Q9Z2I6
Gene name |
Sv2c |
Protein name |
Synaptic vesicle glycoprotein 2C |
Names |
Synaptic vesicle protein 2C |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:29643 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9Z2I6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5JMC | X-ray | 264 A | B/D/F/H | 455-577 | PDB |
| AF-Q9Z2I6-F1 | Predicted | AlphaFoldDB |
No variants for Q9Z2I6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9Z2I6 | |||||
No associated diseases with Q9Z2I6
No regional properties for Q9Z2I6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9Z2I6 | |||
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of synaptic vesicle membrane | The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
| synaptic vesicle membrane | The lipid bilayer surrounding a synaptic vesicle. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| neurotransmitter transport | The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q17QN9 | SLC22A16 | Solute carrier family 22 member 16 | Bos taurus (Bovine) | PR |
| Q1JP63 | SVOP | Synaptic vesicle 2-related protein | Bos taurus (Bovine) | PR |
| Q9H015 | SLC22A4 | Solute carrier family 22 member 4 | Homo sapiens (Human) | PR |
| Q7L1I2 | SV2B | Synaptic vesicle glycoprotein 2B | Homo sapiens (Human) | PR |
| Q8N4V2 | SVOP | Synaptic vesicle 2-related protein | Homo sapiens (Human) | PR |
| A6NKX4 | SLC22A31 | Putative solute carrier family 22 member 31 | Homo sapiens (Human) | PR |
| Q496J9 | SV2C | Synaptic vesicle glycoprotein 2C | Homo sapiens (Human) | PR |
| Q9Z0E8 | Slc22a5 | Solute carrier family 22 member 5 | Mus musculus (Mouse) | PR |
| Q9Z306 | Slc22a4 | Solute carrier family 22 member 4 | Mus musculus (Mouse) | PR |
| Q9D9E0 | Slc22a17 | Solute carrier family 22 member 17 | Mus musculus (Mouse) | PR |
| Q8BFT9 | Svop | Synaptic vesicle 2-related protein | Mus musculus (Mouse) | PR |
| Q497L8 | Slc22a16 | Solute carrier family 22 member 16 | Mus musculus (Mouse) | PR |
| Q69ZS6 | Sv2c | Synaptic vesicle glycoprotein 2C | Mus musculus (Mouse) | PR |
| Q70BM6 | SLC22A8 | Organic anion transporter 3 | Sus scrofa (Pig) | PR |
| Q9Z2I7 | Svop | Synaptic vesicle 2-related protein | Rattus norvegicus (Rat) | PR |
| Q9R141 | Slc22a4 | Solute carrier family 22 member 4 | Rattus norvegicus (Rat) | PR |
| Q7Z118 | B0361.11 | Putative transporter B0361.11 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEDSYKDRTS | LMKGAKDIAK | EVKKQTVKKV | NQAVDRAQDE | YTQRSYSRFQ | DEDDDDDYYP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PGETYSGEAN | DDEGSSEATE | GHDEEDEIYE | GEYQGIPSTN | QGKDSIVSVG | QPKGDEYKDR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RELESERRAD | EEELAQQYEL | IIQECGHGRF | QWALFFVLGM | ALMADGVEVF | VVGFVLPSAE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TDLCIPNSGS | GWLGSIVYLG | MMVGAFFWGG | LADKVGRKQS | LLICMSVNGF | FAFLSSFVQG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YGFFLLCRLL | SGFGIGGAIP | TVFSYFAEVL | AREKRGEHLS | WLCMFWMIGG | IYASAMAWAI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IPHYGWSFSM | GSAYQFHSWR | VFVIVCALPC | VSSVVALTFM | PESPRFLLEV | GKHDEAWMIL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KLIHDTNMRA | RGQPEKVFTV | NKIKTPKQID | ELIEIESDTG | TWYRRCFVRI | RTELYGIWLT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FMRCFNYPVR | ENTIKLTIVW | FTLSFGYYGL | SVWFPDVIKH | LQSDEYALLT | RNVQKDKYAN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FSINFTMENQ | VHTGMEYDNG | RFLGVKFKSV | TFKDSVFKSC | TFDDVTSVNT | YFKNCTFIDT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LFENTDFEPY | KFIDSEFQNC | SFLHNKTGCQ | ITFDDDYSAY | WIYFVNFLGT | LAVLPGNIVS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ALLMDRIGRL | TMLGGSMVLS | GISCFFLWFG | TSESMMIGML | CLYNGLTISA | WNSLDVVTVE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LYPTDRRATG | FGFLNALCKA | AAVLGNLIFG | SLVSITKAIP | ILLASTVLVC | GGLVGLRLPD |
| TRTQVLM |