AiPD: Autoinhibited Protein Database

Gene name	Slc22a16
Protein name	Solute carrier family 22 member 16
Names	Carnitine transporter 2, CT2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:70840
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

577-649 (Predicted disordered autoinhibitory region) PR

577-649 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q497L8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3401171117	9	I>L	No	EVA
rs47565055	17	G>D	No	EVA
rs3389063583	43	F>I	No	EVA
rs3389092114	97	E>G	No	EVA
rs265749368	99	T>M	No	EVA
rs3389095939	105	W>R	No	EVA
rs3389039467	110	S>P	No	EVA
rs3389096475	111	H>Y	No	EVA
rs29323015	126	F>S	No	EVA
rs3389089561	134	S>N	No	EVA
rs50100637	138	N>S	No	EVA
rs3389098158	156	M>V	No	EVA
rs3389063527	165	V>L	No	EVA
rs3389075690	202	I>K	No	EVA
rs3389075672	225	V>E	No	EVA
rs46130335	238	A>S	No	EVA
rs3412992140	273	I>L	No	EVA
rs3389106212	277	V>M	No	EVA
rs3389063526	282	I>V	No	EVA
rs3389106186	301	Y>C	No	EVA
rs3389089580	308	V>M	No	EVA
rs3389039463	310	T>S	No	EVA
rs3389092063	311	M>T	No	EVA
rs3389095941	322	L>M	No	EVA
rs3389096105	335	N>S	No	EVA
rs265128842	345	R>G	No	EVA
rs3389070487	353	L>Q	No	EVA
rs3401060020	356	A>V	No	EVA
rs258954827	362	V>I	No	EVA
rs46044427	434	V>A	No	EVA
rs3389106208	443	K>N	No	EVA
rs3389063566	476	L>F	No	EVA
rs3389097983	480	S>T	No	EVA
rs50094974	557	S>I	No	EVA
rs265683958	599	A>T	No	EVA
rs231578934	619	E>K	No	EVA
rs50759051	635	E>K	No	EVA
rs585191283	642	K>E	No	EVA
rs578265918	642	K>R	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q497L8

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein	Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
amine transmembrane transporter activity	Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.
carnitine transmembrane transporter activity	Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
organic cation transmembrane transporter activity	Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage.

Name	Definition
acid secretion	The controlled release of acid by a cell or a tissue.
carnitine transport	The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
flagellated sperm motility	The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.
organic cation transport	The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.
single fertilization	The union of male and female gametes to form a zygote.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q1JP63	SVOP	Synaptic vesicle 2-related protein	Bos taurus (Bovine)	PR
Q17QN9	SLC22A16	Solute carrier family 22 member 16	Bos taurus (Bovine)	PR
Q9H015	SLC22A4	Solute carrier family 22 member 4	Homo sapiens (Human)	PR
Q7L1I2	SV2B	Synaptic vesicle glycoprotein 2B	Homo sapiens (Human)	PR
Q496J9	SV2C	Synaptic vesicle glycoprotein 2C	Homo sapiens (Human)	PR
Q8N4V2	SVOP	Synaptic vesicle 2-related protein	Homo sapiens (Human)	PR
A6NKX4	SLC22A31	Putative solute carrier family 22 member 31	Homo sapiens (Human)	PR
Q69ZS6	Sv2c	Synaptic vesicle glycoprotein 2C	Mus musculus (Mouse)	PR
Q9Z0E8	Slc22a5	Solute carrier family 22 member 5	Mus musculus (Mouse)	PR
Q9Z306	Slc22a4	Solute carrier family 22 member 4	Mus musculus (Mouse)	PR
Q9D9E0	Slc22a17	Solute carrier family 22 member 17	Mus musculus (Mouse)	PR
Q6PDF3	Svopl	Putative transporter SVOPL	Mus musculus (Mouse)	PR
Q8BFT9	Svop	Synaptic vesicle 2-related protein	Mus musculus (Mouse)	PR
Q70BM6	SLC22A8	Organic anion transporter 3	Sus scrofa (Pig)	PR
Q9Z2I7	Svop	Synaptic vesicle 2-related protein	Rattus norvegicus (Rat)	PR
Q9Z2I6	Sv2c	Synaptic vesicle glycoprotein 2C	Rattus norvegicus (Rat)	PR
Q9R141	Slc22a4	Solute carrier family 22 member 4	Rattus norvegicus (Rat)	PR
Q7Z118	B0361.11	Putative transporter B0361.11	Caenorhabditis elegans	PR