AiPD: Autoinhibited Protein Database

Gene name	Sv2c (Kiaa1054)
Protein name	Synaptic vesicle glycoprotein 2C
Names	Synaptic vesicle protein 2C
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:75209
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-163 (Predicted disordered autoinhibitory region) PR

1-163 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q69ZS6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389226639	22	V>M	No	EVA
rs3389306124	53	E>G	No	EVA
rs46793090	69	V>A	No	EVA
rs51063592	70	N>I	No	EVA
rs3404509363	102	G>R	No	EVA
rs49945581	109	V>I	No	EVA
rs3389299433	151	Q>H	No	EVA
rs3389296175	162	L>H	No	EVA
rs3389298840	167	V>L	No	EVA
rs3389280942	174	F>C	No	EVA
rs3389313481	200	G>V	No	EVA
rs3389299376	203	V>E	No	EVA
rs3389299435	233	F>L	No	EVA
rs3389265173	376	K>M	No	EVA
rs3389301599	403	Y>H	No	EVA
rs3389265134	429	V>I	No	EVA
rs3389298843	434	I>N	No	EVA
rs3389294677	477	K>R	No	EVA
rs3389296274	508	K>*	No	EVA
rs3389272527	536	T>M	No	EVA
rs3389272506	542	F>L	No	EVA
rs3403764837	577	Y>*	No	EVA
rs3389265145	599	V>L	No	EVA
rs3410819161	619	L>I	No	EVA
rs3389299392	619	L>R	No	EVA
rs3404531809	624	C>W	No	EVA
rs3404823701	683	V>A	No	EVA
rs3389309676	699	I>T	No	EVA
rs3389272517	706	T>I	No	EVA
rs3389313483	724	Q>L	No	EVA

Type	Name	Position	InterPro Accession
repeat	Pentapeptide repeat	499 - 566	IPR001646
conserved_site	Sugar transporter, conserved site	250 - 275	IPR005829
domain	Major facilitator superfamily domain	154 - 722	IPR020846

		Description
EC Number
Subcellular Localization	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein	Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
anchoring junction	A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of synaptic vesicle membrane	The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
synaptic vesicle	A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
synaptic vesicle membrane	The lipid bilayer surrounding a synaptic vesicle.

Name	Definition
transmembrane transporter activity	Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Name	Definition
chemical synaptic transmission	The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
neurotransmitter transport	The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q17QN9	SLC22A16	Solute carrier family 22 member 16	Bos taurus (Bovine)	PR
Q1JP63	SVOP	Synaptic vesicle 2-related protein	Bos taurus (Bovine)	PR
Q9H015	SLC22A4	Solute carrier family 22 member 4	Homo sapiens (Human)	PR
Q7L1I2	SV2B	Synaptic vesicle glycoprotein 2B	Homo sapiens (Human)	PR
Q8N4V2	SVOP	Synaptic vesicle 2-related protein	Homo sapiens (Human)	PR
A6NKX4	SLC22A31	Putative solute carrier family 22 member 31	Homo sapiens (Human)	PR
Q496J9	SV2C	Synaptic vesicle glycoprotein 2C	Homo sapiens (Human)	PR
Q9Z0E8	Slc22a5	Solute carrier family 22 member 5	Mus musculus (Mouse)	PR
Q9Z306	Slc22a4	Solute carrier family 22 member 4	Mus musculus (Mouse)	PR
Q9D9E0	Slc22a17	Solute carrier family 22 member 17	Mus musculus (Mouse)	PR
Q8BFT9	Svop	Synaptic vesicle 2-related protein	Mus musculus (Mouse)	PR
Q497L8	Slc22a16	Solute carrier family 22 member 16	Mus musculus (Mouse)	PR
Q70BM6	SLC22A8	Organic anion transporter 3	Sus scrofa (Pig)	PR
Q9Z2I7	Svop	Synaptic vesicle 2-related protein	Rattus norvegicus (Rat)	PR
Q9R141	Slc22a4	Solute carrier family 22 member 4	Rattus norvegicus (Rat)	PR
Q9Z2I6	Sv2c	Synaptic vesicle glycoprotein 2C	Rattus norvegicus (Rat)	PR
Q7Z118	B0361.11	Putative transporter B0361.11	Caenorhabditis elegans	PR