Q17QN9

PR
Gene name
SLC22A16
Protein name
Solute carrier family 22 member 16
Names
Carnitine transporter 2, CT2
Species
Bos taurus (Bovine)
KEGG Pathway
bta:614380
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

508-572 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q17QN9

Entry ID Method Resolution Chain Position Source
AF-Q17QN9-F1 Predicted AlphaFoldDB

36 variants for Q17QN9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs452120162 3 S>A No EVA
rs475294245 3 S>F No EVA
rs452120162 3 S>T No EVA
rs475294245 3 S>Y No EVA
rs454400321 5 N>D No EVA
rs474563786 7 E>G No EVA
rs443123537 8 L>R No EVA
rs470275593 24 Y>N No EVA
rs799287689 26 I>L No EVA
rs472533922 41 S>F No EVA
rs447313969 50 H>N No EVA
rs109094734 94 A>E No EVA
rs451610812 121 S>I No EVA
rs471642295 122 S>C No EVA
rs443426555 134 S>R No EVA
rs463456955 143 Q>H No EVA
rs442464352 151 E>D No EVA
rs470850632 228 V>F No EVA
rs379949690 249 F>S No EVA
rs438211808 310 T>M No EVA
rs3423603928 391 L>V No EVA
rs208969900 446 A>S No EVA
rs465210648 452 F>I No EVA
rs459284962 455 G>R No EVA
rs437051144 459 G>C No EVA
rs450618117 461 I>L No EVA
rs210999485 461 I>T No EVA
rs446904389 484 V>G No EVA
rs716122002 514 A>S No EVA
rs456368168 521 T>A No EVA
rs476434206 526 E>A No EVA
rs441825962 527 T>S No EVA
rs472307646 528 L>F No EVA
rs440846897 528 L>P No EVA
rs477853724 531 P>A No EVA
rs439910279 542 E>D No EVA

No associated diseases with Q17QN9

1 regional properties for Q17QN9

Type Name Position InterPro Accession
domain Major facilitator superfamily domain 113 - 529 IPR020846

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
organic cation transmembrane transporter activity Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage.

3 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
organic cation transport The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q1JP63 SVOP Synaptic vesicle 2-related protein Bos taurus (Bovine) PR
Q9H015 SLC22A4 Solute carrier family 22 member 4 Homo sapiens (Human) PR
Q7L1I2 SV2B Synaptic vesicle glycoprotein 2B Homo sapiens (Human) PR
Q496J9 SV2C Synaptic vesicle glycoprotein 2C Homo sapiens (Human) PR
Q8N4V2 SVOP Synaptic vesicle 2-related protein Homo sapiens (Human) PR
A6NKX4 SLC22A31 Putative solute carrier family 22 member 31 Homo sapiens (Human) PR
Q9Z0E8 Slc22a5 Solute carrier family 22 member 5 Mus musculus (Mouse) PR
Q9Z306 Slc22a4 Solute carrier family 22 member 4 Mus musculus (Mouse) PR
Q9D9E0 Slc22a17 Solute carrier family 22 member 17 Mus musculus (Mouse) PR
Q8BFT9 Svop Synaptic vesicle 2-related protein Mus musculus (Mouse) PR
Q69ZS6 Sv2c Synaptic vesicle glycoprotein 2C Mus musculus (Mouse) PR
Q497L8 Slc22a16 Solute carrier family 22 member 16 Mus musculus (Mouse) PR
Q70BM6 SLC22A8 Organic anion transporter 3 Sus scrofa (Pig) PR
Q9Z2I7 Svop Synaptic vesicle 2-related protein Rattus norvegicus (Rat) PR
Q9Z2I6 Sv2c Synaptic vesicle glycoprotein 2C Rattus norvegicus (Rat) PR
Q9R141 Slc22a4 Solute carrier family 22 member 4 Rattus norvegicus (Rat) PR
Q7Z118 B0361.11 Putative transporter B0361.11 Caenorhabditis elegans PR
10 20 30 40 50 60
MGSSNLELIF DSVGHFGRYQ IFLYFICAFQ NISCGIHYLA SVFLSVSPQH TCRPPGNVSQ
70 80 90 100 110 120
VLFQDLSTWQ LEDIWTQFSV GREDRILVQL QDGAIWELTS CQRFRRDDQS SLDYEYSGQK
130 140 150 160 170 180
SSFPCLDGYI YDRSKWLSTV VTQWDLVCNR EWFGRLIQPT FMFGVLLGAV IFGYLSDRAG
190 200 210 220 230 240
RRLVLWASST GVFLFGIAAA FTFDYYSFIV ARFLLAISGS GYLVVVFVYV TEFVGMKSRT
250 260 270 280 290 300
WASIHLHSFF AFGTMVVALT GYFVRTWWIY QIVLSSVTVP FVLCCWMLPE TPFWLISGGK
310 320 330 340 350 360
YEEAQKVIDT MAKWNRTRPC KLSEILSLDH DGSAGNKPSQ VEKHTLSELF YDWSIGTRTL
370 380 390 400 410 420
ILWLIWFTGC LGFYTFSLNS VHLGGSEYLN LFLMGVVEIP AYVLVCLGMD RVGRRNILIF
430 440 450 460 470 480
SLLSSAVTSG VIMVIPKDYH VWLVVASMAG KFFIGAAFGL IYLYTAELYP TIVRSLAVGS
490 500 510 520 530 540
GSTVGRVGSI VAPLCIYLSS VWIFMPQLLV GTLALVSGVL TFLLPETLRR PLTTTWEETE
550 560 570
KESSSGKLLS TTSNTVLENV TVENSEDSSL NK