Q70BM6

PR
Gene name
SLC22A8 (OAT3)
Protein name
Organic anion transporter 3
Names
pOAT3, Organic anion/dicarboxylate exchanger, Solute carrier family 22 member 8
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:407774
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

482-543 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q70BM6

Entry ID Method Resolution Chain Position Source
AF-Q70BM6-F1 Predicted AlphaFoldDB

2 variants for Q70BM6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs690189492 138 G>V No EVA
rs705518454 358 V>L No EVA

No associated diseases with Q70BM6

1 regional properties for Q70BM6

Type Name Position InterPro Accession
domain GNAT domain 4 - 160 IPR000182

Functions

Description
EC Number
Subcellular Localization
  • Basolateral cell membrane ; Multi-pass membrane protein
  • Localizes on the brush border membrane of the choroid epithelial cells
  • Localizes to the basolateral membrane of the proximal tubular cells
  • Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
ion transmembrane transporter activity Enables the transfer of an ion from one side of a membrane to the other.

1 GO annotations of biological process

Name Definition
response to toxic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q17QN9 SLC22A16 Solute carrier family 22 member 16 Bos taurus (Bovine) PR
Q1JP63 SVOP Synaptic vesicle 2-related protein Bos taurus (Bovine) PR
Q9H015 SLC22A4 Solute carrier family 22 member 4 Homo sapiens (Human) PR
Q7L1I2 SV2B Synaptic vesicle glycoprotein 2B Homo sapiens (Human) PR
Q496J9 SV2C Synaptic vesicle glycoprotein 2C Homo sapiens (Human) PR
Q8N4V2 SVOP Synaptic vesicle 2-related protein Homo sapiens (Human) PR
A6NKX4 SLC22A31 Putative solute carrier family 22 member 31 Homo sapiens (Human) PR
Q9Z0E8 Slc22a5 Solute carrier family 22 member 5 Mus musculus (Mouse) PR
Q9Z306 Slc22a4 Solute carrier family 22 member 4 Mus musculus (Mouse) PR
Q9D9E0 Slc22a17 Solute carrier family 22 member 17 Mus musculus (Mouse) PR
Q8BFT9 Svop Synaptic vesicle 2-related protein Mus musculus (Mouse) PR
Q497L8 Slc22a16 Solute carrier family 22 member 16 Mus musculus (Mouse) PR
Q69ZS6 Sv2c Synaptic vesicle glycoprotein 2C Mus musculus (Mouse) PR
Q9Z2I7 Svop Synaptic vesicle 2-related protein Rattus norvegicus (Rat) PR
Q9Z2I6 Sv2c Synaptic vesicle glycoprotein 2C Rattus norvegicus (Rat) PR
Q9R141 Slc22a4 Solute carrier family 22 member 4 Rattus norvegicus (Rat) PR
Q7Z118 B0361.11 Putative transporter B0361.11 Caenorhabditis elegans PR
10 20 30 40 50 60
MTFAELVDRV GSKGPFQLLH TVLLGLPILG MANHNLLQIF TAPTPAHHCR PPPNASAGPW
70 80 90 100 110 120
VLPTGLNGKP ETCLRFVYPP NASLPNDTRG ATEPCLDGWI YNIVDRDSIV TEWDLVCSSS
130 140 150 160 170 180
KLKEMAQSVF MAGILVGGLV LGALSDRFGR KPILIFSYLL LGASGSGAAF SPTFSIYAVF
190 200 210 220 230 240
RFLCGFSISG ISLSTAILNV EWVSTRFRAI KSIAVGFFYT FGQFILPGLA YAIPQWRWLQ
250 260 270 280 290 300
LTVSVPFLTF FLLSWWLPES IRWMVLSGKS SKALKTLRQV AIFNGKKEEG EKLSLEELKL
310 320 330 340 350 360
NLQKEISLAK ARHGIADLFR TPVLRRVTLC LSLAWFATGF AYYSLAMGVE EFGVNLYVLQ
370 380 390 400 410 420
LIFGGVDVPA KFITMLSISY LGRHITEGIV LLLAGGCILA LIFVPLDLMT LRTVLAVFGK
430 440 450 460 470 480
GCLSGSFSCL FLYTSELYPT VIRQTGMGAS NLWARVGSMT APLVKITGEL QPFIPNIIFG
490 500 510 520 530 540
TIALLGGSAA LFLPETLNRP LPETIEDIET WSLRAKEPKP EPEAEKSSQR IPLQPCEPGP
GPS