Q9D9E0

PR
Gene name
Slc22a17 (Boct)
Protein name
Solute carrier family 22 member 17
Names
24p3 receptor, 24p3R, Brain-type organic cation transporter, Lipocalin-2 receptor
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:59049
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

355-401 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9D9E0

Entry ID Method Resolution Chain Position Source
AF-Q9D9E0-F1 Predicted AlphaFoldDB

23 variants for Q9D9E0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389320512 78 V>G No EVA
rs3389334429 88 A>S No EVA
rs3389324475 89 L>I No EVA
rs3389311497 99 R>L No EVA
rs3389334439 102 T>I No EVA
rs3389334510 138 R>M No EVA
rs3389327389 152 G>R No EVA
rs30155947 160 Q>H No EVA
rs233962051 171 T>M No EVA
rs3389320506 181 N>K No EVA
rs3389328821 185 I>T No EVA
rs3389311450 203 R>H No EVA
rs3389283406 208 P>T No EVA
rs3389327408 253 M>I No EVA
rs3389334515 268 D>N No EVA
rs3389324714 269 Y>H No EVA
rs3389292750 310 L>R No EVA
rs3389320517 316 L>I No EVA
rs3389283431 324 C>W No EVA
rs3389334500 325 P>T No EVA
rs3389254065 372 E>G No EVA
rs3389283439 374 C>Y No EVA
rs3389324685 387 R>H No EVA

No associated diseases with Q9D9E0

No regional properties for Q9D9E0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9D9E0

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Vacuole membrane ; Multi-pass membrane protein
  • Upon LCN2-binding, it is internalized
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
integral component of organelle membrane The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
vacuolar membrane The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

2 GO annotations of molecular function

Name Definition
transmembrane signaling receptor activity Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
transmembrane transporter activity Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

2 GO annotations of biological process

Name Definition
iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
siderophore transport The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

18 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q17QN9 SLC22A16 Solute carrier family 22 member 16 Bos taurus (Bovine) PR
Q1JP63 SVOP Synaptic vesicle 2-related protein Bos taurus (Bovine) PR
Q9H015 SLC22A4 Solute carrier family 22 member 4 Homo sapiens (Human) PR
Q7L1I2 SV2B Synaptic vesicle glycoprotein 2B Homo sapiens (Human) PR
Q496J9 SV2C Synaptic vesicle glycoprotein 2C Homo sapiens (Human) PR
Q8N4V2 SVOP Synaptic vesicle 2-related protein Homo sapiens (Human) PR
A6NKX4 SLC22A31 Putative solute carrier family 22 member 31 Homo sapiens (Human) PR
Q69ZS6 Sv2c Synaptic vesicle glycoprotein 2C Mus musculus (Mouse) PR
Q9Z0E8 Slc22a5 Solute carrier family 22 member 5 Mus musculus (Mouse) PR
Q9Z306 Slc22a4 Solute carrier family 22 member 4 Mus musculus (Mouse) PR
Q497L8 Slc22a16 Solute carrier family 22 member 16 Mus musculus (Mouse) PR
Q6PDF3 Svopl Putative transporter SVOPL Mus musculus (Mouse) PR
Q8BFT9 Svop Synaptic vesicle 2-related protein Mus musculus (Mouse) PR
Q70BM6 SLC22A8 Organic anion transporter 3 Sus scrofa (Pig) PR
Q9Z2I7 Svop Synaptic vesicle 2-related protein Rattus norvegicus (Rat) PR
Q9Z2I6 Sv2c Synaptic vesicle glycoprotein 2C Rattus norvegicus (Rat) PR
Q9R141 Slc22a4 Solute carrier family 22 member 4 Rattus norvegicus (Rat) PR
Q7Z118 B0361.11 Putative transporter B0361.11 Caenorhabditis elegans PR
10 20 30 40 50 60
MPSARFGRRG IVLLTLGLVG PCGVGGAAAG SSTGIMALRF LLGFLLAGVD LGVYLMRLEL
70 80 90 100 110 120
CDPTQRLRVA LAGELVGVGG HFLFLGLALV SKDWRFLQRM ITAPCILFLF YGWPGLFLES
130 140 150 160 170 180
ARWLIVKRQI EEAQSVLRIL AERNRPHGQM LGEEAQEALQ ELENTCPLPA TSTFSFASLL
190 200 210 220 230 240
NYRNIWKNLL ILGFTNFIAH AIRHCYQPVG GGGSPSDFYL CSLLASGTAA LACVFLGVTV
250 260 270 280 290 300
DRFGRRGILL LSMTLTGIAS LVLLGLWDYL NDAAITTFSV LGLFSSQASA ILSTLLASEV
310 320 330 340 350 360
IPTTVRGRGL GLIMALGALG GLSCPAQRLH MGHGAFLQHV VLAACALLCI LSIMLLPETK
370 380 390 400
RKLLPEVLRD GELCRRPSLL RQPPPNRCDH VPLLATPNPA L