
| carnitine metabolic process | The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. |
| carnitine transport | The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. |
| quaternary ammonium group transport | The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| triglyceride metabolic process | The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. |
| xenobiotic transport | The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
18 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q17QN9 | SLC22A16 | Solute carrier family 22 member 16 | Bos taurus (Bovine) | PR |
| Q1JP63 | SVOP | Synaptic vesicle 2-related protein | Bos taurus (Bovine) | PR |
| Q7L1I2 | SV2B | Synaptic vesicle glycoprotein 2B | Homo sapiens (Human) | PR |
| Q496J9 | SV2C | Synaptic vesicle glycoprotein 2C | Homo sapiens (Human) | PR |
| Q8N4V2 | SVOP | Synaptic vesicle 2-related protein | Homo sapiens (Human) | PR |
| A6NKX4 | SLC22A31 | Putative solute carrier family 22 member 31 | Homo sapiens (Human) | PR |
| Q9H015 | SLC22A4 | Solute carrier family 22 member 4 | Homo sapiens (Human) | PR |
| Q69ZS6 | Sv2c | Synaptic vesicle glycoprotein 2C | Mus musculus (Mouse) | PR |
| Q8BFT9 | Svop | Synaptic vesicle 2-related protein | Mus musculus (Mouse) | PR |
| Q9Z0E8 | Slc22a5 | Solute carrier family 22 member 5 | Mus musculus (Mouse) | PR |
| Q9D9E0 | Slc22a17 | Solute carrier family 22 member 17 | Mus musculus (Mouse) | PR |
| Q497L8 | Slc22a16 | Solute carrier family 22 member 16 | Mus musculus (Mouse) | PR |
| Q6PDF3 | Svopl | Putative transporter SVOPL | Mus musculus (Mouse) | PR |
| Q70BM6 | SLC22A8 | Organic anion transporter 3 | Sus scrofa (Pig) | PR |
| Q9Z2I7 | Svop | Synaptic vesicle 2-related protein | Rattus norvegicus (Rat) | PR |
| Q9Z2I6 | Sv2c | Synaptic vesicle glycoprotein 2C | Rattus norvegicus (Rat) | PR |
| Q9R141 | Slc22a4 | Solute carrier family 22 member 4 | Rattus norvegicus (Rat) | PR |
| Q7Z118 | B0361.11 | Putative transporter B0361.11 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRDYDEVIAF | LGEWGPFQRL | IFFLLSASII | PNGFNGMSVV | FLAGTPEHRC | LVPDTVNLSS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SWRNHSIPLE | TKDGRQVPQS | CRRYRLATIA | NFSAMGLEPG | QDVDLEQLEQ | ESCLDGWEYD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KDIFLSTIVT | EWNLVCEDDW | KTPLTTSLFF | VGVLCGSFVS | GQLSDRFGRK | KVLFATMAVQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TGFSFVQIFS | TNWEMFTVLF | AIVGMGQISN | YVVAFILGTE | ILSKSVRIIF | STLGVCTFFA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IGYMVLPLFA | YFIRDWRMLL | LALTLPGLFC | VPLWWFIPES | PRWLISQRRF | AEAEQIIQKA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AKMNSIVAPA | GIFDPLELQE | LNSLKQQKVI | ILDLFRTRNI | ATITVMAVML | WMLTSVGYFA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LSLNVPNLHG | DVYLNCFLSG | LIEVPAYFTA | WLLLRTLPRR | YIIAGVLFWG | GGVLLLIQVV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PEDYNFVSIG | LVMLGKFGIT | SAFSMLYVFT | AELYPTLVRN | MAVGITSMAS | RVGSIIAPYF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VYLGAYNRLL | PYILMGSLTV | LIGIITLFFP | ESFGVTLPEN | LEQMQKVRGF | RCGKKSTVSV |
| 550 | |||||
| DREESPKVLI | TAF |